Enzymes dans les Protéines Recombinantes

CYP2C19 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.

N/A.

HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/AcuC/APhA family.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.The first two PCSK9 inhibitors,

TIGAR Protein, Human, Recombinant (TAT) is expressed in E. coli with C-TAT. The accession number is Q9NQ88.

Fructose-6-phosphate kinase (Phosphofructokinase, PFK, EC 2.7.1.11) is an enzyme that catalyzes the following reaction:  F6P + ATP ⇌ F1,6BP + ATP  One unit of PFK will convert 1.0 μmole of fructose 6-phosphate and ATP to fructose 1,6-diphosphate and ADP per minute at pH 9.0 at 30 °C.

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and

Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to

Oxalate Oxidase, freeze-dried, from Wheat is an enzyme preparation which is derived from wheat and functions through the oxidative degradation of oxalate. This enzyme catalyzes the conversion of oxalate into carbon dioxide and hydrogen peroxide, utilizing oxygen as a co-substrate in the process. The activity of Oxalate Oxidase is crucial in biological and biochemical applications where oxalate degradation is required. This enzyme is commonly applied in the analysis of oxalate levels in various biological specimens, facilitating research in fields such as plant pathology and clinical diagnostics. In plants, Oxalate Oxidase contributes to resistance against pathogens by generating hydrogen peroxide, a reactive oxygen species that plays a role in defense mechanisms. In clinical settings, it aids in the study of hyperoxaluria, a condition characterized by excessive oxalate excretion. The ability of Oxalate Oxidase to effectively break down oxalate without side reactions makes it valuable in these contexts, offering precise and reliable results for scientific investigations.

Glucosyltransferase (GTase) is the enzyme that transfers glucose to another organic molecule (aglycon), establishing glycosidic linkage. UDP-glucose dependent GTases are part of the enzyme family of glucosyltransferases, they are versatile tools in glucosylation reactions. Different GTases have different substrate specificities. For the specificity of GT206 Glucosyltransferase, please see Table 1 that lists the available GTases with GT206 highlighted.Color: beigeForm: lyophilisateProtein content: 0.5 mg/mgThe glucosyltransferase was tested in a glucosylation reaction of a preferred substrate. High conversion after up to 24 h reaction time was observed. Not sure which GTase to choose? Consider our Glucosyltransferase kit, which contains all 8 Glucosyltransferases.

Transforming protein RhoA, also known as Rho cDNA clone 12, Ras homolog gene family member A, RHOA and ARH12, is a cell membrane and cytoplasm protein that

N/A.

Carbonic Anhydrase 9 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag.

Plays a key role in glycolysis and gluconeogenesis.

G3BP1 Protein, Human, Recombinant (His) is expressed in E. coli.

CYLD Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli with N-10xHis, C-Myc. The accession number is Q80TQ2.

D-serine dehydratase Protein, Salmonella heidelberg, Recombinant (His & SUMO) is expressed in E.

Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family.

Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate.

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.

SUC2 Protein, Saccharomyces cerevisiae, Recombinant (His) is expressed in yeast with His tag.

PARP Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag.

GPD1 Protein, Mouse, Recombinant (His) is expressed in E. coli with C-6xHis. The accession number is P13707.

Alpha Amylase (Amylase, α-Amylase, 1,4-α-D-glucan glucanohydrolase, glycogenase, systematic name 4-α-D-glucan glucanohydrolase; EC 3.2.1.1, CAS Number [9000-90-2]) is an enzyme that catalyses hydrolysis of large polysacharides into smaller fragments. Alpha amylase targets alpha bonds of 1→4 glycosidic linkages of poly- and oligosaccharides with three or more D-glucose units. One unit of Alpha Amylase will catalyze the hydrolysis of 1.0 μmol of 2-chloro-4-nitrophenyl-α-D-maltotrioside to yield 2-chloro-4-nitrophenol per minute at 37°C. Human pancreatic Alpha Amylase is supplied as clear, colorless to light yellow liquid solution at ≥400U/mL, specific activity ≥100 U/mg protein.Store at 2-8 °C on arrival.

Pappalysin-2/PAPP-A2 is the second member of the pappalysin family of metzincin superfamily, of which PAPP-A is the first member.

IL-1RAPL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

PPP1CB Protein, Human, Recombinant (His) is expressed in E. coli.

RAB10 Protein, Human, Recombinant (His) is expressed in E. coli.

TOP1 Protein, Mouse, Recombinant (aa 193-767, His) is expressed in Baculovirus-Insect Cells. The accession number is Q04750.

Has DNA hydrolytic activity.

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell

Nicotinate-Nucleotide Pyrophosphorylase (QPRT) belongs to the nadC/modD family.

Alkaline phosphatase can be considered "our favorite enzyme" for reasons apparent to those who diagnose and treat metabolic bone diseases or who study skeletal

IL-1R1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.8 kDa and the accession number is P14778.

ALAS1 Protein, Mouse, Recombinant (His & Myc) is expressed in E.

β Galactosidase is a lysosomal β Galactosidase that hydrolyzes the terminal β Galactose from Ganglioside and Keratan sulfate.

Alpha Amylase is an enzyme that catalyses hydrolysis of large polysacharides into smaller fragments. Alpha amylase targets alpha bonds of 1→4 glycosidic linkages of poly- and oligosaccharides with three or more D-glucose units. Systematic name of alpha-amylase is 4-α-D-glucan glucanohydrolase, EC 3.2.1.1. One unit of Alpha Amylase will produce 1.0 mg of maltose from starch in 1 minute at pH 4.9 and 40 °C.

RET Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

Argininosuccinate Synthase (ASS1) is an urea cycle enzyme with a tetrameric structure composed of identical subunits.

FabB Protein, E.

Carboxypeptidase M Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,

Lipase 38 recombinantly expressed in E. coli comes in a spray-dried formulation. It has its pH optimum at 6-8 and temp. optimum at >50°C. Lipases belong to the family of esterases and naturally act on triglycerides at lipid-water interfaces catalyzing hydrolytic reactions, esterifications and transesterification reactions in industrial and food applications. Lipase 38 was shown to hydrolyze p-Nitrophenyl esters of acetate (27 % activity compared to butyrate), butyrate (100 %), octanoate (9 %) and caprate (5 %).

Nitrilase (nitrile aminohydrolase; EC 3.5.5.1) in an enzyme that catalyzes hydrolysis of nitriles to carboxilic acids and ammonia:  R-CN + 2 H2O → R-COO- + NH4+  One unit of nitrilase will yield 1.0 μmol of ammonia per minute under optimal reaction conditions using acrylonitrile as a substrate.

Peroxiredoxin 5 Protein, Mouse, Recombinant (His) is expressed in E.

Poly(ethylene terephthalate) hydrolase is an enzyme involved in the breakdown of Polyethylene terephthalate which is present in many plastics Polyethylene terephthalate hydrolytic enzymes may be useful in biotechnology, for use in waste treatment, biocatalysis and biorecycling

RIPK3 Protein, Human, Recombinant (His & SUMO) is expressed in E.

CES1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).

Aspartic acid proteinase is a type of proteolytic enzyme, which originates from various biological sources including humans, fungi, and plants. It is characterized by its action via two critical aspartic acid residues in the active site, which facilitate the hydrolysis of peptide bonds in proteins. This enzyme operates optimally in acidic environments, making it crucial in processes like digestion and protein processing within cellular compartments such as lysosomes. In scientific research, aspartic acid proteinases are extensively studied for their role in physiological processes and their potential as therapeutic targets. For instance, they are involved in the maturation of viral proteins, hence playing a pivotal role in the life cycle of certain viruses. Additionally, they are implicated in disease states such as Alzheimer’s due to their involvement in amyloid precursor protein processing. Applications of aspartic acid proteinases extend to industrial processes like cheese production, where they assist in milk protein coagulation. Understanding their mechanism and specificity aids in the development of inhibitors that can regulate their activity, presenting significant implications in both therapeutic contexts and biotechnological innovations.

E3 ubiquitin ligase.

CGAS Protein, Human, Recombinant (His) is expressed in E. coli.

Aminopeptidase N/CD13 Protein, Pig, Recombinant (His & Myc) is expressed in E.

Penicillin G acylase, 10mg/ml aqueous solution, is a biocatalytic enzyme used in pharmaceutical research and production. This enzyme is typically sourced from various microbial species, predominantly bacteria, through fermentation processes. Its primary mode of action involves the hydrolysis of penicillin G, catalyzing the cleavage of the side chain amide bond to produce 6-aminopenicillanic acid (6-APA), a core building block for the synthesis of a variety of semi-synthetic penicillins. The uses and applications of Penicillin G acylase are extensive within the field of antibiotic modification and production. It is pivotal in the creation of antibiotics with enhanced properties, such as improved efficacy or reduced resistance. Scientists leverage its specificity and efficiency to modify penicillin derivatives, making it a cornerstone in the development of new generations of beta-lactam antibiotics. The enzyme’s role in sustainable production processes also supports green chemistry initiatives by reducing reliance on chemical synthesis and minimizing byproducts.

