Molécules organiques diverses avec substitutions isotopiques

Applications DL-p-Hydroxyphenyllactic Acid-d3 is the isotope labelled analog of DL-p-Hydroxyphenyllactic Acid (H953665); a reagent in the synthesis of 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactic acid which is an important intermediate of rosmarinic acid biosynthesis. References Matsuno, M., et al.: Chem. Pharm. Bull., 49, 1644 (2001)

Applications An isotopically labelled version of Valsartan (V095750), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive. References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)

Applications A deuterated metabolite of the potent and selective inhibitor of HIV-1 replication, AZT.This compounds contains Sodium Chloride. Water content not determined.

Applications 1-Bromonaphthalene-d7 (cas# 37621-57-1) is a compound useful in organic synthesis.

Applications 10α-Methoxy-9,10-dihydrolysergol-d3 is the labeled analogue of 10α-Methoxy-9,10-dihydrolysergol (M262280), a derivative of Lysergol and Dehydrolysergol-I which act as partial agonists and antagonists at 5-HT2A, 5-HT2C and 5-HT1B receptors, and at α1-andrenergic receptors. References Pertz, H.H., et al.: J. Pharm. Pharmacol., 51, 319 (1999)

Stability Easily Oxidized Applications 1-Bromo-4-nitrobenzene-d4 (cas# 350820-19-8) is a compound useful in organic synthesis. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications N4-Acetylcytidine-13C5 is a labeled analogue of N4-Acetylcytidine (CAS# 3768-18-1), which is a nucleotide-derived metabolite used as biomarkers for diagnosis of inflammation-related diseases. References Faustin, B.: Eur. Pat. Appl. 47 pp. (2017)

Stability Hygroscopic Applications Dopamine receptor blocker; parent compound of sulforidazine and mesoridazine. Antipsychotic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Goldenthal, E.I., Toxicol. Appl. Pharmacol., 18, 185 (1971), Abdel-Moety, E.M., et al.: Anal. Profile Drug Subs., 18, 459 (1989),

Applications 2'-O-Methyl Adenosine-d3 is the labeled analogue of 2'-O-Methyl Adenosine (M276150), which is an Adenosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. References Eldrup, A.B., et al.: J. Med. Chem., 47, 2283 (2004), Shim, J., et al.: Antiviral Res., 243 (2003), Wang, M., et al.: J. Biol. Chem., 278, 9489 (2003),

Applications: A labelled nitrogenous base component in the nucleic acid of DNA. References Keum, Y., et al.: App. Microbiol. Biotechnol., 80, 863 (2008), Redzic, Z., et al.: Neurochem. Res., 34, 566 (2009), Lanevskij, K., et al.: J. Pharm. Sci., 98, 122 (2009), Rajendar, B., et al.: Bioorg. Med. Chem., 17, 351 (2009),

Applications 1-Hydroxypyrene-d9 is found in humane urine after exposure to coal tar and a coal derived product. References Jongeneelen, F.J., et al.: Int. Arch. Occup. Environ. Health, 57, 47 (1985)

Applications DHPMA-d5 is the labeled isotope of DHPMA (D965260(M), of which has a (S)-isomer, S-​(2,​3-​Dihydroxypropyl)​mercapturic Acid (CAS# 23255-​33-​6), which was identified as a metabolite in rats. References Jones, A. R., et al.: Experientia, 35, 1432 (1979)

Applications Labelled analogue of Resorcinol, a benzene derivative used as keratolytic and antiseborrheic. Also used in veterinary medicine as a topical antipruritic and antiseptic (has been used as intestinal antiseptic). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Strakosch, E.A. et al.: Arch. Dermat. Syphil., 48, 393 (1943); Dyson, G.M.: Pharm. J., 120, 582 (1928); Sabalitschka, T. et al.: Pharmazeutiche Zeitung, 81, 335 (1936);

Applications Fenchlorphos-D6 is a labelled analogue of Fenchlorphos (F247402). Fenchlorphos is an organophosphorus pesticide that is used to maintain pest control. Fenchlorphos is highly toxic, and is known to exhibit toxic effects on animals such as rats. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Curini, M., et al.: Talanta, 27, 45 (1980); Johnson, W. & Langford, G.: J. Econ. Entomol., 53, 477 (1960); McCollister, D., et al.: J. Agr. Food Chem., 7, 689 (1959); Sulinski, A., et al.: Neuro. Pols., 14, 451 (1976)

Applications An important isooptically labelled metabolite of benzene. References Muller, G., et al. : Anal. Hazard. Sust. Biol. Mater., 5, 143 (1997)

