Signalisation du cytosquelette
Les inhibiteurs de la signalisation du cytosquelette sont des composés qui perturbent les voies de signalisation régulant le cytosquelette, essentiel pour la forme, la motilité, la division des cellules et le transport intracellulaire. Ces inhibiteurs sont utilisés pour étudier la dynamique des protéines du cytosquelette, telles que l'actine et la tubuline, et leur rôle dans des processus comme la migration cellulaire, l'adhésion et la métastase du cancer. Les inhibiteurs de la signalisation du cytosquelette sont précieux dans la recherche en biologie cellulaire, en cancérologie et en neurobiologie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la signalisation du cytosquelette de haute qualité pour soutenir vos recherches dans ces domaines.
Produits appartenant à la catégorie "Signalisation du cytosquelette"
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FRAX486
CAS :FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.Formule :C25H23Cl2FN6ODegré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :513.39AKT-IN-26
CAS :AKT-IN-26 (Compound 453) is an AKT inhibitor that binds to the Pleckstrin Homology (PH) domain of AKT. It is useful for research related to cell proliferation and cancer involving the AKT pathway.Formule :C21H17N5O4SCouleur et forme :SolidMasse moléculaire :435.456JG-231
CAS :JG-231, a JG-98 analog, shows anticancer properties by blocking Hsp70-BAG3 interaction and hindering TNBC in MDA-MB-231 models.Formule :C22H18BrCl2N3OS4Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :619.47TN-16
CAS :TN-16 is a microtubule polymerization inhibitor (IC50 :0.4-1.7 μM)Formule :C19H18N2O2Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :306.36LXW7
CAS :LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (Formule :C29H48N12O12S2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :820.89Batatasin III
CAS :Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancerFormule :C15H16O3Degré de pureté :99.16%Couleur et forme :SolidMasse moléculaire :244.29HM03
CAS :HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.Formule :C26H27ClN4O2Degré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :462.97AT7867
CAS :AT7867 inhibits Akt1/2/3 & p70S6K/PKA (IC50: 32/17/47 nM & 85/20 nM), minimal effect beyond AGC kinases.Formule :C20H20ClN3Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :337.85Ref: TM-T6304
2mg44,00€5mg65,00€10mg86,00€25mg135,00€50mg210,00€100mg313,00€200mg452,00€1mL*10mM (DMSO)65,00€2-Methylbutyrylcarnitine chloride
2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.Formule :C12H24ClNO4Couleur et forme :SolidMasse moléculaire :281.78Arginine-glycine-aspartic acid
CAS :RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.Formule :C12H22N6O6Degré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :346.34Valategrast hydrochloride
CAS :Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.Formule :C30H33Cl4N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :641.41Irigenin
CAS :Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the ExtraFormule :C18H16O8Degré de pureté :99.50% - 99.85%Couleur et forme :SolidMasse moléculaire :360.31Afuresertib hydrochloride
CAS :Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)Formule :C18H18Cl3FN4OSDegré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :463.8Ref: TM-T7885
2mg52,00€5mg74,00€10mg95,00€25mg163,00€50mg253,00€100mg437,00€200mg568,00€1mL*10mM (DMSO)86,00€Bersanlimab
CAS :Bersanlimab (BI-505) is a fully human monoclonal antibody targeting Intercellular Adhesion Molecule-1 (ICAM-1).Bersanlimab has anticancer properties.Degré de pureté :> 95% - > 95%Couleur et forme :LiquidMasse moléculaire :144.22 kDaDolastatin 10
CAS :Dolastatin 10 (DLS 10) is a powerful peptide with antimitotic properties, effectively inhibiting tubulin polymerization.Formule :C42H68N6O6SDegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :785.09Shepherdin 79-87 acetate
Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability.Formule :C43H68N12O14SDegré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :1009.14G-5555
