CAS 136572-09-3: Cloridrato di irinotecano triidrato
Descrizione:
Cloridrato di irinotecano triidrato è un agente chemioterapico utilizzato principalmente nel trattamento del cancro colorettale. È un sale solubile in acqua derivato dall'alcaloide naturale camptotecina e funge da inibitore della topoisomerasi I, interrompendo la replicazione e la trascrizione del DNA nelle cellule tumorali. La sostanza appare come una polvere cristallina bianca a bianco sporco ed è igroscopica, il che significa che può assorbire umidità dall'ambiente. La sua formula molecolare include un componente cloridrato e tre molecole d'acqua, contribuendo alla sua stabilità e solubilità in soluzioni acquose. L'irinotecano viene somministrato per via endovenosa ed è spesso utilizzato in combinazione con altri agenti chemioterapici per aumentare l'efficacia. Gli effetti collaterali comuni includono diarrea, nausea e mielosoppressione, richiedendo un attento monitoraggio durante il trattamento. La farmacocinetica del composto implica un metabolismo principalmente da parte del fegato, con metaboliti attivi che contribuiscono ai suoi effetti terapeutici e tossicità. In generale, Cloridrato di irinotecano triidrato gioca un ruolo significativo in oncologia, in particolare nella gestione dei tumori in stadi avanzati.
Formula:C33H38N4O6·ClH·3H2O
InChI:InChI=1S/C33H38N4O6.ClH.3H2O/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;;;;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H;3*1H2/t33-;;;;/m0..../s1
InChI key:InChIKey=KLEAIHJJLUAXIQ-JDRGBKBRSA-N
SMILES:C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(OC(=O)N6CCC(CC6)N7CCCCC7)=CC5.Cl.O
Sinonimi:- (+)-7-Ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin, monohydrochloride, trihydrate
- (+)-7-Ethyl-10-hydroxycamptothecine 10-(1,4'-bipiperidine)-1'-carboxylate, monohydrochloride, trihydrate
- (1,4'-Bipiperidine)-1'-Carboxylicacid,4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hyd Monohydrochloride, Trihydrate
- (1,4'-Bipiperidine)-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester, monohydrochloride, trihydrate, (S)-
- (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl [1,4'-bipiperidine]-1'-carboxylate trihydrate hydrochloride
- (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate
- (S)-[1,4'-Bipiperidine]-1'-Carboxylic Acid 4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hydroxy-3,14-Dioxo-1H-Pyrano
- (S)-[1,4'-Bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline, [1,4′-bipiperidine]-1′-carboxylic acid deriv.
- Camptosar
- Irinotecan HCl trihydrate
- Vedi altri sinonimi
Ordinare per
Irinotecan for system suitability 2 CRS
CAS:Irinotecan for system suitability 2 CRSFormula:C33H38N4O6Colore e forma:Powder. Yellow. Light Yellow.Peso molecolare:586.678Irinotecan hydrochloride trihydrate CRS
CAS:Irinotecan hydrochloride trihydrate CRSFormula:C33H38N4O6Colore e forma:Powder. Yellow. Light Yellow.Peso molecolare:586.678Irinotecan for peak identification CRS
CAS:Irinotecan for peak identification CRSFormula:C33H38N4O6Colore e forma:Powder. Yellow. Light Yellow.Peso molecolare:586.678Irinotecan, Hydrochloride Salt
CAS:Purezza:98.0%Colore e forma:SolidPeso molecolare:623.1500244140625Irinotecan Hydrochloride
CAS:Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoiFormula:C33H38N4O6·HCl·3H2OColore e forma:Pale Yellow Yellow PowderPeso molecolare:586.27913Irinotecan hydrochloride trihydrate
CAS:Formula:C33H38N4O6·HCl·3(H2O)Purezza:≥ 99.0% (anhydrous)Colore e forma:Off-white to yellow crystalline powderPeso molecolare:623.14 (anhydrous)Irinotecan Hydrochloride Trihydrate
CAS:Prodotto controllatoFormula:C33H38N4O6·ClHH2OColore e forma:NeatPeso molecolare:677.18Irinotecan hydrochloride trihydrate
CAS:Irinotecan hydrochloride trihydratePurezza:≥98%Peso molecolare:677.18g/molIrinotecan Hydrochloride Trihydrate
CAS:Prodotto controllatoApplications Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor. References Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987), Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993)Formula:C33H38N4O6·ClH·3H2OColore e forma:Light YellowPeso molecolare:677.18Irinotecan hydrochloride trihydrate - Bio-X ™
CAS:Irinotecan hydrochloride trihydrate is a topoisomerase I inhibitor that is used as chemotherapy drug for colorectal cancer. By inhibiting topoisomerase I, Irinotecan hydrochloride trihydrate prevents the replication of DNA in cells, and stops the cancer cells from growing and dividing. When used for chemotherapy, Irinotecan hydrochloride trihydrate is usually part of combination therapy with other chemotherapy drugs, such as 5-fluorouracil (5-FU) and leucovorin for other cancers. Irinotecan hydrochloride trihydrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C33H38N4O6•HCl•(H2O)3Purezza:Min. 95%Colore e forma:PowderPeso molecolare:677.18 g/molIrinotecan hydrochloride trihydrate
CAS:Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.Formula:C33H45ClN4O9Purezza:98.22% - 99.79%Colore e forma:Pale Yellow To Yellow Crystalline PowderPeso molecolare:677.18Irinotecan Hydrochloride Trihydrate
CAS:Irinotecan Hydrochloride TrihydratePurezza:98%Peso molecolare:677.18g/molIrinotecan hydrochloride trihydrate
CAS:Inhibitor of DNA topoisomerase IFormula:C33H38N4O6•HCl•(H2O)3Purezza:Min. 97 Area-%Colore e forma:Yellow PowderPeso molecolare:677.18 g/molIrinotecan Hydrochloride Trihydrate
CAS:Formula:C33H38N4O6HCl(H2O)Peso molecolare:586.69 : 36.46 : 3(18.0)Ref: ST-EA-CP-I9016
10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiestaIrinotecan Hydrochloride Trihydrate
CAS:Formula:C33H38N4O6·HCl·3H2OPurezza:>98.0%(T)(HPLC)Colore e forma:White to Orange to Green powder to crystalPeso molecolare:677.20(R)-Irinotecan Hydrochloride-d10 Trihydrate
CAS:Prodotto controllatoFormula:C33H35D10ClN4O9Colore e forma:NeatPeso molecolare:687.25(R)-Irinotecan Hydrochloride Trihydrate
CAS:Prodotto controllatoFormula:C33H38N4O6·HCl·3H2OColore e forma:NeatPeso molecolare:677.21Irinotecan hydrochloride trihydrate
CAS:Formula:C33H45ClN4O9Purezza:98%Colore e forma:SolidPeso molecolare:677.1848
