Stéroïdes

Stability Hygroscopic Applications Halobetasol is a corticosteroid, an anti-inflammatory drug that is used to treat various dermatological conditions which mainly consist of various forms of psoriasis. References Marrero-Ponce, Y. et al.: Eur. J. Med. Chem., 46, 5736 (2011); Spuls, P. I. et al.: J. Dermatolog. Treat., 14, 21 (2003); Wong, J. et al.: J. Drugs, Dermatol., 11, 957 (2012);

Applications A derivative of Danazol (D145000). References Dowsett, M. et al.: Clin. Endocrinol., 24, 555 (1986);

Liriope muscari baily saponins C has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of TF and IL-6.

Applications 2α-Cyano Mestanolone is a derivative of Mestanolone (M225790), an anabolic steroid. References Arriza, J., et al.: Science, 237, 268 (1987); Lill, M., et al.: J. Med. Chem., 47, 6174 (2004); Bledsoe, R., et al.: J. Biol. Chem., 280, 31283 (2005)

Stability Hygroscopic Applications Prednisolone 21-Sulfate is a metabolite of Prednisolone (P703740). References Hutzler, J., ET AL.: Drug Metab. Dispos., 30, 355 (2002), Sugiyama, D., et al.: J. Biol. Chem., 278, 43489 (2003), Hagenbuch, B., et al.: Xenobiotica, 38, 778 (2008),

Estetrol (E4) is a naturally occurring estrogen, which is synthesized by the human fetal liver. It acts as a selective estrogen receptor modulator with a unique mode of action differentially impacting various tissues. Estetrol selectively binds to estrogen receptors, thereby facilitating a range of estrogenic activities. Interestingly, it exhibits modest estrogenic effects on both the endometrium and breast tissue, reducing potential risks typically associated with hormone therapies. In its applications, Estetrol is primarily focused on the field of hormonal contraception and menopausal hormone therapy. Its selective receptor binding contributes to favorable efficacy and safety profiles. Estetrol is explored for use in contraceptive formulations, where its function as a mild estrogen aims to minimize adverse effects commonly associated with synthetic estrogens. Additionally, its role in menopausal treatment seeks to alleviate symptoms while mitigating risks such as thromboembolic events. The dual functionality in contraception and menopause, combined with a novel mechanism that offers tissue selectivity, makes Estetrol a promising agent in hormonal therapies.

Applications Labelled analogue of Testosterone Cypionate, an anabolic steroid with androgenic properties. Testosterone Cypionate is used for testosterone therapy in males with hypogonadism. Controlled Substance. References Rabkin, J.G., et al.: J. Clin. Psychopharmacol., 19, 19 (1999); Hajjar, R., et al.: J. Clin. Endocrinol. Metab., 82, 3793 (1997); Rhoden, E., et al.: J. Sex Med., 7, 277 (2010);