ACE2 Protein, Paguma larvata, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag.

Carboxypeptidase B2 (CPB2) is a secreted enzyme that belongs to the peptidase M14 family.

Bifunctional enzyme that possesses chorismate synthase and intrinsic flavin reductase activity, it uses NADPH to reduce FMN.

Lipase 16 recombinantly expressed in E. coli comes in a spray-dried formulation. It has its pH optimum at 7-8 and temp. optimum at >40°C. Lipases belong to the family of esterases and naturally act on triglycerides at lipid-water interfaces catalyzing hydrolytic reactions, esterifications and transesterification reactions in industrial and food applications. Lipase 16 was shown to hydrolyze p-Nitrophenyl esters of butyrate (58 % activity compared to octanoate), octanoate (100 %), laurate (40 %), palmitate (27 %), stearate (13 %), arachidate (2 %) and behenate (0.2 %).

IMPA1 (Inositol Monophosphatase 1) is a Protein Coding gene.

Terminal deoxynucleotidyl transferase (TdT) is a highly conserved vertebrate enzyme that possesses the unique ability to catalyze the random addition of

Cutinase belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds.

Nitrile hydratase 22 recombinantly expressed in E. coli comes in a freeze-dried formulation. Nitrile hydratases can be utilized to convert nitriles into their corresponding amides, e.g. to produce acrylamide from acrylonitrile. Additional applications include the removal of nitriles from industrial wastewater. Our nitrile hydratases have been tested for hydrolysis of the following substrates:cyclohexanecarbonitrile, cinnamonitrile, benzonitrile, methacrylonitrile, pivalonitrile.

Thrombopoietin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides.

Granzymes are key components of the immune response that play important roles in eliminating host cells infected by intracellular pathogens.

Alpha amylase/AMY2A Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT-1) are two active chitinases expressed in humans.

Catalyzes the ketonization of 2-hydroxymuconate stereoselectively to yield 2-oxo-3-hexenedioate.

Fibroblast activation protein (FAP) is a serine protease that has been reported in fibroblasts and some carcinoma cells, which correlates with poor patient

The enzyme oligosaccharyltransferase (dolichyl-diphosphooligosaccharide-protein glycosyltransferase) (DDOST), or 48-kDa subunit (OST48) is one of the catalytic

Ubiquitin carboxyl-terminal hydrolase 5, also known as Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thiolesterase 5, Ubiquitin-specific-processing

Glutamine Synthetase reglutes intracellular concentration of glutamate.

NLRP1 Protein, Human, Recombinant (GST) is expressed in E.

Glutamine:fructose-6-phosphate amidotransferase 1 (GFAT), also known as GFPT1, is a member of the N-terminal nucleophile aminotransferases and the first

MUSK Protein, Mouse, Recombinant (His & Myc & SUMO) is expressed in E. coli.

Carboxypeptidase B is an enzyme responsible for the cleavage of arginine and lysine from a peptide's C-terminus

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Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family.

CYP3A4 is an important member of the cytochrome P450 enzyme superfamily, with 33 allelic variants.

20mg/ml aq. solution.  Proteinase K is used for the general digestion of proteins and removal of protein contamination in nucleic acids. Addition of Protease K also stabilizes nucleic acids but degrading any nucleases present. Proteinase K is active in wide range of pH range, in the presence of SDS, urea and Guanidinium chloride at low to moderate concentrations. Proteinase K is also known under names of protease K and endopeptidase K.

FAM20B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.

Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity

AADAC Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli.

Cleaves peptides in various proteins in a process that requires ATP hydrolysis.

N6AMT1 (N-6 Adenine-Specific DNA Methyltransferase 1) is a Protein Coding gene.

LAP3 (Leucine Aminopeptidase 3) is a Protein Coding gene.

RPB1 Protein, Drosophila melanogaster, Recombinant (His) is expressed in yeast with N-6xHis tag.

ADI Protein, Metamycoplasma hominis, Recombinant (His) is expressed in HEK293 expression system. The predicted molecular weight is 48.0 kDa and the accession number is P41141.

Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids.

Catalyzes the dehydrogenation of 17-beta-hydroxysteroids.

DPYS Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 56.8 kDa and the accession number is Q14117.

Carbonic Anhydrase 8 Protein, Mouse, Recombinant (His) is expressed in E.

Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB).