Signalisation du cytosquelette
Les inhibiteurs de la signalisation du cytosquelette sont des composés qui perturbent les voies de signalisation régulant le cytosquelette, essentiel pour la forme, la motilité, la division des cellules et le transport intracellulaire. Ces inhibiteurs sont utilisés pour étudier la dynamique des protéines du cytosquelette, telles que l'actine et la tubuline, et leur rôle dans des processus comme la migration cellulaire, l'adhésion et la métastase du cancer. Les inhibiteurs de la signalisation du cytosquelette sont précieux dans la recherche en biologie cellulaire, en cancérologie et en neurobiologie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la signalisation du cytosquelette de haute qualité pour soutenir vos recherches dans ces domaines.
Produits appartenant à la catégorie "Signalisation du cytosquelette"
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GLPG0187
CAS :GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).Formule :C29H37N7O5SDegré de pureté :100% - 99.70%Couleur et forme :SolidMasse moléculaire :595.71PAK4-IN-3
PAK4-IN-3 (compound 27e) is a PAK4 inhibitor exhibiting an IC50 of 10 nM and demonstrates antiproliferative effects on A549 cells with an IC50 of 0.61μM.Degré de pureté :98%Couleur et forme :Odour SolidAurothiomalate sodium
CAS :Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.Formule :C4H3AuNa2O4SDegré de pureté :99.66%Couleur et forme :SoildMasse moléculaire :390.07Capivasertib
CAS :Capivasertib (AZD5363) is a broad-spectrum AKT inhibitor with inhibitory activity against Akt1, Akt2, and Akt3 (IC50=3/7/7 nM) with oral activity.Formule :C21H25ClN6O2Degré de pureté :97.59% - 99.6%Couleur et forme :SolidMasse moléculaire :428.92Ref: TM-T1920
1mg40,00€2mg52,00€5mg70,00€10mg99,00€25mg168,00€50mg246,00€100mg378,00€200mg610,00€1mL*10mM (DMSO)89,00€Onalespib
CAS :Onalespib (AT13387) is an oral Hsp90 inhibitor with anticancer potential, disrupting tumor cell growth and survival.Formule :C24H31N3O3Degré de pureté :98.05% - 99.82%Couleur et forme :SolidMasse moléculaire :409.52Norathyriol
CAS :Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.Formule :C13H8O6Degré de pureté :98.90% - 98.93%Couleur et forme :SolidMasse moléculaire :260.2Ref: TM-TN1990
1mg149,00€5mg354,00€10mg528,00€25mg852,00€50mg1.159,00€100mg1.568,00€1mL*10mM (DMSO)522,00€α7β1 integrin modulator-1
CAS :α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].Formule :C23H29N3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.56AS2521780
CAS :AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).Formule :C30H41N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :547.76Dasatinib hydrochloride
CAS :Dasatinib hydrochloride is an oral Src/Bcr-Abl inhibitor with potent antitumor effects, Ki values of 16 pM (Src) and 30 pM (Bcr-Abl).Formule :C22H27Cl2N7O2SDegré de pureté :99.88% - 99.98%Couleur et forme :SolidMasse moléculaire :524.47Pep2m, myristoylated acetate
Pep2m, a myristoylated acetate, inhibits GluA2-NSF interaction, reducing AMPA receptor function and expression in neurons.Formule :C65H122N18O16SDegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :1443.96PKC 20-28,myristoylated
Myristoylated protein kinase C inhibitor 20-28 (PKC 20-28,myristoylated) is a cell-permeable inhibitor of protein kinase C, utilized in cancer research [1].Formule :C60H106N18O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1255.6CMPD101
CAS :CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Formule :C24H21F3N6ODegré de pureté :98.34% - 99.01%Couleur et forme :SolidMasse moléculaire :466.46TPPB
CAS :TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).Formule :C27H30F3N3O3Degré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :501.54DCP-LA
CAS :DCP-LA (FR236924), linoleic acid derivatives, selective and direct activation of PKCε.Formule :C20H36O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :308.5Abrilumab
CAS :Abrilumab (MEDI-7183) is a fully human monoclonal antibody against α4β7 that inhibits the α4β7 integrin.Couleur et forme :LiquidEgaptivon pegol
