Signalisation du cytosquelette
Les inhibiteurs de la signalisation du cytosquelette sont des composés qui perturbent les voies de signalisation régulant le cytosquelette, essentiel pour la forme, la motilité, la division des cellules et le transport intracellulaire. Ces inhibiteurs sont utilisés pour étudier la dynamique des protéines du cytosquelette, telles que l'actine et la tubuline, et leur rôle dans des processus comme la migration cellulaire, l'adhésion et la métastase du cancer. Les inhibiteurs de la signalisation du cytosquelette sont précieux dans la recherche en biologie cellulaire, en cancérologie et en neurobiologie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la signalisation du cytosquelette de haute qualité pour soutenir vos recherches dans ces domaines.
Produits appartenant à la catégorie "Signalisation du cytosquelette"
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NVS-PAK1-1
CAS :NVS-PAK1-1 is an effective and selective allosteric PAK1 inhibitor (IC50: 5 nM).Formule :C23H25ClF3N5ODegré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :479.93Volociximab
CAS :Volociximab (M200) is an IgG4 monoclonal antibody targeting the α5β1 integrin , with antiangiogenic, antitumor and anticancer activity, inhibits the growth of rabbit VX2 tumors and is used to study solid tumors.Degré de pureté :95%Couleur et forme :Liquid2119738-71-3
CAS :Compound 2119738-71-3 interacts with the FAK receptor.Formule :C25H29ClFN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.99AD57
CAS :AD57 is a potent inhibitor of both c-Src and Abl with IC50 of 0.025 μM and 0.041 μM, respectively.Formule :C22H20F3N7ODegré de pureté :98.23%Couleur et forme :SoildMasse moléculaire :455.44Ref: TM-T22552L
1mg34,00€2mg52,00€5mg116,00€10mg212,00€25mg359,00€50mg512,00€100mg695,00€200mg939,00€1mL*10mM (DMSO)134,00€Fasudil
CAS :Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Formule :C14H17N3O2SDegré de pureté :99.79% - 99.84%Couleur et forme :SolidMasse moléculaire :291.37PKCη pseudosubstrate inhibitor,myristoylated
CAS :Myristoylated PKCη pseudosubstrate inhibitor is a cell-permeable compound utilized to investigate the mechanism of action of PKCη [1].Formule :C101H185N41O23SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :2373.88Dynamin IN-2
CAS :Dynamin IN-2 (compound 43) is a Wiskostatin analogue.Formule :C22H21ClN2ODegré de pureté :98.81% - 98.83%Couleur et forme :SoildMasse moléculaire :364.87Ref: TM-T64369
1mg140,00€5mg331,00€10mg439,00€25mg667,00€50mg894,00€100mg1.198,00€200mg1.596,00€1mL*10mM (DMSO)341,00€Ifebemtinib hydrochloride
Ifebemtinib (BI-853520) hydrochloride is a potent FAK (focal adhesion kinase) inhibitor with oral bioavailability, exhibiting an IC50 of 1 nM for recombinant FAK. Ifebemtinib hydrochloride demonstrates antiproliferative activity against cancer cells.Formule :C28H29ClF4N6O4Couleur et forme :SolidMasse moléculaire :625.01Ponatinib
CAS :Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectivelyFormule :C29H27F3N6ODegré de pureté :98% - 99.60%Couleur et forme :SolidMasse moléculaire :532.56Compound 1T-0219 (SC)
CAS :Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620Formule :C20H19N3O7Degré de pureté :90%Couleur et forme :SolidMasse moléculaire :413.38PF-AKT400
CAS :PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective and ATP-competitive inhibitor of Akt.Formule :C20H22F2N6ODegré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :400.43Ref: TM-T5508
1mg95,00€5mg227,00€10mg325,00€25mg550,00€50mg787,00€100mg1.093,00€1mL*10mM (DMSO)250,00€BIO-1211
CAS :BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).Formule :C36H48N6O9Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :708.8D-ERYTHRO-SPHINGOSINE
CAS :D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activatorFormule :C18H37NO2Degré de pureté :98% - ≥98%Couleur et forme :SolidMasse moléculaire :299.49Arimoclomol
CAS :Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (Formule :C14H20ClN3O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :313.78Ref: TM-T13553
1mg115,00€5mg249,00€10mg369,00€25mg562,00€50mg787,00€100mg1.054,00€200mg1.406,00€1mL*10mM (DMSO)249,00€Taurolithocholic acid sodium salt
