Autophagie
Les inhibiteurs de l'autophagie ciblent le processus cellulaire de l'autophagie, qui implique la dégradation et le recyclage des composants cellulaires via les lysosomes. L'autophagie est un mécanisme crucial pour maintenir l'homéostasie cellulaire, mais sa dérégulation est impliquée dans diverses maladies, y compris le cancer, les maladies neurodégénératives et les infections. Les inhibiteurs de l'autophagie peuvent bloquer ce processus, ce qui en fait des outils précieux pour étudier le rôle de l'autophagie dans les maladies et développer des stratégies thérapeutiques. Chez CymitQuimica, nous proposons des inhibiteurs de l'autophagie pour soutenir vos recherches en biologie cellulaire, oncologie et maladies neurodégénératives.
Produits appartenant à la catégorie "Autophagie"
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Regorafenib monohydrate
CAS :Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murineFormule :C21H17ClF4N4O4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :500.83Ref: TM-T1792L
5mg35,00€10mg48,00€25mg69,00€50mg88,00€100mg140,00€200mg207,00€500mg348,00€1mL*10mM (DMSO)58,00€Thalidomide
CAS :Thalidomide, a glutamic acid derivative, has teratogenic and immunomodulatory effects.Formule :C13H10N2O4Degré de pureté :98.88% - 99.88%Couleur et forme :White SolidMasse moléculaire :258.23Taxifolin
CAS :Taxifolin (Dihydroquercetin) is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.Formule :C15H12O7Degré de pureté :94.91% - 98.9%Couleur et forme :Yellowish PowderMasse moléculaire :304.25Beclin1-ATG14L interaction inhibitor 1
CAS :Beclin1-ATG14L Interaction Inhibitor 1 (COM 19) is a selective inhibitor targeting the specific interaction between Beclin1 and ATG14L.Formule :C23H24N4O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.53Matrine
CAS :Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.Formule :C15H24N2ODegré de pureté :100% - 97.16%Couleur et forme :SolidMasse moléculaire :248.36SLW131
CAS :SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.Formule :C21H27N5O5SCouleur et forme :SolidMasse moléculaire :461.535Alginic acid
CAS :Alginic acid, a polysaccharide from brown seaweed, has anti-anaphylactic and anti-inflammatory properties and is used in food industry.Formule :C14H22O13Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :398.317GSK-690693
CAS :GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.Formule :C21H27N7O3Degré de pureté :100% - 98.78%Couleur et forme :SolidMasse moléculaire :425.48Brivanib
CAS :Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold againstFormule :C19H19FN4O3Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :370.38Ref: TM-T6036
1mg47,00€5mg88,00€10mg144,00€25mg259,00€50mg375,00€100mg560,00€200mg815,00€1mL*10mM (DMSO)97,00€SGI-1776
CAS :SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Formule :C20H22F3N5ODegré de pureté :100% - 99.84%Couleur et forme :SolidMasse moléculaire :405.42Carboplatin
CAS :Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor.Formule :C6H12N2O4PtDegré de pureté :98% - 99.72%Couleur et forme :White Crystalline PowderMasse moléculaire :371.25Licochalcone A
CAS :Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.Formule :C21H22O4Degré de pureté :98.11% - 98.96%Couleur et forme :White Crystalline PowderMasse moléculaire :338.4PD 169316
CAS :PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.Formule :C20H13FN4O2Degré de pureté :98.65%Couleur et forme :SolidMasse moléculaire :360.34URB-597
CAS :URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.Formule :C20H22N2O3Degré de pureté :98.24%Couleur et forme :SolidMasse moléculaire :338.4LRRK2-IN-10
CAS :LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2Formule :C20H15N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :341.37LC3-mHTT-IN-AN1
CAS :LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B.Formule :C15H9Br2NO3Degré de pureté :97.26%Couleur et forme :SolidMasse moléculaire :411.04Spautin-1
CAS :Spautin-1 is an autophagy inhibitor that can suppress the deubiquitination activity of ubiquitin-specific peptidase USP10 and USP13. Cost-effective and quality-assured.Formule :C15H11F2N3Degré de pureté :97.69% - 98.99%Couleur et forme :SolidMasse moléculaire :271.26Nesolicaftor
CAS :Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.Formule :C18H18N4O4Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :354.36Ref: TM-T16681
1mg96,00€5mg215,00€10mg378,00€25mg650,00€50mg927,00€100mg1.254,00€1mL*10mM (DMSO)236,00€2-Methoxyestradiol
CAS :2-ME2, an estradiol derivative, hinders angiogenesis and tumor growth, causes cell apoptosis, and stops mitosis.Formule :C19H26O3Degré de pureté :98% - 99.95%Couleur et forme :Off-White SolidMasse moléculaire :302.41Schisandrin
CAS :Schisandrin (Wuweizi alcohol-A) is a compound with anti-asthmatic, anti-cancer, and anti-inflammatory effects.Formule :C24H32O7Degré de pureté :98.97% - 99.32%Couleur et forme :White PowderMasse moléculaire :432.51