CAS :Egaptivon pegol (ARC1779) is an aptamer that inhibits the interaction of von Willebrand Factor (VWF) with platelet GPIb receptors, exhibiting anti-thromboticDegré de pureté :98%Couleur et forme :LiquidKinesore
CAS :Kinesore is a cell-permeable modulator that binds to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 and SKIP.Formule :C20H16Br2N4O4Degré de pureté :97.24%Couleur et forme :SolidMasse moléculaire :536.17Ref: TM-T15663
2mg43,00€5mg66,00€10mg94,00€25mg159,00€50mg230,00€100mg346,00€200mg520,00€1mL*10mM (DMSO)74,00€Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base)
Gly-Arg-Gly-Asp-Ser (GRGDS) acetate is a cell binding protein domain derived from the cell-binding region of fibronectin.Formule :C19H34N8O11Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :550.52(R)-Fangchinoline
CAS :(R)-Fangchinoline ((+)-Thalrugosine) is extracted from Stephania tetrandra S. Moore.Formule :C37H40N2O6Degré de pureté :98% - 99.72%Couleur et forme :SolidMasse moléculaire :608.72Protein Kinase C (19-31)
CAS :Protein Kinase C (19-31), a PKC inhibitor derived from PKCa, has a serine at position 25 and tests PKC activity.Formule :C67H118N26O16Degré de pureté :98%Couleur et forme :Lyophilized PowderMasse moléculaire :1543.82Mps1-IN-3
CAS :Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).Formule :C26H31N7O4SDegré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :537.63Ref: TM-T16130
2mg42,00€5mg64,00€10mg92,00€25mg170,00€50mg311,00€100mg449,00€200mg630,00€1mL*10mM (DMSO)74,00€Antitumor agent-86
CAS :Antitumor agent-86 targets MCF-7 cells with 2.62 µM IC50, induces apoptosis, and disrupts RAS/PI3K/Akt/JNK pathways.Formule :C29H31N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.65[Ala107]-MBP (104-118) acetate
[Ala107]-MBP (104-118) acetate ([Ala107]-MBP ) is synthetic peptide analog of bovine myelin basic protein (MBP).Formule :C59H108N20O21Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :1553.72Myosin V-IN-1
CAS :Myosin V-IN-1: potent, selective Myosin V inhibitor, Ki of 6 μM; hinders actin-activated ATPase by blocking ADP release.Formule :C29H26N6O3SDegré de pureté :97.31% - 97.31%Couleur et forme :SolidMasse moléculaire :538.62Ref: TM-T72060
1mg314,00€5mg663,00€10mg944,00€25mg1.396,00€50mg1.890,00€100mg2.547,00€1mL*10mM (DMSO)677,00€DPH
CAS :DPH is a potent cell permeable activator of c-Abl. It shows potent enzymatic and cellular activity in stimulating c-Abl activation.Formule :C18H13FN4O2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :336.32BOS-172722
CAS :BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).Formule :C24H30N8ODegré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :446.55AKT Kinase Inhibitor
CAS :AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner.Cost-effective and quality-assured.Formule :C16H19N7O3Degré de pureté :98.53% - 99.86%Couleur et forme :SolidMasse moléculaire :357.37Ref: TM-T10276
1mg136,00€5mg329,00€10mg567,00€25mg887,00€50mg1.188,00€100mg1.605,00€1mL*10mM (DMSO)360,00€CCB02
CAS :CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity.Formule :C14H9N3ODegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :235.24Ref: TM-T10704
1mg115,00€5mg274,00€10mg432,00€25mg845,00€50mg1.293,00€100mg1.768,00€1mL*10mM (DMSO)303,00€p5 Ligand for Dnak and DnaJ acetate
p5 Ligand for Dnak and DnaJ acetate is a nonapeptide. It is a high-affinity ligand for DnaK (E. coli Hsp70) and DnaJ (E. coli Hsp40).Formule :C46H85N15O13SDegré de pureté :96.33%Couleur et forme :SolidMasse moléculaire :1088.32DOTA-cyclo(RGDfK)
CAS :DOTA-cyclo(RGDfK) is a and DOTA-like chelator peptide,the αvβ3 integrin receptor ,radionuclide coupled compounds RDCs cancer diagnostics and therapy.Formule :C43H67N13O14Couleur et forme :SoildMasse moléculaire :990.07Psychosine
CAS :Psychosine (Galactosylsphingosine) is a PKC inhibitor, and is highly cytotoxic, inducing cell death in a variety of cells.Formule :C24H47NO7Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :461.63BI-1950
CAS :BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.Formule :C32H26Cl2FN7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :646.5KU-177
