Signalisation du cytosquelette
Les inhibiteurs de la signalisation du cytosquelette sont des composés qui perturbent les voies de signalisation régulant le cytosquelette, essentiel pour la forme, la motilité, la division des cellules et le transport intracellulaire. Ces inhibiteurs sont utilisés pour étudier la dynamique des protéines du cytosquelette, telles que l'actine et la tubuline, et leur rôle dans des processus comme la migration cellulaire, l'adhésion et la métastase du cancer. Les inhibiteurs de la signalisation du cytosquelette sont précieux dans la recherche en biologie cellulaire, en cancérologie et en neurobiologie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la signalisation du cytosquelette de haute qualité pour soutenir vos recherches dans ces domaines.
Produits appartenant à la catégorie "Signalisation du cytosquelette"
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PKCθ pseudosubstrate peptide inhibitor,myristoylated
Myristoylated PKCθ pseudosubstrate peptide inhibitor is a synthetic peptide utilized to investigate the mechanism of action of protein kinase C theta (PKCθ) [1Formule :C105H184N36O21SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2318.88Miransertib
CAS :Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor.Formule :C27H24N6Degré de pureté :98.83% - ≥95%Couleur et forme :SolidMasse moléculaire :432.52Ref: TM-T3467
1mg52,00€5mg97,00€10mg169,00€25mg344,00€50mg567,00€100mg908,00€500mg1.795,00€1mL*10mM (DMSO)114,00€Defactinib hydrochloride
CAS :Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.Formule :C20H22ClF3N8O3SDegré de pureté :98.06% - 98.78%Couleur et forme :SolidMasse moléculaire :546.95Midostaurin
CAS :PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.Formule :C35H30N4O4Degré de pureté :100% - 99.47%Couleur et forme :SolidMasse moléculaire :570.64Ref: TM-T3211
1mg51,00€5mg88,00€10mg126,00€25mg216,00€50mg328,00€100mg487,00€500mg1.093,00€1mL*10mM (DMSO)96,00€LY3372689
CAS :LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor for tau protein-based disorders including Alzheimer's disease.Formule :C16H22FN5O3SDegré de pureté :99.27% - 99.45%Couleur et forme :SolidMasse moléculaire :383.44Ref: TM-T61661
1mg99,00€5mg235,00€10mg354,00€25mg635,00€50mg935,00€100mg1.415,00€1mL*10mM (DMSO)259,00€Multi-kinase inhibitor 1
CAS :Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor.Formule :C20H17F3N4O3Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :418.37FRAX597
CAS :FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM).Formule :C29H28ClN7OSDegré de pureté :97.34% - 99.85%Couleur et forme :SolidMasse moléculaire :558.1Ansamitocin P 3'
CAS :Ansamitocin P 3' (Maytansinol butyrate) is an antibody-drug conjugate cytotoxin with antitumor activity.Formule :C32H43ClN2O9Degré de pureté :98.16% - 99.16%Couleur et forme :SolidMasse moléculaire :635.14Ref: TM-T1910
2mg34,00€5mg50,00€10mg84,00€25mg145,00€50mg229,00€100mg340,00€200mg472,00€1mL*10mM (DMSO)70,00€Ifebemtinib
CAS :Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.Formule :C28H28F4N6O4Degré de pureté :98.07% - 99.82%Couleur et forme :SolidMasse moléculaire :588.55Ionomycin calcium
CAS :Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.Formule :C41H70CaO9Degré de pureté :98% - 98.11%Couleur et forme :SolidMasse moléculaire :747.07NAMI-A
CAS :NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.Formule :C8H15Cl4N4ORuSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :458.18Ipfencarbazone
CAS :Ipfencarbazone herbicide agent, is a substance being developed for the control of weeds such as watergrass in rice.Formule :C18H14Cl2F2N4O2Couleur et forme :SolidMasse moléculaire :427.23Dynapyrazole A
CAS :Dynapyrazole A inhibits dynein 1 and 2 (IC50s: 2.3, 2.6 μM) and Hedgehog signaling (IC50: 1.9 μM).Formule :C20H12ClIN4ODegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :486.69RWJ 50271
CAS :RWJ 50271 inhibits LFA-1/ICAM-1 interaction with IC50 5.0 μM in HL60 cells.Formule :C18H17F3N4O2SDegré de pureté :99.09%Couleur et forme :SolidMasse moléculaire :410.41Ref: TM-T12783
