Signalisation du cytosquelette
Les inhibiteurs de la signalisation du cytosquelette sont des composés qui perturbent les voies de signalisation régulant le cytosquelette, essentiel pour la forme, la motilité, la division des cellules et le transport intracellulaire. Ces inhibiteurs sont utilisés pour étudier la dynamique des protéines du cytosquelette, telles que l'actine et la tubuline, et leur rôle dans des processus comme la migration cellulaire, l'adhésion et la métastase du cancer. Les inhibiteurs de la signalisation du cytosquelette sont précieux dans la recherche en biologie cellulaire, en cancérologie et en neurobiologie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la signalisation du cytosquelette de haute qualité pour soutenir vos recherches dans ces domaines.
Produits appartenant à la catégorie "Signalisation du cytosquelette"
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Lenaldekar
CAS :Lenaldekar (LDK) inhibits T-cell expansion and autoimmune encephalomyelitis.Formule :C18H14N4Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :286.33Ref: TM-T24398
1mg87,00€2mg124,00€5mg187,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.159,00€1mL*10mM (DMSO)178,00€H2-Gamendazole
CAS :H2-Gamendazole: inhibits spermatogenesis, cancer therapy, targets heat shock proteins & EF1α, regulates Hsp90.Formule :C18H13Cl2F3N2O2Degré de pureté :97.36%Couleur et forme :SolidMasse moléculaire :417.21Ref: TM-T72076
1mg78,00€5mg190,00€10mg284,00€25mg505,00€50mg677,00€100mg929,00€200mg1.225,00€1mL*10mM (DMSO)215,00€TAS-301
CAS :TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries.Formule :C23H19NO3Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :357.4Tubulin/AKT1-IN-1
Tubulin/AKT1-IN-1 (Compound D1-1) serves as an inhibitor of both tubulin polymerization and AKT pathway activation, effectively suppressing proliferation andFormule :C38H34ClNO11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :716.13Sovilnesib
CAS :Sovilnesib is a kinesin-like protein KIF18A inhibitor. Sovilnesib can be used for the cancer research.Formule :C26H34F2N6O4SDegré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :564.65Ref: TM-T39994
1mg96,00€5mg235,00€10mg376,00€25mg630,00€50mg898,00€100mg1.216,00€1mL*10mM (DMSO)259,00€Fasudil hydrochloride
CAS :Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formule :C14H18ClN3O2SDegré de pureté :100% - ≥95%Couleur et forme :White SolidMasse moléculaire :327.83AKT-IN-3
CAS :AKT-IN-3: potent oral Akt inhibitor with low hERG blockage. IC50: 1.4-1.7 nM for Akt1-3. Inhibits AGC kinases like PKA, PKC.Formule :C23H23Cl2F2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :526.36Empesertib
CAS :Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.Formule :C29H26FN5O4SDegré de pureté :97.45% - 98.44%Couleur et forme :SolidMasse moléculaire :559.61Ref: TM-T8487
1mg90,00€5mg183,00€10mg275,00€25mg449,00€50mg615,00€100mg848,00€200mg1.121,00€1mL*10mM (DMSO)245,00€CC-99677
CAS :CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.Formule :C22H20ClN5O3SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :469.94Ulacamten
CAS :Ulacamten is an effective inhibitor of cardiac myosin (cardiacmyosin).Formule :C21H25F2N3O3Couleur et forme :SolidMasse moléculaire :405.44Enzastaurin
CAS :Enzastaurin (LY317615) (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε.Formule :C32H29N5O2Degré de pureté :100% - 99.24%Couleur et forme :SolidMasse moléculaire :515.6BT100
BT100, an aptamer, impedes the interaction of von Willebrand factor (VWF) with platelet glycoprotein GPIb, thus obstructing arterial thrombosis [1].Degré de pureté :98%Couleur et forme :Odour SolidCilengitide
CAS :Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Formule :C27H40N8O7Degré de pureté :98% - 99.8%Couleur et forme :SolidMasse moléculaire :588.66Ref: TM-T2494
1mg49,00€2mg70,00€5mg96,00€10mg160,00€25mg274,00€50mg439,00€100mg632,00€1mL*10mM (DMSO)137,00€NMS-E973
CAS :NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Formule :C22H22N4O7Degré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :454.43Ref: TM-T6609
2mg42,00€5mg64,00€10mg97,00€25mg197,00€50mg310,00€100mg442,00€200mg622,00€1mL*10mM (DMSO)70,00€Hypericin
CAS :Hypericin (Cyclosan) is a natural anthraquinone compound. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant effects. Cost-effective and quality-assured.Formule :C30H16O8Degré de pureté :99.05% - ≥98%Couleur et forme :Red-Coloured Anthraquinone-DerivativeMasse moléculaire :504.44Ref: TM-T6S0923
1mg57,00€5mg127,00€10mg182,00€25mg360,00€50mg532,00€100mg743,00€500mg1.510,00€1mL*10mM (DMSO)140,00€Ispinesib
