Signalisation du cytosquelette
Les inhibiteurs de la signalisation du cytosquelette sont des composés qui perturbent les voies de signalisation régulant le cytosquelette, essentiel pour la forme, la motilité, la division des cellules et le transport intracellulaire. Ces inhibiteurs sont utilisés pour étudier la dynamique des protéines du cytosquelette, telles que l'actine et la tubuline, et leur rôle dans des processus comme la migration cellulaire, l'adhésion et la métastase du cancer. Les inhibiteurs de la signalisation du cytosquelette sont précieux dans la recherche en biologie cellulaire, en cancérologie et en neurobiologie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la signalisation du cytosquelette de haute qualité pour soutenir vos recherches dans ces domaines.
Produits appartenant à la catégorie "Signalisation du cytosquelette"
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AZ82
CAS :AZ82 is an inhibitor of the kinesin-like protein KIFC1, which induces multipolar mitosis and apoptosis in prostate cancer cells.Formule :C28H31F3N4O3SDegré de pureté :99.31%Couleur et forme :SolidMasse moléculaire :560.63Kazinol B
CAS :Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity byFormule :C25H28O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :392.49Procyanidin A1
CAS :Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+.Formule :C30H24O12Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :576.5AKT Kinase Inhibitor HCl
AKT Kinase Inhibitor HCl is an Akt inhibitor with antitumor activity.Formule :C16H20ClN7O3Degré de pureté :98.87%Couleur et forme :SoildMasse moléculaire :393.83Taurochenodeoxycholic Acid
CAS :Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.Formule :C26H45NO6SDegré de pureté :99.69% - 99.86%Couleur et forme :SolidMasse moléculaire :499.7C16Y
CAS :C16Y, a short peptide, serves as an inhibitor for the integrins αvβ3 and α5β1. It targets the cell membrane and exerts its antitumor activity by inhibiting angiogenesis.Formule :C78H115N17O17Couleur et forme :SolidMasse moléculaire :1562.85Gedunin
CAS :Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.Formule :C28H34O7Degré de pureté :99.38% - 99.68%Couleur et forme :SolidMasse moléculaire :482.57Ref: TM-T21883
1mg393,00€5mg1.169,00€10mg1.596,00€25mg2.365,00€50mg3.192,00€100mg4.304,00€1mL*10mM (DMSO)1.283,00€Si306
CAS :Si306, an Src inhibitor, exhibits antitumor activity by reducing the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), thereby inhibiting the invasion of human glioblastoma (GBM).Formule :C25H26BrClN6OSCouleur et forme :SolidMasse moléculaire :573.94Cucurbitacin B
CAS :Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Formule :C32H46O8Degré de pureté :97.10% - 99.33%Couleur et forme :SolidMasse moléculaire :558.7Afuresertib
CAS :Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplasticFormule :C18H17Cl2FN4OSDegré de pureté :97.51% - 99.17%Couleur et forme :SolidMasse moléculaire :427.32Ref: TM-T1911
1mg39,00€2mg50,00€5mg79,00€10mg97,00€25mg170,00€50mg274,00€100mg477,00€500mg1.035,00€1mL*10mM (DMSO)79,00€Ζ-Stat
CAS :ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis inFormule :C10H8O10S3Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :384.36FRAX1036
CAS :FRAX-1036 is a effective and selective PAK1 inhibitor.Formule :C28H32ClN7ODegré de pureté :97.66% - 99.95%Couleur et forme :SolidMasse moléculaire :518.05Ref: TM-T6839
1mg51,00€2mg69,00€5mg87,00€10mg119,00€25mg210,00€50mg354,00€100mg512,00€1mL*10mM (DMSO)97,00€JB002
CAS :JB002, a myosin II inhibitor, exhibits potent activity with an IC50 of ≤10 μM.Formule :C18H15NO3Degré de pureté :99.02%Couleur et forme :SoildMasse moléculaire :293.32Ref: TM-T72023
1mg77,00€5mg169,00€10mg264,00€25mg535,00€50mg747,00€100mg1.035,00€500mg2.072,00€1mL*10mM (DMSO)180,00€Monomethyl lithospermate
CAS :Monomethyl lithospermate shows antiviral traits, aids ischemic stroke via PI5K/Akt, protects SHSY-3Y cells, and reduces oxidative stress in MCAO rats.Formule :C28H24O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :552.48CFI-402257
