Signalisation du cytosquelette
Les inhibiteurs de la signalisation du cytosquelette sont des composés qui perturbent les voies de signalisation régulant le cytosquelette, essentiel pour la forme, la motilité, la division des cellules et le transport intracellulaire. Ces inhibiteurs sont utilisés pour étudier la dynamique des protéines du cytosquelette, telles que l'actine et la tubuline, et leur rôle dans des processus comme la migration cellulaire, l'adhésion et la métastase du cancer. Les inhibiteurs de la signalisation du cytosquelette sont précieux dans la recherche en biologie cellulaire, en cancérologie et en neurobiologie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la signalisation du cytosquelette de haute qualité pour soutenir vos recherches dans ces domaines.
Produits appartenant à la catégorie "Signalisation du cytosquelette"
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Plinabulin
CAS :Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM).Formule :C19H20N4O2Degré de pureté :100% - 98.69%Couleur et forme :SolidMasse moléculaire :336.39Staurosporine
CAS :Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFormule :C28H26N4O3Degré de pureté :99.24% - 99.98%Couleur et forme :Off-White PowderMasse moléculaire :466.53Ref: TM-T6680
1mg62,00€2mg87,00€5mg97,00€10mg145,00€25mg246,00€50mg401,00€100mg597,00€500mg1.283,00€1mL*10mM (DMSO)109,00€Carbenoxolone disodium
CAS :Carbenoxolone disodium treats stomach ulcers; derived from licorice, often has antidiuretic effects, low toxicity.Formule :C34H48Na2O7Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :614.72Tubulin inhibitor 1
CAS :Tubulin inhibitor 1 blocks tubulin polymerization, with strong anti-tumor effects, induces apoptosis and G2/M mitotic arrest.Formule :C21H24N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :368.43Eribulin
CAS :Eribulin binds microtubules, halts cancer cell growth, treating metastatic breast cancer.Formule :C40H59NO11Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :729.90Hypocrellin A
CAS :Hypocrellin A is a natural PKC inhibitor with light-induced antitumor, antifungal and antiviral activities.Cost-effective and quality-assured.Formule :C30H26O10Degré de pureté :98% - 99.81%Couleur et forme :SolidMasse moléculaire :546.52Conteltinib
CAS :Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.Formule :C32H45N9O3SDegré de pureté :98.12% - 99.54%Couleur et forme :SolidMasse moléculaire :635.82Ref: TM-T14997
1mg77,00€5mg167,00€10mg240,00€25mg409,00€50mg572,00€100mg800,00€1mL*10mM (DMSO)227,00€Hsp110-STAT3 interaction-IN-2
Hsp110-STAT3 interaction-IN-2 (compound 10b) is an inhibitor of the Hsp110-STAT3 interaction. It is utilized in research related to pulmonary arterial hypertension (PAH).Formule :C24H18F3N5O3Couleur et forme :SolidMasse moléculaire :481.43AKT-IN-25
CAS :AKT-IN-25 (Compound 14a) is an inhibitor of Akt that prevents the phosphorylation of Akt, thereby hindering the PI3K/Akt/mTOR signaling pathway. It arrests the cell cycle at the G1 phase, inhibits the migration of PANC-1 cells, and suppresses the proliferation of cancer cells PANC-1, PATU-T, and SUIT-2, with IC50 values of 3.05, 1.32, and 3.85 μM, respectively.Formule :C14H16N4OCouleur et forme :SolidMasse moléculaire :256.3Tasidotin hydrochloride
CAS :Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.Formule :C32H59ClN6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :643.30CLT-28643
CAS :CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.Formule :C19H17N3O4Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :351.36Dasatinib
CAS :Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive.Formule :C22H26ClN7O2SDegré de pureté :99.59% - 99.86%Couleur et forme :Pale-Yellow SolidMasse moléculaire :488.01DM1-SMe
CAS :DM1-SMe (DM1-SSMe) potently inhibits microtubules, 3-10x stronger than Maytansine with IC50s of 0.003-0.01 nM in human cancer cells.Formule :C36H50ClN3O10S2Degré de pureté :97.19%Couleur et forme :SolidMasse moléculaire :784.38JB062
CAS :JB062 is a chemical compound acting as a nonmuscle myosin inhibitor, exhibiting IC50 values of 1.6, 5.4, and >100 μM against skeletal muscle myosin, cardiacFormule :C19H17NO4Degré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :323.34Ref: TM-T67952
1mg185,00€5mg465,00€10mg680,00€25mg1.035,00€50mg1.406,00€100mg1.882,00€500mg3.771,00€1mL*10mM (DMSO)457,00€Gap19