CAS :Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplasticFormule :C30H33ClN4O2Degré de pureté :98% - 98.59%Couleur et forme :SolidMasse moléculaire :517.06Ref: TM-T2103
1mg39,00€2mg50,00€5mg79,00€10mg118,00€25mg210,00€50mg339,00€100mg557,00€500mg1.216,00€1mL*10mM (DMSO)89,00€NCT-58
CAS :NCT-58 is a potent HSP90 inhibitor that blocks Akt, downregulates HER family, and induces apoptosis in HER2+ breast cancer without triggering HSR.Formule :C27H34N2O5Degré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :466.57Ref: TM-T9996
2mg46,00€5mg85,00€10mg126,00€25mg259,00€50mg415,00€100mg662,00€200mg889,00€1mL*10mM (DMSO)207,00€Trimethyloctadecylammonium bromide
CAS :Trimethyloctadecylammonium bromide is an inhibitor of Dynamin I(IC50 : 1.9 μM) and also inhibits Dynamin Ⅱ.Formule :C21H46N·BrDegré de pureté :99.09%Couleur et forme :Solid SolidMasse moléculaire :392.5cis-trismethoxy Resveratrol
CAS :cis-trismethoxy Resveratrol ((Z)-3,5,4'-Trimethoxystilbene) inhibits tubulin polymerization (IC50 = 4 μM) and has anti-mitotic effects.Formule :C17H18O3Degré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :270.32Vinflunine Tartrate
CAS :Vinflunine Tartrate, a uniquely fluorinated vinca alkaloid, exhibits mitotic-arresting and tubulin-interacting properties.Formule :C45H54F2N4O8·xC4H6O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :967.02Ref: TM-T6722
2mgÀ demander5mgÀ demander10mgÀ demander25mgÀ demander50mgÀ demander1mL*10mM (DMSO)À demanderNU074381b
NU074381b (compound 5b) is an effective inhibitor of S100A4, disrupting the formation of the S100A4-NMII complex with an IC50 value of 0.48 µM. Additionally, it inhibits cell proliferation and migration.Formule :C23H25ClN2O2Couleur et forme :SolidMasse moléculaire :396.91NDNA3
NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10AFormule :C28H32N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.63CMPF
CAS :CMPF is a microtubule protein inhibitor that can be used to study tumors.Formule :C12H16O5Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :240.25HSF1A
CAS :HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.Formule :C21H19N3O2S2Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :409.52Ref: TM-T4125
1mg55,00€2mg88,00€5mg139,00€10mg207,00€25mg462,00€50mg677,00€100mg938,00€1mL*10mM (DMSO)130,00€Olverembatinib dimesylate
CAS :Olverembatinib dimesylate (GZD824 Dimesylate) is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I).Formule :C29H27F3N6O·2CH4O3SDegré de pureté :100% - 99.81%Couleur et forme :SolidMasse moléculaire :724.77Ref: TM-T2429
1mg39,00€2mg51,00€5mg84,00€10mg119,00€25mg229,00€50mg319,00€100mg474,00€1mL*10mM (DMSO)120,00€VnP-16
VnP-16 enhances bone formation by stimulating the differentiation and activity of osteoblasts via direct β1 integrin engagement, which subsequently activatesFormule :C82H112N20O17Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1649.89BCR-ABL-IN-7
CAS :BCR-ABL-IN-7 is an inhibitor of ABL kinase activity in WT and T315I mutants.BCR-ABL-IN-7 can be used in chronic myeloid leukemia (CML) research.Formule :C19H16FN3O3SDegré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :385.41PKCε Inhibitor Peptide acetate
PKCε Inhibitor Peptide acetate is a selective PKCε inhibitor containing the site for its specific receptor for activated C kinase (RACK).Formule :C39H69N9O15Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :904.02Ref: TM-T35827L
1mg65,00€2mg94,00€5mg116,00€10mg187,00€25mg314,00€50mg452,00€100mg620,00€200mg835,00€OSIP-486823
CAS :OSIP-486823(CP248) is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.Formule :C29H28FNO4Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :473.54Valecobulin hydrochloride
CAS :Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516.Cost-effective and quality-assured.Formule :C26H29ClN6O5SDegré de pureté :98.63%Couleur et forme :SolidMasse moléculaire :573.06Ref: TM-T13278
1mg88,00€5mg170,00€10mg259,00€25mg429,00€50mg605,00€100mg815,00€200mg1.093,00€1mL*10mM (DMSO)207,00€Monastrol
CAS :Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Formule :C14H16N2O3SDegré de pureté :98.59% - 99.19%Couleur et forme :SolidMasse moléculaire :292.35Ref: TM-T4048
1mg48,00€5mg78,00€10mg97,00€25mg188,00€50mg311,00€100mg502,00€500mg1.074,00€1mL*10mM (DMSO)87,00€HB-3-20
HB-3-20 induces the degradation of integrin αVβ5 on the cell surface. Transglutaminase 2 (TG2) specifically interacts with HB-3-20, exhibiting a catalytic efficiency (kcat/KM) of 0.16 μM^-1min^-1.Formule :C69H102N20O20Couleur et forme :SolidMasse moléculaire :1531.67Bosutinib