CAS :Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, butFormule :C26H44NNaO5SDegré de pureté :99.79% - 99.93%Couleur et forme :SolidMasse moléculaire :505.69Indatuximab
Indatuximab is a chimeric antibody targeting CD13, used in the synthesis of ADC compound Indatuximab ravtansine.Couleur et forme :LiquidMasse moléculaire :145.5 kDaBalamapimod
CAS :Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.Formule :C30H32ClN7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :574.14AG1024
CAS :AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).Formule :C14H13BrN2ODegré de pureté :98% - 99.37%Couleur et forme :SolidMasse moléculaire :305.17Tirbanibulin
CAS :Tirbanibulin (KX2-391) is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of a variety of cancers.Formule :C26H29N3O3Degré de pureté :99.43% - 99.67%Couleur et forme :SolidMasse moléculaire :431.53Ref: TM-T6345
1mg35,00€5mg66,00€10mg81,00€25mg159,00€50mg280,00€100mg470,00€500mg1.035,00€1mL*10mM (DMSO)70,00€BMS-688521
CAS :BMS-688521 is an LFA-1/ICAM interaction inhibitor, a small molecule antagonist of LFA-1 with potential anti-inflammatory activity.Formule :C26H19Cl2N5O4Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :536.37Ref: TM-T14676
1mg183,00€5mg464,00€10mg655,00€25mg1.169,00€50mg1.539,00€100mg1.882,00€1mL*10mM (DMSO)547,00€AT-533
CAS :AT-533 inhibits Hsp90, HSV, hinders HIF-1α/VEGF/VEGFR-2, Erk1/2, FAK, Akt/mTOR/p70S6K, and blocks tumor growth, angiogenesis, and HUVEC activities.Formule :C23H30N4O3Degré de pureté :99.54%Couleur et forme :SoildMasse moléculaire :410.51Ref: TM-T67836
1mg51,00€5mg111,00€10mg170,00€25mg313,00€50mg467,00€100mg672,00€200mg905,00€1mL*10mM (DMSO)117,00€Azelaoyl PAF
CAS :Azelaoyl PAF is a potent PPARγ agonist that competitively binds thiazolidinediones.promotes the uptake of oxLDL by macrophages by upregulating CD36 expression.Formule :C33H66NO9PCouleur et forme :SolidMasse moléculaire :651.85BAY1217389
CAS :BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).Formule :C27H24F5N5O3Degré de pureté :95.71% - 98.78%Couleur et forme :SolidMasse moléculaire :561.5CIB-L43
CAS :CIB-L43 is an orally active TRBP inhibitor (KD = 4.78 nM) that disrupts the TRBP-dicer interaction (IC50 = 2.34 μM). It suppresses the biosynthesis of oncogenic miR-21, elevates PTEN and Smad7 expression, and inhibits AKT and TGF-β signaling, thereby reducing the proliferation and migration of HCC cells.Formule :C15H16N2O3SCouleur et forme :SolidMasse moléculaire :304.364BCR-ABL-IN-8
CAS :BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor featuring a trimethoxy group [1].Formule :C30H33N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :571.63Abciximab
CAS :Abciximab: chimeric antibody, anti-platelet, blocks glycoprotein IIb/IIIa, vitronectin, Mac-1.Degré de pureté :SDS-PAGE:95.2%;SEC-HPLC:95.9%Couleur et forme :LiquidMasse moléculaire :95.18 kDaVerbascoside
CAS :Verbascoside (Kusaginin) is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.Formule :C29H36O15Degré de pureté :97.46% - 99.55%Couleur et forme :SolidMasse moléculaire :624.59ML-B01
ML-B01 is an orally active inhibitor targeting Akt and PKA, with IC50 values of 2 nM and 136 nM, respectively. It demonstrates good blood-brain barrier (BBB) permeability in mice.Formule :C24H31Cl2N5OCouleur et forme :SolidMasse moléculaire :476.44MSN-125
CAS :MSN-125 inhibits Bax/Bak apoptosis, protects neurons, prevents MOMP with IC50 of 4μM.Formule :C36H38BrN3O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :688.61Dihydrocytochalasin B
CAS :Dihydrocytochalasin B (H2CB) is a cell division inhibitor that inhibits cytokinesis and alters cell morphology.Formule :C29H39NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :481.62Ipatasertib
CAS :Ipatasertib (GDC-0068) is a selective, ATP-competitive pan-Akt inhibitor that can lead to p53-independent PUMA activation.Cost-effective and quality-assured.Formule :C24H32ClN5O2Degré de pureté :98.28% - 99.21%Couleur et forme :SolidMasse moléculaire :458αVβ8-IN-1