CAS :Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.Formule :C55H96N14O13Degré de pureté :97.67%Couleur et forme :SolidMasse moléculaire :1161.44Verubulin hydrochloride
CAS :Verubulin hydrochloride (MPC-6827 hydrochloride) is an agent of blood brain barrier permeable microtubule-disrupting, with potent and broad-spectrum cytotoxicFormule :C17H18ClN3ODegré de pureté :98.29% - 99.77%Couleur et forme :SolidMasse moléculaire :315.8Ref: TM-T13298
5mg50,00€10mg78,00€25mg145,00€50mg210,00€100mg300,00€200mg434,00€1mL*10mM (DMSO)56,00€SAMβA TFA
SAMβA TFA, a selective antagonist of Mfn1-βIIPKC association conjugated to the cell permeable peptide TAT47-57, is a rationally designed inhibitor that improvesFormule :C50H73N17O16·xC2HF3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1168.22 (free acid)Calyxin H
CAS :Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.Formule :C35H34O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.64K-252c
CAS :K-252c is a staurosporine analog isolated from Nocardiopsis sp.Formule :C20H13N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.34Drp1 peptide inhibitor P110
CAS :Compound P110 (Drp1 peptide inhibitor P110) is a selective Drp1 peptide inhibitor with neuroprotective effects. It inhibits the activation of Drp1, prevents Drp1 mitochondrial translocation induced by MPTP, and alleviates dopamine neuron loss, dopaminergic terminal damage, and behavioral deficits caused by MPTP. This compound is useful for Alzheimer's disease research. Additionally, Compound P110 reduces mitochondrial and organ damage in animal models of Huntington's disease, cerebral ischemia, and myocardial infarction.Formule :C100H179N45O25Couleur et forme :SolidMasse moléculaire :2411.78Albendazole sulfoxide
CAS :Albendazole sulfoxide (Ricobendazole) is a metabolite of Albendazole, an anthelmintic.Formule :C12H15N3O3SDegré de pureté :98.04%Couleur et forme :White To Off-White PowderMasse moléculaire :281.33CCT251455
CAS :CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.Formule :C26H26ClN7O2Degré de pureté :99.1% - 99.1%Couleur et forme :SolidMasse moléculaire :503.98NSC668394
CAS :NSC668394 is an ezrin phosphorylation inhibitor.NSC668394 has antitumor activity and increases ezrin cleavage.NSC668394 can be used to study tumor metastasis.Formule :C17H12Br2N2O3Degré de pureté :99.29% - 99.29%Couleur et forme :SolidMasse moléculaire :452.1SNX0723
CAS :SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.Formule :C22H26FN3O3Degré de pureté :99.86%Couleur et forme :SolidMasse moléculaire :399.46Ref: TM-T28824
1mg89,00€5mg188,00€10mg316,00€25mg512,00€50mg702,00€100mg940,00€500mgÀ demander1mL*10mM (DMSO)207,00€Vedolizumab
CAS :Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis.Degré de pureté :SDS-PAGE:98.4%;SEC-HPLC:99.1%Couleur et forme :LiquidMasse moléculaire :146.80 kDa7-Aminocephalosporanic acid
CAS :7-Aminocephalosporanic acid (7-ACA) is used for synthesis of cephalosporin antibiotics and intermediates.Formule :C10H12N2O5SDegré de pureté :91.05% - 98.22%Couleur et forme :White Solid PowderMasse moléculaire :272.282-Chlorophenoxazine
CAS :2-Chlorophenoxazine is an Akt inhibitor that demonstrates an in vitro inhibitory concentration (IC50) of 2-5 μM and has the capacity to induce apoptosis.Formule :C12H8ClNODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :217.65PD173955
CAS :PD173955 is src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase; less potent for FGFRα and no activity on InsR andFormule :C21H16Cl2N4OSDegré de pureté :98.52% - 99.28%Couleur et forme :SolidMasse moléculaire :443.35Olverembatinib
CAS :Olverembatinib (GZD 824) is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT, IC50: 0.34 nM) and Bcr-Abl(T315I, IC50: 0.68 nM).Formule :C29H27F3N6ODegré de pureté :100% - 99.29%Couleur et forme :SolidMasse moléculaire :532.56Ref: TM-T3071
1mg35,00€2mg48,00€5mg70,00€10mg96,00€25mg210,00€50mg338,00€100mg535,00€1mL*10mM (DMSO)82,00€Thiocolchicine
CAS :Thiocolchicine inhibits tubulin polymerization (IC50: 2.5 µM, Ki: 0.7 µM), induces apoptosis, and serves as an ADC cytotoxin.Formule :C22H25NO5SDegré de pureté :98.19%Couleur et forme :SolidMasse moléculaire :415.5Kanosamine hydrochloride
CAS :Kanosamine hydrochloride is an antibiotic which inhibits the growth of plant-pathogenic oomycetes, certain fungi and a few bacterial species.Formule :C6H14ClNO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :215.63Imatinib Mesylate
