Hétérocycles azotés (N)

4-Acetoxymethylpyridine is a synthetic compound that belongs to the anion group. It has been used as a stationary phase in gas chromatography and as an eluent in liquid chromatography. 4-Acetoxymethylpyridine is also commonly used as a reagent to convert alcohols into their corresponding pyridinium salts. This compound undergoes nucleophilic attack by hydroxide ions, which leads to bond cleavage and the formation of the n-oxide. 4-Acetoxymethylpyridine is soluble in polar solvents such as ethanol, but insoluble in nonpolar solvents such as hexane. Spectroscopic data indicates that this compound contains an oxygen atom with two hydrogen atoms bonded to it, along with four carbon atoms and two nitrogen atoms.

2-Methyl-3-(methylthio)pyrazine is a surface methodology that can be used to detect sulfide in high concentrations. It is metastable and can be detected by solid phase microextraction. This compound has been shown to react with alkylpyrazines and aldehydes to produce quinoxalines, which are used as model systems for the study of molecular ions. 2-Methyl-3-(methylthio)pyrazine is also used in headspace analysis, which involves the use of microextraction techniques to identify reaction products such as furfuryl acetate.

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2-[4-(2-{(2R)-2-Cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}e thyl)-2 -fluorophenyl]-2 methylpropane nitrile (GSK1265744) is a replication inhibitor that targets the HIV virus and inhibits its ability to replicate. GSK1265744 is a prodrug that is activated by protease and is phosphorylated intracellularly by NS3 protease. It has been shown to be effective against drug resistant mutants of HIV and has a high level of resistance in human serum and plasma. GSK1265744 also has pharmacokinetic properties that are similar to other HIV

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2,3-Diamino-6-chloropyridine is a chemical compound that is an ethylated derivative of 2,3-diamino-6-chloropyridine. It has been shown to be hydrolyzed by esters and in acidic environments, although it can also be esterified with ethanolates or malonates. 2,3-Diamino-6-chloropyridine is a mixture of compounds with different structures that are cyclized in different ways. The most common form of this compound is its morpholine derivative, which is formed when the amine group on the nitrogen atom reacts with a carbonyl group (C=O) on another molecule. This reaction results in the formation of an amide bond between the two molecules. 2,3-Diamino-6-chloropyridine can also react with an alcohol to form an ester bond. This reaction produces a 2,3 diaminometh

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Pyrazine-2-carboxylic acid is a potent inhibitor of bacterial x-lactamase. It was found that the inhibition of x-lactamase by pyrazine-2-carboxylic acid could be attributed to hydrogen bonding interactions with the active site of the enzyme and a high rate constant for the reaction. The antibacterial efficacy of pyrazine-2-carboxylic acid against wild type Streptococcus pneumoniae and methicillin resistant Staphylococcus aureus (MRSA) was tested and found to be comparable to that of benzylpenicillin. Pyrazine-2-carboxylic acid also has biological properties, such as an inhibitory effect on protein synthesis in bacteria, which may be due to its ability to bind to ribosomes.

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Applications 4-Chloropyridine is used to synthesize Thrombin inhibitors, compounds that have potent anticoagulant activity. 4-Chloropyridine is also used as a reagent to synthesize Botryllazine A, a pyrazine alkaloid that exhibits cytotoxicity against human tumour cells. References de Candia, M., et al.: J. Med. Chem., 56, 8696 (2013); Kodimuthali, A., et al.: Tetrahedron Lett., 50, 1618 (2009); Singh, P., et al.: J. Org. Chem., 78, 2639 (2013)

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6-Methylpurine is a product of the nucleotide metabolism in E. coli, which is a model organism for protein synthesis. 6-Methylpurine inhibits protein synthesis and exerts significant cytotoxicity. It has been shown to inhibit the enzyme activities of DNA polymerase alpha, DNA ligase, and RNA polymerase, as well as other enzymes involved in nitrogen metabolism. 6-Methylpurine has been shown to be an analog of adenine and has a similar reaction mechanism. The uptake of 6-methyl purine by cells is mediated by hydrogen bonds with amino acid residues on the cell membrane surface. This molecule also forms glycosidic bonds with ribose sugar groups on cellular surfaces. 6-Methylpurine plays an important role in energy metabolism through its incorporation into glucose and glycogen molecules.

Applications 5-Benzylthio-1H-tetrazole is used in the preparation of organosilicon compounds that have antibacterial activity. References Baghershiroudi, Mahrokh. et al., J. IRAN. CHEM. SOC. 15,1279-1286(2018);

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2,4-Dichloro-5-iodopyrimidine is a nucleophilic chemical reagent that can be used to synthesize uracil. It is made by the hydrolysis of 2,4-dichloro-5-iodopyrimidine with sodium hydroxide in water. The reaction yields two isomers which are separated by chromatography. The chemical is used in the synthesis of alkoxides and pyrroles, as well as the synthesis of furans and benzene derivatives. 2,4-Dichloro-5-iodopyrimidine reacts with phosphorus oxychloride to form acetonitrile and oxychloride.

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Applications 4-(chloromethyl)-3,5-dimethyl-1H-pyrazole (cas# 152239-41-3) is a useful research chemical.

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Intermediate in the synthesis of tofacitinib

4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid is a drug that is used to treat cancer. It is a divalent molecule that functions as a kinase inhibitor and inhibits the activity of ATP. This drug has been shown to inhibit the activation of guanyl nucleotide-dependent protein kinase and phosphorylate ERK in vitro. The potential target of 4-chloro-2-(methylthio)pyrimidine-5-carboxylic acid is not known, but it may be involved in the regulation of cellular proliferation or apoptosis. Functional studies have shown that 4-chloro-2-(methylthio)pyrimidine-5-carboxylic acid inhibits the growth of cancer cells in vitro and has little effect on healthy cells. This drug also shows potential for treating a variety of other diseases, such as type II diabetes mellitus, asthma, and arthritis.

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Applications 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is a reagent in the synthesis and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone which is an antibacterial agent. Benzoxazinyl-oxazolidinone had potent activity against Gram-positive pathogens. 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is also an intermediate in the synthesis of Tedizolid (T013750). References Xin, Q., et al.: J. Med. Chem., 54, 7493 (2011)

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6-Bromoimidazo[1,2-a]pyridine is a synthetic compound that can be prepared by cross-coupling reactions. 6-Bromoimidazo[1,2-a]pyridine is an unsymmetrical molecule with a pyridine ring and can be synthesized through the reaction of hydrochloric acid with a boronic acid. This versatile intermediate has been used in the synthesis of various other heterocycles. The reaction time for 6-Bromoimidazo[1,2-a]pyridine to form a bond cleavage is generally short, making it an efficient method for producing this compound. 6-Bromoimidazo[1,2-a]pyridine has also shown potential as an agent for environmental pollution control because it contains two functional groups that are reactive towards many pollutants.

Intermediate in the synthesis of tedizolid

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