Hétérocycles azotés (N)

1-Pyridin-2-yl-propan-2-one is a reactive compound that can undergo cross coupling reactions. It reacts with terminal alkynes to form 1,3-dipoles and reactive carbenes. This process is selective for the desired product, providing a high yield of the desired product in the presence of other products. The reaction products are hydrogenated to produce ethyl bromoacetate and cyclohexanol. The ligation of 1-pyridin-2-yl-propan-2-one with pyridinium chloride produces a complex mixture of reaction products.

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9-Fluoro-6,7-dihydro-5-methyl-8-(4-methylpiperazin)-1,7-dioxo-1H,5Hbenzo(ij)quinolizine-2-carboxylic acid monohydrochloride (9FDA) is an antibacterial agent that inhibits the growth of bacteria by inhibiting bacterial DNA synthesis. It has been shown to be active against Staphylococcus aureus and Staphylococcus epidermidis. 9FDA has also been shown to inhibit the growth of Enterococcus faecalis and Streptococcus faecalis. 9FDA has minimal activity against Streptococcus pyogenes and no activity against Enterobacteriaceae or Pseudomonas aeruginosa.

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2-Cyano-3-chloro-5-(trifluoromethyl)-pyridine is a chemical compound that can be synthesized from pyridine and chlorinated carbon compounds. It is used in the treatment of wastewater, with a high yield and low yield. 2-Cyano-3-chloro-5-(trifluoromethyl)-pyridine is also used as a catalyst for reactions, such as the Raney reaction. The palladium catalysts are transferred to the surface of the metal powder by reaction with water vapor. This reaction creates a thin layer of palladium on the surface of the metal powder, which facilitates catalytic activity. 2-Cyano-3-chloro-5-(trifluoromethyl)-pyridine has been shown to be effective against pesticide and herbicide resistance in plants.

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2-Amino-3,5-dichloropyridine is a molecule that is synthesized by the reaction of hydrochloric acid with copper chloride. The synthesis of 2-amino-3,5-dichloropyridine is a two step process. In the first step 2-chloroethanol reacts with an excess of hydrochloric acid to produce chloroethane and hydrogen chloride gas. In the second step, chloroethane reacts with an excess of copper chloride to produce 2-amino-3,5-dichloropyridine. 2-Amino-3,5-dichloropyridine can be used in organic synthesis for a number of reactions including as a substrate molecule for enzymes that require chloride ions as cofactors. 2-Amino-3,5-dichloropyridine has been shown to inhibit cancer cells by inhibiting DNA and protein synthesis.

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1-Phenyl-piperidine is a psychoactive compound that has been shown to have strong binding affinity for the κ-opioid receptors. It has also been shown to increase locomotor activity in mice and produce hallucinations. 1-Phenyl-piperidine has a number of biological properties including inhibition of dopamine uptake, induction of myocardial infarcts, and toxicity to the ischemic brain. It binds with high affinity to the multidrug efflux pumps such as P-glycoprotein (Pgp) and MDR1, which are responsible for removing drugs from cells. Pgp is induced by cytochrome P450 3A4 (CYP3A4) inhibitors such as ketoconazole, erythromycin, fluconazole, itraconazole, clarithromycin, telithromycin, nefazodone, and grapefruit juice.

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Applications Methyl 4-Amino-3,6-dichloropyridine-2-carboxylate is an intermediate in the synthesis of Arylex (A794890), which exhibits potent dicot weed control; Herbicide. References Schmitzer, P. R., et al.: ACS Symp. Ser., 1204, 247-260 (2015); Epp, J. B., et al.: Bioorg. Med. Chem., 24, 362-371 (2016); Zhao, H., et al.: J. Sep. Sci., 38, 1164-1171 (2015)

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2-Amino-5-nitropyridine (2ANP) is a chemical compound that belongs to the group of pyridines. It is an organic base with a basic structure, consisting of a nitrogen atom bound to two hydrogen atoms and two carbon atoms. 2ANP has been shown to be stable in neutral and acidic pH solutions, but decomposes in alkaline solutions. This chemical compound has been shown to exhibit strong hydrogen bonding interactions, as well as intramolecular hydrogen bonds. 2ANP can form complexes with copper ions and other metals by donating its lone pair of electrons. This behavior leads to its use in analytical chemistry for the determination of copper compounds. 2ANP has also been shown to have transport properties, which are related to its ability to bind metals through hydrogen bonding interactions. Finally, it has been shown that 2ANP can react with acetic acid in order to produce acetamide and nitrite ions through a mechanism involving the loss of

2-Pentylpyridine is structurally similar to the amino acid alanine and its reaction mechanism is analogous to that of alanine. The optimal reaction temperature for 2-pentylpyridine is between 130 and 180 degrees Celsius. 2-Pentylpyridine reacts with amide groups in proteins, leading to the formation of a new amide bond. It has been shown that 2-pentylpyridine can react with fatty acids. The chemical reactions of 2-pentylpyridine can include addition, elimination, substitution, or rearrangement reactions. The product of these reactions are typically a salt or an ester.

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Applications 2-Pyridineethanol is a metabolite of the anti-vertigo drug Betahistine (B324000). References Botta, L. et al.: Acta Oto-Laryngol., 120, 25 (2000); Fossati, A. et al.: Pharmacol. Res., 43, 389 (2001); Konzett, H. et al.: J. Pharmacol. Exp. Ther., 178, 122 (1977);

Pyridine-3,4-dicarbonitrile (PDC) is a ligand that can be synthesized in the laboratory and is used to study the magnetic resonance spectroscopy of organic molecules. PDC binds to metal ions and forms coordination complexes. It has been shown that these complexes have synergistic effects with cancer drugs such as cisplatin and doxorubicin. This ligand also has been shown to bind to copper or iron ions and form stable coordination compounds. PDC can be used in organic solvents, which makes it an ideal candidate for use in organic synthesis.

1-(Trifluoroacetyl)-4-(dimethylamino)pyridinium Trifluoroacetate (1-TACAP) is an acylating agent that reacts with nucleophiles such as amines, chlorides, and alcohols to produce esters. The trifluoroacetyl group is the reactive group in this reagent. 1-TACAP is able to form amides, nitriles, and ureas. It has been used in the synthesis of peptides. 1-TACAP has also been shown to react with aluminum chloride to form a product that is more soluble in organic solvents than the starting material. This process can be used to synthesize products that are difficult to access using conventional synthetic methods.

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Applications Methyl 4,6-dichloropyridazine-3-carboxylate

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Imidazo[1,2-a]pyridine-6-carbonitrile is a chemical compound that is an efficient catalyst for the acetoxylation of aromatic bromides. It has been shown to have intriguingly selective deacetylation activity towards aryl bromides. Imidazo[1,2-a]pyridine-6-carbonitrile can be used as a carbon monoxide source in organic chemistry reactions and has been used as a catalyst for bond activation reactions. This chemical compound is also an efficient catalyst for the carbonylation of alcohols and other compounds with weak C-H bonds.

5-Bromo-3-methoxypyridin-2-amine is a colorless solid that can be obtained by reacting ethanol with methylamine and pyridine. 5-Bromo-3-methoxypyridin-2-amine is an amide of pyridine and methylamine, which can be easily hydrolyzed to the corresponding pyridines. The transformation of 5-bromo-3-methoxypyridin-2-amine is mainly catalyzed by acid or alkali. 5 - Bromo - 3 - methoxypyridin - 2 - amine has a strong oxidizing power, which can be used as a reagent for oxidation and reduction reactions.

2-Bromo-3-fluoropyridine is a chemical intermediate that belongs to the group of heterocyclic compounds. It is synthesized by the reaction of sodium methanethiolate and formaldehyde with magnesium. The product yield is not very high, but 2-bromo-3-fluoropyridine can be used for the synthesis of other heterocyclic compounds. The compound was first isolated in 1887 by J. Grignard from a reaction between bromine and formaldehyde. It has been shown to have formylation, nucleophilic substitution, and condensation reactions as its transition states. 2-Bromo-3-fluoropyridine can be prepared from the Grignard reagent, methanethiolate, and chlorine or magnesium chloride in an ether solution at room temperature. This compound has also been used as a reagent for the preparation of difluoromethoxybenz

2,3-Dihydro-1H-pyrrolo[3,4-c]pyridine dihydrochloride (2,3-DHP) is an industrial chemical used as a chain transfer agent in the production of polymers. It is also used as a catalyst in polymerization reactions and as a structural reagent. 2,3-DHP is an additive to gasoline to control the formation of sulphur compounds that can lead to the formation of particles and smog. 2,3-DHP is also used in the manufacture of nylon 6 and nylon 12 by reacting with hexamethylene diamine. The coordination properties of 2,3-DHP allow it to be used as a catalytic agent for cyclopentadienyl complexes.

Chelating agent used to detect aqueous copper ions by electrochemiluminescence

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2-Chloro-4-fluoropyridine is a chlorinated pyridine that can be synthesized by the methylation of an aldehyde with 2-chloro-4-fluoroaniline. This compound has been used to introduce the chloro group into molecules in order to produce red shift in their spectra, as well as to introduce other functional groups such as amines or alcohols. The synthesis of 2-chloro-4-fluoropyridine is scalable and it can be used for various applications including devices and emissions. It has also shown efficiency in heterocyclic amine formation.

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