CAS :αVβ8-IN-1 is an inhibitor of the αVβ8 integrin. It exhibits growth-suppressive activity against tumors such as EMT6, CT26, KPC, and TKCC-10. αVβ8-IN-1 is suitable for research related to idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), and various cancers.Formule :C25H32ClN5O4Couleur et forme :SolidMasse moléculaire :502.01FRAX486 HCL(1232030-35-1 free base)
FRAX486 HCL is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.Formule :C25H24Cl3FN6ODegré de pureté :98.85% - 99.82%Couleur et forme :SolidMasse moléculaire :549.86Anti-EMMPRIN/CD147 Antibody
Anti-EMMPRIN/CD147 Antibody is a human-derived antibody expressed in CHO cells, targeting Basigin. For an isotype control, refer to HumanIgG1kappa, Isotype Control.Couleur et forme :Odour LiquidPF-04929113 Mesylate
CAS :PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37Formule :C26H34F3N5O7SDegré de pureté :99% - 99.46%Couleur et forme :SolidMasse moléculaire :617.63Ref: TM-T4342
1mg78,00€2mg100,00€5mg159,00€10mg288,00€25mg419,00€50mg615,00€100mg878,00€500mg1.776,00€1mL*10mM (DMSO)233,00€TCS 21311
CAS :TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Formule :C27H25F3N4O4Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :526.51Bimosiamose
CAS :Bimosiamose has anti-inflammatory effects[1].Formule :C46H54O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :862.91αvβ1 integrin-IN-1
CAS :αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.Formule :C26H34N6O6SDegré de pureté :100% - 99.74%Couleur et forme :SolidMasse moléculaire :558.65Ref: TM-T13473
1mg115,00€5mg274,00€10mg432,00€25mg697,00€50mg938,00€100mg1.293,00€200mg1.738,00€1mL*10mM (DMSO)349,00€Cilengitide TFA
CAS :Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.Formule :C29H41F3N8O9Couleur et forme :SolidMasse moléculaire :702.68DB07107
CAS :DB07107 is a potent inhibitor of drug resistant T315I mutant Bcr-Abl tyrosine kinase and a potent Akt1 inhibitor (IC50: 360 nM).Formule :C23H22N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :370.45Estramustine
CAS :Estramustine (LEO-275), a nitrogen mustard-estradiol compound, treats prostate cancer and protects against radiation.Formule :C23H31Cl2NO3Degré de pureté :98.09%Couleur et forme :SolidMasse moléculaire :440.4Ref: TM-T20681
5mg47,00€10mg70,00€25mg126,00€50mg202,00€100mg329,00€200mg487,00€1mL*10mM (DMSO)50,00€Lifitegrast sodium
CAS :Lifitegrast sodium (SAR-1118-023 sodium) is an integrin antagonist that reduces ocular surface inflammation and can be used to study dry eye.Formule :C29H23Cl2N2NaO7SDegré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :637.46Ro 31-8220 Mesylate
CAS :Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.Formule :C25H23N5O2S·CH4O3SDegré de pureté :98.79% - 99.02%Couleur et forme :SolidMasse moléculaire :553.65Ref: TM-T6643
1mg52,00€2mg67,00€5mg97,00€10mg159,00€25mg244,00€50mg338,00€100mg500,00€1mL*10mM (DMSO)140,00€Blinatumomab
CAS :Blinatumomab (AMG-10,MT-103) is a CD19/CD3 bispecific B-cell and T-cell binding antibody that in acute lymphoblastic leukemia and non-Hodgkin's lymphoma.Couleur et forme :LiquidPironetin
CAS :Pironetin, from Streptomyces, inhibits microtubule polymerization and tumor growth, and causes cell cycle arrest.Formule :C19H32O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :324.45ALK inhibitor 2
CAS :ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.Formule :C23H28ClN7O3SDegré de pureté :99% - 99.77%Couleur et forme :SolidMasse moléculaire :518.03HS-27
CAS :HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC.Formule :C52H60N6O12SDegré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :993.13Ref: TM-T18018
1mg90,00€5mg215,00€10mg344,00€25mg612,00€50mg848,00€100mg1.159,00€1mL*10mM (DMSO)378,00€Chelerythrine chloride
CAS :Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect toFormule :C21H18ClNO4Degré de pureté :95% - 99.19%Couleur et forme :Yellow To Orange SolidMasse moléculaire :383.83Bosutinib hydrate
CAS :Bosutinib hydrate (SKI-606 hydrate) is a kinase inhibitor of BCR-ABL and Src tyrosine kinases for the study of leukemia.Formule :C26H31Cl2N5O4Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :548.46Synstatin (92-119)
CAS :Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 andFormule :C133H207N35O46Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3032.27
