Building Blocks

8-Methylimidazo[1,2-a]pyridine-3-carbaldehyde

1-(Cyclopropyl)-1H-pyrazole-4-carbaldehyde

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Bromo-3,4-dimethoxybenzaldehyde (BDMB) is a fluorescent aldehyde that can be used as an analog for 2,4-dinitrofluorobenzene. It has been shown to have cytotoxic effects on cancer cells. BDMB binds to microtubules and inhibits their polymerization and depolymerization, preventing the formation of the cytoskeleton in the cell. This leads to cell death by apoptosis. The affinity of BDMB for microtubules is much higher than its affinity for other cellular components. BDMB also has been shown to inhibit DNA synthesis in cancer cells through inhibition of RNA polymerase II transcription.

1-Chloro-2-methoxy-3-methylbenzene is an intermediate in the preparation of 1,2,4-trihydroxybenzene. It can be prepared by chlorination of 2-chloro-6-fluorobenzaldehyde followed by carbonylation with methylmagnesium chloride and potassium chloride. The reaction is carried out in a solvent such as methanol or ethanol. The product is isolated by recrystallization from water or petroleum ether to give a white crystalline solid that melts at about 82°C. This process is efficient and gives high yields of product for this chemical compound.

1H-Indole-6-boronic acid

Versatile small molecule scaffold

Methyl 2-hydroxybut-3-enoate is an organic solvent that can be used for the synthesis of monomers and polymers. This molecule has a functional group, a metal ion, and an acid catalyst. It is also efficient for the synthesis of lipids and fatty acids. Methyl 2-hydroxybut-3-enoate is synthesized by reacting with potassium ions in an alcohol solution with a lipase as the catalyst. This reaction may be carried out using radiation or metathesis reactions. The product may also be used as a solid catalyst for other reactions such as hydrogenation, esterification, dehydrogenation, oxidation, hydrolysis, and polymerization.

Versatile small molecule scaffold

N-a-Benzoyl-L-arginine is a fluorescent substrate for soybean trypsin. It is hydrolyzed by the enzyme to release an amide and p-nitrophenyl phosphate. The amide is then hydrolyzed by esterase to produce caproic acid, which can be detected at an excitation wavelength of 340 nm and emission wavelength of 495 nm. N-a-Benzoyl-L-arginine has been shown to have proteolytic activity in cell culture, with a pH optimum of 6.8 and temperature optimum of 37 degrees Celsius. This product has been shown to be effective in women as well as in men.

Versatile small molecule scaffold

8-Bromo-6-chloroimidazo[1,2-a]pyridine hydrochloride

4-Chloro-8-methyl-2-(trifluoromethyl)quinoline

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

L-Phenylalanine, 4-chloro-, methyl ester is a steroid compound with antiviral properties. It is known to have an effect on adipose tissue and can regulate the production of hydroxylysine, dopamine, and collagen. This compound is derived from L-lysine and has been found to have antinociceptive properties, making it potentially useful for pain relief. Additionally, L-Phenylalanine, 4-chloro-, methyl ester has been used in research as a chemical tool for studying various biological processes. It is available in the form of potassium or sodium salts and can be hydrogenated to produce fatty acids.

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Chloroindole-3-carboxylic acid

1-[6-(4-Methoxyphenoxy)-2-methylpyridin-3-yl]ethan-1-one

2-Methyl-1,3-thiazole-4-carboxaldehyde

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Thiophene-3-thiocarboxamide

Versatile small molecule scaffold

Versatile small molecule scaffold

Applications 2,6-Diethylaniline-15N (CAS# 287488-24-8) is a useful isotopically labeled research compound.

Versatile small molecule scaffold

2-(Trifluoromethyl)pyridine

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Acetylmorpholine

Versatile small molecule scaffold

3-Benzylcyclobutanone is a chiral, cyclic, sulfoxide that is synthesized via the asymmetric synthesis of 3-benzoylcyclobutanone and benzaldehyde. It can be used in the preparation of oxazolidinones, which are synthetic drugs with anti-inflammatory, analgesic and antipyretic properties. The optical purity of 3-benzylcyclobutanone has been shown to be greater than 99% by chiral GC analysis. This compound has also been synthesized using a preparative yield of 92%.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

6-Chloro-3-(difluoromethyl)-8-fluoro-[1,2,4]triazolo[4,3-a]pyridine

Versatile small molecule scaffold

Methyl 3-amino-4-chlorobenzothiophene-2-carboxylate

Versatile small molecule scaffold

N-(3-Hydroxyphenyl)-4-methylbenzene-1-sulfonamide has a moiety that is dihedral and forms hydrogen bonds with the phenol, toluene, and hydrogen bonds. It has a phenol that is substituted with a methyl group at the 3 position. The chemical name of this molecule is 3-[(3-hydroxyphenyl)amino]-4-methylbenzenesulfonamide.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 1-Methyl-7-indolecarboxylate

Versatile small molecule scaffold

1-Benzyl-3-(trifluoroacetyl)pyrrolidine

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Iodo-N-methylacetamide is a vasotocin analogue that is used as a research tool to study the interaction of arginine vasotocin in the pancreas. 2-Iodo-N-methylacetamide has been shown to inhibit pancreatic enzyme activity and intestinal absorption of glucose, while enhancing insulin release. This drug also binds to the beta cells of the pancreas, inhibiting melatonin synthesis and increasing bovine serum albumin (BSA) hydroxyindoleacetic acid (HIAA) levels. The effects are reproducible in rats, with 2-iodo-N-methylacetamide binding to glutamic acid decarboxylase and inhibiting HIAA synthesis in vitro.

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Amino-1-methylpyridin-2-one

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2,3-Dihydro-1H-1-benzazepine is a receptor binding drug that has been shown to have inhibitory effects on autoimmune diseases, cancer, bowel disease and chemokines. It also has anti-inflammatory properties in the treatment of infectious diseases, borane-tetrahydrofuran complex, brain infarction and inflammatory bowel disease. 2,3-Dihydro-1H-1-benzazepine is not active against infectious diseases caused by viruses or fungi. The n-oxide can be formed by nitric oxide synthase (NOS) in the body. This compound is thought to cause inflammation by inhibiting cyclooxygenase (COX) activity and prostaglandin synthesis.

Versatile small molecule scaffold

Applications n-Hexyl-5,5,6,6,6-d5-triphenylphosphonium Bromide (CAS# 1169764-53-7) is a useful isotopically labeled research compound. It can be used for mass spectrometric characterization of protein modifications. References Zhu, X., et.al., Chem. Res. Toxicol., 22, 1386-1397, (2009);

5-(3,4-Dichlorophenyl)furfural (5F) is a hepatotoxic agent that has been shown to cause liver cancer in animal studies. 5F binds to the casein kinase II (CKII) and inhibits its kinase activity, leading to apoptosis of cancer cells. This compound also inhibits the proliferation of human cancer cells by inhibiting the protein kinases involved in cell cycle regulation.

Versatile small molecule scaffold

Versatile small molecule scaffold

2'-Deoxy-5-trifluoromethyluridine

3-(3?-Chlorophenyl)coumarin

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Benzyloxycarbonyl-4-(ethoxycarbonylmethylcarbamoyl)piperidine

6-Methoxypyridine-2-boronic acid

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold