Building Blocks

Versatile small molecule scaffold

4-(4-Bromophenyl)morpholine

2,2-Dimethyl-4-phenyl-2,5-dihydro-1H-imidazole-5-thione

Versatile small molecule scaffold

[1,3']Bipyrrolidinyl (BPY) is an antibacterial agent that binds to the receptor site on bacteria and inhibits bacterial growth. It has been shown to be effective against a number of Gram-negative bacteria including Haemophilus influenzae, Escherichia coli, and Pseudomonas aeruginosa. BPY has been found to hydrate at physiological pH and is eliminated from the body primarily in urine. BPY has also been found to have good plasma exposure due to its high lipid solubility. The affinity of BPY for bacterial ribosomes is greater than other antibacterial agents such as carboxylates or fluoroquinolones. The binding of BPY with bacterial ribosomes inhibits protein synthesis and cell division, leading to cell death by inhibiting the production of proteins vital for cell division.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Fluoro-3-iodobenzonitrile is a deactivated aromatic compound that has been iodinated. The fluorine atom in this molecule is highly reactive and can be used to react with other molecules to form new compounds. 4-Fluoro-3-iodobenzonitrile is not toxic, but its reactions with other chemicals may produce toxic byproducts. This chemical belongs to the group of halogenated aromatic compounds, which are often used as solvents or disinfectants. Bromination of 4-fluoro-3-iodobenzonitrile produces 4-bromo-3,5,6,7,8,9,10-hexahydrobenzo[a]pyrene (BHP), a known carcinogenic agent.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(2-Chloro-6-((4-(tetrahydrofuran-3-yl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine

Versatile small molecule scaffold

5-Bromo-7-methoxybenzofuran

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Bromo-1H-imidazole-4-carbaldehyde

2-Bromomethyl-6-chloro-4-trifluoromethyl-pyridine

5-Nitro-2-(piperidine-1-yl)pyridine is a product that is formed by the nucleophilic addition of nitric acid to 1,3-diketones. It has been used in the synthesis of phenyl and isoxazole derivatives. The reaction was rationalized using amines as nucleophiles, which attack the electrophilic carbon atom in the ketone. This product has also been shown to be an effective nucleophile for attacking other molecules, such as azides and nitrates. In the Australian outback, 5-Nitro-2-(piperidine-1-yl)pyridine can be found in soils and plants.

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Hydrazinyl-2-phenyl-1,3-oxazole-4-carbonitrile is a sulfide that is used as a precursor for the synthesis of other compounds. It can be prepared by reacting acetylacetone with sodium azide in hydroxylamine solution. 5HPCN has been shown to have an electrophilic nature and reacts with nucleophiles such as cyano group, hydrogen sulfide, and hydroxylamine. The reaction product of 5HPCN with cyano group is a nitrile that can undergo alkylation reactions with various electrophiles to form different derivatives. 5HPCN has also been shown to react with ammonia to produce a nitrile, which can be oxidized to an amine or reduced to an imine.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(Phthalimidomethyl)benzeneboronic acid, pinacol ester

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4,4'-Dinonyl-2,2'-bipyridine

Versatile small molecule scaffold

Thieno[2,3-b]pyridin-5-ylboronic acid

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2,3-Dihydro-1H-indole-2-carboxamide is a synthetic peptidomimetic that inhibits NS3 protease, which is involved in the viral life cycle. 2,3-Dihydro-1H-indole-2-carboxamide has been shown to have potent inhibitory activity against the hepatitis C virus (HCV) and HIV. It also inhibits the replication of HCV in mammalian cells. This drug has pharmacokinetic properties that are similar to glibenclamide and penetrates the blood brain barrier. Clinical studies have been conducted on patients with chronic hepatitis B and C infection.

3,6-Dichloro-4-methylpyridazine

Versatile small molecule scaffold

Versatile small molecule scaffold

Applications n-Propyl-1,1-d2 Alcohol (CAS# 40422-04-6) is a useful isotopically labeled research compound.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Methoxy-1-phenylethan-1-ol is a derivatised compound that contains a hydroxyl group. It is structurally similar to styrene and has been found to be catalysed by proton, as well as by the presence of other compounds such as cytochrome P450. 2-Methoxy-1-phenylethan-1-ol is an ether with two ether linkages in its backbone, which form at the alpha carbon of the ethyl group and the oxygen atom of the methoxy group. The ether linkage can be cleaved by peroxide to produce an alcohol and an aldehyde. 2-Methoxy-1-phenylethan-1-ol has been shown to reduce inflammation in mice by inhibiting the synthesis of inflammatory cytokines, such as TNFα.

Versatile small molecule scaffold

Versatile small molecule scaffold

5-(4-Bromophenoxy)-2-furoic acid

Versatile small molecule scaffold

1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(Piperidin-4-yl)benzoic acid hydrochloride

Methyl 4-hydroxy-5-oxo-1-(2-pyridinylMethyl)-2,5-dihydro-1H-pyrrole-3-carboxylate

4-(Morpholine-4-sulfonyl)-2-nitrophenol is an analytical standard that is used as a reference material for the determination of purity and quality of other compounds. It has been isolated from plants and is a secondary metabolite. 4-(Morpholine-4-sulfonyl)-2-nitrophenol also acts as a plant derived phytochemical that can be used to study the chemical properties, biological activities, and chemical structures of natural products. This compound can be used in research and development by pharmaceutical companies to synthesize new drugs or as HPLC standards for quality control.

Versatile small molecule scaffold

Versatile small molecule scaffold

2,4,5-Trimethoxybenzene-1-sulfonyl chloride is a potent antimicrobial agent that is effective against gram-positive and gram-negative bacteria. It prevents the growth of microorganisms by inhibiting the production of thiols and nitric oxide. 2,4,5-Trimethoxybenzene-1-sulfonyl chloride has been shown to be a potent antagonist of CRTH2 receptors in vitro. This receptor is involved in the inflammatory response and its inhibition may have therapeutic potential for the treatment of inflammatory diseases such as hepatitis and rheumatoid arthritis.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(2E)-3-Amino-3-(4-methylpiperazin-1-yl)prop-2-enenitrile

2-(4-Chlorophenyl)-5-pentafluorosulfanyl-1H-indole

Versatile small molecule scaffold

3-Hydroxyphthalic anhydride

Methyl 3-bromo-1H-indazole-6-carboxylate

Phenylamino-cyclopentanecarboxylic acid is a cyclopentanone that can be synthesized by the condensation of aniline and formaldehyde. This compound is also known as 4-aminophenylcyclohexene-1-carboxylic acid. Phenylamino-cyclopentanecarboxylic acid has been used to produce 1,4-dichloro-2,5-diethoxybenzene, which is a useful intermediate for the synthesis of pharmaceuticals.

Methyl 4-iodosalicylate is a redox potential molecule that can be used in the treatment of HIV infections. Studies have shown that methyl 4-iodosalicylate is able to enhance the activity of antiretroviral therapies, and is also able to increase the light emission from fluorophores when combined with sodium triflate. This compound has been shown to have pharmacokinetic properties that are similar to those of salicylic acid. Methyl 4-iodosalicylate has been shown to transport into human erythrocytes, and fluoresce when excited by light with a wavelength of 365 nm. Methyl 4-iodosalicylate has been studied as a possible therapy for various conditions including cancer, arthritis, and heart disease. It may also be useful for improving skin health or for use as a topical antimicrobial agent.