CAS :CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.Formule :C28H30N6O3Degré de pureté :96.66% - 99.51%Couleur et forme :SolidMasse moléculaire :498.58HIV-1 protease-IN-10
HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) andFormule :C23H40O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :396.56PS315
CAS :PS315, a PS48 derivative, allosterically inhibits PKCζ/η (IC50: 10/30 μM), targeting aPKC's PIF-pocket, with anti-cancer properties.Formule :C23H19ClO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :362.85PKN1/2-IN-1
CAS :PKN1/2-IN-1 is a potent and selective PKN2 inhibitor, membrane permeability and anticancer.Protein kinase N proteins (PKN) are effectors of Rho GTPases.Formule :C14H15N3OCouleur et forme :SolidMasse moléculaire :241.29POSH-IN-2
CAS :POSH-IN-2 (MIDI) is a mitochondrial fission inhibitor and a DRP1 inhibitor that effectively prevents mitochondrial fragmentation caused by cellular stress and genetic mitochondrial damage. It covalently interacts with DRP1-C367 to target the interaction of DRP1 with multiple receptors.Formule :C22H16N2O2Couleur et forme :SolidMasse moléculaire :340.37BCR-ABL-IN-9
BCR-ABL-IN-9 (Compound B1) is an inhibitor of BCR-ABL that achieves sustained suppression through the formation of stable covalent bonds with the ABL kinase. It effectively inhibits the activity of ABL kinase (IC50 = 1.2 nM) and possesses anticancer activity.Formule :C22H20N4O3Couleur et forme :SolidMasse moléculaire :388.42KW-2449
CAS :KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Formule :C20H20N4ODegré de pureté :98.43% - 99.89%Couleur et forme :SolidMasse moléculaire :332.4TRAP1-IN-1
TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90.Formule :C45H39F7N2O4P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :866.74Ifebemtinib FA
BI-853520 FA (Ifebemtinib FA) is an orally active inhibitor of adhesion patch kinase with anticancer and antiproliferative activity for ovarian and lung cancer.Formule :C29H30F4N6O6Degré de pureté :98.40% - 99.62%Couleur et forme :SolidMasse moléculaire :634.58HSP90-IN-25
HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].Formule :C29H48O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :556.69KUNG65
CAS :KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.Formule :C23H20ClFO4Couleur et forme :SolidMasse moléculaire :414.85KIF18A-IN-15
CAS :KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, both with an IC50 range of 0.01-0.1 μM. These compounds inhibit the viability of OVCAR-3 cells, with IC50 values of 0.01-0.1 μM for EX36-A and 0-0.01 μM for EX36-B. KIF18A-IN-15 is applicable in research on tumors, including colon, breast, and lung cancers.Formule :C25H33F3N6O5SCouleur et forme :SolidMasse moléculaire :586.63CCT128930
CAS :'CCT128930, potent Akt2 inhibitor (IC50=6 nM), 28x more selective over PKA.'Formule :C18H20ClN5Degré de pureté :99.07% - 99.18%Couleur et forme :SolidMasse moléculaire :341.84Ref: TM-T6303
2mg42,00€5mg65,00€10mg94,00€25mg170,00€50mg273,00€100mg409,00€200mg652,00€1mL*10mM (DMSO)71,00€BTB-1
CAS :BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.Formule :C12H8ClNO4SDegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :297.71Kif15-IN-2
CAS :Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.Formule :C20H20N6O4SDegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :440.48PKCε inhibitor peptide,myristoylated
Myristoylated PKCε inhibitor peptide (Myr-PKCε-) is a cell-permeable inhibitor consisting of a peptide linked to myristic acid that specifically inhibitsFormule :C51H91N9O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1054.32PU-H71 HCl
CAS :PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.Formule :C18H22ClIN6O2SDegré de pureté :98.95%Couleur et forme :SoildMasse moléculaire :548.83αvβ1 integrin-IN-2
CAS :αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.Formule :C29H38N4O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.64Vinblastine
