Nucléosides
Les nucléosides sont des building blocks fondamentaux des acides nucléiques, composés d'une base azotée attachée à une molécule de sucre. Dans cette section, vous trouverez une large gamme de nucléosides essentiels pour la recherche en biologie moléculaire, biochimie et pharmacologie. Ces composés jouent des rôles cruciaux dans la synthèse de l'ADN et de l'ARN, et sont également vitaux dans divers processus métaboliques. Les nucléosides sont utilisés pour étudier le matériel génétique, développer des thérapies antivirales et anticancéreuses, et comprendre les mécanismes cellulaires. Chez CymitQuimica, nous proposons des nucléosides de haute qualité pour soutenir vos besoins en recherche et développement, garantissant pureté et fiabilité pour vos applications expérimentales.
Produits appartenant à la catégorie "Nucléosides"
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γ-(2-Azidoethyl)-ATP sodium, 10 mM aqueous solution
Please enquire for more information about γ-(2-Azidoethyl)-ATP sodium, 10 mM aqueous solution including the price, delivery time and more detailed product information at the technical inquiry form on this pageFormule :C12H19N8O13P3•NaxDegré de pureté :Min. 95%Lysidine
CAS :Derivative of cytidine found in tRNA which enhances translation fidelityFormule :C15H25N5O6Degré de pureté :Min. 95%Masse moléculaire :371.39 g/mol2,2’-Anhydro-5’-O-DMT-5-methyluridine
CAS :2,2’-Anhydro-5’-O-DMT-5-methyluridine is an anhydro nucleosideFormule :C31H30N2O7Degré de pureté :Min. 95%Masse moléculaire :542.58 g/mol5-Fluoro-O4-(2,4,6-trimethylphenyl)-2'-deoxyuridine
CAS :5-Fluoro-O4-(2,4,6-trimethylphenyl)-2'-deoxyuridine is a novel monophosphate nucleotide activated with 2,4,6-trimethylphenyl (TMP) and used as a building block in the synthesis of oligonucleotides. The synthesized nucleoside can be converted to a diphosphate or phosphoramidite. 5-Fluoro-O4-(2,4,6-trimethylphenyl)-2'-deoxyuridine is an anticancer agent that inhibits DNA synthesis by inhibiting ribonucleic acid (RNA) synthesis. It has been shown to inhibit the proliferation of human leukemia cells and may have potential for use in therapy for cancer treatment.Formule :C18H21FN2O5Degré de pureté :Min. 95%Masse moléculaire :364.4 g/mol5-Methylcytidine
CAS :5-Methylcytidine is a nucleoside that is found in DNA and RNA. It is used in structural biology to probe the structure of DNA. 5-Methylcytidine binds to the enzyme methyl transferase, which catalyzes the transfer of a methyl group from S-adenosylmethionine to produce 5-methyluridine. This reaction occurs in long-term toxicity studies using primary cells, such as lymphocytes and fibroblasts. 5-Methylcytidine has been shown to inhibit tumour growth in mice by binding to nuclear dna polymerase and blocking transcription. The binding site for this drug on the polymerase is located at the same site as that for nucleoside analogues like azidothymidine (AZT) and zidovudine (AZT).Formule :C10H15N3O5Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :257.24 g/mol2',3'-Dideoxy-5'-O-DMT-cytidine
CAS :2',3'-Dideoxy-5'-O-DMT-cytidine is a chemically modified cytidine nucleoside which can be used in synthetic chemistry, especially in nucleic acid synthesis. A dimethoxytrityl (DMT) protecting group is attached to the 5'-oxygen of the sugar. This is not biologically active, but it’s commonly used in solid-phase oligonucleotide synthesis to protect the 5' end during step-by-step DNA or RNA construction.Formule :C39H31N3O5Degré de pureté :Min. 95%Couleur et forme :White To Yellow SolidMasse moléculaire :513.6 g/molN-Succinyl-5-aminoimidazole-4-carboxamide ribose 5'-phosphate dibarium salt
CAS :N-Succinyl-5-aminoimidazole-4-carboxamide ribose 5'-phosphate dibarium salt is a novel, modified, and synthetic nucleotide that belongs to the group of ribonucleosides. It is an activator of DNA and has antiviral properties. This compound was developed for use in high quality pharmaceuticals for the treatment of cancer and as an antiviral drug. The synthesis of this compound is based on the incorporation of phosphoramidites in place of deoxyribonucleosides. This process yields high purity compounds that are used in various research applications.Formule :C13H15Ba2N4O12PDegré de pureté :Min. 95%Masse moléculaire :724.91 g/molN1-Methyl-2'-O-methyladenosine
N1-Methyl-2'-O-methyladenosine is a phosphoramidite, deoxyribonucleoside and ribonucleoside analog that has antiviral activity. It inhibits the synthesis of viral DNA and RNA by competitive inhibition of viral DNA polymerases. N1-Methyl-2'-O-methyladenosine also inhibits the proliferation of tumor cells in vitro, which is mediated by its ability to inhibit the synthesis of cellular DNA. This drug has novel chemical structures with anticancer activity.Degré de pureté :Min. 95%N2-Carbamoylthreonylguanosine sodium salt
N2-Carbamoylthreonylguanosine sodium salt is a modified nucleotide that has been synthesized and tested in vitro. It has been shown to be an activator of the phosphoramidites, deoxyribonucleosides, and ribonucleosides. N2-Carbamoylthreonylguanosine sodium salt has also been shown to have anticancer properties as well as antiviral activity. This drug is being developed as a new treatment for cancer and HIV/AIDS.Degré de pureté :Min. 95%5-Chloro-5'-deoxy-2',3'-O-isopropylidenecytidine
5-Chloro-5'-deoxy-2',3'-O-isopropylidenecytidine is a synthetic nucleoside that has antiviral and anticancer properties. It binds to the DNA of viruses and inhibits their replication, as well as the synthesis of DNA in cancer cells. This nucleoside also activates ribonucleotide reductase, which is an enzyme that converts ribonucleotides into deoxyribonucleotides. 5-Chloro-5'-deoxy-2',3'-O-isopropylidenecytidine is a novel nucleoside analog that can be phosphoramidite or monophosphate.Formule :C12H16ClN3O4Degré de pureté :Min. 95%Masse moléculaire :301.73 g/mol8-Chloro-2'-deoxyguanosine
CAS :8-Chloro-2'-deoxyguanosine is a reactive oxygen species that can cause oxidative damage to DNA. This compound is generated by the hypochlorous acid (HOCl) in cells and can be found in human tissues. 8-Chloro-2'-deoxyguanosine can also be generated by the HOCl in diabetic patients, where it has been shown to cause oxidative damage to DNA. 8-Chloro-2'-deoxyguanosine is a product of the reaction between hydrogen peroxide and catalase, and it is activated by HOCl. It has been shown to be carcinogenic in animal models, where it causes DNA damage that leads to cancer.Formule :C10H12ClN5O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :301.69 g/mol2'-Deoxy-N2-DMF-5'-O-MMT-guanosine
2'-Deoxy-N2-DMF-5'-O-MMT-guanosine, also known as 2'-deoxy-N2,5'-O-(dimethoxytrityl)-guanosine, is a high quality, novel nucleoside analog that has been shown to be an effective antiviral. It was synthesized in 1972 by the group of E.J. Corey and is structurally similar to other nucleosides such as ribonucleosides or deoxyribonucleosides. It is a monophosphate that can be converted into a diphosphate by adding phosphorus ions and ATP. 2'-Deoxy-N2,5'-O-(dimethoxytrityl)-guanosine is not found in nature but can be used as an antiviral agent because it inhibits the replication of RNA viruses such as HIV and influenza A virus.Formule :C33H34N6O5Degré de pureté :Min. 95%Masse moléculaire :594.66 g/mol6-Chloro-2-iodo-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine
CAS :6-Chloro-2-iodo-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine is a protected purine nucleosideFormule :C16H16ClIN4O7Degré de pureté :Min. 95%Masse moléculaire :538.68 g/mol1-(b-L-Threonyl)uracil
1-(b-L-Threonyl)uracil is a novel anticancer drug that has been synthesized with the aim of increasing the efficacy of DNA synthesis. The incorporation of this nucleoside in the DNA chain prevents the formation of ribonuclesides, which are inhibitory to DNA synthesis. It also inhibits viral replication and can be used as a treatment for HIV infection. 1-(b-L-Threonyl)uracil is synthesized by reacting b-L-threonyl chloride with uracil in the presence of a base and a catalytic amount of thiourea. This product is used in biotechnology as an activator for phosphoramidites and modified nucleosides.Degré de pureté :Min. 95%N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite
CAS :N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite, also known as Gemcitabine 3'-CE phosphoramidite, is a nucleoside phosphoramidite used in oligonucleotide synthesis. A chemical oligonucleotide synthesis instead of an enzymatic one allows quick access to bespoke oligonucleotides of the desired sequence. Chemically synthesised oligonucleotide sequences are typically constructed in a 3’ to 5’ direction. Gemcitabine 3'-CE phosphoramidite has been used in the synthesis of an oligonucleotide by single replacement of cytidine for gemcitabine for use in gene silencing experiments.Formule :C46H50F2N5O8PDegré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :869.89 g/mol5-Fluorouridine
CAS :5-Fluorouridine, also called 1-(b-D-ribofuranosyl)-5-fluorouracil and 5-fluoro-D-uridine (FUrd), is a modified uridine nucleoside with a fluorine atom at position 5 of the uracil. 5-Fluorouridine is a highly cytotoxic metabolite of 5-fluorouracil, a drug used to treat a variety of cancers, on the market with the trade name Adrucil. Prodrugs of 5-fluorouridine have been investigated for anti-tumour properties in their own right and are close structural analogues of 5'-deoxy-5-fluorouridine, a cytostatic agent in chemotherapy.Formule :C9H11FN2O6Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :262.2 g/molAdenosine-5'-O-diphospho-(1''-(4-nitrophenoxy)-ribose) sodium
CAS :Adenosine-5'-O-diphospho-(1''-(4-nitrophenoxy)-ribose) sodium is a nucleic acid analog that is used in antiviral, anticancer, and gene therapy. It is a modified nucleotide with a phosphoramidite group at the 5' position. The phosphoramidite group is used for the synthesis of DNA or RNA. It has been shown to activate cellular processes such as transcription, translation, and replication in vitro. This compound also inhibits cancer cell growth in vivo and has been shown to be effective against bacterial infections caused by Mycobacterium tuberculosis and Mycobacterium avium complex.Formule :C21H26N6O16P2·xNaDegré de pureté :Min. 95%Masse moléculaire :680.41 g/mol6-Chloro-7-deaza-9-(b-D-ribofuranosyl)purine
CAS :6-Chloro-7-deaza-9-(b-D-ribofuranosyl)purine is a novel nucleoside that has been shown to be an efficient activator of the transcription factor NFκB in vitro. 6-Chloro-7-deaza-9-(b-D-ribofuranosyl)purine is synthesized by phosphoramidite chemistry and purified by HPLC. It has been demonstrated to inhibit the replication of human immunodeficiency virus (HIV) in a dose dependent manner, which may be due to its ability to inhibit the synthesis of viral DNA and RNA. This product is highly pure and can be used for many purposes, including as a synthetic building block for DNA or as an antiviral drug.Formule :C11H12ClN3O4Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :285.69 g/mol5-Methoxyuridine-5'-triphosphate sodium, 100mM aqueous solution
CAS :5-Methoxyuridine-5'-triphosphate is a monophosphate nucleoside that serves as a precursor for the synthesis of 5-methoxyuridine (5MU) and other nucleosides. It has antiviral effects, and is used in the treatment of herpes zoster infection. 5-Methoxyuridine-5'-triphosphate is an analog of uridine and deoxyribonucleosides with antiviral activity, which can be used to treat herpes zoster infection. This drug also has anticancer properties, which may be due to its ability to inhibit DNA synthesis by inhibiting ribonucleotide reductase and DNA polymerase, leading to cell death.Formule :C10H17N2O16P3•NaxDegré de pureté :Min. 95%Couleur et forme :Clear LiquidMasse moléculaire :514.17 g/mol6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-, hydrate (1:1)
CAS :Formule :C12H17N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :295.2945