CAS :G-5555 is a potent inhibitor of p21-activated kinase 1 (PAK1) (Kis: 3.7 nM and 11 nM for PAK1 and PAK2, respectively).Formule :C25H25ClN6O3Degré de pureté :99.76% - 99.87%Couleur et forme :SolidMasse moléculaire :492.96Flumatinib
CAS :Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.Formule :C29H29F3N8ODegré de pureté :99.52% - 99.95%Couleur et forme :SolidMasse moléculaire :562.59Ref: TM-T4320
1mg35,00€5mg66,00€10mg87,00€25mg127,00€50mg163,00€100mg273,00€200mg409,00€500mg677,00€1mL*10mM (DMSO)87,00€Betamethasone 17-benzoate
CAS :Betamethasone 17-benzoate is a representative steroid. It also can be used in the treatment of recurrent aphothous ulcers (RAU).Formule :C29H33FO6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :496.57EC 144
CAS :EC 144, a second-generation selective inhibitor of Hsp90 , inhibits tumor growth for Hsp90α and degradation of Her-2 in MCF-7 cells.Formule :C21H24ClN5O2Couleur et forme :SolidMasse moléculaire :413.9BRD9876
CAS :BRD9876 is a selective inhibitor of MM1S growth.Formule :C16H14N2Degré de pureté :97.81%Couleur et forme :SolidMasse moléculaire :234.3FAK-IN-15
FAK-IN-15 is a highly potent focal adhesion kinase (FAK) inhibitor with antitumor activity.Formule :C21H24ClN7OSDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :457.98Palmitic acid
CAS :Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms.Formule :C16H32O2Degré de pureté :99.17% - 99.67%Couleur et forme :White Crystalline Scales SolidMasse moléculaire :256.42Cyclo(RADfK)
CAS :Cyclo(RADfK) is a selective α(v)β(3) integrin ligand used in neoangiogenesis research, therapy, and diagnostics; it's a control for RGD peptides.Formule :C28H43N9O7Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :617.7Auristatin F
CAS :Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.Formule :C40H67N5O8Degré de pureté :98.41% - 99.25%Couleur et forme :SolidMasse moléculaire :745.99AM-5308
CAS :AM-5308 is a kinesin KIF18A inhibitor that can be used to study cancer.Formule :C26H35N5O5SDegré de pureté :98.06% - 99.58%Couleur et forme :SolidMasse moléculaire :529.65MMAF
CAS :MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.Formule :C39H65N5O8Degré de pureté :97.00%Couleur et forme :SolidMasse moléculaire :731.96GRGDSPK
CAS :GRGDSPK (EMD 56574) is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules.Formule :C28H49N11O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :715.76Amiprofos methyl
CAS :Amiprofos methyl (BAY-NTN 6867) is an organophosphorus herbicide that specifically and competitively inhibits microtubule polymerization in plant cells.Formule :C11H17N2O4PSDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :304.3Elarofiban
CAS :Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.Formule :C22H32N4O4Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :416.51cemadotin free base
CAS :Cemadotin free base(LU103793 free base) is a novel anti-limiting peptide , an analog of Dolastatin 15, a naturally occurring cytotoxic peptide that blocksFormule :C35H56N6O5Degré de pureté :99% - 99.69%Couleur et forme :SolidMasse moléculaire :640.86JH-VIII-157-02
CAS :JH-VIII-157-02 inhibits ALK, specifically EML4-ALK variants, with IC50s of 2 nM.Formule :C28H27N5O2Degré de pureté :98.02%Couleur et forme :SolidMasse moléculaire :465.55Ref: TM-T15612
1mg116,00€5mg240,00€10mg358,00€25mg558,00€50mg753,00€100mg1.035,00€1mL*10mM (DMSO)246,00€N-Desmethyltamoxifen hydrochloride
CAS :N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.Formule :C25H28ClNODegré de pureté :99.15%Couleur et forme :SolidMasse moléculaire :393.95Ref: TM-T12148
2mg35,00€5mg52,00€10mg78,00€25mg139,00€50mg202,00€100mg305,00€200mg426,00€1mL*10mM (DMSO)52,00€Dasatinib monohydrate
CAS :Dasatinib monohydrate, an oral SRC-kinase inhibitor, counters imatinib-resistant chronic myeloid leukemia.Formule :C22H28ClN7O3SDegré de pureté :100% - 99.68%Couleur et forme :SolidMasse moléculaire :506.03Bisindolylmaleimide I
CAS :Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.Formule :C25H24N4O2Degré de pureté :98.19% - 99.08%Couleur et forme :Orange SolidMasse moléculaire :412.48C086
