Hétérocycles azotés (N)

Please enquire for more information about 2-(Pyridin-3-yl)acetohydrazide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 2-(2-Oxopiperazin-1-yl)acetic acid (cas# 24860-46-6) is a useful research chemical.

Please enquire for more information about tert-Butyl 2-methyl-5-oxo-1,4-diazepane-1-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Pyrido[2,3-b]pyrazin-3(4H)-one is a molecule that has been shown to inhibit the growth of pancreatic β-cells. It binds to the β-cell receptor and induces apoptosis, which is caused by the activation of caspase-8, caspase-9, and caspase-3. Pyrido[2,3-b]pyrazin-3(4H)-one has also been shown to be effective in preventing skin cancer in mice by inhibiting expression of suppressor genes. This drug also inhibits metabolic disorders such as diabetes and obesity by blocking pathways involved in these diseases.

Please enquire for more information about 4-Chloro-3-iodopyridine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N-(3,5-bis(trifluoromethyl)phenyl)-2-pyrimidin-2-ylthioethanamide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Ethyl cyano{1-[(4-methylphenyl)sulfonyl]piperidin-4-ylidene}acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3-[4-(3,4-Dichlorophenyl)piperazin-1-yl]-3-oxopropanenitrile including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 6-(Aminomethyl)-N,N-dimethyl-1,3,5-triazine-2,4-diamine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

1-(2-Chloroethyl)piperidine hydrochloride is a chemical compound that has photochemical properties. It is used as an amine and in the synthesis of other chemicals. The crystal structure of 1-(2-Chloroethyl)piperidine hydrochloride has been determined by X-ray crystallography. It also has antibacterial activity and inhibits the growth of bacteria by binding to single-stranded DNA, which prevents DNA replication. 1-(2-Chloroethyl)piperidine hydrochloride binds to DNA with tetradentate coordination, forming a stable complex which does not allow the DNA polymerase to bind to the single strand. 1-(2-Chloroethyl)piperidine hydrochloride can be detected using mass spectrometry and nuclear magnetic resonance spectra.

Please enquire for more information about 3-({[4-(Difluoromethyl)-6-methylpyrimidin-2-yl]thio}methyl)-4-methoxybenzaldehyde including the price, delivery time and more detailed product information at the technical inquiry form on this page

2,5-Dibromopyrazine is a heterocyclic compound that can be synthesized by the Suzuki coupling reaction of 2-bromo-1,3-dibromopropane with an acceptor. It has been shown to have glycemic parameters and a high rate enhancement for the water molecule photophysical isomerization reaction. Structural isomers of 2,5-dibromopyrazine exist as well and are thought to have different rates of photocatalytic activity. The rate enhancement may be due to the increase in electron density on the heteroatoms in the ring.

Please enquire for more information about 8-(1,1-Dimethylethyl) 5,6,7,9-tetrahydro-8H-pyrido[3,4-c]azepine-4,8-dicarboxylate  including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4(1H)-Pyrimidinone, 5-methoxy- (9CI) including the price, delivery time and more detailed product information at the technical inquiry form on this page

4,4',4''-(1,3,5-Triazine-2,4,6-triyl)tris-benzoic acid is a chemical substance that is synthesized by the reaction of 1,3,5-triazine with an aromatic compound. It has been shown to have a hemolytic activity and to generate light emission when it reacts with fetal bovine serum. This chemical substance has been used in gel permeation chromatography as a detector molecule for the determination of other substances. It is also used in clinical diagnostics and photocatalytic applications.

Applications Diethyl Pyridine-2,3-dicarboxylate is a useful reagent in preparation of herbicides. References Doehner, R.: Eur. Pat. Appl. (1988), EP 254951 A2 19880203.

Please enquire for more information about (1-Piperidin-1-ylcyclohexyl)methylamine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 6-Amino-2-[(2-methoxyphenyl)amino]pyrimidin-4(3H)-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 5-Chloro-4-(3-pyridinyl)-2-pyrimidinamine is an intermediate in the synthesis of 3-((5-Chloro-4-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide (C179120), an impurity of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia. References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),

4-Chloro-6-trifluoromethylpyrimidine is a phosphorus oxychloride that can be used as an insecticide. It has high yield and is easy to synthesize. 4-Chloro-6-trifluoromethylpyrimidine is a highly alkaline compound that can be used for the treatment of phomopsis, botrytis cinerea, and other fungi. It also has chlorantraniliprole, which is active against insects and nematodes. The compound also has a number of bioactivities in alcohols, such as being antibacterial, antifungal, and antiviral.

Applications Reagent used to synthesize many pyrrole derivatives

2-[3,5-Bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-morpholin-4-ylpyridin-3-yl]propanamide is a serotonin receptor antagonist that blocks the binding of serotonin to its receptors. It is used in the treatment of chronic cough and emetogenic chemotherapy. Netupitant is also an antagonist of the NK1 receptor and is used in combination with other antiemetics for cancer patients receiving high doses of emetogenic chemotherapy. Netupitant has been shown to have an antidepressant effect, which may be due to its ability to inhibit the release of serotonin from platelets. Netupitant may also cause some side effects such as nausea, vomiting, diarrhea, constipation, or headache. These side effects are usually temporary and can be minimized by taking the drug with food or milk.

Please enquire for more information about 1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine dihydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Vinylboronic anhydride pyridine complex is a synthetic molecule that is used as a linker to attach fluoroquinolones to boronic acids, which are used in the synthesis of receptor binding molecules. Studies have shown that this compound has inhibitory activities against inflammation and cancer. Vinylboronic anhydride pyridine complex binds to the malonic acid residues on the surface of proteins and inhibits the release of inflammatory signals. It also inhibits certain enzymes such as phospholipase A2, which play a role in inflammatory diseases. This molecule has been shown to bind with halides and hydroxyl groups, making it useful for attaching other molecules to surfaces or for attaching other molecules together.

Please enquire for more information about Fmoc-4-(3-carboxymethyl-2-keto-one-benzimidazolyl)piperidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Ethyl 4-Methyl-1-(1-phenylpropan-2-yl)-1H-pyrrole-2-carboxylate is an intermediate used in the synthesis of 4-Methyl-1-(1-phenylpropan-2-yl)-1H-pyrrole-2-carboxylic Acid (M339120), which is an impurity of the drug Amphetamine (A634248).

Please enquire for more information about 4-Aminocarbethoxypiperidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

3,5-Dicarboxy-4-(1,3-benzodioxol-4-yl)-2,6-dimethylpyridine is a drug that inhibits the activity of the 5-HT2A receptor which is involved in regulating numerous physiological functions including cardiac function. In vitro studies have shown that 3,5-Dicarboxy-4-(1,3-benzodioxol-4-yl)-2,6-dimethylpyridine has antihypertensive and haemodynamic effects. These effects are due to its ability to inhibit the sodium dependent glucose transport and to block 5HT2A receptors. Animal models have demonstrated that 3,5-Dicarboxy-4-(1,3-benzodioxol-4-)methyl)-2,6 -dimethylpyridine can be used to treat ventricular dysfunction.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Please enquire for more information about N-[(2-Methylpyrimidin-4-yl)methyl]propan-2-amine dihydrochloride propan-2-ol including the price, delivery time and more detailed product information at the technical inquiry form on this page

Pemetrexed is a cancer drug that belongs to the group of diacids. It is chemically stable and has been shown to have anticancer activity in mammalian cells. Pemetrexed inhibits the growth of mesothelioma, a type of lung cancer, by binding to DNA and inhibiting DNA synthesis. The process optimization for pemetrexed was done by investigating different salt formulations, such as sodium salts or carboxylates. This drug can be used in combination with other anticancer drugs to treat other types of cancer, such as pleural mesothelioma or heptahydrate. Pemetrexed has been approved for use in Canada as an anticancer agent for the treatment of mesothelioma and lung cancers (e.g., non-small cell lung cancer).

Please enquire for more information about 5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

7-Azaindole is a chemical compound that can be used as a building block in organic synthesis. It can be used as a reactant in the preparation of other chemicals, such as dyes, rubber accelerators, and pharmaceuticals. 7-Azaindole is also useful as an intermediate in the production of polymers, such as polyurethanes and polyesters. This chemical is soluble in water and alcohols, but insoluble in ethers and chloroform. 7-Azaindole has been classified by the International Agency for Research on Cancer (IARC) as Group 3: Not Classifiable as to its Carcinogenicity to Humans.

Please enquire for more information about 2-Ethynylpiperazine dihydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 6-Nitrothieno[2,3-D]Pyrimidin-4(3H)-One including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 2,4-Diaminopyrimidine-5-carbonitrile is used as an intermediate for the preparation of medicines and agrochemicals (1). References (1) Otzen, T., et al.: J. Med. Chem., 47, 240 (2004)

Please enquire for more information about 5-Chloro-3-iodopyridin-2-ylhydrazine including the price, delivery time and more detailed product information at the technical inquiry form on this page

6-Methyl-1H-pyrrolo[2,3-b]pyridine is a molecule that is used as a chemical alkylation agent. It has been shown to be cytotoxic against hepatoma cell lines in vitro and in vivo, and also inhibits replication of hepatitis B virus in cell culture. The mechanism of action is not yet known but may be related to the ability of 6-methyl-1H-pyrrolo[2,3-b]pyridine to form covalent bonds with cellular DNA. 6-Methyl-1H-pyrrolo[2,3-b]pyridine can react with anions such as chloride ion or sulfate ion to form an anion radical. This reaction is reversible and the product can then react with other molecules to form adducts that can be measured by electron spin resonance (ESR) spectroscopy.

Please enquire for more information about 1-Benzyl-1,2,3,6-tetrahydropyridine-4-carboxylicacid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1,4-Phenylenebis(1,4'- bipiperidin-1'- ylmethanone including the price, delivery time and more detailed product information at the technical inquiry form on this page

3-Phenyl-1'-(phenylmethyl)-(3,4'-bipiperidine)-2,6-dione monohydrochloride is a drug that has been shown to be effective in the treatment of inflammatory bowel disease. It works by inhibiting acetylcholinesterase and thereby increasing acetylcholine levels. 3-Phenyl-1'-(phenylmethyl)-(3,4'-bipiperidine)-2,6-dione monohydrochloride also inhibits locomotor activity in mice. This drug may also be used as a potential therapeutic agent for other autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.

Please enquire for more information about 6-Amino-2-anilinopyrimidin-4(3H)-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4-Iodopyrimidin-2-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Methyl 6-formylpyridine-2-carboxylate is a compound that can be used as a label for hybridization and bioconjugation. It is also useful in the separation of organic materials, such as triazines and bipyridines. Methyl 6-formylpyridine-2-carboxylate has been shown to bind selectively to metal ions, forming coordination complexes. It has an oxime group that can be cleaved using hydrogen peroxide or hydrazine to form an aziridine moiety, which can react with other molecules. Methyl 6-formylpyridine-2-carboxylate can also be used in photophysical studies due to its chromophore properties.

Tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one is an organic compound that is used in the synthesis of drugs and other organic compounds. It can be synthesized by reacting hydrogen fluoride with nitrogen atoms. Tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one can form stable complexes with iodination reactions and has been used to prepare monoclonal antibodies. This molecule has also been studied using x-ray crystal structures and titration calorimetry to investigate its reaction mechanism. The light emission from this molecule is due to intermolecular hydrogen bonding between a pyrazole ring and a phenyl ring.

Please enquire for more information about 6-Chloro-1-methyl-1H-imidazo[4,5-c]pyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-[(Tert-Butyl)Oxycarbonyl]-3-(4-Fluorobenzyl)Piperidine-3-Carboxylic Acid including the price, delivery time and more detailed product information at the technical inquiry form on this page