CAS :KU-177 is an Aha1 inhibitor that disrupts the interaction between Hsp90 and Aha1, eliminating cell proliferation and PI resistance induced by elevated AHSA1.Formule :C27H23NO8Degré de pureté :97.34% - 98.54%Couleur et forme :SolidMasse moléculaire :489.47KIF18A-IN-16
CAS :KIF18A-IN-16 (Compound 15) is a polycyclic KIF18A inhibitor. It is applicable in research related to tumors, including colon cancer, breast cancer, and lung cancer.Formule :C30H37N5O4SCouleur et forme :SolidMasse moléculaire :563.71N-[2-(5-Chloro-1H-indol-3-yl)ethyl]-4'-cyanobiphenyl-2-carboxaMide
CAS :N-[2-(5-Chloro-1H-indol-3-yl)ethyl]-4'-cyanobiphenyl-2-carboxaMide, a TAU cytotoxicity inhibitor, inhibits LDH leakage of M17-TAU P301L cells with EC50 of 325nMFormule :C24H18ClN3ODegré de pureté :98.65%Couleur et forme :SoildMasse moléculaire :399.87Ref: TM-T60041
1mg115,00€5mg255,00€10mg375,00€25mg562,00€50mg787,00€100mg1.074,00€200mg1.454,00€1mL*10mM (DMSO)279,00€GNF-7
CAS :GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.Formule :C28H24F3N7O2Degré de pureté :97.05% - 99.47%Couleur et forme :SolidMasse moléculaire :547.53(-)-Indolactam V
CAS :(-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for C1 domains.Formule :C17H23N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :301.38ZINC194100678
CAS :ZINC194100678 is an effective PAK1 inhibitor with IC50 of 8.37μM.Formule :C10H13N5ODegré de pureté :98.3%Couleur et forme :SolidMasse moléculaire :219.24Tau-aggregation and neuroinflammation-IN-1
CAS :Potent tau aggregate inhibitor, anti-inflammatory, low cytotoxicity, reverses memory impairment in rats.Formule :C25H20N2O7Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :460.44VER49009
CAS :VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).Formule :C19H18ClN3O4Degré de pureté :100% - 99.17%Couleur et forme :SolidMasse moléculaire :387.82Ref: TM-T2268
1mg60,00€2mg85,00€5mg111,00€10mg167,00€25mg283,00€50mg472,00€100mg643,00€1mL*10mM (DMSO)96,00€HSDVHK-NH2 acetate
P11 acetate is an integrin αvβ3-vitronectin interaction antagonist(IC50 = 2.74 nM).Formule :C32H52N12O11Degré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :780.39Gantofiban
CAS :Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.Formule :C21H29N5O6Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :447.48FAK inhibitor 7
CAS :FAK inhibitor7, a potent FAK inhibitor, demonstrates an IC50 of 3.58 nM. This compound effectively inhibits downstream signaling cascades of FAK (such as Src and AKT), which leads to cell cycle arrest at the G0/G1 phase and induces cytotoxic autophagy in ovarian cancer cells. Additionally, FAK inhibitor7 has been shown to suppress tumor metastasis and growth in ovarian cancer mouse models.Formule :C32H37N7O3Couleur et forme :SolidMasse moléculaire :567.68ALK-IN-29
ALK-IN-29 (compound 4c) exhibits inhibitory effects on tyrosine protein kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, displaying a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is applicable in cancer research.Formule :C29H32FN3OCouleur et forme :SolidMasse moléculaire :457.58MPT0B014
CAS :MPT0B014 is a potent tubulin polymerization inhibitor. MPT0B014 can induce cancer cell apoptosis.Formule :C19H17NO4Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :323.34PF-04691502
CAS :PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.Formule :C22H27N5O4Degré de pureté :96.27% - ≥95%Couleur et forme :SolidMasse moléculaire :425.48KU-32
CAS :KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.Formule :C20H25NO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.41iRGD peptide
CAS :iRGD peptide: 9-amino acid cyclic compound (CRGDKGPDC), found through phage display in mice with tumors.Formule :C35H57N13O14S2Degré de pureté :98.77%Couleur et forme :SolidMasse moléculaire :948.04S-methyl DM1
CAS :S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin(Kd of 0.93 μM) and inhibts microtubule polymerization.Formule :C36H50ClN3O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :752.31HSP90-IN-22
CAS :HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM inFormule :C25H30N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :434.53
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