Hétérocycles azotés (N)

Please enquire for more information about 1H-Pyrrolo[3,2-b]pyridine-5-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about (5-(Pyrrolidin-1-yl)pyridin-3-yl)boronic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-Methyl-2-oxo-1,2-dihydropyridine-3-carbaldehyde including the price, delivery time and more detailed product information at the technical inquiry form on this page

Pyrazine-2-carbothioamide (PZCA) is a drug that has been used in clinical trials for the treatment of depression. It also has bactericidal properties, which are due to its ability to coordinate metal ions in the bacterial cell wall, thereby preventing the formation of essential enzymes and inhibiting protein synthesis. PZCA is active against Mycobacterium avium. The mechanism of action of this drug is not yet fully understood, but it has shown strong activity against Trichophyton mentagrophytes and moderate activity against Staphylococcus aureus. PZCA also has anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.

Please enquire for more information about 4-Chloro-2-phenyl-5-piperazin-1-ylpyridazin-3(2H)-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 3,5-Dimethyl-4-nitropyridine 1-Oxide is an intermediate used to prepare 2-[(2-pyridylmethyl)thio or -sulfinyl]benzimidazoles as antiulcer agents. References Nohara, A., et al.: U.S., US 4689333 A 19870825. (1987)

Please enquire for more information about 1-Methyl-3-{[3-(pyrrolidin-1-ylcarbonyl)piperidin-1-yl]carbonyl}-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

It is a synthetic building block. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

5-Aminoorotic acid is an antimicrobial agent that has been shown to have anticancer activity. It has a nitrogen atom and two oxygen atoms in the molecule. The chemical structure of 5-aminoorotic acid can be determined using NMR spectroscopy and its biological properties are dependent on hydrogen bonding interactions with other molecules. 5-Aminoorotic acid is a chelate ring, which means it can bind to metal ions such as lanthanum (La3+). 5-Aminoorotic acid has been shown to inhibit the glycol oxidation reaction and may also be able to inhibit other enzymatic reactions. This drug is stable for use in model systems and may also be used for cancer treatment.

Please enquire for more information about N-(3-Chloro-2,5-dimethoxyphenyl)-N'-(4,6-dimethylpyrimidin-2-yl)guanidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-(3-Chlorophenyl)-2-(4-Methylpiperazin-1-Yl)Ethanamine Hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Apixaban is a novel, orally active, and selective factor Xa inhibitor. It is the first oral anticoagulant that has been developed to inhibit both free and clot-bound thrombin. Apixaban binds reversibly to the active site of factor Xa and inhibits factor Xa-mediated conversion of prothrombin to thrombin, resulting in an increased concentration of prothrombin in blood. Apixaban also inhibits the activity of thrombin-activated protein C (APC) that degrades fibrin clots by proteolytic cleavage of fibrinogen. This drug has a crystalline form with a particle size between 10 and 100 μm.

Please enquire for more information about 3-(4-(Benzyloxy)Benzylidene)Piperidine Hydrogen Chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-[(Dimethylamino)sulfonyl]piperidine-3-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Ethyl 4-Chloro-1-M-Tolyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

2-Fluoro-5-methylpyridine (2FM) is an organic compound that can be used in the production of potassium permanganate. It is a byproduct of the reaction between pyridine and chlorinated hydrocarbons, such as chloride or thionyl chloride. 2FM can also be produced when potassium reacts with oxalyl or chloropyridine. This product has been used in organic chemistry as a reagent for the synthesis of substituted pyridines.

4-Benzylpiperazine-1-carboximidamide sulfate is a versatile building block that can be used in the synthesis of complex compounds. It is a useful intermediate that can be used in the production of research chemicals and speciality chemicals. 4-Benzylpiperazine-1-carboximidamide sulfate is also an excellent reagent for reactions involving complex substrates, such as high quality and useful scaffolds.

Please enquire for more information about 2-Amino-5-iodopyridine-3-carboxaldehyde including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications N-[2-(Phenylthio)phenyl]-1-piperazine-d8-carboxamide Hydrochloride is the labeled analog of N-[2-(Phenylthio)phenyl]-1-piperazinecarboxamide Hydrochloride, an impurity of Quetiapine (Q510000), a benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties; used as an antipsychotic. References Stolarczyk, E.U., et. al.: Pharm. Develp. Tech., 14, 27 (2009); Wetzel, H., et al.: Psychopharmacology, 119, 231 (1995)

Stability Hygroscopic Applications 2-(2-Fluorophenyl)pyrrolidine

Please enquire for more information about [3-(Piperidin-1-ylsulfonyl)phenyl]amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