Stability Hygroscopic Applications Isotope labelled N-Acetyl-S-(2-cyanoethyl)-L-cysteine Ammonium Salt is a metabolite of Acrylonitrile (AN) and acrylamide (AM). Are commonly used in the synthesis of plastics and polymers. References van Bladeren, P., et al.: Drug Metab. Dispos., 9, 246 (1981), Guengerich, F., et al.: Chem. Res. Toxicol., 4, 168 (1991),

Applications A labelled metabolite of Theophylline. References ottrup, A., et al.: Pharmacol. Toxicol., 67, 340 (1990), El-Kadi, A., et al.: Drug Metab. Dispos., 28, 1112 (2000), Kim, S., et al.: J. Med. Chem., 45, 2131 ( 2002), Hansel, T., et al.: Drugs Today, 40, 55 (2004),

Applications: Isotope labelled analogue of 2-Methoxyacetic Acid, a synthetic intermediate in the synthesis of dimethyl(alkyloxy)[(methylsulfonyl)phenyl]furanones as COX-2 inhibitors. Dangerous Goods Info: Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Leblanc, Y., et al.: Bioorg. Med. Chem. Lett., 9, 2207 (1999);

Applications Isotope labelled Sodium D-Gluconate has use as an additive in processed foods, with the potential to improve taste. It has also been shown through study to alter gene expression in the colon of colorectal cancer model subjects. This is the labeled isomer. References Narukawa, M. et al.: Biosci. Biotech. Biochem., 76, 2282 (2012); Kameue, C. et al.: Biosci. Biotech. Biochem., 70, 606 (2006);

Stability Hygroscopic Applications 2-Methylcitric Acid-d3 is the isotope labelled analog of 2-Methylcitric Acid (M265080); a metabolite of Citric Acid (C521000) that can be formed from the condensation of propionoyl-CoA and oxaloacetic acid catalyzed by a citrate synthase enzyme. References Allen, R. H., et al.: Metabolism, 42, 978 (1993)

Applications Labelled Deoxycorticosterone. A mineralocorticoid that occurs in adrenal cortex. It acts as a precursor to Aldosterone (A514700). References Bohl, C., et al.: J. Med.Chem., 47, 3765 (2004), Smith, J., et al.: Steroids, 73, 1160 (2008),

Applications Labelled ester analog of Rapamycin. References Raymond, E., et al.: J. Clin. Oncol., 22, 2336 (2004), Galanis, E., et al.: J. Clin. Oncol., 23, 5294 (2005)

Stability Light Sensitive Applications A labelled antioxidant for grape and apple juice. References Kim, K., et al.: Agric. Biol. Chem., 38, 53 (1974), Vichi, S., et al.: Food Chem., 102, 1260 (2007),

Applications 7-Hydroxy Granisetron-d3 Hydrochloride is a labelled Granisetron (G780000) metabolite. References Bloomer, J., et al.: Brit. J. Clin. Pharmacol., 38, 557 (1994), Vernekar, S.,e t al.: J. Med. Chem., 53, 2324 (2010),

Applications A novel labelled metabolite of Perchloroethene (PER) in humans after inhalation. It is an important biomarker for the glutathione dependent biotransformation of PER. References Urban, G., et al.: Xenobiotica, 24, 881 (1994), Birner, G., et al.: Drug Metab. Dispos., 24, 41 (1996), Dekant, W., et al.: Drug Metab. Dispos., 15, 702 (1987),

Applications Butyric-2,2,3,3-d4 Acid (CAS# 1219794-99-6) is a useful isotopically labeled research compound.

Applications The labelled aglucon of apiin and of apigenin-7-glucoside. References Chaumontet, C., et al.: Carcinogenesis, 15, 2325 (1994), Sato, F., et al.: Biochem. Biophys. Res. Commun., 204, 578 (1994), Kuo, M.L. et al.: Biochem. Biophys. Res. Commun., 212, 767 (1995)

Applications Metabolite of Salicylic Acid (S088125). References Jurkowski, W., et al.: Current Drug Metab., 10, 448 (2009), Appeldoorn, M., et al.: J. Agric. Food Chem., 57, 7693 (2009), van Oijen, M., et al.: Pharmacol., 83, 237 (2009),

Stability Hygroscopic Applications Lauramine Oxide-d6 is the isotope labelled analog of Lauramine Oxide. Lauramine Oxide, is an frequently-used amine oxide surfactant. It is strongly hydrophilic , and it forms normal micelles and normal liquid crystalline phases. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Kocherbitov, v., et al.: J. Molec. Struct.: Theochem., 808, 111 (2007); Kocherbitov, v., et al.: J. Phys. Chem. B., 110 (27), 13649 (2006);

