Hétérocycles azotés (N)

Please enquire for more information about 1H-Pyrrolo[3,2-b]pyridin-5-amine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Please enquire for more information about 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

7H-Pyrrolo[2,3-d]pyrimidine-6-carboxylicacid is a kinase inhibitor that inhibits the cyclin-dependent kinases. It is used in the treatment of breast and lung cancer. 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxylicacid has been shown to inhibit the activity of pyrimidine kinases with IC50 values of 0.5 μM for ab1 and 0.8 μM for cdk1. This drug also inhibits the activity of succinate salt hydrate (SSH) with IC50 values of 1 μM for ab1, 2 μM for cdk1, and 4 μM for cdk2/cyclin E. 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxylic acid also inhibits pancreatic cancer cells in culture with an IC50

Please enquire for more information about 5-Chloropyridine-2-boronicacid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-Chloro-3-fluoro-2-pyridinecarboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Indole-4-carboxaldehyde is a natural compound that can be found in the acetate extract of the roots of Scopolia japonica. It has been shown to have an inhibitory effect on locomotor activity and may also have an inhibitory effect on protein synthesis. The mechanism of this inhibition is not yet known, but it may be due to an intramolecular hydrogen bond or other interactions with proteins. Indole-4-carboxaldehyde has also been shown to induce apoptotic cell death in 3T3-L1 preadipocytes by inducing mitochondrial dysfunction and oxidative stress.

Applications 4-(2-Phenoxyethyl)-5-ethyl-1,2,4-triazol-3-one is used as a reagent to synthesize Nefazodone (N389100), a 5HT2-receptor antagonist and a serotonin selective reuptake inhibitor used to treat depression. References Fontaine, R., et al.: J. Clin. Psych., 55, 234 (1994); Rush, A., et al.: Biol. Psych., 44, 3 (1998)

Please enquire for more information about 6-Trifluoromethylpyridine-3,4-diamine HCl including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about (S)-1-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

2,3-Dimethylpiperidine hydrobromide is an analgesic drug that has been used in the treatment of pain. It is a phenacyl derivative and has been found to be an effective agonist at opioid receptors. 2,3-Dimethylpiperidine hydrobromide binds to the opioid receptors, activating them and leading to the release of neurotransmitters such as dopamine and serotonin. This compound has been shown to be effective against both acute and chronic pain. The pharmacophore for this drug is based on a pethidine core with two phenacyl groups attached, which are part of a chromatographic resolution. The amide group gives the molecule its solubility in water, while the other groups act as blockers against naphthyridine derivatives and piperidines (e.g., propionate).

7,8-Dimethoxy-9-oxo-9H-indeno[1,2-B]pyrazine-2,3-dicarbonitrile is a fine chemical that is useful for research and as a building block in the synthesis of more complex compounds. It can be used in the synthesis of a range of pharmaceuticals and other chemicals. 7,8-Dimethoxy-9-oxo-9H-indeno[1,2-B]pyrazine is also an excellent reagent for the preparation of other compounds. This compound has been shown to bind to DNA and RNA and its reaction with nucleophiles produces a variety of products.

Please enquire for more information about 4-(2-Hydroxyethyl)piperazine-1-carboximidamide sulfate (salt) including the price, delivery time and more detailed product information at the technical inquiry form on this page

2,6,8-Trichloropurine ammonium salt is a reaction product of 2,6,8-trichloropurine and ammonium hydroxide. It has been shown to inhibit the synthesis of protein in tissue cultures and to be cytotoxic. 2,6,8-Trichloropurine ammonium salt reacts with proteins in the cells. This reaction produces chloropurine dimers that are not soluble in water and can only be solubilized with organic solvents such as acetonitrile or methanol. The formation of these chloropurine dimers is what inhibits protein synthesis in cell cultures. The activation energy for this reaction is approximately 15 kJ/mol. Inactivation of virus by 2,6,8-trichloropurine ammonium salt has been observed at concentrations greater than 1 mM.