2-Amino-4,6-dichloropyridine is a reactive dye that can be used for the detection of cellulose in cotton. It reacts with the amine groups on the surface of cotton and produces a red color. The dye was also found to be reactive with electron fields and infrared radiation. The chemical structure of 2-Amino-4,6-dichloropyridine consists of a chloropyrimidine group and two amino groups. It has been observed under microscopy and diffraction, as well as studied using spectroscopy. 2-Amino-4,6-dichloropyridine is thermally stable and does not react with water or other solvents. It has been shown to have strong absorption bands at wavelengths between 740 nm - 800 nm and 860 nm - 900 nm when exposed to infrared light. 2-Amino-4,6-dichloropyridine is

3,6-Dimethylpyrimidine-2,4(1H,3H)-dione is a chemical compound that has been found to be active against influenza virus. It is an acidic compound that binds to positively charged amino acids on the viral envelope and inhibits viral fusion with host cells. The linker group in 3,6-dimethylpyrimidine-2,4(1H,3H)-dione is the same as that of dimethylsulfate, which is a chemical compound used for the synthesis of other compounds. X-ray diffraction data for this compound have been obtained at high resolution and show it to be a chloride salt. The chloride ion may be important in the antiviral activity of 3,6-dimethylpyrimidine-2,4(1H,3H)-dione because it can react with radicals formed during influenza replication. This compound also has antiradical activities against Coxsackievirus B3 (

Please enquire for more information about 1-Benzyl-4-methylpiperidin-3-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

Metronidazole is a limited spectrum antibiotic that actively deters the growth of protozoa, anaerobic gram-positive, and anaerobic gram-negative bacteria. The first use of this antibiotic was to suppress protozoans such as Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis. It has been used to repress the growth of gram-negative anaerobes belonging to the Bacteroides and Fusobacterium, and gram-positive anaerobes such aspeptostreptococcus and Clostridia. The advantages of this antibiotic is that it affects a high percentage of gram-negative bacteria and has greater tissue penetration. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2-Methyl-6-phenylpyridine is a pyridinium salt that reacts with proton to form the corresponding pyridinium cation. It forms a mesoporous metal ion complex with titanium, which has been shown to catalyze the hydrogenation of alkyl halides. The reaction mechanism for this process is thought to proceed through a hydride transfer mechanism in which 2-methyl-6-phenylpyridine donates its hydride ion to the substrate, forming an intermediate c-h bond. This bond is then cleaved by a nucleophilic attack from the metal ion, followed by release of the product and regeneration of 2-methyl-6-phenylpyridine. 2-Methyl-6-phenylpyridine has also been shown to react with electrophiles such as alkylating agents and aldehydes, leading to bond cleavage and formation of heterocycles

Applications 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzonitrile (cas# 31489-18-6) is a useful research chemical.

Please enquire for more information about {2-[(4-Benzoylpiperazin-1-yl)carbonyl]phenyl}amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-Fluoro-5-methoxypyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4-[(5-Bromo-4,6-dichloro-2-pyrimidinyl)amino]benzonitrile including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Methyl piperazin-1-ylacetate dihydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Ethyl 4-hydroxy-4-(2-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about [4-Fluoro-3-(1-piperidinylcarbonyl)phenyl]boronic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

2-Chloro-4-(trifluoromethyl)-5-pyrimidinecarboxylic acid phenylmethyl ester (PT16) is a synthetic compound that inhibits the production of the prelamin A protein. PT16 has been shown to inhibit progeria in mice. This drug also prevents the splicing of dystrophin mRNA, which is a genetic disorder that causes muscle degeneration and heart disease. PT16 can be used as a treatment for Duchenne muscular dystrophy.

Please enquire for more information about 3-Bromo-4-chloro-5-nitropyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about [3-(3-Methylpiperidin-1-yl)propyl](2-thienylmethyl)amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 2,3,7,8-Tetrachloro-[1,4]dioxino[2,3-b:5,6-b']dipyridine is used in analytical studies for the presence and formation of dioxin-like compounds in heat-treated chlorpyrifos herbicide, a potential precursor of pyridine analog of 2,3,7,8-Tetrachloro-p-dioxin (T291370). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Sakiyaama, T., et al.: Organohalogen Compounds, 73, 146 (2011);

Please enquire for more information about (4R,5S)-1,5-Dimethyl-4-phenylimidazolidin-2-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

1-Thiazol-2-yl-piperazine is a 2,4-thiazolidinedione that binds to the GABA receptor. The binding of this compound to the GABA receptor has been shown to be reversible and competitive. 1-Thiazol-2-yl-piperazine has been shown to be an antagonist at the GABA receptor, which can be used to screen for other compounds with similar binding properties or as a tool for focusing on heterocyclic analogues with increased potency. This drug has also been shown to have physiological effects in vivo, and may be useful for the treatment of conditions such as anxiety and epilepsy.

Please enquire for more information about 2- Bromo- 3- methyl- 5- (trifluoromethyl) pyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

(S)-(-)-1-Methyl-2-(1-piperidinomethyl)pyrrolidine is a chiral, organic solvent. It is soluble in ether and diethyl ether and has been used as a synthetic intermediate.

Please enquire for more information about 1H-Pyrazolo[4,3-b]pyridine-6-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

4-Chloro-5,6-dimethylpyrimidine is a neutral molecule with a basic character. It has two substituents, one of which is dichlorocarbene. The other substituent is not known. 4-Chloro-5,6-dimethylpyrimidine can be synthesized by combining chloroform and trichloroacetate in a flow system. This compound is used as an intermediate for the synthesis of imidazoles.

Please enquire for more information about 2-Pyridinemethanamine,6-amino-(9CI) including the price, delivery time and more detailed product information at the technical inquiry form on this page

4-Aminopyridine, sometimes abbreviated as 4-AP, is an organic compound and one of the three isomeric amines of pyridine. It is an ion channel modulator used as a research tool in characterizing subtypes of the potassium channel (K channel), which is associated with multiple sclerosis disease.  4-Aminopyridine (4AP) acts a K channel blocker that is useful clinically. It is reported that the use of 4-AP can potentially improve cognitive functions. 4-aminopyridine has shown strong evidence as potent neurotransmitter modulator with the capacity to target the damaged nervous system through blockage of voltage-gated potassium channels. This fact widen the spectrum for new therapies for another related diseases such as Parkinson.

7-Methylindole-2-carboxylic acid (7MICA) is an indole that can be synthesized by the condensation of phenylhydrazine and pyruvic acid. It has been used as a precursor in the synthesis of styphnates, picrates, and ethyl pyruvate. 7MICA is also known to have antimicrobial activity against gram positive bacteria.

Please enquire for more information about 2-Amino-7-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

4-(Methylnitrosoamino)-1-(3-pyridinyl)-1-butanone (NNK) is a carcinogenic chemical that has been identified in tobacco smoke. It induces squamous cell carcinomas in the respiratory tract of rodents and induces lung cancer in the offspring of pregnant rats exposed to NNK. This compound binds to double-stranded DNA, with high affinity for the minor groove, and inhibits DNA synthesis by binding to enzymes such as polymerase chain. In addition, it has been shown to cause transformation of epithelial cells into mesenchymal cells in vitro. 4-(Methylnitrosoamino)-1-(3-pyridinyl)-1-butanone binds to α7 nicotinic acetylcholine receptors and increases the response element activity.

2,6-Pyridinedicarboxaldehyde is a benzimidazole compound that has been studied for its potential as a fluorescent probe to monitor biological processes. It has been shown to be a good fluorescence probe for basic proteins and was used in the study of group P2 enzymes. In addition, 2,6-pyridinedicarboxaldehyde has been used in asymmetric synthesis. The enantiopure form of 2,6-pyridinedicarboxaldehyde is commercially available as an ester hydrochloride. This substance is also an x-ray crystal structure and has been shown to have nitrogen atoms and oxygen nucleophiles. 2,6-Pyridinedicarboxaldehyde binds to coordination geometry in xenograft tumor growth studies.

Please enquire for more information about Methyl (+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methansulphonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about [4-(4-Methylpiperazin-1-yl)benzylidene]malononitrile including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Ethyl 4-methyl-2-piperidin-1-ylpyrimidine-5-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Piperidine is a chemical compound that has the chemical formula CH3CONH2. It is a colorless, water-soluble liquid with an ammonia-like odor. Piperidine reacts with many other compounds in chemical reactions to form piperidines, which are used in the manufacture of pharmaceuticals, dyes, pesticides, and rubber products. The molecule is planar and all three N-H bonds are equivalent, which indicates that it is not chiral. Piperidine has been shown to react with chlorine and chloramine under conditions of microwave irradiation to produce 2-chloro-4,6-dihydroxy-5-nitropyrimidine (2CDNP). This reaction was found to be efficient at low temperatures and atmospheric pressure. 2CDNP has also been shown to be reactive with nitro groups in molecules such as aniline hydrochloride or benzene diazonium chloride to form nitroso derivatives. These reactions were found

Applications 5-Phenyl-4h-1,2,4-triazol-3-amine, is an intermediate in the synthesis of WP155. 5-Phenyl-4h-1,2,4-triazol-3-amine is also used in biological studies to evaluate its pharmacological activity as it can be applied to a method for reducing susceptibility to tumor formation induced by 3-deoxyglucosone and precursors thereof. References Truman, B., et al.: U.S. Pat. Appl. Publ.

Applications A useful synthetic intermediate.

Please enquire for more information about N-[Amino(imino)methyl]-4-phenylpiperazine-1-carboximidamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about (1H-Pyrazolo[3,4-C]pyridin-4-yl)boronic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page