CAS :C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.Formule :C29H28O8Couleur et forme :SolidMasse moléculaire :504.53Mertansine
CAS :Mertansine is a tubulin inhibitor and an antibody-conjugable maytansinoid alkaloid. The IC50 of Mertansine against HCT-15 and A431 cells is 0.750 and 0.04nM.Cost-effective and quality-assured.Formule :C35H48ClN3O10SDegré de pureté :100% - 99.76%Couleur et forme :SolidMasse moléculaire :738.29SB273005
CAS :SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.Formule :C22H24F3N3O4Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :451.44Dynasore
CAS :Dynasore, a cell-permeable dynamin inhibitor, blocks GTPase of dynamin 1/2 and Drp1 (IC50: 15 μM) without affecting other small GTPases.Formule :C18H14N2O4Degré de pureté :95.85% - 99.22%Couleur et forme :SolidMasse moléculaire :322.31Ref: TM-T1848
5mg49,00€10mg79,00€25mg140,00€50mg259,00€100mg374,00€200mg560,00€500mg883,00€1mL*10mM (DMSO)87,00€c-ABL-IN-5
C-ABL-IN-5, a selective c-Abl inhibitor, exhibits neuroprotective properties and has favorable characteristics including blood-brain barrier permeability,Formule :C19H17F2N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :341.35KIF18A-IN-14
CAS :KIF18A-IN-14 (Compound Example 81) is an inhibitor of KIF18A that exists in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit the viability of OVCAR-3 cells with IC50 values of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be utilized in tumor research, including studies on colon cancer, breast cancer, and lung cancer.Formule :C26H32F3N5O6SCouleur et forme :SolidMasse moléculaire :599.62REDV TFA
REDV TFA, the minimal active sequence of the CS5 site in the alternatively spliced type III connecting segment (IIICS) of fibronectin, mediates adhesion to theFormule :C20H35N7O9·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.53 (free acid)Lyn-IN-1
CAS :Lyn-IN-1 (Bafetinib analog) is a selective and potent dual inhibitor of Bcr-Abl and LynFormule :C30H31F3N8ODegré de pureté :97% - 99.33%Couleur et forme :SolidMasse moléculaire :576.62Ref: TM-T11916
1mg47,00€2mg56,00€5mg84,00€10mg124,00€25mg250,00€50mg393,00€100mg560,00€200mg815,00€1mL*10mM (DMSO)97,00€PVZB1194
CAS :PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis throughFormule :C13H9F4NO2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.28Defactinib analogue-1
CAS :Defactinib analogue-1 (Compound 7) serves as a ligand for the target protein FAK, and is utilized in the synthesis of PROTAC FAK degrader 1.Formule :C20H20F3N5O3SCouleur et forme :SolidMasse moléculaire :467.47Tubulysin D
CAS :Tubulysin D is a tetrapeptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and displays potent antitumor activity.Formule :C43H65N5O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :828.07Triciribine
CAS :Triciribine (NSC-154020) is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.Formule :C13H16N6O4Degré de pureté :99.01% - 99.87%Couleur et forme :SolidMasse moléculaire :320.3Ref: TM-T6065
1mg43,00€2mg57,00€5mg93,00€10mg135,00€25mg236,00€50mg394,00€100mg588,00€1mL*10mM (DMSO)93,00€S516
CAS :S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.Formule :C21H19N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :437.47Nic-15
CAS :Nic-15 (compound 4n) serves as an anti-constrictive agent targeting the low vascular characteristics of pancreatic tumors. These characteristics enable cancer cells to adapt to the nutrient-deficient tumor microenvironment and develop resistance to treatment. Nic-15 modulates the PI3K/Akt/mTOR pathway and alleviates ER stress induced by Gemcitabine. It significantly inhibits migration and colony formation in MIA PaCa-2 and PANC-1 pancreatic cancer cells. When used in combination with Gemcitabine, Nic-15 effectively addresses resistance issues in pancreatic tumors. In xenograft models in vivo, Nic-15 notably enhances the efficacy of Gemcitabine.Formule :C25H26F2O3Couleur et forme :SolidMasse moléculaire :412.47Dasatinib N-oxide
CAS :Dasatinib N-oxide is a key metabolite and potential impurity of the kinase inhibitor dasatinib.Formule :C22H26ClN7O3SDegré de pureté :98.54% - 99.85%Couleur et forme :SolidMasse moléculaire :504
