Signalisation du cytosquelette
Les inhibiteurs de la signalisation du cytosquelette sont des composés qui perturbent les voies de signalisation régulant le cytosquelette, essentiel pour la forme, la motilité, la division des cellules et le transport intracellulaire. Ces inhibiteurs sont utilisés pour étudier la dynamique des protéines du cytosquelette, telles que l'actine et la tubuline, et leur rôle dans des processus comme la migration cellulaire, l'adhésion et la métastase du cancer. Les inhibiteurs de la signalisation du cytosquelette sont précieux dans la recherche en biologie cellulaire, en cancérologie et en neurobiologie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la signalisation du cytosquelette de haute qualité pour soutenir vos recherches dans ces domaines.
Produits appartenant à la catégorie "Signalisation du cytosquelette"
Trier par
Tubulin inhibitor 6
CAS :Tubulin inhibitor 6 (iHAP1) is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.Formule :C20H14ClNO2SDegré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :367.85Ref: TM-T13224
5mg50,00€10mg80,00€25mg117,00€50mg170,00€100mg259,00€200mg369,00€1mL*10mM (DMSO)51,00€PKC-θ inhibitor 1
CAS :PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)Formule :C17H15F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.32FGFRs-IN-1
FGFRs-IN-1 (Compound A16) is an orally active inhibitor targeting FGFR1/2/3/4, with IC50 values of 2.3, 7, 11, and 163 nM respectively. It also inhibits VEGFR1/2/3, Abl, and Flt3, with IC50 values of 61, 176, 112, 26, and 353 nM. The compound shows weak inhibition of CYP enzymes. FGFRs-IN-1 reduces the expression of α-SMA and collagen I, and it inhibits epithelial-mesenchymal transition (EMT) in A549 cells stimulated by TGF-β1. Additionally, FGFRs-IN-1 demonstrates anti-inflammatory activity in mouse models of lung fibrosis induced by Bleomycin and liver fibrosis induced by CCl4.Formule :C28H26Cl2N4O3Couleur et forme :SolidMasse moléculaire :537.44HSP90-IN-27
CAS :HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].Formule :C18H21N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :343.44PF-431396
CAS :PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).Formule :C22H21F3N6O3SDegré de pureté :98.83% - 99.82%Couleur et forme :SolidMasse moléculaire :506.5Dynole 34-2
CAS :Dynole 34-2 is a non-competitive inhibitor of dynamin1 and dynamin2 GTPases that inhibits receptor-mediated endocytosis and synaptic vesicle endocytosis.Formule :C25H36N4ODegré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :408.58Tonabersat
CAS :Tonabersat (SB-220453) is a novel and orally available gap-junction modulator and CSD (Cortical spreading depression) inhibitor that,migraine and epilepsy.Formule :C20H19ClFNO4Degré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :391.82Uprosertib
CAS :Uprosertib (GSK2141795) is a potent, selective Akt broad-spectrum inhibitor for Akt1/Akt2/Akt3.Cost-effective and quality-assured.Formule :C18H16Cl2F2N4O2Degré de pureté :95.62% - 99.54%Couleur et forme :SolidMasse moléculaire :429.25Ref: TM-T6849
1mg47,00€2mg59,00€5mg85,00€10mg124,00€25mg202,00€50mg324,00€100mg535,00€200mg752,00€1mL*10mM (DMSO)108,00€Xentuzumab
CAS :Xentuzumab (BI836845) is a recombinant monoclonal antibody to humanised IGF ligand that inhibits AKT activation and can be used to study solid tumours.Degré de pureté :95% - > 95%Couleur et forme :LiquidMasse moléculaire :143.7 kDaEV206
CAS :EV206 is an effective inhibitor of Hsp70, exhibiting antiproliferative properties. This compound induces cell apoptosis (apoptosis) and enhances the protein expression of cleaved PARP and caspase-3. Additionally, EV206 demonstrates antitumor activity.Formule :C21H19N3OCouleur et forme :SolidMasse moléculaire :329.40ILK-IN-3
CAS :ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Formule :C10H12N6ODegré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :232.24(±)-1,2-Diolein
CAS :(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx.Formule :C39H72O5Couleur et forme :SolidMasse moléculaire :620.99Alvespimycin
CAS :Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.Formule :C32H48N4O8Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :616.75IIQLPEIVVV TFA