CAS :Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.Formule :C46H58N4O9Degré de pureté :97.42%Couleur et forme :PowderMasse moléculaire :810.97CYP51/Hsp90-IN-1
CYP51/Hsp90-IN-1 (Compound MM4) is a dual inhibitor of CYP51 and Hsp90. This compound exhibits antifungal activity against Candida albicans and effectively suppresses key fungal virulence factors. CYP51/Hsp90-IN-1 shows potential for research in treating invasive candidiasis.Formule :C38H40F2N6O4Couleur et forme :SolidMasse moléculaire :682.76A-205804
CAS :A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.Formule :C15H12N2OS2Degré de pureté :98.07% - 98.52%Couleur et forme :SolidMasse moléculaire :300.4Ref: TM-T2254
2mg44,00€5mg52,00€10mg81,00€25mg160,00€50mg271,00€100mg532,00€500mg1.169,00€1mL*10mM (DMSO)71,00€GPRP
CAS :GPRP (Gly-Pro-Arg-Pro) is a fibrin polymerization inhibitor.Formule :C18H31N7O5Couleur et forme :White To Off-White PowderMasse moléculaire :425.48Gap 26
CAS :Gap 26 is a mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.Formule :C70H107N19O19SDegré de pureté :98.26%Couleur et forme :SolidMasse moléculaire :1550.78Bepranemab
CAS :Bepranemab (UCB 0107) - humanized IgG4 monoclonal antibody targeting tau (235-250) for Alzheimer's research.Degré de pureté :95% - 95%Couleur et forme :LiquidSU6656
CAS :SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.Formule :C19H21N3O3SDegré de pureté :97% - 98.21%Couleur et forme :SolidMasse moléculaire :371.45Ref: TM-T6997
1mg40,00€2mg51,00€5mg85,00€10mg139,00€25mg269,00€50mg449,00€100mg667,00€1mL*10mM (DMSO)88,00€TRC051384
CAS :TRC051384 is a HSP70 inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke.Formule :C25H31N5O4Degré de pureté :92.66%Couleur et forme :SolidMasse moléculaire :465.54Ref: TM-T3527
1mg37,00€5mg80,00€10mg111,00€25mg210,00€50mg298,00€100mg432,00€200mg622,00€1mL*10mM (DMSO)81,00€Meclofenamic acid
CAS :Meclofenamic acid: non-selective gap-junction blocker, FTO inhibitor, anti-inflammatory.Formule :C14H11Cl2NO2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :296.15Tubulin polymerization-IN-47
CAS :Tubulin polymerization-IN-47 is a tubulin polymerization inhibitor and mitotic inhibitor with antitumor activity and inhibitory effects on neuroblastoma cancerFormule :C22H21N3O3Degré de pureté :99.69%Couleur et forme :SoildMasse moléculaire :375.42Adhibin
Adhibin is an allosteric inhibitor of RhoGAP class IX myosin (RhoGAP class IXmyosin), effectively inhibiting Myo9 ATPase in both mammals and invertebrates with an IC50 of 2.5 µM and 2.6 µM, respectively. It binds to ATPase, disrupting myosin's motor functions, blocking RhoGTPase-related signaling pathways, and affecting cellular migration, adhesion, and division. Adhibin is applicable for research in cancer metastasis.Formule :C13H9Br2NOCouleur et forme :SolidMasse moléculaire :355.02Terflavoxate
CAS :Terflavoxate is a novel, orally active, semisynthetic statin microtubule inhibitor commonly used in combination with capecitabine.Formule :C26H29NO4Degré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :419.51Meclofenamic acid sodium
CAS :Meclofenamic acid sodium (Movens), a non-steroidal anti-inflammatory agent, has properties of antipyretic and antigranulation activities.Formule :C14H10Cl2NNaO2Degré de pureté :98% - 98.96%Couleur et forme :SolidMasse moléculaire :318.14PKCα (C2-4) inhibitor peptide
PKCα (C2-4) inhibitor peptide is a specific antagonist to PKCα that impedes the α1A-adrenoreceptor agonist A-61603 [1] from inhibiting I_Kr.Formule :C47H74N14O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1107.17TAT-Gap19 acetate
TAT-Gap19 acetate, a Cx43 HC inhibitor, crosses blood-brain barrier, reduces liver fibrosis in mice, and spares Cx43 GJCs.Formule :C119H212N46O26Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :2703.25Dimethylenastron
CAS :Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.Formule :C16H18N2O2SDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :302.39Ref: TM-T3118
1mg35,00€2mg48,00€5mg62,00€10mg87,00€25mg156,00€50mg235,00€100mg354,00€1mL*10mM (DMSO)67,00€MKLP2-IN-1
