Hétérocycles azotés (N)

Please enquire for more information about (2E)-4-Oxo-4-[[2-(piperidin-1-ylsulfonyl)ethyl](pyridin-4-ylmethyl)amino]but-2-enoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 5-(1-Piperazinyl)-2-Benzofurancarboxylic Acid Ethyl Ester Diydrochloride Hydrate cas# 1422956-31-7) is a useful research chemical.

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Stability Very Hygroscopic Applications (S)-Isopropyl-2-aminopropanoate Hydrochloride, is a chemical reagent used in the synthesis of anti-HCV prodrugs based on imidazotriazine and pyrrolotriazine molecules. References Tyndall, E. Bioorg. Med. Chem. Lett., 25, 869 (2015);

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5-Bromo-2-hydrazinopyridine is a potent anticancer drug that inhibits the synthesis of DNA and RNA. It is used for the treatment of acute promyelocytic leukemia. 5-Bromo-2-hydrazinopyridine has been shown to be active against cancer cells in culture and has demonstrated antitumor activity in vivo. The mechanism of action involves inhibition of DNA polymerase II, which is responsible for the synthesis of DNA. This leads to cell cycle arrest and apoptosis induction. 5-Bromo-2-hydrazinopyridine also binds to terminal alkynes, which are intermediates in the production of polymers that are implicated in carcinogenesis. It inhibits this process by binding to a critical site on the enzyme acetaldehyde dehydrogenase and thereby preventing its activation by acetaldehyde.

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(6-Chloropyridin-2-yl)methanol is an insecticide that is used in the control of insects. It is a chloride yielding chemical that has been shown to be detectable by irradiation and can cause ecosystem effects. (6-Chloropyridin-2-yl)methanol has been studied for its toxicity and advances have been made in the area of kinetics and yields. This chemical also provides chlorides as well as organic chemicals, which are nutrients for the growth of plants. It is a pesticide that has been found to yield both chloride and n-oxide during decomposition.

Applications 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is used in preparation and structure of alkaline earth iodide phosphine oxide and urea complexes as reactant or reagents. References Fitts, Lacey S., et al.: New J. of Chem., (2016); Hall, Jessica E., et al.: Angew. Chem. Int. Ed., 55, 11153-11157 (2016)

Thieno[3,2-c]pyridine is an organic compound that contains both a phenoxy and alcohol group. It can be used to treat hyperproliferative diseases such as cancer. Thieno[3,2-c]pyridine has shown anticancer activity in mice and inhibits the growth of cancer cells by binding to 5-HT2 receptors. The safety profile of this drug is good and it has been shown to have a low incidence of side effects. Thieno[3,2-c]pyridine also has an anti-inflammatory effect on inflammatory diseases such as rheumatoid arthritis. Thieno[3,2-c]pyridine binds with clopidogrel (a platelet aggregation inhibitor) and has been shown to inhibit the activation of nitric oxide synthase (NOS).

Applications 4-PIPERAZIN-1-YL-QUINOLINE DIHYDROCHLORIDE (cas# 1350361-89-5) is a useful research chemical.

Please enquire for more information about 5-(4-Chlorophenyl)pyrimidine-4-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Olmesartan intermediate. References Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996),

3-Carbethoxy-2-piperidone is a cycloaddition product of formaldehyde and an amine. This reaction proceeds through the formation of a dicarbonyl intermediate, which then reacts with chloride to form the final product. The absorption maximum of 3-carboxy-2-piperidone is at 270 nm, and its structure can be determined by using infrared spectroscopy. 3-Carbethoxy-2-piperidone has a dipole moment of 1.3 D and is electron deficient due to the absence of a hydrogen atom on the nitrogen atom. It also has an amido group (C=O) that is bonded to the carbonyl group (C=O). 3-Carbethoxy-2-piperidone is not soluble in water, but it does dissolve in polar organic solvents such as acetone or dimethylformamide (DMF). The chemical reactions

