
DUB
Les inhibiteurs de déubiquitinases (DUB) ciblent les enzymes qui retirent les molécules d'ubiquitine des protéines, régulant ainsi la stabilité, la localisation et l'activité des protéines dans la cellule. Les déubiquitinases jouent un rôle essentiel dans divers processus cellulaires, notamment la régulation du cycle cellulaire, la réparation de l'ADN et les réponses immunitaires. La dérégulation de l'activité des DUB est liée au cancer, aux troubles neurodégénératifs et aux infections virales. Les inhibiteurs de DUB peuvent moduler ces processus, offrant des approches thérapeutiques potentielles pour ces conditions. Chez CymitQuimica, nous proposons des inhibiteurs de DUB pour soutenir vos recherches en homéostasie des protéines, en oncologie et en neurobiologie.
Produits appartenant à la catégorie "DUB"
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FT827
CAS :FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.Formule :C27H28N6O5SDegré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :548.61HBX 41108
CAS :HBX 41108: non-competitive, reversible USP7 inhibitor; IC50: 424nM; blocks USP7-p53 deubiquitination; IC50: 0.8μM.Formule :C13H3ClN4ODegré de pureté :95.63%Couleur et forme :SolidMasse moléculaire :266.64ML-323
CAS :ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.Formule :C23H24N6Degré de pureté :99.87% - 99.96%Couleur et forme :SolidMasse moléculaire :384.48Ref: TM-T1757
1mg89,00€5mg207,00€10mg331,00€25mg512,00€50mg775,00€100mg1.140,00€1mL*10mM (DMSO)245,00€USP7-IN-3
CAS :USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).Formule :C29H31F3N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :568.59Vialinin A
CAS :Vialinin A, a p-terphenyl with antioxidant properties, inhibits TNF-α/USP4/5/SENP1, used in autoimmune/cancer research.Formule :C34H26O8Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :562.57USP7-797
CAS :USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.Formule :C27H28ClN3O3SDegré de pureté :96.18%Couleur et forme :SolidMasse moléculaire :510.05USP30 inhibitor 11
CAS :USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Formule :C17H16N6O2SDegré de pureté :100% - 96.31%Couleur et forme :SolidMasse moléculaire :368.41USP8-IN-2
CAS :USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.Formule :C19H20ClF3N4OSDegré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :444.9Ref: TM-T67876
1mg88,00€5mg210,00€10mg329,00€25mg548,00€50mg782,00€100mg1.035,00€1mL*10mM (DMSO)245,00€NSC632839
CAS :NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2Formule :C21H22ClNODegré de pureté :99.74% - 99.87%Couleur et forme :SolidMasse moléculaire :339.86USP7-IN-8
CAS :Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.Formule :C21H21N3O2Degré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :347.41Ref: TM-T9217
1mg48,00€5mg97,00€10mg156,00€25mg284,00€50mg411,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)105,00€TCID
CAS :TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Formule :C9H2Cl4O2Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :283.92OTUB1/USP8-IN-1 HCl
OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemiaFormule :C22H17Cl2FN2O4Degré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :463.29DUB-IN-3
CAS :DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.Formule :C16H9N5ODegré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :287.28Ref: TM-T11112
1mg137,00€2mg188,00€5mg325,00€10mg465,00€25mg743,00€50mg1.035,00€100mg1.406,00€500mg2.802,00€1mL*10mM (DMSO)341,00€USP30 inhibitor 18
CAS :USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Formule :C26H28FN3O4SDegré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :497.58Ref: TM-T36682
1mg144,00€5mg298,00€10mg472,00€25mg753,00€50mg1.074,00€100mg1.444,00€500mg2.822,00€1mL*10mM (DMSO)325,00€P005091
CAS :P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.Formule :C12H7Cl2NO3S2Degré de pureté :99.53% - 99.87%Couleur et forme :SolidMasse moléculaire :348.22DUB-IN-1
CAS :DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).Formule :C20H11N5ODegré de pureté :98.33% - 98.96%Couleur et forme :SolidMasse moléculaire :337.33Ref: TM-T11110
1mg65,00€5mg116,00€10mg183,00€25mg353,00€50mg495,00€100mg652,00€200mg895,00€1mL*10mM (DMSO)128,00€MF-094
CAS :MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Formule :C30H37N3O4SDegré de pureté :98.46%Couleur et forme :SolidMasse moléculaire :535.7Ref: TM-T12024
1mg43,00€5mg87,00€10mg144,00€25mg283,00€50mg454,00€100mg655,00€500mg1.454,00€1mL*10mM (DMSO)120,00€I-138
CAS :I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Formule :C26H23F3N6ODegré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :492.5Ref: TM-T73560
1mg188,00€2mg255,00€5mg369,00€10mg597,00€25mg1.121,00€50mg1.700,00€100mg2.205,00€1mL*10mM (DMSO)425,00€EOAI3402143
CAS :EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.Formule :C25H28Cl2N4O3Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :503.42Ref: TM-T11209
1mg66,00€5mg144,00€10mg227,00€25mg445,00€50mg717,00€100mg1.064,00€1mL*10mM (DMSO)160,00€STD1T
CAS :STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.Formule :C19H19N3O4S2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :417.5