CAS :MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.Formule :C23H19BrFN3O2Couleur et forme :SolidMasse moléculaire :468.318M2698
CAS :M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.Formule :C21H19ClF3N5ODegré de pureté :99.36%Couleur et forme :SolidMasse moléculaire :449.86Ref: TM-T11928
1mg50,00€5mg105,00€10mg170,00€25mg329,00€50mg475,00€100mg655,00€200mg883,00€1mL*10mM (DMSO)123,00€JB061
JB061 is a nonmuscle myosin inhibitor, demonstrating selective inhibitory activity with IC50 values of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscleFormule :C19H17NO4Degré de pureté :98.76%Couleur et forme :SoildMasse moléculaire :323.34Ref: TM-T67951
1mg39,00€5mg84,00€10mg114,00€25mg202,00€50mg304,00€100mg452,00€500mg938,00€1mL*10mM (DMSO)92,00€KTC1101
CAS :KTC1101 is a pan-PI3K inhibitor with antiproliferative and anticancer activities, reducing phosphorylation of downstream AKT and mTOR.Formule :C21H26F2N8O3Degré de pureté :98.75%Couleur et forme :SoildMasse moléculaire :476.48Ref: TM-T89831
1mg80,00€5mg158,00€10mg248,00€25mg495,00€50mg800,00€100mg1.283,00€1mL*10mM (DMSO)158,00€BJE6-106
CAS :BJE6-106 (B106) is a potent, selective PKCδ inhibitor (IC50: 0.05 μM) and targets selectivity over classical PKCα (IC50: 50 μM).Formule :C26H23NO2Couleur et forme :SolidMasse moléculaire :381.47RO0270608
CAS :RO0270608 is an α4β1/α4β7 integrin antagonist with anti-inflammatory activity for the study of allergic inflammatory responses.Formule :C24H19Cl3N2O4Degré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :505.78Chelerythrine
CAS :1.Formule :C21H18NO4Degré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :348.37Danegaptide Hydrochloride
CAS :Danegaptide Hydrochloride (GAP-134 (Hydrochloride)) (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein.Formule :C14H18ClN3O4Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :327.76Rifabutin
CAS :Rifabutin (LM-427), a semisynthetic ansamycin, blocks bacterial RNA synthesis by inhibiting RNA polymerase.Formule :C46H62N4O11Degré de pureté :99.27% - 99.8%Couleur et forme :Red-Violet Crystalline PowderMasse moléculaire :847GNF-5
CAS :GNF-5, non-ATP Bcr-Abl inhibitor (IC50: 0.22±0.1 uM, wild-type), improves upon GNF-2 with better pharmacokinetics.Formule :C20H17F3N4O3Degré de pureté :98% - 99.98%Couleur et forme :SolidMasse moléculaire :418.37CK-636
CAS :CK-636 (CK-0944636), an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human, fission yeast and bovine Arp2/3 complex.Formule :C16H16N2OSDegré de pureté :98.10% - 98.88%Couleur et forme :SolidMasse moléculaire :284.38Gap 27
CAS :Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker.Formule :C60H101N15O17Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :1304.53Pivanex
CAS :Pivanex, an oral HDAC inhibitor, targets metastasis, angiogenesis, reduces Bcr-Abl protein, and promotes apoptosis.Formule :C10H18O4Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :202.25MMAD
CAS :MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).Formule :C41H66N6O6SDegré de pureté :99.25% - 99.91%Couleur et forme :SolidMasse moléculaire :771.06Tasiamide B
CAS :Tasiamide B is a linear peptide and Cathepsin D inhibitor discovered in the marine cyanobacterium Symploca sp. This compound serves as an excellent template for the development of aspartic protease inhibitors. Tasiamide B effectively targets skin cancer through its strong interaction with the protein HSP90.Formule :C50H74N8O12Couleur et forme :SolidMasse moléculaire :979.17Crolibulin
CAS :Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.Formule :C18H17BrN4O3Degré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :417.26Ref: TM-T15012
1mg64,00€2mg92,00€5mg137,00€10mg216,00€25mg376,00€50mg562,00€100mg753,00€1mL*10mM (DMSO)150,00€LXW7 TFA (1313004-77-1 free base)
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect.Formule :C31H49F3N12O14S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :934.92GSK 3008348 hydrochloride
CAS :GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis.Formule :C29H37N5O2xHClDegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :0Cyclo(RGDyK) trifluoroacetate
CAS :Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Formule :C31H43F6N9O12Degré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :847.72SS28
CAS :SS28 inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase.Formule :C18H20O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :284.35AST 487
CAS :AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.Formule :C26H30F3N7O2Degré de pureté :98.17% - 99.56%Couleur et forme :SolidMasse moléculaire :529.56Ref: TM-T4053
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg187,00€50mg354,00€100mg528,00€500mg1.159,00€1mL*10mM (DMSO)92,00€Eg5-IN-1
Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.Formule :C23H16ClFN4ODegré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :418.85PKCTheta-IN-2
CAS :PKCTheta-IN-2 (compound 14) is a potent and selective inhibitor of PKCθ, with an IC50 value of 0.25 nM. It demonstrates good selectivity across a broad range of kinases, including the PKC subfamily (30 kinases). Additionally, PKCTheta-IN-2 effectively inhibits the production of IL-2 in mice, where it exhibits an IC50 of 682 nM.Formule :C24H23N5O2Couleur et forme :SolidMasse moléculaire :413.47Sabeluzole
CAS :Sabeluzole (R-58735) has antiepileptic and cognitive enhancing properties and may be used in the study of Alzheimer's disease.Formule :C22H26FN3O2SDegré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :415.52Zagotenemab
CAS :Zagotenemab: humanized antibody targeting tau protein to study neurological disorders, including Alzheimer's.Degré de pureté :95% - > 95%Couleur et forme :LiquidMasse moléculaire :145.3 kDaNilotinib
CAS :Nilotinib (AMN107) is a Bcr-Abl tyrosine kinase inhibitor. Nilotinib has antitumor activity and may be used in CML. Cost-effective and quality-assured.Formule :C28H22F3N7ODegré de pureté :99.61% - 99.83%Couleur et forme :Off-White SolidMasse moléculaire :529.52PKC-iota inhibitor 1
CAS :PKC-iota inhibitor 1 is an inhibitor of protein kinase C-iota (PKC-ι ; IC50 : 0.34 μM)Formule :C21H22N6ODegré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :374.44Ref: TM-T8764
1mg113,00€2mg160,00€5mg230,00€10mg369,00€25mg615,00€50mg879,00€100mg1.198,00€500mg2.395,00€1mL*10mM (DMSO)240,00€gp96-II
Gp96-II is a gp96-blocking peptide that antagonizes cytokine production induced by gp96-mediated LPS. This compound is useful for research into inflammatory diseases.Formule :C200H353N59O53SCouleur et forme :SolidMasse moléculaire :4464.37ZINC00640089
CAS :ZINC00640089: Selective LCN2 inhibitor; curbs SUM149 cell growth and AKT activity; useful for IBC research.Formule :C20H13F3N2O2Degré de pureté :98.13% - 99.27%Couleur et forme :SolidMasse moléculaire :370.32AMP-PCP
CAS :AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.Formule :C11H18N5O12P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.21Aurothiomalate tetramer sodium
Aurothiomalate tetramer sodium, a tetrameric form of Aurothiomalate sodium, functions as an anti-arthritis gold agent. It also acts as a potent and selective inhibitor of the oncogenic PKCι signaling pathway.Couleur et forme :Odour Solid2-Methoxyhydroquinone
CAS :2-Methoxyhydroquinone is a phenolic compound that reduces the production of TNF-α-induced chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 64.3 µM. It also serves as a synthetic precursor to the Hsp90 inhibitor Geldanamycin.Formule :C7H8O3Couleur et forme :SolidMasse moléculaire :140.14Gly3-VC-PAB-MMAE
CAS :Gly3-VC-PAB-MMAE Compound consisting of the ADC linker Gly3-VC-PAB and the microtubule inhibitor MMAE, which can be used to synthesize ADC compounds.Formule :C64H103N13O15Couleur et forme :SolidMasse moléculaire :1294.58T-900607
CAS :T-900607 is a novel microtubule protein active agent that disrupts microtubule polymerization through a unique mechanism of action. t-900607 is cardiotoxic.Formule :C14H10F5N3O4SDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :411.3HG-7-85-01
CAS :HG-7-85-01 is a novel ATP-competitive and type II tyrosine kinase inhibitor targeting both wild-type and watchman mutant BCR-ABL, PDGFRα, Kit, and Src kinases.Formule :C31H31F3N6O2SDegré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :608.68MKT-077
CAS :MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines.Formule :C21H22ClN3OS2Degré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :432BIIB021
CAS :BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).Formule :C14H15ClN6ODegré de pureté :98% - 99.82%Couleur et forme :SolidMasse moléculaire :318.76αvβ6-IN-2
αvβ6-IN-2 (compound 20) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 7.8. It shows potential for use in research on idiopathic pulmonary fibrosis.Formule :C25H30F3N3O3Couleur et forme :SolidMasse moléculaire :477.523-Phenyltoxoflavin
CAS :3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.Formule :C13H11N5O2Degré de pureté :98.84%Couleur et forme :SolidMasse moléculaire :269.26Ref: TM-T36123
1mg57,00€5mg120,00€10mg187,00€25mg338,00€50mg512,00€100mg753,00€200mg1.035,00€1mL*10mM (DMSO)133,00€Elarofiban TFA
CAS :Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.Formule :C26H34F6N4O8Degré de pureté :100%Couleur et forme :SoildMasse moléculaire :644.56CH5138303
CAS :CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.Formule :C19H18ClN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :415.9Imatinib impurities3
CAS :Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively.Formule :C24H20ClN5ODegré de pureté :97.05%Couleur et forme :SolidMasse moléculaire :429.9TRC051384 HCl
CAS :TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.Formule :C25H32ClN5O4Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :502.01AMP-PCP disodium
CAS :AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.Formule :C11H16N5Na2O12P3Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :549.17VER-82576
CAS :VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.Formule :C21H23Cl2N5O2SDegré de pureté :98% - 99.16%Couleur et forme :SolidMasse moléculaire :480.41Bafetinib
CAS :Bafetinib (INNO-406): Dual Bcr-Abl/Lyn inhibitor; IC50: 5.8/19 nM; ineffective against T315I mutant, less on c-Kit/PDGFR.Formule :C30H31F3N8ODegré de pureté :94.16% - 99.68%Couleur et forme :SolidMasse moléculaire :576.62Ref: TM-T6311
1mg37,00€2mg52,00€5mg79,00€10mg103,00€25mg159,00€50mg188,00€100mg350,00€200mg455,00€1mL*10mM (DMSO)90,00€HSP90-IN-35
CAS :HSP90-IN-35 is an inhibitor targeting Hsp90, exhibiting anticancer activity. It demonstrates an IC50 ranging from 0.05 to 0.5 μM against Her2. Additionally, HSP90-IN-35 can be utilized in the synthesis of PROTAC.Formule :C27H33N5O5Couleur et forme :SolidMasse moléculaire :507.58Pyrintegrin
CAS :Pyrintegrin: β1-integrin agonist, boosts embryonic stem cell survival, and podocyte protection, improves cell-matrix adhesion.Formule :C23H25N5O3SDegré de pureté :97.81%Couleur et forme :SolidMasse moléculaire :451.54Ref: TM-T16695
1mg82,00€2mg96,00€5mg159,00€10mg226,00€25mg435,00€50mg648,00€100mg924,00€200mg1.225,00€1mL*10mM (DMSO)168,00€KX2-361
CAS :KX2-361 is a orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastomaFormule :C24H24FN3O2Degré de pureté :98.52% - 99.86%Couleur et forme :SolidMasse moléculaire :405.46Ref: TM-T9411
1mg81,00€5mg170,00€10mg235,00€25mg386,00€50mg543,00€100mg730,00€200mg938,00€1mL*10mM (DMSO)182,00€Erbulozole
CAS :Erbulozole (R 55104) is a synthetic microtubule inhibitor with anti-invasive activity that induces Wernicke's encephalopathy-like neurotoxicity.Formule :C24H27N3O5SDegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :469.55Darovasertib
CAS :Darovasertib (LXS196) is a potent PKC inhibitor, orally active, with IC50 of 1.9 nM (PKCα), 0.4 nM (PKCθ), 3.1 μM (GSK3β).Formule :C22H23F3N8ODegré de pureté :98.72% - ≥95%Couleur et forme :SolidMasse moléculaire :472.47Ref: TM-T5600
1mg52,00€5mg136,00€10mg188,00€25mg350,00€50mg522,00€100mg750,00€200mg1.026,00€1mL*10mM (DMSO)149,00€CEP-37440
CAS :CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Formule :C30H38ClN7O3Degré de pureté :98.86% - 99.98%Couleur et forme :SolidMasse moléculaire :580.12