6-Hydroxy-4-pyrimidinecarboxylic acid is a physiochemical that has been found to have a variety of therapeutic effects. It is synthesized by dihydroxylation of 4-pyrimidinecarboxylic acid, and can be oxidized to form 6-hydroxy-4-(1H)-pyrimidinone carboxylic acid. It is also known as DHPPA. This drug has been used in the treatment of HIV infection, but its use for this purpose has been discontinued because it was found to be toxic to cells. 6-Hydroxypyrimidinecarboxylic acid is metabolized by cytochrome P450 (CYP) enzymes and hydroxylated by CYP2E1, CYP2B6, and CYP3A4. The pharmacokinetic properties of this drug are influenced by the metabolic enzyme profile and the excretion rate of each individual. Nitrous oxide may

2-(Chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine (CMP) is a heterocycle that can be synthesized by the condensation of 2-chloro-4-hydroxymethylpyridine with 3-methoxypropionic acid chloride. This compound is a thionyl, n-oxide, chloride, hydrolyzed, halogenated, and anhydride. CMP has been used as an intermediate for the synthesis of other compounds.

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Applications rac-α-N-Boc-Amino-4-pyridineaceic Acid is a reagent used in the preparation of lactam-containing diaminoalkanes, β/α-amino acids and derivatives of Xa inhibitors.

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Firocoxib is a non-steroidal anti-inflammatory drug that belongs to the class of NSAIDs. It is used for the treatment of osteoarthritis, rheumatoid arthritis, and acute pain. Firocoxib has been shown to significantly reduce the number of patients with inflammatory diseases who require surgery. This drug also has significant interactions with other drugs and can cause life-threatening side effects. Firocoxib inhibits the production of prostaglandins in response to inflammation, which are molecules that promote inflammation and increase pain sensitivity. Firocoxib also inhibits cholinergic activity, serotonergic activity, and bladder function. Clinical trials have been performed to test firocoxib on ovary cancer cells in vitro and in vivo assays have been performed on rats with bladder cancer. The uptake of firocoxib by these cells was found to be low, suggesting that it may not be effective against this type of cancer.

Applications Methyl 4-[(Pyridine-3-carbonylamino)methyl]benzoate (CAS# 554407-47-5) may be a derivative of 4-​[[(3-​Quinolinylcarbonyl)​amino]​methyl]​-​benzoic Acid Methyl Ester (CAS# 591217-99-1), which is an antitumor agent. References Maeda, T., et al.: Bioorg. Med. Chem., 12, 4351 (2004)

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2,4-Dichlorofuro[3,2-d]pyrimidine (2,4-DFPD) is a potent inhibitor of the enzyme dihydropyrimidine dehydrogenase. It is structurally related to vismodegib and has been shown to inhibit the synthesis of purines and pyrimidines in cells by blocking their conversion into nucleotides. 2,4-DFPD has been shown to have inhibitory activity against the enzyme dihydropyrimidine dehydrogenase and to be a worthy inhibitor for further study.

3,5-Dimethylpyrazin-2-ol is a specific ligand that binds to the disulfide bond in the antimicrobial peptide. The 3,5-dimethylpyrazin-2-ol binds to an allosteric site on the protein, which is a region of the protein that is different from the active site. This binding causes an alteration in protein conformation and changes its activity. The 3,5-dimethylpyrazin-2-ol has been shown to bind to dna binding domains and transcriptional regulation architectures. It has also been shown to have biological function and a paradigm shift effect on cellular function and analytical methods.

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Please enquire for more information about 7-AMINOPYRIDO[2,3-B]PYRAZINE including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4,4'-Bis[2-(4-N,N-dimethylaminophenyl)ethenyl]-2,2'-bipyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N,N-Dimethylpiperidine-4-sulfonamide hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 2-(Ethylthio)-1H-benzimidazole is the active substance or the active ingredient in the synthesis of the drug Metaprot. Performs a transplacental function: daily administration of bemithyl (20 mg/kg) from 6 th to 16 th day of pregnancy in female rats led to the decrease in fetal death after the implantation and increased fetal body weight. References Kibal'chich, D. A., et al.: Eksperimental'naya i Klinicheskaya Farmakologiya, 74, 30 (2011); Bugaeva, L. I., et al.: Eksperimental'naya i Klinicheskaya Farmakologiya, 70, 40 (2007).

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Please enquire for more information about 1-Pyrimidin-2-yl-[1,4]diazepane including the price, delivery time and more detailed product information at the technical inquiry form on this page

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