IIQLPEIVVV TFA serves as a specific inhibitor targeting the Drp1-Mff interaction. This compound discriminates between physiological and pathological fission, hindering physiological fission which leads to mitochondrial dysfunction. IIQLPEIVVV TFA is also utilized in research related to Huntington's disease.Formule :C54H95N11O14·xC2HF3O2Couleur et forme :SolidMasse moléculaire :1122.40 (free base)Tyrosine kinase-IN-9
CAS :Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.Formule :C20H14ClN3O3Couleur et forme :SolidMasse moléculaire :379.796PF-03814735
CAS :PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.Formule :C23H25F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.48Tirofiban
CAS :Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.Formule :C22H36N2O5SDegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :440.63-Hydroxyxanthone
CAS :3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical veinFormule :C13H8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :212.2NPX800
CAS :NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.Formule :C32H32FN5O4Degré de pureté :99.26%Couleur et forme :SolidMasse moléculaire :569.63Ref: TM-T9804
1mg96,00€5mg240,00€10mg375,00€25mg627,00€50mg893,00€100mg1.216,00€1mL*10mM (DMSO)300,00€AKT-IN-6
CAS :AKT-IN-6 (INCB-047775) inhibits Akt, a key signaling protein linked to type 2 diabetes and cancer.Formule :C22H20FN5ODegré de pureté :98.83%Couleur et forme :SolidMasse moléculaire :389.43Ref: TM-T36310
1mg35,00€5mg74,00€10mg111,00€25mg216,00€50mg354,00€100mg567,00€200mg805,00€1mL*10mM (DMSO)84,00€Radicicol
CAS :Radicicol is an antifungal antibiotic, a inhibitor of Hsp90 & FTO, Anti-malarial , inhibits iNOS gene expression by blocking the p38 kinase and NF-κB/Rel.Formule :C18H17ClO6Degré de pureté :98%Couleur et forme :White/Yellow PowderMasse moléculaire :364.78Phorbol 12-myristate 13-acetate
CAS :Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB.Formule :C36H56O8Degré de pureté :100% - 99.5%Couleur et forme :White To Off-White SolidMasse moléculaire :616.83Eg5 Inhibitor V, trans-24
CAS :Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.Formule :C26H21N3O3Degré de pureté :97.45%Couleur et forme :SolidMasse moléculaire :423.46Ref: TM-T11155
1mg92,00€5mg205,00€10mg305,00€25mg495,00€50mg677,00€100mg905,00€200mg1.216,00€1mL*10mM (DMSO)227,00€A-286982
CAS :A 286982 blocks the LFA-1 and ICAM-1 integrin-ligand interaction.Formule :C24H27N3O4SDegré de pureté :97.81%Couleur et forme :SolidMasse moléculaire :453.55Ref: TM-T21781
1mg35,00€2mg50,00€5mg74,00€10mg107,00€25mg210,00€50mg350,00€100mg522,00€1mL*10mM (DMSO)81,00€BX517
CAS :BX517 (PDK1 inhibitor 2) is a potent and selective inhibitor of PDK1.Formule :C15H14N4O2Degré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :282.3DTHIB
CAS :DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.Formule :C13H9ClFN3O3Degré de pureté :98.86% - 99.29%Couleur et forme :SolidMasse moléculaire :309.68Ref: TM-T8858
1mg35,00€5mg70,00€10mg104,00€25mg210,00€50mg338,00€100mg540,00€500mg1.130,00€1mL*10mM (DMSO)78,00€AN-019
CAS :AN-019 (NRC-019) is a Bcr-Abl kinase inhibitor with antitumor activity for the study of chronic myelogenous leukemia (CML) and breast cancer.Formule :C25H17F6N5ODegré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :517.43ZIP acetate(863987-12-6 free base)
ZIP acetate inhibits PKMζ (protein kinase Mζ), affecting LTP maintenance and spatial memory, with an IC50 of 1-2.5 μM.Formule :C92H158N30O19Degré de pureté :94.68%Couleur et forme :SolidMasse moléculaire :1988.43Tilavonemab
CAS :Tilavonemab (ABBV-8E12), a humanized anti-tau antibody, halts tau uptake in neurons and may help with Alzheimer's research.Degré de pureté :95% - 95%Couleur et forme :LiquidSuprafenacine
CAS :Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) is a cell-permeable microtubule destabilizer that inducesFormule :C16H18N4ODegré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :282.34GRGDSP acetate(91037-75-1 free base)
GRGDSP acetate(91037-75-1 free base) is a synthetic linear RGD peptide and is an integrin inhibitor.Formule :C24H41N9O12Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :647.64Auristatin E
CAS :Auristatin E, MMAE analog, blocks tubulin polymerisation, has cytotoxic and potent antitumor effects, used in ADCs.Formule :C40H69N5O7Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :732.01SB-216