CAS :Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.Formule :C26H29Cl2N5O3Degré de pureté :98.98% - 99.9%Couleur et forme :Yellowish-Orange Or Pink To Brownish Solid Solid PowderMasse moléculaire :530.45AC 7739
CAS :AC 7739 is a microtubule protein binding agent with anticancer and antitumor activity that inhibits advanced solid tumors and in situ transplanted tumors.Formule :C18H22ClNO4Degré de pureté :100% - 99.38%Couleur et forme :SoildMasse moléculaire :351.83Decursinol angelate
CAS :Decursinol angelate is anti-tumor, anti-inflammatory, anti-oxidant, hepatoprotective, and inhibits VEGF and cancer cell invasion.Formule :C19H20O5Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :328.36(S)-Monastrol
CAS :Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.Formule :C14H16N2O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :292.35Nocodazole
CAS :Nocodazole: synthetic microtubule polymerization blocker, also impedes Abl with low IC50; binds to beta-tubulin.Formule :C14H11N3O3SDegré de pureté :98% - 99.91%Couleur et forme :Physical Description White Powder (Ntp 1992)Masse moléculaire :301.32Ref: TM-T2802
5mg37,00€10mg55,00€25mg99,00€50mg168,00€100mg283,00€200mg420,00€500mg682,00€1mL*10mM (DMSO)40,00€R59949
CAS :R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.Formule :C28H25F2N3OSDegré de pureté :97.04%Couleur et forme :SolidMasse moléculaire :489.58Ref: TM-T26019
1mg47,00€5mg92,00€10mg145,00€25mg298,00€50mg465,00€100mg702,00€200mg938,00€1mL*10mM (DMSO)96,00€BCR-ABL-IN-10
BCR-ABL-IN-10 (compound B4) is a covalent BCR-ABL inhibitor featuring an arylvinylsulfonate (AVS) moiety, demonstrating an IC50 of 43.1 nM against ABL kinase. It forms a covalent and stable adduct with ABL kinase, enabling the sustained inhibition of intrinsic BCR-ABL activity. This compound is utilized in the study of chronic myeloid leukemia (CML).Formule :C24H22N4O5SCouleur et forme :SolidMasse moléculaire :478.52PKC ζ pseudosubstrate acetate
PKC ζ pseudosubstrate acetate is an inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide.Formule :C78H132N30O18Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :1778.10Daphnoretin
CAS :1.Formule :C19H12O7Degré de pureté :98% - 99.85%Couleur et forme :SolidMasse moléculaire :352.29Myoseverin
CAS :Myoseverin triggers myotube fission into single cells, influencing genes for growth, immunity, matrix remodeling, and stress, aiding healing and regeneration.Formule :C24H28N6O2Degré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :432.52Ref: TM-T21632
5mg35,00€10mg52,00€25mg101,00€50mg170,00€100mg255,00€200mg374,00€1mL*10mM (DMSO)38,00€Etaracizumab
CAS :Etaracizumab (LM 609) is a humanized monoclonal antibody targeting integrin αvβ3, inhibiting angiogenesis and melanoma growth, used in the study of melanoma.Degré de pureté :>95% - >95%Couleur et forme :LiquidMasse moléculaire :144.3 (kDa)Carotegrast methyl
CAS :Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.Formule :C28H26Cl2N4O5Degré de pureté :99.40%Couleur et forme :SolidMasse moléculaire :569.44Ref: TM-T30751
10g9.508,00€1mg74,00€5mg160,00€10mg264,00€25mg528,00€50mg785,00€100mg1.130,00€200mg1.549,00€1mL*10mM (DMSO)170,00€AZ3146
CAS :AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.Formule :C24H32N6O3Degré de pureté :100% - 97.84%Couleur et forme :SolidMasse moléculaire :452.55GNF-2
CAS :GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl.Formule :C18H13F3N4O2Degré de pureté :98.17% - ≥95%Couleur et forme :SolidMasse moléculaire :374.32αvβ6 integrin inhibitor 2
CAS :αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.Formule :C21H30N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :386.49Corosolic acid
CAS :Corosolic acid inhibits angiogenesis, suppresses FAK, fights various cancers, induces apoptosis, and degrades β-catenin.Formule :C30H48O4Degré de pureté :99.46% - 99.88%Couleur et forme :Fine-Brown Yellow PowderMasse moléculaire :472.7Hsp90-IN-38
CAS :Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein). It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 μM. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 μM, respectively.Formule :C28H35N3O5Couleur et forme :SolidMasse moléculaire :493.595OSU-T315
CAS :OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.Formule :C30H30F3N5ODegré de pureté :98.03%Couleur et forme :SolidMasse moléculaire :533.59Ref: TM-T5485
1mg97,00€2mg144,00€5mg235,00€10mg378,00€25mg647,00€50mg920,00€100mg1.225,00€500mg2.498,00€1mL*10mM (DMSO)306,00€
