Molécules organiques diverses avec substitutions isotopiques

Applications A metabolite of Dimetridazole (D479660). References Voogd, C., et al.: Mutat. Res., 86, 243 (1981), Polzer, J., et al.: Anal. Chim. Acta., 529, 299 (2005), Mohamed, R., et al.: J. Agric .Food Chem., 56, 3500 (2008),

Applications Labelled Imazalil Sulfate, an imidazole derivative used as a fungicide. Imazalil Sulfate controlled epidermis anthracnosis caused by Colletotrichum musae and crown rot in harvested bananas. Imazalil Sulfate is used for fungal protection of citrus fruits such as oranges and lemons as well as other fruits. Imazalil Sulfate is an effective fungicide allowing induction of barley callusin culture media. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Frossard, P. et al.: Fruits, 361 (1976); Van Gestel, J. et al.: Plant Dis. Rep., 63, 283 (1979); Laencina, J. et al.: EFCE Pub. Ser., 12, 295 (1980); Coppens, L. et al.: Meded. Fac. Landbouw. Uni. Gent., 49, 351 (1984);

Applications A labelled metabolite of Dimetridazole (D479660). References Voogd, C., et al.: Mutat. Res., 86, 243 (1981), Polzer, J., et al.: Anal. Chim. Acta., 529, 299 (2005), Mohamed, R., et al.: J. Agric .Food Chem., 56, 3500 (2008),

Applications Labelled Mesoridazine (M225760). Mesoridazine is an antipsychotic. References Rossato, G., et al.: ChemMedChem, 5, 2088 (2010), Sudeshna, G., et al.: Eur. J. Pharmacol., 648, 6 (2010), Hidaka, S., et al.: J. Toxicol. Sci., 35, 393 (2010),

Applications Isotope labelled Cinobufagine (C475500) is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Yin, J.Q., et al.: Toxicol. Lett., 218, 129 (2013); Xing, J.F., et al.: J. Separat. Sci., 35, 1884 (2012);

Applications Labelled Cyproterone (C989090). An antiandrogen, suppresses Testosterone and its metabolites. Derivatives of Cyproterone are administered to patients suffering from hypersexuality and to help facilitate the sexual transformation of male-to-female transsexuals. References Gracia, T., et al.: Toxicol. App. Pharmacol., 225, 142 (2007), Ahlin, G., et al.: J. Med. Chem., 51, 5932 (2008), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Bovee, T., et al.: J. Steroid Biochem. Mol. Biol., 118, 85 (2010),

Applications 4-Hydroxy-3-methoxybenzaldehyde-d3 is a useful intermediate used in the synthesis of deuterated dietary antioxidants like ferulic acid derivatives and α-tocopherol. References Parikka, K., et al.: J. Label. Compds and Radiopharm., 50, 475 (2007)

Applications Benzo[a]pyrene-d12 is deuterium labelled and a useful compound for determining polycyclic aromatic hydrocarbons in cigarette mainstream smoke. It can also be used to prepare isotope internal standard solutions suitable for analyzing polycyclic aromatic compounds from complex mixtures in mass spectrometry. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Wang, X., et al.: Faming Zhuanli Shenqing CN 103439443 A 20131211 (2013); Sim, P. G., et al.: Polycyclic Aromat. Compd 3, 55 (1993)

Applications Sodium Cholesterol-25,26,26,26,27,27,27-d7 Sulfate is a useful isotopically labeled compound of Cholesterol 3-Sulfate Sodium Salt (C432500)

Applications Nonadecanoic-d37 Acid (CAS# 1219798-49-8) is a useful isotopically labeled research compound.

Applications 2,3,4,4',5-Pentachlorobiphenyl-2',3',5',6'-d4 (CAS# 1219799-24-2) is the labelled version of 2,3,4,4',5-Pentachlorobiphenyl (P238200(M)), which is a toxic organic pollutant. References Noren, K., Meironyte, D.: Chemosphere, 40, 1111 (2000); Shoeib, M., Harner, T.: Environ. Sci. Technol., 36, 4142 (2002);

Applications A biologically active labelled metabolite of Desogestrel. References Croxatto, H.B., et al.: Hum. Reprod., 14, 976 (1999), Edwards, J.E., et al.: Brit. J. Fam. Plan., 24, 3 (1999),

Applications (S)-Naproxen-d3 is the labeled analogue of (S)-Naproxen (N377520), an anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Harrison, I.T., et al.: J. Med. Chem., 13, 203 (1970)

Applications Nor Lidocaine-d6 Hydrochloride is the labeled analogue of Nor Lidocaine Hydrochloride (N713500), a hydrochloride salt metabolite of Lidocaine (L397800), a local anesthetic; antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Fukuda, S., et al.: Anesthesiology, 53, 106 (1980); Duce, R., et al.: J. Pharmacol. Exp. Ther., 179, 580 (1971); Kronberg, G.H., et al.: J. Med. Chem., 16, 739 (1973); Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985); Davies, P.S., et al.: Drugs, 64, 937 (2004)

Stability Light Sensitive Applications Moxidectin-d3 is a the labelled form of Moxidectin (M744800). Moxidectin is a macrocyclic lactone and semisynthetic derivative of nemadectin. Moxidectin is a parasiticide used for the prevention and control of heartworm and intestinal worms. Moxidectin is found in veterinary medicine used to treat animals such as dogs, cats, horses, cattle and sheep. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bisset, S.A. et al.: New Zeal. Vet. J., 40, 97 (1992); Monahan, C.M. et al.: Vet. Parasitol., 63, 225 (1996); Glickman, L.T. et al.: Int. J. Appl. Res. Vet. Med., 3, 49 (2005)

Stability Volatile Applications 1,2-Dichloroethane-D4 is a labelled analogue of 1,2-Dichloroethane (D434325). 1,2-Dichloroethane is one of the major waste products of the Vinyl Chloride industries, and has also been classified as a potential human carcinogen. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Hung, W., et al.: Appl. Surf. Sci., 255, 2205 (2008); Rannug, U., et al.: Chem.-Biol. Int., 20, 1 (1978)

Applications Labelled Intedanib (I666650). It is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases; an indolinone as triple angiokinase inhibitors. An antitumor agent. References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998), Xie, H., et al.: J. Med. Chem., 50, 4898 (2007), Hilberg, F., et al.: Cancer Res., 68, 4774 (2008),

Applications Pentanoic-5,5,5-d3 Acid acts as a reagent used in the isomerization and fragmentation of pentanoic and methylbutanoic acid cation radicals in gas phase. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Audier, H., et al.: Bull. Soc. Chim. Fr., 5, 833 (1985)

Applications Labelled Benzoisothiazol-3-one (B204035). Antimicrobial agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Endo, J., et al.: Biosci. Biotechnol. Biochem., 73, 183 (2009), Zhang, X., et al.: Bioorg. Med. Chem., 17, 855 (2009),

Applications CMPF-d3 is the labeled analogue of CMPF (C595000). CMPF is a drug-binding inhibitor which is also a constituent of urine. CMPF can inhibit specific T4 binding in serum by increasing the free concentration of direct competitors. References Mabuchi, H., Nakahashi, H.: Nephron, 44, 277 (1986); Lim, C.F., et. al.: Metabolism Clin. Exp., 42, 1468 (1993);

Applications Labelled Diazepam, an anxiolytic; muscle relaxant (skeletal); anticonvulsant.Diazepam is a Controlled substance (depressant). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 79 (1972), Mandelli, M., et al.: Clin. Pharmacokinet., 3, 72 (1978), Bertilsson, L., et al.: Pharmacol. Ther., 45, 85 (1990), Murray, J.B., et al.: J. Psychol., 124, 655 (1990), Pellock, J.M., et al.: Drug Saf., 27, 383 (2004),

Applications Deuterated Tolterodine (T535800), a muscarinic receptor antagonist. Used in the treatment of urinary incontinence. References Nilvebrant, L., et al.: Life Sci., 60, 1129 (1997), Nilvebrant, L., et al.: Eur. J. Pharmacol., 327, 195 (1997), Brynne, N., et al.: Int. J. Clin. Pharmacol. Ther., 35, 287 (1997)

Applications Desmethyl Bromethalin-13C is the labeled form of Desmethyl Bromethalin(D291200), is a metabolite of Bromethalin rodenticide found in the blood and liver of treated animals. References Van Lier, R.B.L., et at.: Fundamental Appl. Toxicol., 11, 664 (1988),

Applications Behenic Acid-d43 is the labelled form of Behenic Acid (B119580) which is used in hair conditioners and moisturizers to give their smoothing properties. Behenic Acid is also used in lubricating oils, as solvent evaporation retarder in paint removers. References Efimenko, S. G., et al.: Maslozhirovaya Promyshlennost, 4, 16 (2012); Cermak, S., et al.: Indust. Crops Prod., 44, 232 (2013);

Applications O-Desmethyl Tramadol-d6 Hydrochloride is the labeled analog of O-Desmethyl Tramadol Hydrochloride (D294740), a metabolite of Tramadol, an analgesic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Frink, M.C., et al.: Arzneim-Forsch., 46, 1029 (1996)

Applications 2-Methyl-d3-pyridine (CAS# 10259-19-5) is a useful isotopically labeled research compound.

Applications Isotope labelled intermediate in the synthesis of Dexamethasone (D298800), a glucocorticoid anti-inflammatory agent. References Liu, Y., et al.: Anal. Bioanal. Chem., 395, 591 (2009), Rodgers, A., et al.: Chem. Res. Toxicol., 23, 724 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),

Applications Dodecane-d26, is the labeled analogue of Dodecane (D494625), which is used in the synthesis of triblock polymers that deliver nanoparticles to the oil/water interface and degrade non-tocxc non-aqueous liquids. References Saleh, N. et al.: Nano. Lett., 2489, 5 (2005); Scarso, A. et al.: J. Am. Chem. Soc., 126, 13512 (2004);

Applications A labelled metabolite of Tryptophan. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Gartside, S., et al.: Eur. J. Pharmacol., 179, 103 (1990), Gijsman, H., et al.: J. Clin. Psychopharmacol., 22, 183 (2002), Schruers, K., et al.: Psychiatry Res., 113, 237 (2002),