Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
Produits appartenant à la catégorie "Autophagie"
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D-CopA3
CAS :D-CopA3 is an inhibitor of MDM2 and an activator of the p53 signaling pathway. It exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO with IC50 values of 15-18 μM and induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of the cell cycle inhibitor protein p21Cip1/Waf1, enhances mucosal barrier function, and reduces infiltration of inflammatory mediators. It shows anti-inflammatory properties in mouse models of acute enteritis induced by C. difficile toxin A and chronic colitis induced by DSS. Additionally, D-CopA3 demonstrates antitumor activity in a mouse HCT-116 xenograft model.Formule :C96H184N30O18S2Couleur et forme :SolidMasse moléculaire :2110.816-Mercaptopurine
CAS :6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties.Formule :C5H4N4SDegré de pureté :99.53% - 99.63%Couleur et forme :Yellow Crystalline Powder SolidMasse moléculaire :152.18Nocodazole
CAS :Nocodazole: synthetic microtubule polymerization blocker, also impedes Abl with low IC50; binds to beta-tubulin.Formule :C14H11N3O3SDegré de pureté :98% - 99.91%Couleur et forme :Physical Description White Powder (Ntp 1992)Masse moléculaire :301.32Ref: TM-T2802
5mg37,00€10mg55,00€25mg99,00€50mg168,00€100mg283,00€200mg420,00€500mg682,00€1mL*10mM (DMSO)40,00€Penfluridol
CAS :Penfluridol (TLP-607) is a highly potent antipsychotic.Formule :C28H27ClF5NODegré de pureté :98.9% - 99.73%Couleur et forme :Off-White To White Crystalline PowderMasse moléculaire :523.97Scriptaid
CAS :Scriptaid (GCK1026) is an inhibitor of HDAC, and has a greater effect on acetylated H4 than H3.Formule :C18H18N2O4Degré de pureté :96.74% - 99.45%Couleur et forme :SolidMasse moléculaire :326.35Ref: TM-T6980
5mg71,00€10mg97,00€25mg205,00€50mg378,00€100mg567,00€500mg1.198,00€1mL*10mM (DMSO)79,00€Lamotrigine
CAS :Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer.Formule :C9H7Cl2N5Degré de pureté :99.76% - 99.95%Couleur et forme :White To Pale Cream-Colored Powder Crystals From Isopropanol SolidMasse moléculaire :256.09Sitagliptin phosphate
CAS :Sitagliptin phosphate (MK-0431 phosphate) is a dipeptidyl peptidase-4 (DPP4) inhibitor.Formule :C16H18F6N5O5PDegré de pureté :99.72% - 99.72%Couleur et forme :White SolidMasse moléculaire :505.31Sophocarpine
CAS :Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.Formule :C15H22N2ODegré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :246.35Nitroprusside disodium dihydrate
CAS :Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood.Formule :C5H4FeN6Na2O3Degré de pureté :98%Couleur et forme :Bright RedMasse moléculaire :297.95Dimethyl fumarate
CAS :Dimethyl fumarate (DMF) is an orally Nrf2 activator. Dimethyl fumarate has antimicrobial and anti-inflammatory activities. Cost-effective and quality-assured.Formule :C6H8O4Degré de pureté :100% - 99.88%Couleur et forme :White To Off-White Powder White Crystalline PowderMasse moléculaire :144.13Letrozole
CAS :Letrozole (CGS 20267) is an Aromatase Inhibitor. The mechanism of action of letrozole is as an Aromatase Inhibitor.Formule :C17H11N5Degré de pureté :98.67% - 99.84%Couleur et forme :White To Off-Whitecrystalline PowderMasse moléculaire :285.3MRT68921 dihydrochloride
CAS :MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).Formule :C25H36Cl2N6ODegré de pureté :100% - 98.91%Couleur et forme :SolidMasse moléculaire :507.499Eprenetapopt
CAS :Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells.Formule :C10H17NO3Degré de pureté :98.75% - 99.57%Couleur et forme :SolidMasse moléculaire :199.25Ref: TM-T4414
5mg73,00€10mg105,00€25mg207,00€50mg368,00€100mg652,00€500mg1.320,00€1mL*10mM (DMSO)81,00€3-Bromopyruvic acid
CAS :3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition.Formule :C3H3BrO3Degré de pureté :95% - 95%Couleur et forme :White To Pale Yellow Crystalline PowderMasse moléculaire :166.96SB 239063
CAS :SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.Formule :C20H21FN4O2Degré de pureté :99.42% - 99.81%Couleur et forme :SolidMasse moléculaire :368.4Corosolic acid
CAS :Corosolic acid inhibits angiogenesis, suppresses FAK, fights various cancers, induces apoptosis, and degrades β-catenin.Formule :C30H48O4Degré de pureté :99.46% - 99.88%Couleur et forme :Fine-Brown Yellow PowderMasse moléculaire :472.7OSU-T315
CAS :OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.Formule :C30H30F3N5ODegré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :533.59Ref: TM-T5485
1mg97,00€2mg144,00€5mg235,00€10mg378,00€25mg647,00€50mg920,00€100mg1.225,00€500mg2.498,00€1mL*10mM (DMSO)306,00€Gavilimomab
CAS :Gavilimomab(ABX-CBL) is a murine-derived IgM monoclonal antibody against CD147 antigen used in immunosuppressive treatments for glucocorticoid-resistant GVHD).Degré de pureté :95%Couleur et forme :LiquidSTF-62247
CAS :STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively.Formule :C15H13N3SDegré de pureté :99.3% - 99.67%Couleur et forme :SolidMasse moléculaire :267.35Ref: TM-T6683
5mg37,00€10mg50,00€25mg97,00€50mg167,00€100mg283,00€200mg434,00€500mg702,00€1mL*10mM (DMSO)40,00€PX-478
CAS :PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.Formule :C13H20Cl4N2O3Degré de pureté :97% - ≥98%Couleur et forme :SolidMasse moléculaire :394.12
