Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Ethyl 2-(3-chlorophenyl)acetate is an orally active small molecule that has been shown to have a potent immunosuppressive activity in mice. It inhibits the production of antibodies and T cells by binding to the antibody-producing cells in the spleen. Ethyl 2-(3-chlorophenyl)acetate also blocks the production of interleukin-4, which is important for eosinophil activation, and it can be used for asthma treatment. This compound is a competitive antagonist of histamine H1 receptors and has been shown to be a bronchodilator in murine models of asthma.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Iodo-1H-pyrazolo[4,3-d]pyrimidin-7-amine

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Ethyl 3-(3-aminophenyl)propanoate is a molecule that can be used as an alkylation cross-linking agent in immobilized systems. It reacts with ethyl decanoate to form a stable ester and can also be used to modify lipase and coumarin derivatives. Ethyl 3-(3-aminophenyl)propanoate has minimal inhibitory concentrations (MICs) of 0.6 μg/mL against lipase and 1 μg/mL against the coumarin derivative, which is indicative of its inhibitory effect on the enzyme. The electrophilicity of this molecule makes it an effective cross-linking agent for immobilized systems because it reacts with electron-deficient molecules such as ethyl decanoate.

Versatile small molecule scaffold

1-(2,6-Diazaspiro[3.3]heptan-2-yl)ethanone oxalate

1-Benzylazepan-3-one is a synthetic dye that has an anionic structure. It is a nutrient for fungi and has a strong affinity with extracellular materials such as laminating and surfactants. 1-Benzylazepan-3-one can be used as a colorant in chemical reactions. When heated, it changes reversibly from white to yellow due to the condensation of its double bonds. This heterocycle also has optical properties that are reversible; when exposed to light, it will turn purple.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Chloro-N,N-dimethylpyridin-4-amine is an amide that is the result of a reaction between formaldehyde and 2-chloropyridine. It has been shown to have antibiotic properties and is used in the synthesis of aziridines, which are active against bacteria. Mechanistic studies have shown that it undergoes a catalytic aziridination process whereby it reacts with an alkene to form an intermediate aziridine. The amine group then attacks the C=O bond, cleaving it and releasing water. This process forms a substituted pyridine ring as a final product.

Versatile small molecule scaffold

Versatile small molecule scaffold

2,6-Dichloro-4-(dimethylamino)nicotinaldehyde

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(5-Chloro-6-methoxy-3-pyridyl)boronic acid

2-Iodobenzenesulfonic acid sodium salt is a synthetic organic compound that is used in organic chemistry as a reagent. It is an acidic ionic compound that contains the sulfonic acid functional group, and can be used to synthesize heterocycles. 2-Iodobenzenesulfonic acid sodium salt can also be used to make oxone, which is an oxidizing agent. Oxone is often used in chemoenzymatic reactions to oxidize alcohols or other organic compounds. 2-Iodobenzenesulfonic acid sodium salt can be made by reacting 5-hydroxymethylfurfural with hydrogen sulfate, followed by the addition of either anhydrous acetonitrile or water.

Versatile small molecule scaffold

6-(2,2,2-Trifluoroethoxy)pyridin-3-amine

Versatile small molecule scaffold

(R)-1-Boc-3-isopropylpiperazine

Versatile small molecule scaffold

2,6-Dichloro-4-methylpyridine

4-(2-Aminoethyl)thiomorpholine

Versatile small molecule scaffold

6-Chloro-2-(4-chlorophenyl)quinoline-4-carboxylic acid

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(Chloromethyl)thiazole hydrochloride

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Methylthien-2-yl isocyanate

Versatile small molecule scaffold

1,3,5-Trimethyl-1H-pyrazole

2-chloro-N-(2,3-dimethoxybenzyl)-4-(trifluoromethyl)nicotinamide

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Acetyl-6-chlorocoumarin

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 4-formyl-1,2,5-trimethyl-1H-pyrrole-3-carboxylate

3-[(4,5-dichloro-1H-imidazol-1-yl)methyl]-4-methyl-5-{[2-nitro-4-(trifluoromethyl)phenyl]thio}-4H-1,

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Bromo-1-trityl-1H-pyrazole

Iodomethyl benzoate (IB) is a nicotinic acetylcholine receptor agonist that has been shown to inhibit the growth of cancer cells, such as those that line the epidermis. IB binds to the α7 nicotinic acetylcholine receptor and inhibits its response to various stimuli, including epidermal growth factor. IB also inhibits a protein known as NF-κB, which is involved in inflammatory responses and cell proliferation. Results from animal studies suggest that IB may be effective against polycystic ovarian syndrome, an endocrine disorder characterized by enlarged ovaries. The anti-inflammatory effects of IB are thought to be due to its ability to inhibit the production of prostaglandin E2 and nitric oxide.

Versatile small molecule scaffold

Versatile small molecule scaffold

Dimethyl pyridine-3,4-dicarboxylate is an organic compound that is used as a precursor to make other chemicals. It is a pyridinedicarboxylic acid and it can be synthesized from the reduction of pyridine with sodium borohydride in ethanol. Dimethyl pyridine-3,4-dicarboxylate is also used in the production of acetaldehyde by way of hydrosilylation with chloride and chloroform. This chemical has been found to be useful for the synthesis of various drugs such as antiepileptics, antihistamines, antipsychotics, and antidepressants.

1-(4-Methoxyphenyl)-2-methylpropan-1-one is an organic compound with the chemical formula CH3COCH(OCH2CH3). It is a colorless liquid that is soluble in water, ether, and most organic solvents. It has a boiling point of 154 °C at 1 atm and its density is 0.921 g/mL at 25 °C. This compound can be used as an alkylating agent for aromatic compounds, acyl halides, carbonyls, and other reactive groups. The reaction mechanism for this compound begins with a nucleophilic attack on the electrophilic carbon atom by the oxygen atom of the methoxy group to form an acetal intermediate. The intermediate then undergoes hydrolysis to form a new c-h bond and a methyl ether product.

4-(4-Methylpiperazin-1-yl)-2-(trifluoromethyl)aniline

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Iodo-4-nitrobenzene is an insecticide with a nitro group. It is synthesized by the asymmetric synthesis of diazonium salt and hydroxyl group in the presence of a solid catalyst, such as palladium. 1-Iodo-4-nitrobenzene can be used as a coupling reagent for Suzuki coupling reactions, halide transfer reactions, and other multi-walled carbon transfer reactions. It has also been reported to have neuroprotective effects against Parkinson's disease in levopimaric acid model system. 1-Iodo-4-nitrobenzene has also been shown to inhibit the proliferation of neuro2a cells.

2-Bromo-5-methyl-3-(methylthio)pyridine

Versatile small molecule scaffold