Hétérocycles azotés (N)

4,6-Dichloro-1H-pyrrolo[2,3-b]pyridine is a nucleophilic reagent that can be used in the synthesis of 7-azaindole derivatives. It has been shown to react efficiently with phenolates and other nucleophiles. 4,6-Dichloro-1H-pyrrolo[2,3-b]pyridine reacts with activated methylene compounds by forming a three membered ring. This reaction is efficient and produces high yields.

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Flunarizine is a nonsteroidal anti-inflammatory drug used to treat migraine. It blocks the calcium channels that cause vasodilation and inhibits mitochondrial function, leading to reduced inflammation. Flunarizine has been shown to have a mechanism of action similar to that of other anti-inflammatory drugs, such as aspirin and ibuprofen. Flunarizine is an antagonist of the angiotensin II type I receptor, which leads to inhibition of inflammation caused by this receptor. Flunarizine also has an effect on cerebral blood flow and can be used for the treatment of head injury.

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6-Chloropyrazine-2-carboxylic acid is a chemical compound that has been shown to have antimycobacterial activity against Mycobacterium avium. This drug inhibits the synthesis of proteins and DNA by binding to the ribosomal subunit, which prevents transcription and replication. 6-Chloropyrazine-2-carboxylic acid also binds to metal ions, such as chloride, which may help explain its effectiveness as an anti-tuberculosis drug. The drug is not active against bacteria that do not contain nucleic acids or chlorides.

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Applications 5-(Chloromethyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]pyridine 97% (cas# 906352-80-5) is a useful research chemical.

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1-Benzyl-4-methyl-1,2,3,6-tetrahydro-pyridine is a chiral compound that is an industrial solvent and can be used in the synthesis of other chemical compounds. It is also used in the production of tofacitinib, a drug that is used to treat rheumatoid arthritis. 1-Benzyl-4-methyl-1,2,3,6-tetrahydro-pyridine has been shown to have oxidizing properties and can be synthesized through the reaction of an imine with a ketone. This chemical compound also has asymmetric properties.

Immunoassay and chemiluminescent assay reagent

5-Acetylpyrimidine is an aminoguanidine analog that inhibits the mammalian tyrosine kinase Bcr-Abl. It is bacteriostatic and has a potent inhibitory activity against Mycobacterium tuberculosis and other bacteria. 5-Acetylpyrimidine has been shown to be effective against drug resistant strains of tuberculosis and against other bacterial species, such as erythromycin resistant Mycobacterium avium, by inhibiting their growth. 5-Acetylpyrimidine binds to the active site of the enzyme bcr-abl kinase and prevents it from phosphorylating its substrate, preventing protein synthesis and cell proliferation.

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Applications A useful synthetic intermediate.

Applications 6-Hydroxy-2,4,5-triaminopyrimidine, Sulfate (cas# 35011-47-3) is a compound useful in organic synthesis.

2-(Pyridin-2-ylthio)acetohydrazide (PTZ) is a thienopyridine compound that inhibits the enzyme hepg2. It is also known as an inhibitor of bacterial growth, and has shown to be cytotoxic. PTZ has been used in screening tests for potential anticancer drugs. The cytotoxicity of PTZ was tested against human breast carcinoma (MCF-7) cells and colon cancer cells (HT-29). It showed inhibitory activities against these cancers and inhibited the growth of MCF-7 and HT-29 cells at concentrations between 10 μM and 100 μM.

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Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione is a purine derivative that blocks the activity of c1-6 alkyl phosphodiesterases. It has been shown to have clinical efficacy in the treatment of muscle wasting and asthma. In cancer cells, pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione inhibits the tyrosine kinase activity of enzymes called protein kinase C (PKC) and mitogen activated protein kinase (MAPK). This inhibition prevents cell proliferation and induces apoptosis. Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione also inhibits cyclooxygenase 2 (COX2) and lipoxygenase activities in the cytoplasmic membrane. This results in decreased production of prostaglandins and leuk

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Applications 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile (cas# 33097-13-1) is a compound useful in organic synthesis.

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Applications 4,6-Diamino-2-chloro-5-pyrimidinecarbonitrile is an intermediate in the synthesis of 2,4,6-Triamino-5-pyrimidinecarbonitrile is a photodegradation product of two isostructural pesticides in aqueous solution: Cyromazine (C989300) and Dicyclanil. References Kimbrough, R., et al.: Environ. Sci. Technol., 30, 908 (1996), Root, D., et al.: Pesticide Sci., 48, 25 (1996), Yokley, R., et al.: J. Agric. Food Chem., 48, 3352 (2000),

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5-Chloropyridine-3-carbaldehyde is a chemical compound that has been studied for its biological effects. It has shown significant activity against DU145 prostate carcinoma cells and human fibroblast cells. This compound has also been shown to have pharmacological properties, including inhibition of thiosemicarbazide, du145, and mcf-7 cells. 5-Chloropyridine-3-carbaldehyde is an aromatic compound that belongs to the group of heterocyclic compounds. It is also known as 2,5-dichloroisonicotinic acid or 3-(2,5-dichlorophenyl)pyridinecarboxaldehyde. The molecular formula is C8H6Cl2O2 and the molecular weight is 228.23 g/mol. The structure was determined by x-ray diffraction techniques and the conformation was determined through techniques such as nuclear magnetic resonance spectroscopy (NMR).

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4-(4-Chlorophenyl)-2,6-piperidinedione is an inhibitor of bacterial hydrolases and it is used as a therapeutic agent. The compound has an optical rotation, which depends on the temperature. 4-(4-Chlorophenyl)-2,6-piperidinedione binds to bacterial glutarimide and gamma-aminobutyric acid (GABA) receptors in vitro, inhibiting the growth of bacteria. This drug is also stereospecific with respect to its inhibition of the GABA receptor.

Imidazo[1,2]pyridazine is an intramolecular hydrogen-bonded heterocyclic compound that can be found in the environment. It has been shown to inhibit the production of tumour necrosis factor-α (TNF-α) and other growth factors in mice with skin stromal tumours. Imidazo[1,2]pyridazine also has a number of inhibitory properties that are enzyme-specific. This drug has been shown to have therapeutic potential for autoimmune diseases and metabolic disorders, as well as cancer. Imidazo[1,2]pyridazine is metabolized by cytochrome P450 enzymes and eliminated through renal excretion.

Applications 5-(2-Pyridyl)isoxazole-3-carboxylic Acid is a useful reagent for the preparation of isoxazoles for treatment of neurological disease. References Wrona, I., et al.: PCT Int. Appl. (2019), WO 2019209962 A1

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4-Methyl-4'-carboxy-2,2'-bipyridine is a fluorescent probe that can be used to detect the presence of hydrogen peroxide in cells. It has been shown to bind to mitochondria and liver cells. The binding constants are in the range of 10 M. When exposed to light, 4-methyl-4'-carboxy-2,2'-bipyridine emits an orange fluorescence. This chemical has been used as an oxidation catalyst for amides and as an enhancer for reactive species in kinetic experiments. It also has been shown to have proton uptake properties.