Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Oxo-6-(2-pyridinyl)-1,2-dihydro-3-pyridinecarbonitrile

1-(4-Pyridyl)-1,2,3,4-tetrahydroisoquinoline

Versatile small molecule scaffold

(5Z)-5-(Ethoxymethylene)-2-thioxo-1,3-thiazolidin-4-one

2-(1-Methylhydrazino)-5-nitropyridine

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Chloro-6-isopropoxypyridine-3-boronic acid

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Bromo-6-iodophenol is a model compound that is used in the study of electrophilic aromatic substitution reactions. It has been shown to be a good substrate for cyclic and hypervalent bromophenols, which are often used as catalysts in organic synthesis. 2-Bromo-6-iodophenol has been shown to undergo substitution reactions with electron-rich olefins and alkynes under mild conditions. This reaction proceeds via coordination of the electron-rich olefin or alkene to the central bromine atom followed by nucleophilic attack by an iodide ion. The regioselectivity of this reaction can be controlled by the addition of reagents such as copper(II) sulfate, which can facilitate substitution at one position over another. This compound also undergoes nucleophilic substitution with pyridine and quinoline, but this reaction does not proceed efficiently under standard conditions due to steric hindrance

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-[5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetohydrazide (MTPA) is a hydrazide derivative that has been shown to be cytotoxic against human cells. MTPA binds to sulfa drugs, which cause crosslinking of proteins and inhibition of the enzyme dihydropyrimidine dehydrogenase. MTPA also has antimicrobial activity, inhibiting the growth of bacteria such as Salmonella enterica serovar Typhi and Staphylococcus aureus. It is also used in pharmacological treatment for infectious diseases.

trans-tert-Butyl N-[4-(pyridin-2-ylamino)cyclohexyl]carbamate

2?Methyl?7?(4,4,5,5?tetramethyl?1,3,2?dioxaborolan?2?yl)?1,2,3,4?tetrahydroisoquinoline

Versatile small molecule scaffold

N-(Prop-2-yn-1-yl)benzamide is a potential drug for the treatment of Parkinson's disease. It has been shown to be an effective inhibitor of the enzyme tyrosine hydroxylase and is able to reduce dopamine levels in animals. N-(Prop-2-yn-1-yl)benzamide has also been shown to have antiinflammatory properties, which may be due to its ability to inhibit cyclooxygenase activity. This drug can be synthesized by a stepwise process starting with propargylamine and benzoyl chloride. The x-ray crystallography studies conducted on this compound show that it is a mononuclear arene with a crystallographic symmetry of C2v. The oxidized form of this molecule shows high reactivity towards electron rich aromatic compounds, such as ferrocene, which may explain its ability to catalyze the oxidation reactions of electron poor arenes such as isoindolines.

Versatile small molecule scaffold

Versatile small molecule scaffold

6-Methoxy-2,3-dihydroquinolin-4(1H)-one is a target compound that can be synthesized in an intramolecular condensation process. In this reaction, two molecules of acetone react with each other to form a cyclic six-membered ring. The hydrolysis of the ester bond then releases the desired product. This process is catalyzed by glutathione reductase and requires NADPH as a cofactor.

Versatile small molecule scaffold

4-Morpholin-4-yl-phenol is a molecule that belongs to the class of organic compounds called morpholines. It is an intermediate in the formation of 4-morpholinoaniline. In this reaction, a nucleophilic oxygen atom (OH) reacts with an electrophilic nitrogen atom (N) and forms a tetrahedral intermediate. This intermediate then undergoes dimerization, which results in the loss of water molecules and produces a double bond between carbon atoms 3 and 4. The product of this reaction is 4-morpholin-4-yl phenol. The kinetics of this reaction are first order with respect to both reactants. The rate constant for this reaction is 0.0029 mol/L/s at 25°C and can be calculated from the equation: k = A[R]*[S]/(R*S) where A is the concentration of R and S is the concentration of S

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(Cyclopropylmethoxy)-5-fluoropyridine-4-boronic acid

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-{1-[(4-Fluorophenyl)methyl]-1H-1,2,3-triazol-4-yl}ethan-1-one

Versatile small molecule scaffold