Building Blocks

Versatile small molecule scaffold

(R)-2-(3-Chloro-2-hydroxypropoxy)isoindoline-1,3-dione

Octisalate is a coumarin derivative that is used in the treatment of skin cancer. It has been shown to be effective against human skin cells, as well as animal cells. Octisalate binds to DNA and inhibits its replication by inhibiting the activity of DNA polymerase and topoisomerase II. Octisalate has also been shown to be effective against bacteria, fungi, and viruses, which may be due to its ability to inhibit protein synthesis. Octisalate can be found in sunscreen products or it may be applied directly to the skin for protection from UV radiation. The analytical method for octisalate is dispersive solid-phase extraction with anhydrous sodium glycol ester as the solvent. Salicylates are a class of compounds that are structurally similar to octisalate and have similar properties; however, their use is limited because they have been shown to increase the risk of developing melanoma or other forms of skin cancer.

Versatile small molecule scaffold

3-Bromo-6-azaindole

Butyl 2-aminoacetate hydrochloride (BAH) is a synthetic chemical that is used in the synthesis of pharmaceuticals, pesticides, and polymers. BAH has been shown to cause acute kidney injury in rats and mice. It is also known to be involved in the synthesis of esters, which are compounds derived from an acid and an alcohol. The piperidinecarboxylic acid metabolite of BAH is well absorbed by the intestine after oral administration but does not appear to be excreted through urine or bile. A study on pancreatitis patients found that BAH can cause pancreatic inflammation when given intravenously as a supplement. This drug may also have potential for the treatment of chronic kidney disease and Alzheimer's disease due to its ability to inhibit cholesterol biosynthesis and inhibit amyloid beta protein production.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(3S)-3-Amino-N-methylpyrrolidine, N-BOC protected

2-Chloro-4,6-dinitrophenol (2C6DNP) is a quinone that is used to treat wastewater. 2C6DNP is activated by an electron to form a reactive oxygen species that can be used as a disinfectant. In addition, 2C6DNP has been shown to inhibit the growth of wild-type strains of E. coli and S. typhimurium in the presence of sodium carbonate and chloride ions. The mechanism by which 2C6DNP inhibits bacterial growth may be due to its ability to react with the hydroxy group on DNA bases, forming adducts that inhibit DNA synthesis.

2-Bromo-6-chloro-4-fluorobenzaldehyde is a reversible and convergent tricyclic aldehyde that can be synthesized from the lactam of 6-chloro-2,4-difluoroaniline. This molecule is an inhibitor drug for tyrosine kinases, with IC50 values in the low micromolar range. It has been used as a linker to make a tyrosine kinase inhibitor.

N-[4-(Trifluoromethoxy)phenyl]-1H-pyrazole-3-carboxamide

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(Piperidin-3-yl)benzamide hydrochloride

1-[6-Chloro-2-(trifluoromethyl)quinol-4-yl]piperazine

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4,5-Dichloro-1,2-phenylenediamine is a cytotoxic agent that can inhibit the enzymes urea amidolyase and fatty acid synthase in tissue culture. This compound also inhibits the production of urea nitrogen and fatty acids in human serum. 4,5-Dichloro-1,2-phenylenediamine may be useful as a cancer treatment because it has been shown to cause leukemia cell death as well as inhibition of t-cell proliferation. The drug may also induce apoptosis by inhibiting DNA synthesis through its reaction with benzimidazole compounds. The basic structure of 4,5-Dichloro-1,2-phenylenediamine is similar to protocatechuic acid and malignant brain tumor cells.

Ethyl 1-Cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthylridine carboxylate

Versatile small molecule scaffold

1-[6-Methyl-2-(trifluoromethyl)quinol-4-yl]homopiperazine

Versatile small molecule scaffold

2-Bromo-5-propylthiophene

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-(But-1-yl)-1,2-dimethyl-1H-imidazol-3-ium hexafluorophosphate

Versatile small molecule scaffold

Biphenyl-2,3,4,5-tetracarboxylic acid dianhydride (BPIPP) is a small molecule that has been shown to be effective in the treatment of chronic diarrhea. It is also able to prevent malignant brain tumors and colorectal carcinomas. BPIPP inhibits intracellular cyclic guanosine monophosphate (cGMP) levels and activates protein kinase G (PKG), which causes an increase in cAMP levels. The increase in cAMP levels is responsible for the decrease in blood pressure. BPIPP also decreases camp levels and increases fluorescence efficiency. With this drug, it was possible to use a more efficient method to measure plasma concentrations of BPIPPA than with other methods.