Please enquire for more information about 5-Bromopyrazolo[1,5-a]pyrimidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(Pyridin-3-yl)piperazine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N-(4-Fluorophenyl)pyridin-2(1H)-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-(5-Methoxy)phenol 4-(N-benzyloxycarbonyl)piperidinyl ketone including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about tert-Butyl2-formyl-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 5-(2-Fluorophenyl)-1H-tetrazole is used in the synthetic preparation of novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors useful in treatment and prevention of CNS diseases and diseases-modulated by mGluR5 receptors. References Gagliardi, S.; et al.: PCT Int. Appl. 45 pp. Patent 2006 CODEN:PIXXD2

Please enquire for more information about (E)-2-(2-(Dimethylamino)ethyl)-1-(1-(pyridin-2-yl)ethylidene)-2,3-dihydro-1H-inden-2-ol including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 6-Chloro-N,N,2-trimethylpyrimidin-4-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Tert-butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate is a carbocyclic molecule that is used as an inhibitor of histone deacetylase. It has been shown to have radical, halogen atoms, and unsaturated substituents. Tert-butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate inhibits the activity of phosphodiesterases, which are enzymes that break down cGMP, leading to vasodilation and relaxation of smooth muscle cells. This inhibition may be due to its ability to inhibit histone deacetylase, an enzyme that regulates the transcription of genes involved in inflammatory responses.

Please enquire for more information about (3-Chlorophenyl)(pyridin-4-yl)methanone including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Please enquire for more information about (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide HCl including the price, delivery time and more detailed product information at the technical inquiry form on this page

Ai Product Descriptions 50 Creative

6-Chloropyridine-3-carbohydrazide is a benzene molecule that has a conformation of a chair with one hydrogen bond. This molecule has an intramolecular hydrogen bond and an intermolecular hydrogen bond. The molecule contains two pyridine rings and the water molecule is located on the opposite side of the molecule from the two pyridine rings. The molecule also has a crystal structure that is orthorhombic. 6-Chloropyridine-3-carbohydrazide is an experimental compound that was synthesized by heating methanol with hydrazine to form this compound.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Please enquire for more information about 4-Amino-2,5-dimethylthieno[2,3-D]pyrimidine-6-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Cationic surfactant; antiseptic

3-Amino-6-bromo-pyrazine-2-carboxylic acidamide is a chemical compound that belongs to the class of imines. It is an intermediate in the synthesis of other compounds, such as 3,5-dimethylbenzaldehyde and formamidine acetate. 3-Amino-6-bromo-pyrazine-2-carboxylic acidamide can be prepared by reacting ethoxymethylene with chlorinating agents, such as thionyl chloride or phosphorous oxychloride. This reaction produces 3-[(E)-2-(chloromethyl)ethenyl]imine (1), which undergoes a nucleophilic substitution reaction with dimethylamine to produce 3-[(E)-2-(aminomethyl)ethenyl]imine (2). The bromide group is then introduced through the action of trimethylsilyl bromide,

Stability Moisture Sensitive Applications Contains approximately 12% dichloromethane and 8% ethyl acetate

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3-Bromo-2-hydroxypyridine is a low potency competitive inhibitor of the HIV protease that binds to the active site of the enzyme. It has been shown to have anti-cancer activity in prostate cancer cells and also inhibits inflammatory bowel disease by inhibiting serine proteases. 3-Bromo-2-hydroxypyridine is synthesized by reacting 1,2,4-triazole with bromine in the presence of hydrochloric acid. This reaction produces a mixture of substituted pyridines, which are purified using column chromatography. The chemical structure is characterized using NMR spectroscopy and mass spectroscopy.

Applications 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is used as the starting material in the preparation of pyrazine derivatives that are AxI and c-Met receptor enzyme inhibitors. These inhibitors are useful in the treatment of tumors. 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is also used in the preparation of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. References Rushton, L.; et al.: PCT Int. Appl. 119 pp. Patent 2009 CODEN:PIXXD2; Charrier, J-D.; et al.: J. Med. Chem, 54, 2320 (2011)

Applications 2-(Dimethylamino)-4-pyridinyl-boronic Acid can be used to synthesize N-biaryl quinolone carboxylic acids as selective M1 positive allosteric modulators. References Yang, F., et al.: Bioorg. Med. Chem. Lett., 20, 531 (2010)

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Applications 2,4-Dihydroxypyrrolo[2,3-d]pyrimidine (cas# 39929-79-8) is a compound useful in organic synthesis.

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Please enquire for more information about 1-[(4-Fluorophenyl)Sulfonyl]Piperazine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Labelled N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide (F595365). Rosuvastatin intermediate.