1mg127,00€5mg311,00€10mg472,00€25mg747,00€50mg1.017,00€100mg1.311,00€200mg1.786,00€1mL*10mM (DMSO)344,00€AMP-945
CAS :AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.Formule :C28H32F3N5O2Degré de pureté :99.60%Couleur et forme :SolidMasse moléculaire :527.58Ref: TM-T9576
1mg97,00€5mg188,00€10mg311,00€25mg533,00€50mg755,00€100mg1.035,00€1mL*10mM (DMSO)254,00€Etrolizumab
CAS :MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.Degré de pureté :95% - 95%Couleur et forme :LiquidAdhesamine diTFA
CAS :Adhesamine diTFA, a dumbbell-shaped molecule, activates the MAPK/FAK pathway. It promotes adhesion and growth in mammalian cells and accelerates differentiation and enhances the survival rate of primary cultured mouse hippocampal neurons.Formule :C28H32Cl2F6N8O6S2Couleur et forme :SolidMasse moléculaire :825.63BX-2819
CAS :BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM .Formule :C21H24N4O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :428.51αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).Formule :C28H35F3N6O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :672.67Hydroxy-Dynasore
CAS :Hydroxy-Dynasore (Dyngo-4a) , a effective dynamin inhibitor, inhibits withDynI (brain), DynI (rec), and DynII (rec) of IC50 of 0.38 μM, 1.1 μM, and 2.3 μM,Formule :C18H14N2O5Degré de pureté :100% - 97.60%Couleur et forme :SolidMasse moléculaire :338.31Ref: TM-T6822
5mg50,00€10mg84,00€25mg137,00€50mg221,00€100mg329,00€200mg490,00€500mg783,00€1mL*10mM (DMSO)55,00€αvβ6-IN-1
αvβ6-IN-1 (compound 28) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 8.1. This compound shows potential for research in idiopathic pulmonary fibrosis.Formule :C25H32F2N4O3Couleur et forme :SolidMasse moléculaire :474.5416-38-Thymosin β4 (cattle) (TFA)
Thymosin β4 (cattle) TFA is a high-affinity activator of MLCK that operates independently of Ca2+ [1].Formule :C120H205F3N32O43Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2841.1K858 (Racemic)
CAS :K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.Formule :C13H15N3O2SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :277.34AZ13705339
CAS :AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM.Formule :C33H36FN7O3SDegré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :629.75FAK-IN-7
CAS :FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.Formule :C16H13N3OSDegré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :295.36AJH-836
CAS :AJH-836 is a compound that activates Munc13-1 and PKC ε/α, demonstrating a dissociation constant (Kd) of 4.5 nM for PKCα, and facilitates the translocation ofFormule :C22H38O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :382.5310-Deacetyltaxol
CAS :10-Deacetyltaxol (10-DAT) is extracted from Taxus brevifolia barks.Formule :C45H49NO13Degré de pureté :94.63% - 99.93%Couleur et forme :SolidMasse moléculaire :811.87Tadocizumab
CAS :Tadocizumab (C4G1) is a humanized monoclonal antibody targeting integrin αIIbβ3 with antiplatelet and antithrombotic effects.Couleur et forme :LiquidKNK437
CAS :KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).Formule :C13H11NO4Degré de pureté :98.90%Couleur et forme :SolidMasse moléculaire :245.23PKC-IN-1
CAS :PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,Formule :C25H37FN8O2Degré de pureté :98% - 98.79%Couleur et forme :SolidMasse moléculaire :500.61Gamitrinib TPP
CAS :Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.Formule :C52H65N3O8PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :891.078API-1
CAS :API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .Formule :C13H15N5O6Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :337.29Ref: TM-T8969
1mg59,00€5mg125,00€10mg207,00€25mg376,00€50mg562,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)133,00€AKT-IN-1
CAS :AKT-IN-1 (AZD-26) is an allosteric AKT inhibitor (IC50: 1.04 μM).Formule :C22H21N3ODegré de pureté :98.63%Couleur et forme :SolidMasse moléculaire :343.42Ref: TM-T4489
1mg113,00€2mg158,00€5mg235,00€10mg400,00€25mg652,00€50mg909,00€100mg1.225,00€1mL*10mM (DMSO)188,00€HSP70/SIRT2-IN-2
