Enzymes dans les Protéines Recombinantes

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Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade.

CYB5R1 Protein, Human, Recombinant (His) is expressed in E.

Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of

UCHL3 Protein, Human, Recombinant (His) is expressed in E.

ERP72 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.

OXA-11 is a β-lactamase enzyme, which is a type of protein produced by certain bacteria. These enzymes are derived from the bacterial source and are responsible for antibiotic resistance. The primary mode of action of OXA-11 is the hydrolysis of the β-lactam ring found in various antibiotics, such as penicillins and cephalosporins, rendering them ineffective. This enzymatic activity allows bacteria to survive exposure to these antimicrobial agents, posing a significant challenge in clinical settings. The study of OXA-11 is crucial for understanding and counteracting antibiotic resistance. It provides insights into the mechanisms by which bacteria adapt to antibiotic pressure, informing the development of novel antimicrobial therapies and inhibitors that can circumvent the action of such enzymes. Research into OXA-11 and other related β-lactamases is a vital part of ongoing efforts to combat the growing problem of antibiotic-resistant bacterial infections, contributing to the development of more effective treatment strategies.

PNGase F is an endoglycosidase that can remove all N-linked carbohydrates from proteins, which is useful if you are uncertain whether the carbohydrate is N-linked or O-linked to the protein or is a high mannose type. It is also the enzyme of choice when you need to study or use the naked protein in your application. PNGase functions as a glycoamidase and hydrolyzes the amide bond between the innermost GlcNac of mammalian asparagine-linked mannose oligosaccharides, whether they are high, complex or hybrid. Specifically, the glycan is removed from the asparagine residue which through the deamination reactions becomes aspartic acid.This enzyme is available as a large-scale bulk supply of liquid enzyme solution. See our PNGase F available as vials for research applications with pre-defined quantities of liquid enzyme solution.Also available is our endoH enzymes (EEH01.3 - research quantities and EEH01.7 - large scale bulk supply).

Tris(benzyltriazolylmethyl)amine (TBTA) is a tertiary amine. It complexes with, and stabilizes, copper(I) to accelerate azide-alkyne cycloadditions.

Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family.

B3GAT3, encoding beta-1,3-glucuronyltransferase 3, has an important role in proteoglycan biosynthesis.

TRIM21 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in Baculovirus-Insect Cells. The accession number is Q3U7K7.

Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (

PCSK9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

PLA2G5 Protein, Mouse, Recombinant (His & SUMO) is expressed in E.

Ectopic expression and knockdown studies showed that GALNT10 indeed promotes proliferation and apoptosis resistance of hepatoma cells in a glycosyltransferase-

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant.

UBE2D3 Protein, Human, Recombinant (His & SUMO) is expressed in E.

USP21 Protein, Human, Recombinant (His) is expressed in E. coli with C-6xHis. The accession number is Q9UK80.

Collagenase is an enzymes that is responsible for breaking peptide bonds in collagen

AMPK (G1/B2/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag.

Group IIE secretory phospholipase A2, also known as GIIE sPLA2, sPLA2-IIE, Phosphatidylcholine 2-acylhydrolase 2E and PLA2G2E is a secreted protein that belongs

DNASE1L2 Protein, Human, Recombinant (His & Myc) is expressed in E. coli with N-10xHis, C-Myc. The accession number is Q92874.

CHST11, also known as C4ST-1, belongs to the sulfotransferase 2 family.

CTRL-1, also known as chymotrypsin-like protease, belongs to thepeptidase S1 family.

PKM2 Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag.

SHH Protein, Human, Recombinant (aa 198-462, His) is expressed in HEK293 mammalian cells with His tag.

RAB1B, a member of the RAS oncogene family, was significantly down-regulated in highly metastatic breast cancer cells.

Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan

Diaphorase (lipoyl dehydrogenase, EC 1.8.1.4) is an NAD+/NADH-dependent oxidoreductase. One unit of diaphorase will convert 1.0 μmole NADH into NAD+ the presence of substrate at pH 7.5 and 25 °C.

NAALADL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

Hyaluronidase-1 (HYAL1) is a secreted lysosomal hyaluronidase that belongs to the glycosyl hydrolase 56 family.

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.

The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron

B3GAT1 is the key enzyme during the biosynthesis of the carbohydrate epitope HNK-1, which is present on a number of cell adhesion molecules important in

N/A.

PPIases accelerate the folding of proteins.

Applications Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction. References Foresti, R., et al: J. Biol. Chem., 272, 18411 (1997); Cardenas, A., et al.: J. Neurochem., 74, 2041 (2000); Degterev, et al.: Nat. Chem. Biol., 1, 112 (2005); Hitomi, J., et al.: Cell, 135, 1311 (2008);

Hydroxylysine kinase Protein, Danio rerio, Recombinant (His & Myc & SUMO) is expressed in E. coli.

An RNase that has 5'-3' exonuclease and possibly endoonuclease activity.

Carboxypeptidase D Protein, Human, Recombinant (hFc & Myc) is expressed in HEK293 mammalian cells with C-hFC-Myc tag.

ACE2/ACEH Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

Adenylate Kinase 1 Protein, Human, Recombinant (His) is expressed in E.

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.

CKMT1A belongs to the ATP:guanido phosphotransferase family.

ACP5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

Fragile histidine triad, also known as FHIT, may play a key role in differentiating humans from apes.

Aminopeptidase P2 (XPNPEP2) is a receptor for TMTP1 tumor-homing peptide.

Carbonic Anhydrase 14 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

TrkA Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag.