Molécules organiques diverses avec substitutions isotopiques

Applications Nonanedioic-D14 acid is a labelled analogue of Nonanedioic acid, a bioactive molecule used in treating acne and other skin disorders. References Gasco, M., et al.: Int. J. Pharm., 69, 193 (2001)

Applications An inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells. References Park, J.M., et al.: J. Urol., 162, 1110 (1999), Watson, M., et al.: Brit. J. Pharmacol., 127, 590 (1999)

Applications Isotope labelled Benzotriazole BT is a low volatile benzotriazole UV light absorber and stabilizer. References Nakata, H., et al.: Environ. Sci. Technol., 43, 6920 (2009)

Applications 1-(3-Pyridyl-d4)-1,4-butanediol is the labeled analogue of 1-(3-Pyridyl)-1,4-butanediol (P992500), a metabloite of NNK (M325750), a carcinogen that readily produces cancer in rats and hamsters. References Koenigs, L., et al.: Drug Metab. Dispos., 25, 1407 (1997); Gu, J., et al.: Toxicol. Appl. Pharmacol., 165, 158 (2000); Jalas, J., et al.: Chem. Res. Toxicol., 18, 95(2005); Zhu, L., et al.: Drug Metab. Dispos., 34, 1672(2006)

Applications Labelled Nizatidine. Histamine H2-receptor antagonist related to Ranitidine (R120000). Antiulcerative. References Callaghan, J.T., et al.: Clin. Pharmacol. Ther., 37, 162 (1985), Secor, J.W., et al.: Br. J. Clin. Pharmacol., 20, 710 (1985), Knadler, M.P., et al.: Drug Metab. Dispos., 14, 175 (1986), Wozniak, T.J., et al.: Anal. Profiles Drug Subs., 19, 397(1990)

Applications A novel, centrally acting oral analgesic with a dual mode of action that has demonstrated efficacy in preclinical and clinical models of pain relief. References Boxenbaum, H., et al.: J. Pharm. Sci., 2, 47 (1999), Boase, S., et al.: Br. J. Clin. Pharmacol., 54, 493 (2002), Armstrong, S., et al.: Psychosomatics, 44, 515 (2003), Bjornsson, T., et al.: Drug Metab. Dispos., 31, 815 ( 2003),

Applications Isotope Labelled Formaldehyde (F691350), used in various organic synthesis and reactions. It is used in the textile industry in the area of crosslinking molecules to vary the properties of cotton fabrics (1). It can help improve the water resistance of biodegradable collagen films (2). In the food industry it is used to reinforce and improve packaging of meats and produce.Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References 1. Liang, T. et al.: Text Res. J. 1992 Sep:62(9) 547-5512. Sommer, I. et al.: J. Appl. Polym. Sci. 2012 Sept:125(S2) ppE27-41

Stability Hygroscopic Applications N,N'-Diphenylguanidine-d10 is the labeled version of 1,3-Diphenylguanidine (CAS 102-06-7), which is a useful intermediate. N,N'-Diphenylguanidine-d10 is also a rubber vulcanizing acclerator.

Applications Labelled glycerol kinase substrate specificity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Castro, C., et al.: Biochemistry, 7, 3213 (1968), Janssen, D., et al.: Eur. J. Biochem., 171, 67 (1988), Kurihara, T., et al.: J. Biochem., 117, 1317 (1995),

Applications Labelled analogue of an essential amino acid found in naturally produced peptides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins. References Karunakaran, S.et al.: Bochem. J., 414, 343 (2008); Pallaghy, P.K. et al.: Biochem., 38, 11553 (1999);

Applications 25-Hydroxyvitamin D2 (6,19,19-D3,97%) 100 Ug/Ml In Ethanol (cas# 1217467-39-4) is a useful research chemical.

Applications Labelled tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant. References Malen, C., et al.: Experientia, 28, 811 (1972), Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987), Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990), Pierre, A., et a.: Cancer Res., 51, 2312 (1991),

Applications Labelled Rasagiline. A selective irreversible MAO-B inhibitor. Rasagiline is an Antiparkinsonian agent. References Rabey, J.M., et al.: Clin. Neuropharmacol., 23, 324 (2000), Glezer, S., et al.: Eur. J. Pharmacol., 472, 173 (2003), Youdim, M.B.H., et al.: Biochem. Pharmacol., 66, 1635 (2003), Chen, J.J., et al.: J. Clin. Pharmacol., 45, 878 (2005),

Applications 5α-Cholestan-3β-ol-d7 is the isotope labelled analog of 5α-Cholestan-3β-ol. 5α-Cholestan-3β-ol is a carbon stanol formed from biohydrogenation of Cholesterol (C432501) in the gut. References Serizawa, S., et al.: J. Biochem., 92, 547 (1982);

Applications A labelled related drug of Clenbuterol (C569998), a β-agonist which can be used as a growth promoter in farm animals. References Mosbach, K., et al.: Biotechnology, 14, 163 (1996), Rashid, B., et al.: J. Pharm. Biomed. Anal., 21, 635 (1999), Brambilla, G., et al.: Toxicol. Lett., 114, 47 (2000),

Applications 2,2,4-Trimethyl-1,3-pentanediol Diisobutyrate-d7 is the deuterated version of 2,2,4-Trimethyl-1,3-pentanediol Diisobutyrate (T798120), which is a plastic additive and was found to associate with newly diagnosed asthma. References Gao, X.L., et al.: Food. Sci. Biotechnol., 18, 1447 (2009); Villberg, K., et al.: Indoor. Built. Environ., 17, 455 (2008)

Stability Hygroscopic Applications Dioxybenzone-d3 is an isotopic analog of Dioxybenzone (D486365), a compound used in sunscreen formulations to block out UVB and UVA harmful rays. References Baumgartner, V. et al.: J. Planar. Chrom. Modern. TLC., 22, 19 (2009); Kunisue, T. et al.: Anal. Meth., 2, 707 (2010);

Applications 3-Methylbutyl Acetate-d3 (CAS# 1219804-75-7) is a useful isotopically labeled research compound.

Applications Labelled Clobazam (C582500). Benzodiazepine psychotherapeutic agent. Clobazam (CLB) has proven efficacy against multiple seizure types. An anxiolytic; anticonvulsant. Controlled substance (depressant). References Gastaut, H., et al.: Epilepsia, 20, 437 (1979), Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990), Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993),

Applications Labelled Glycidyl Oleate. Used for preparation of Lysophosphatidic acid analogs as agonists of the edg2 lysophosphatidic acid receptor. References Lee, M., et al.: J. Biol. Chem., 271, 11272 (1996), Macrae, A., et al.: Mol. Brain Res., 42, 245 (1996), Hopper, D., et al.: J. Med. Chem., 42, 963 (1999),

Applications Loratadine-d5 (ethyl-d5) (CAS# 1398065-63-8) is a useful isotopically labeled research compound.

Stability Hygroscopic Applications Labelled 3-Aminoisobutyric Acid (A611585). Substituted β-alanines. Used for preparation and isolation of D(-)-β-aminoisobutyric acid. References Kakimoto, Y., et al.: J. Biol. Chem., 236, 3288 (1961),

Applications The active metabolite of Racecadotril (R070600). References Roques, B.P., et al.: Nature, 288, 286 (1980), Tiraboschi, G., et al.: Protein Engineering, 12, 2, 141 (1999)

Applications Chloramphenicol-d5, is the labeled analogue of Chloramphenicol (C325030), which has a broad spectrum of activity against Gram-positive and gram-negative bacteria. It is also antibacterial, and antirickettsial. References Bartz, et al.: J. Biol. Chem., et al.: 172, 445 (1948), Gottlieb, et al.: J. Bacteriol., 55, 409 (1948), Szulczewski, D., et al.: Anal. Profiles Drug Subs., 4, 47 (1975), Price, A., et al.: J. Antibiot., 43, 118 (1981), Shalit, I., et al.: Drugs, 28, 281 (1984),

Applications A labelled β-adrenergic agonist, related to Clenbuterol and Mabuterol. A repartitioning agent. References Engelhardt, G., et al.: Arzneim.-Forsch., 34, 1625 (1984),

Applications Labelled Melengestrol acetate (M215352). Orally active progestational steroid. Progestogen; growth promotant. References Patton, M., et al.: Zoo Biol., 26, 311(2007), Sellin, M., et al.: Environ. Toxicol. Chem., 28, 2443 (2009), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Sanseverino, J., et al.: Toxicol. Sci., 107, 122 (2009),

Applications Labelled analogue of L-Phenylalanine, an essential amino acid. References Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);

Applications o-Cresol-d3 (methyl-d3) (CAS# 70837-27-3) is a useful isotopically labeled research compound.

Applications Bisphenol Z-d6 is the isotope labelled analog of Bisphenol Z. Bisphenol Z is one of the many derivatives of Bisphenol A (B519495) that can be used as HIF (hypoxia-inducible factor) inhibitors, antitumor agents, angiogenesis inhibitors, and antihypoxic agents. References Imaoka, S., Bisphenol A derivatives as HIF inhibitors. Jpn. Kokai Tokkyo Koho. JP 2011195574 A 20111006. Oct 6, 2011

Applications A 5-HT3 receptor antagonist. Used as an antiemetic. References Sato, N., et al.: Japan J. Pharmacol., 59, 443 (1992), Haga, K., et al.: Japan J. Pharmacol., 63, 377 (1993)

Stability Volatile Applications 2,​2,​3,​3,​3-​Pentafluoropropanoic Acid-13C is the labeled analogue of 2,​2,​3,​3,​3-​Pentafluoropropanoic Acid (P227235), which is used in the analysis of gentamicin with Gemini column by liquid chromatographic (LC) methods. It was also used to prepare [(R)-(amino)(oxo)(fluorophenyl)butyl]tetrahydro(fluoroethyl)-1,2,4-triazolo[4,3-a]pyrazine using (fluoro)propanoic acid. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Manyanga, V., et al.: J. Pharm. Biomed. Analysis, 45, 257 (2007); Kim, D., et al.: J. Med. Chem., 48, 141 (2005)

Applications A labelled protein kinase C inhibitor. References Marki, H.P., et al.: Helv. Chimica Acta, 71, 320 (1988), Iwagami, H., et al.: Bull. chem. Soc. Jpn., 63, 3073 (1990), Funahashi, T., et al.: J. Bacteriol., 184, 936 (2002),

Applications 17-epi-Testosterone-d3 is the labelled analog of 17-epi-Testosterone.Testosterone (T155000) and epitestosterone (T155005) are endogenous steroids that differ in the configuration of the hydroxyl-bearing carbon at C-17. Testosterone is the predominant male sex hormone, whereas the role of epitestosterone is largely unclear. In humans, both androgens are excreted mainly as glucuronide conjugates. References Wudy, S., et al.: Steroids, 66, 759 (2001), Kootstra, P., et al.: Anal. Chim. Acta., 586, 82 (2007), Sten, T., et al.: Drug Metab. Dispos., 37, 417 (2009),

Applications Diethyl Methyl-d3-malonate (cas# 54840-57-2) is a compound useful in organic synthesis. References Bartell, L., et al.: J. Chem. Phys., 42, 85 (1965), Suzuki, T., et al.: Agric. Biol. Chem., 44, 2519 (1980), Suzuki, T., et al.: Appl. Ent. Zoo., 18, 134 (1983),

Applications A potent, selective, cell permeable histone deacetylase inhibitor (HDAC). Displays anti-angiogenic activity by interfering with VEGF signaling in human umbilical vein endothelial cells (HUVECs). Induces differentiation in uman breast cancer cells. References Richon, V.M., et al.: Proc. Natl. Acad.Sci. USA, 95, 3003 (1988), Munster, P.N., et al.: Cancer Res., 61, 8492 (2001), Deroanne, C.F., et al.: Oncogene, 21, 247 (2002),

Stability Hygroscopic Applications Formic Acid-d is the isotope labelled analog of Formic Acid (F692900). Formic Acid is used as a potential energy source in the preparation of fuel cells. Also used in chemical synthesis of various anti-inflammatory and anti-microbial agents. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Yu, X. et al.: J. Power Source., 182, 124 (2008); Bekhit, A. et al.: Bioorg. Med. Chem., 12, 1935 (2004);

Applications Tiglyl Glycine-13C2,15N is a labelled derivative of Tiglyl Glycine (T440100).