CAS :HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].Formule :C17H13N3S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :355.5LXH254
CAS :LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.Formule :C25H25F3N4O4Degré de pureté :98.3% - 99.92%Couleur et forme :SolidMasse moléculaire :502.49Ref: TM-T11898
1mg52,00€5mg122,00€10mg185,00€25mg363,00€50mg567,00€100mg690,00€200mg948,00€500mg1.444,00€1mL*10mM (DMSO)135,00€Debio 0932
CAS :Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Formule :C22H30N6O2SDegré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :442.58AT9283
CAS :AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Formule :C19H23N7O2Degré de pureté :99.83% - 99.98%Couleur et forme :SolidMasse moléculaire :381.43Ref: TM-T3068
1mg47,00€2mg60,00€5mg95,00€10mg170,00€25mg299,00€50mg499,00€100mg723,00€1mL*10mM (DMSO)97,00€Bisindolylmaleimide III
CAS :Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).Bisindolylmaleimide III selectively interacts with PKCα or ribosomal S6Formule :C23H20N4O2Degré de pureté :98.6%Couleur et forme :SolidMasse moléculaire :384.43Pifithrin-μ
CAS :Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.Formule :C8H7NO2SDegré de pureté :99.33% - 99.79%Couleur et forme :SolidMasse moléculaire :181.21KP-23172
CAS :KP-23172 is a inhibitor of PI3-K/Akt pathway.Formule :C10H4N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :224.18ML346
CAS :ML346 is a novel activator of Hsp70.Formule :C14H12N2O4Degré de pureté :99.25% - 99.29%Couleur et forme :SolidMasse moléculaire :272.26Ref: TM-T3594
1mg40,00€2mg52,00€5mg85,00€10mg115,00€25mg172,00€50mg274,00€100mg427,00€500mg938,00€1mL*10mM (DMSO)85,00€Degrasyn
CAS :Degrasyn (WP1130) inhibits DUBs (USP5, UCH-L1, USP9x, USP14, UCH37) and Bcr/Abl without affecting the 20S proteasome.Formule :C19H18BrN3ODegré de pureté :98.32% - 99.98%Couleur et forme :SolidMasse moléculaire :384.27Ref: TM-T6300
2mg44,00€5mg64,00€10mg97,00€25mg198,00€50mg340,00€100mg532,00€200mg747,00€1mL*10mM (DMSO)69,00€Phorbol 12,13-dibutyrate
CAS :Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that induces contraction of isolated rabbit vascular smooth muscle.Formule :C28H40O8Degré de pureté :100% - 99.32%Couleur et forme :SolidMasse moléculaire :504.61Ref: TM-T16526
1mg62,00€5mg169,00€10mg283,00€25mg557,00€50mg795,00€100mg1.074,00€1mL*10mM (DMSO)180,00€Akt3 degrader 1
CAS :Akt3 degrader 1 counters Osimertinib resistance in NSCLC, inhibits cell growth, and reduces mouse tumors.Formule :C53H72N8O4Degré de pureté :98.18% - 99.14%Couleur et forme :SolidMasse moléculaire :885.19VTX-27
CAS :VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).Formule :C20H24ClFN6ODegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :418.9Ref: TM-T13314
1mg93,00€2mg125,00€5mg244,00€10mg364,00€25mg562,00€50mg780,00€100mg1.035,00€1mL*10mM (DMSO)225,00€Ruboxistaurin hydrochloride
CAS :Ruboxistaurin HCl (LY 333531) selectively inhibits PKCβI/II with IC50 of 4.7/5.9 nM; much less effective on other PKC types and ATP-kinases.Formule :C28H28N4O3·HClDegré de pureté :98.44% - 99.22%Couleur et forme :SolidMasse moléculaire :505.01Ref: TM-T3689
1mg71,00€2mg93,00€5mg157,00€10mg256,00€25mg513,00€50mg740,00€100mg1.035,00€500mg2.072,00€1mL*10mM (DMSO)202,00€Imatinib
CAS :Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kitFormule :C29H31N7ODegré de pureté :100% - 99.94%Couleur et forme :Off White PowderMasse moléculaire :493.6Tetradecyltrimethylammonium bromide
CAS :Tetradecyltrimethylammonium bromide (MitMAB) is a Dynamin GTPase activity inhibitor and a cationic surfactant with asymmetrical structure.Formule :C17H38BrNDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :336.39K-252b
CAS :K-252b, an indolocarbazole derived from the actinomycete Nocardiopsis, functions as a protein kinase C (PKC) inhibitor.Formule :C26H19N3O5Degré de pureté :98%Couleur et forme :Ready-To-Use SolutionMasse moléculaire :453.45Larazotide acetate
CAS :Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state.Formule :C34H59N9O12Degré de pureté :95.53%Couleur et forme :SolidMasse moléculaire :785.89