Applications Ibrutinib-d4 is the labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor. References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)

Applications A labelled metabolite of Toluene. References Gargas, M., et al.: Toxicol. Appl. Pharmacol., 98, 87 (1989), Commandeur, J., et al.: Pharmacol. Rev., 47(2), 271 (1995), Campo, P., et al.: Neurotoxicol. Teratol., 21, 427 (1999), Lohse, C., et al.: J. Agr. Food Chem., 48, 5913 (2000),

Applications Labelled Nitisinone. Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I. References Lindstedt, S., et al.: Lancet, 340, 813 (1992), Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1995), Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1998),

Applications Glycochenodeoxycholic-d5 Acid-3-O-β-glucuronide Disodium Salt is an isotope labelled compound of Glycochenodeoxycholic Acid-3-O-β-glucuronide Disodium Salt (G641275), used in steriod studies and also in the synthesis of conjugated and unconjugated bile acids. References Goto, J., et al.: Chem. Pharm. Bull., 28, 1258 (1980)

Applications Phenol is purified here for molecular genetics applications. It is naturally found in tea leaves and plants, and has uses in the synthesis of antioxidant compounds due to the antioxidant activity caused by the phenol moiety. This structure also allows it to be used for syntheses of anti-bacterial & anti-carcinogenic compounds. This is the labelled analog. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Nam, S. et al.: J. Agri. Chem., 60, 9097 (2012); Xia, J. et al.: J. Agri. Chem., 57, 99 (2009); Khanal, P. et al.: Carcinogenesis, 32, 545 (2011);

Applications Labelled Diltiazem (D460620). A calcium channel blocher with vasodilating activity. Antianginal; antihypertensive; antiarrhythmic (class IV). References Sato, et al.: Arzneim.-Forsch., 21, 1338 (1971), Smirnov, S.R.: Eur. J. Pharmacol., 360, 81 (1998), Hansson, L., et al.: Lancet, 356, 359 (2000),

Stability Hygroscopic Applications A labelled serotonin 5-HT2A receptor antagonist. Used as potential controls in various biological studies. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Wong, D.F., et al.: Science, 226, 1393 (1984), Blin, J., et al.: Eur. J. Pharmacol., 147, 73 (1988), Kehne, J.H., et al.: J. Pharmacol. Exp. Ther., 277, 968 (1996),

Stability Hygroscopic Applications Analog of Cisplatin with reduced nephrotoxicity. Antineoplastic. References Harland, S.J., et al.: Cancer Res., 44, 1693 (1984), Smith, I.E., et al.: Cancer Treat. Rep., 69, 43 (1985), Lygidakis, N.J., et al.: Interferon Cytokine Res., 15, 467 (1995),

Applications Menaquinone 9-d7 is the labeled analogue of Menaquinone 9 (M218610), which are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone 9 is a form of vitamin K2 which acts as a prothrombogenic agent and is also a functional electron transfer component in nitrate reductase. References Hugenholtz, P., et al.: J. Bacteriol., 180, 4765 (1998); Ginet, N., et al.: Biochemistry, 40, 1812 (2001); Cape, J., et al.: J. Biol. Chem., 280, 34654 (2005)

Applications Labelled Ethambutol. Antibacterial (tuberculostatic). References Wilkinson, et al.: J. Med. Chem., 5, 835 (1962), Kulig, et al.: Diss. Pharm. Pharmacol., 23, 463 (1971), Lee, C.S., et al.: Anal. Profiles Drug Subs., 7, 231 (1978)

Applications Uridine-2-13C-1,3-15N2 is labelled Uridine (U829910) which is a nucleoside widely distributed in nature. Uridine is one of the four basic components of ribonucleic acid (RNA) References Lorine, P., et al.: J. Biol. Chem., 178, 439 (1949); Grakoui, A., et al.: J. Virol., 63, 5216 (1989); Strauss, J., et al.: Microbiol. Rev., 58, 491 (1994); Lin, Y., et al.: Virology, 292, 78 (2002);

Applications A labelled anabolic steroid.Controlled substance (anabolic steroid). References Gradeen, C., et al.: J. Anal. Toxicol., 14, 120 (1990), Teale, P., et al.: Biol. Mass Spectrom., 20, 109 (1991), Yamada, M., et al.: J. Pharm. Biomed. Anal., 45, 125 (2007), Yamada, M., et al.: J. Anal. Toxicol., 32, 387 (2008),