CAS :Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR,Formule :C29H31N7O·CH4SO3Degré de pureté :100% - 99.97%Couleur et forme :White Crystalline PowderMasse moléculaire :589.71KG-548
CAS :KG-548 is a dual inhibitor of ARNT/TACC3 and HIF-1α, inhibiting lactate production, and can be used in cancer research.Formule :C9H4F6N4Degré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :282.15Y15
CAS :Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity,Formule :C6H14Cl4N4Degré de pureté :98% - 98%Couleur et forme :Dark Brown CrystalsMasse moléculaire :284.01Ref: TM-T7119
10mg50,00€25mg69,00€50mg82,00€100mg137,00€200mg188,00€500mg331,00€1mL*10mM (DMSO)48,00€Tubulin polymerization-IN-55
CAS :Tubulin polymerisation-IN-55 is a Tubulin Polymerization inhibitor that displays antiproliferative effects on A549, K562, HepG2, MDA-MB-231 and HFL-1.Formule :C22H24N2O4Degré de pureté :98.68%Couleur et forme :SoildMasse moléculaire :380.44T807
CAS :T807 (AV-1451) is a novel tracer of tau positron emission tomography (PET).Formule :C16H10FN3Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :263.27Ref: TM-T19573
2mg47,00€5mg70,00€10mg107,00€25mg187,00€50mg323,00€100mg550,00€200mg758,00€500mg1.159,00€BCR-ABL-IN-1
CAS :BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia.Formule :C23H21F4N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :459.44MK-2206 free base
CAS :MK-2206 free base is an allosteric Akt inhibitor that is both potent and selective, administered orally, exhibiting IC50 values of 8, 12, and 65 nM for Akt1,Formule :C25H21N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.47ARQ 621
CAS :ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.Formule :C28H24Cl2FN5O2Degré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :552.43PKC-θ inhibitor hcl
CAS :PKC-theta inhibitor hcl is a selective PKC-θinhibitor(IC50:12 nM).Formule :C20H26ClF3N6O3Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :490.91Ref: TM-T5817
1mg93,00€2mg120,00€5mg233,00€10mg376,00€25mg628,00€50mg895,00€100mg1.216,00€500mg2.432,00€KT D606
CAS :KT D606 is a PAK kinase family inhibitor with an IC50 of 4 μM. It selectively inhibits the proliferation of cancer cells transformed by oncogenic RAS mutants, making it useful for studying RAS/PAK1-induced cancers.Formule :C59H50N6O10Couleur et forme :SolidMasse moléculaire :1003.06Cyclo(RGDyK)
CAS :Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Formule :C27H41N9O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :619.68Cyclo(-RGDfK) TFA
CAS :Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).Formule :C29H42F3N9O9Degré de pureté :98.99% - 99.54%Couleur et forme :SolidMasse moléculaire :717.69HSP90-IN-23
HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM.Formule :C22H24N2O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.5FAK activator 1
CAS :ZINC40099027 is a FAK activator that induces gastric mucosal repair in persistent aspirin-associated gastric injury.Formule :C23H26F3N3O3Degré de pureté :98.85%Couleur et forme :SoildMasse moléculaire :449.47Ref: TM-T77665
1mg99,00€5mg229,00€10mg383,00€25mg627,00€50mg1.005,00€100mg1.589,00€200mg2.078,00€1mL*10mM (DMSO)296,00€DN401
CAS :DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.Formule :C13H9BrClN5O2Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :382.6Ref: TM-T27193
1mg185,00€5mg409,00€10mg605,00€25mg938,00€50mg1.293,00€100mg1.738,00€500mg3.496,00€1mL*10mM (DMSO)406,00€TRAP1-IN-2
CAS :TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients.Formule :C46H42F6N2O5P2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :878.77Ethoxyquin
CAS :Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.Formule :C14H19NODegré de pureté :95.94%Couleur et forme :Yellow Liquid Mercaptan-Like Odor (Ntp 1992)Masse moléculaire :217.31CWHM-12
CAS :CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).Formule :C26H32BrN5O6Degré de pureté :98.05% - 98.5%Couleur et forme :SolidMasse moléculaire :590.47Ref: TM-TQ0250
1mg40,00€2mg52,00€5mg88,00€10mg126,00€25mg221,00€50mg369,00€100mg550,00€1mL*10mM (DMSO)96,00€Protein Kinase C 19-31 acetate
PKC 19-31 acetate, a serine-altered PKCa-derived PKC inhibitor, tests PKC activity.Formule :C69H122N26O18Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :1603.9
