Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
Produits appartenant à la catégorie "Autophagie"
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20-DEOXYINGENOL
CAS :20-DEOXYINGENOL is a natual product.Formule :C20H28O4Degré de pureté :99.98% - ≥95%Couleur et forme :SolidMasse moléculaire :332.43Ulipristal acetate
CAS :Ulipristal acetate (CDB-2914) is an oral selective progesterone modulator used for emergency contraception and suppressing uterine growths.Formule :C30H37NO4Degré de pureté :98.83% - 99.94%Couleur et forme :SolidMasse moléculaire :475.62SB 216763
CAS :SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Formule :C19H12Cl2N2O2Degré de pureté :99.13% - 99.61%Couleur et forme :SolidMasse moléculaire :371.22Ref: TM-T3077
2mg39,00€5mg52,00€10mg79,00€25mg131,00€50mg197,00€100mg334,00€500mg803,00€1mL*10mM (DMSO)52,00€SHP2-IN-35
SHP2-IN-35 (Compound 3f) functions as an inhibitor of SHP2. It exhibits antiproliferative activity in cancer cell lines RKO, SW480, and CT26, with IC50 values of 5.72 μM, 3.71 μM, and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the expression of cell cycle-related genes, and induces mitochondrial autophagy (autophagy). Within the tumor microenvironment (TME), SHP2-IN-35 suppresses the expression of certain cytokines and chemokines, thereby modulating tumor progression.Formule :C34H32FeO6Couleur et forme :SolidMasse moléculaire :592.46Norepinephrine
CAS :Norepinephrine (Levophed) can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway.Formule :C8H11NO3Degré de pureté :98.56% - 99.84%Couleur et forme :Colorless Micr°Crystals SolidMasse moléculaire :169.18PAC-1
CAS :PAC-1 (Procaspase activating compound 1) has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer and Thoracic Cancers.Formule :C23H28N4O2Degré de pureté :96.78% - 99.77%Couleur et forme :SolidMasse moléculaire :392.49Momelotinib
CAS :Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.Formule :C23H22N6O2Degré de pureté :97.47% - 99.56%Couleur et forme :SolidMasse moléculaire :414.46Ref: TM-T1849
1mg38,00€2mg49,00€5mg81,00€10mg95,00€25mg166,00€50mg259,00€100mg406,00€200mg625,00€1mL*10mM (DMSO)88,00€AGN 193109
CAS :AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).Formule :C28H24O2Degré de pureté :98.81% - 99.89%Couleur et forme :SolidMasse moléculaire :392.49Ginsenoside Rb1
CAS :Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.Formule :C54H92O23Degré de pureté :99.12% - 99.76%Couleur et forme :SolidMasse moléculaire :1109.29Rasagiline Mesylate
CAS :Rasagiline Mesylate (AGN1135) is a novel MAO-B inhibitor, which can treat idiopathic Parkinson's disease.Formule :C13H17NO3SDegré de pureté :99.33%Couleur et forme :White PowderMasse moléculaire :267.34Cucurbitacin E
CAS :Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.Formule :C32H44O8Degré de pureté :98.88% - 99.19%Couleur et forme :SolidMasse moléculaire :556.69Ref: TM-T5S1467
1mg59,00€5mg115,00€10mg177,00€25mg300,00€50mg445,00€100mg643,00€1mL*10mM (DMSO)140,00€Nutlin-3a
CAS :Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction. Nutlin-3a has antitumor activity. Cost-effective and quality-assured.Formule :C30H30Cl2N4O4Degré de pureté :95.62% - 99.71%Couleur et forme :SolidMasse moléculaire :581.49Ref: TM-T6023
1mg49,00€2mg70,00€5mg96,00€10mg164,00€25mg268,00€50mg398,00€100mg587,00€1mL*10mM (DMSO)135,00€Valinomycin
CAS :Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes ParkinFormule :C54H90N6O18Degré de pureté :100%Couleur et forme :White SolidMasse moléculaire :1111.32Sophocarpine monohydrate
CAS :Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.Formule :C15H22N2ODegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :246.35AM580
CAS :AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )Formule :C22H25NO3Degré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :351.44Ref: TM-T5854
2mg39,00€5mg57,00€10mg87,00€25mg164,00€50mg316,00€100mg469,00€500mg1.064,00€1mL*10mM (DMSO)64,00€LYN-1604
CAS :LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.Formule :C33H43Cl2N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :584.62Stavudine
CAS :Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.Formule :C10H12N2O4Degré de pureté :100% - 99.74%Couleur et forme :White PowderMasse moléculaire :224.213-Methyladenine
CAS :3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).Formule :C6H7N5Degré de pureté :98.02% - 99.51%Couleur et forme :SolidMasse moléculaire :149.15Typhaneoside
CAS :Typhaneoside (Aervitrin) is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Shaofu Zhuyu decoction.Formule :C34H42O20Degré de pureté :98.92% - 99.95%Couleur et forme :SolidMasse moléculaire :770.69Glycycoumarin
CAS :Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.Formule :C21H20O6Degré de pureté :97.64% - 99.78%Couleur et forme :SolidMasse moléculaire :368.38Ref: TM-TN1702
1mg42,00€5mg81,00€10mg122,00€25mg235,00€50mg348,00€100mg515,00€200mg743,00€1mL*10mM (DMSO)89,00€
