Molécules organiques diverses avec substitutions isotopiques

Applications An isotopically labelled analog of a serum lipid regulating agent used as an antihyperlipoproteinemic. References Kissebach, A.H., et al.: Atherosclerosis, 24, 199 (1976), Lewis, J.E., et al.: Pract. Cardiol., 9, 99 (1983), Rubins, H.B., et al.: N. Engl. J. Med., 341, 410 (1999)

Applications Isotope labelled analogue of D-arabinitol, a sugar alcohol. D-arabinitol was used as a diagnostic tool for the detection of fungal infections in neutropenic patients. References Salonen, J.H., et al.: Eur. J. Clin. Microbiol. Infect. Dis., 20, 179 (2001);

Applications Clothianidin-d3 (N-methyl-d3) (CAS# 1262776-24-8) is a useful isotopically labeled research compound. This compound can be used to detect trace levels of neonicotinoid insecticides in honey bee royal jelly using ultra-sound assisted liquid-liquid extraction-UHPLC/MS. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Giroud, B., et.al., Microchemical J., 151,104249,(2019);

Applications Clozapine-d4 can act as modulators of dopamine receptors, serotonin receptors, adrenergic receptors, acetylcholine receptors, and/or histamine receptors. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Gant, T. G., U.S. Pat. Appl. Publ. (2010), US 20100166887 A1, 20100701

Applications 2-Methylpropionic-2-d1 Acid (CAS# 19136-93-7) is a useful isotopically labeled research compound.

Applications Isotope labelled Vinclozolin (V314050), which is an agricultural fungicide which acts through an anti-androgenic mode of action, however is incapable of disrupting endocrine homeostasis (1). Affects male reproductive organs through increased gonad activity with spermatogenesis with deformities (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References 1. Flick, B. et al.: Arch. Toxicol. 2017 Apr;91(4):1941-1956.2. Watermann, B. et al.: J. Environ. Sci Health A Tox Hazard Subst Environ Eng. 2016 Nov 9;51(13):1111-20.

Applications Labelled Pyrovalerone (P997750). A CNS stimulant. Controlled substance (stimulant). References Stille, et al.: Arzneim.-Forsch., 13, 871 (1963), Michaelis, et al.: J. Med. Chem., 13, 497 (1970),