CAS :SB-216, a potent anti-cancer compound, inhibits tubulin polymerization and curbs growth in various cancer cells.Formule :C17H18N4O2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :310.35Ref: TM-T60757
1mg54,00€5mg116,00€10mg188,00€25mg331,00€50mg475,00€100mg655,00€1mL*10mM (DMSO)133,00€Dynamin inhibitory peptide, myristoylated acetate
Myristoylated acetate peptide inhibits DynaMin, blocking amphiphysin binding; myristoylated TFA variant hinders endocytosis.Formule :C63H111N19O16Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :1390.67SC-10
CAS :SC-10 is a direct activator of PKC with potential antiproliferative activity, useful in leukemia research.Formule :C17H22ClNO2SDegré de pureté :99.24% - 99.58%Couleur et forme :SolidMasse moléculaire :339.88GRP78-IN-3
CAS :GRP78-IN-3: Potent Hsp70 blocker, selective Grp78 (HSPA5) inhib., IC50 0.59 μM, 7x more vs HspA9, 20x vs HspA2.Formule :C17H18N4O2SDegré de pureté :99.11%Couleur et forme :SoildMasse moléculaire :342.42ALK inhibitor 1
CAS :ALK inhibitor 1 is a selective ALK kinase inhibitor.Formule :C23H28BrN7O3SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :562.48Ref: TM-T10285
1mg52,00€5mg116,00€10mg170,00€25mg340,00€50mg472,00€100mg645,00€1mL*10mM (DMSO)143,00€KIF18A-IN-3
CAS :KIF18A-IN-3 is a KIF18A inhibitor (IC50=61 nM) that causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues.Formule :C28H38N4O5S2Degré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :574.76Combretastatin A-1
CAS :Combretastatin A-1 is a microtubule inhibitor with anti-tumour and can be used to study liver cancer.Formule :C18H20O6Degré de pureté :97.49% - 97.49%Couleur et forme :SolidMasse moléculaire :332.35Lifitegrast
CAS :Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.Formule :C29H24Cl2N2O7SDegré de pureté :99.39% - 99.66%Couleur et forme :SolidMasse moléculaire :615.48CGP 53353
CAS :CGP 53353 (DAPH-7) is a PKC inhibitor with inhibitory effects on PKCβII and PKCβI and can be used to study atherosclerosis.Formule :C20H13F2N3O2Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :365.33PKC-θ inhibitor
CAS :PKC-theta inhibitor is PKC-θinhibitor, with an IC50 of 12 nM.Formule :C20H25F3N6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :454.45Ref: TM-T5423
1mg106,00€5mg250,00€10mg329,00€25mg467,00€50mg612,00€100mg944,00€200mg1.264,00€1mL*10mM (DMSO)274,00€Borussertib
CAS :Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt(IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt)Formule :C36H32N6O3Degré de pureté :99.00%Couleur et forme :SolidMasse moléculaire :596.68Ref: TM-T8427
1mg133,00€5mg274,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€1mL*10mM (DMSO)360,00€FAK-IN-11
FAK-IN-11 (Compound 4l), a FAK inhibitor, specifically targets the ATP binding pocket of FAK to prevent its phosphorylation.Formule :C25H41NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :403.6Tirbanibulin Mesylate
CAS :Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).Formule :C27H33N3O6SDegré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :527.63Ref: TM-T15675
2mg38,00€5mg56,00€10mg70,00€25mg126,00€50mg243,00€100mg416,00€200mg562,00€1mL*10mM (DMSO)65,00€IPI-493
CAS :IPI-493 is a bioactive chemical.Formule :C28H39N3O8Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :545.62WAY-118959-A
CAS :WAY-118959-A is a potential microtubule acetylation inhibitor.Formule :C16H14N4OS2Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :342.44Ref: TM-T60065
1mg115,00€5mg255,00€10mg375,00€25mg562,00€50mg787,00€100mg1.074,00€200mg1.454,00€1mL*10mM (DMSO)261,00€Sangivamycin
CAS :Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.Formule :C12H15N5O5Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :309.28Ref: TM-T9605
1mg126,00€5mg274,00€10mg416,00€25mg677,00€50mg944,00€100mg1.264,00€1mL*10mM (DMSO)360,00€AKT-IN-2
CAS :AKT-IN-2 is a selective, and orally bioavailable AKT inhibitor (IC50: 5 nM for AKT1).Formule :C25H34F3N7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :505.583CAI
CAS :3CAI inhibits AKT1/2, reduces mTOR/GSK3β, and triggers apoptosis in colon cancer cells.Formule :C10H8ClNODegré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :193.63Ref: TM-T14034
5mg55,00€10mg77,00€25mg125,00€50mg220,00€100mg330,00€200mg485,00€500mg787,00€1mL*10mM (DMSO)64,00€
