Hétérocycles azotés (N)

Tert-butyl(2-chloropyridin-3-yl)carbamate is a tertiary amine that can be used as an intermediate in organic chemistry. It is the product of the intramolecular reaction between tert-butanol and 2-chloropyridine. The two products of this reaction are tert-butyl alcohol and tert-butyl (2-chloropyridin-3-yl)carbamate. This reaction can be used to produce polyfunctional molecules from simple starting materials. Tert-butyl (2-chloropyridin-3-yl)carbamate can also be hydrolyzed to form aniline and tertiary butanol, which are both useful compounds in organic chemistry.

Applications N-Iodosuccinimide is a iodo substituted succinimide that is used as an iodinating agent in chemical synthesis. References Castanet, A.-S. et al.: Tetrahed. Lett., 43, 5047 (2002);

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Used in the study of red blood cell growth and differentiation. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

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a-Methyl-2-piperidinemethanol is an optical active compound that is used in the production of industrial chemicals. It is a chiral molecule and has two different forms, dextrorotatory and levorotatory. In order to produce enantiomerically pure compounds, it is necessary to use the dextrorotatory form. The synthesis of a-methyl-2-piperidinemethanol starts with the formation of aluminium hydride from aluminium and hydrogen gas. This reacts with sodium hypochlorite in an organic solvent to produce a mixture that contains the desired product, as well as some byproducts. A second reaction produces chromium trioxide which reacts with vinyl ether to produce the desired product.

2-Chloro-6-methylpyrimidin-4-ylamine is a crystalline compound with the chemical formula C8H9ClN3. It has the molecular weight of 143.8 and molecular formula of C8H9ClN3. 2-Chloro-6-methylpyrimidin-4-ylamine is an amine that forms hydrogen bonds with other molecules. The crystal structure of 2-chloro-6-methylpyrimidin-4-ylamine has been determined by XRD, revealing a dimeric form. Crystals of this compound are typically found in the form of x, y, or z axes along with their corresponding angles and lengths in degrees. 2CMPY consists of intramolecular hydrogen bonds between N and H atoms on adjacent molecules forming dimers. In addition to hydrogen bonding, 2CMPY also has intermolecular interactions with neighboring molecules, as well

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

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Applications (2R,4S)-4-Aminopyrrolidine-2-carboxylic acid dihydrochloride (cas# 263407-17-6) is a useful research chemical.

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Applications 3-(2,5-Dioxo-2,5-Dihydro-1h-Pyrrol-1-yl)benzoic Acid (cas# 17057-07-7) is a useful research chemical.

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4-Chloro-2-pyridinecarbaldehyde is a kinetic fluorescent probe that reacts with nucleophilic amines. It has a linear response in the range of 10-100 μM and fluorescence properties that are sensitive to pH. 4-Chloro-2-pyridinecarbaldehyde is used as a fluorescence probe for the detection and identification of biomolecules. It can be used for the determination of ethylene acetal concentrations in wastewater, as well as for the alkylation of proteins. This chemical also exhibits excellent fluorescence properties and can be used as a substrate for thiosemicarbazide.

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3-Amino-2-bromopyridine is a synthetic compound that has been found to be a potential antitumor agent. It undergoes a palladium-catalyzed coupling reaction with 3-phenylpropene, forming an amide. The reaction yield is dependent on the temperature of the reaction, which must be low enough for the desired product to form. 3-Amino-2-bromopyridine has been shown to possess pharmacokinetic properties and can be transported by amide, hydroxyl, and carboxyl groups. This compound also undergoes acid formation reactions at elevated temperatures.

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Applications 2-Benzylbenzimidazole Hydrochloride is an inhibitor of nuclear factor kB activity. References Boggu, P., et al.: Bioorg.Med.Chem, 24, 1872-1878 (2016)

Ropivacaine is a local anaesthetic of the amino ester group that is used to provide relief from pain caused by surgery or other medical procedures. It is a potent inhibitor of the enzyme activity of cholinesterases, which are enzymes responsible for the degradation of acetylcholine. Ropivacaine also inhibits the activity of cardiac Na+/K+ ATPase and Na+-Ca2+ exchanger, thereby reducing the excitability and contractility of heart muscle. This drug has shown pharmacokinetic properties in maternal blood that are similar to those observed in plasma, indicating that it can cross the placenta. Ropivacaine has been shown to have bactericidal effects against bacterial strains such as Escherichia coli and Staphylococcus aureus. In addition, ropivacaine has been shown to inhibit colorectal adenocarcinoma cells in vitro and in vivo. Levobupivacaine

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5-Amino-2-chloropyrimidine is a chemical compound that contains the pyrimidine ring. It is a weak base with a conjugative nature, and has substituents on the amino group, which is attached to the 2-position of the pyrimidine ring. The 5-amino group is substituted by chloro and 2-chloro groups. The chemical shift for this molecule ranges from 0 to -5 ppm in dimethyl sulfoxide (DMSO) and benzene. The NH proton appears at 3.2 ppm in DMSO and 4.8 ppm in benzene, while the HN proton appears at 1.8 ppm in DMSO and 2.9 ppm in benzene.

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Phenazopyridine hydrochloride is a drug that is used for the treatment of bladder disorders. It is a chemical compound with a molecular weight of 275. It has been shown to have intramolecular hydrogen bonds and synchronous fluorescence, which are indicative of its chemical stability. The regression analysis data demonstrates that phenazopyridine hydrochloride has anti-infective properties. This drug also has a linear calibration curve in the concentration range of 0.01-1 mg/mL and is used as an anti-inflammatory agent in the treatment of bladder disorders. Phenazopyridine hydrochloride is believed to inhibit bacterial growth by affecting the synthesis of DNA and protein, which are essential for maintaining cellular function.

Applications 2,5-Dimethyl-piperidine is a useful synthetic intermediate in synthesizing chromen-2-ones and chromen-4-ones derivatives. These compounds are inhibitors that act against DNA-PK. References Griffin, R.J., et al.: J. Med. Chem., 48, 569 (2005)

Methyl 4-(2,3,4-trimethoxyphenyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine-6-carboxylate hydrochloride (MTIC) is a polypeptide that has been shown to have an inhibitory effect on cancer cells. MTIC is a potent inhibitor of the enzyme protein kinase C and can also be used as an adjuvant for immunotherapy. MTIC's mechanism of action is not well understood; however it has been hypothesized that it may act by tethering to the target cell or by binding to endogenous moieties such as proteins and nucleic acids. MTIC has also been shown to inhibit immune cells such as macrophages and T cells.

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Applications 2,4,6-Trimethylpyridine-d11 (CAS# 1219805-54-5) is a useful isotopically labeled research compound.

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