Building Blocks

2-Methyl-3-morpholinone

Versatile small molecule scaffold

4-Butyl-2-methylphenol is a phenolic compound that is found in the essential oils of plants such as rosemary. It has been shown to inhibit the growth of animal cells, and this effect may be due to its ability to induce apoptosis. 4-Butyl-2-methylphenol also inhibits the production of basic fibroblast growth factor and epidermal growth factor by inhibiting protein synthesis and DNA synthesis. This chemical is an analog of platelet derived growth factor and has been shown to stimulate angiogenesis in vitro. 4-Butyl-2-methylphenol has been found to increase vessel density in animals when applied topically.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

[(2-Aminoethyl)sulfanyl]sulfonic acid is an inorganic compound and a corrosion inhibitor. It is the ammonium salt of sulfonic acid, with a pK of 3.75. The molecule has two nitrogen atoms and one sulfur atom, which are unreactive with other compounds and do not form bonds. It is soluble in water, alcohols, ethers, chloroform, and carbon tetrachloride. [(2-Aminoethyl)sulfanyl]sulfonic acid can be used as a corrosion inhibitor for metals such as iron or copper because it does not corrode the metal like some other substances containing sulfur or nitrogen would. This compound also has an acidic nature because it can act as a proton donor to cleave bonds that are second-order rate constants. [(2-Aminoethyl)sulfanyl]sulfonic acid also reacts with aziridine in simulated gas phase reactions to form sulf

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(4-Trifluoromethylphenoxy)pyridine-5-boronic acid

1-(Benzenesulfonyl)-1H-indole-5-carbaldehyde

5-Methoxy-3-methyl-1H-indole is an oxygenated aromatic amine that is produced as a phytoalexin. It has been shown to inhibit the growth of gram negative bacteria, such as Salmonella and E. coli, by inhibiting the synthesis of proteins required for cellular respiration. 5-Methoxy-3-methyl-1H-indole also inhibits the activity of an enzyme called phospholipase A2, which is responsible for the hydrolysis of lipid molecules in cell membranes. This inhibition prevents the release of arachidonic acid from phospholipids, leading to a decrease in prostaglandins and leukotrienes. 5-Methoxy-3-methyl-1H indole has also been shown to have antioxidant properties due to its ability to scavenge free radicals.

4-(5-Amino-6-benzylpyrazin-2-yl)phenol is a synthetic compound that can be used in animal studies. It is aequorin, a photoprotein that emits light when it reacts with Ca++ ions. Aequorin's luminescence is stimulated by the addition of an aldoxime, a prosthetic group, and luciferin. This molecule has also been shown to have bioluminescent properties in the presence of Renilla luciferase and can be used as a molecular marker for tracking purposes. The methyl group on the pyridine ring makes this molecule easily trackable with gas chromatography/mass spectroscopy (GC/MS).

Versatile small molecule scaffold

Ethyl 1H-pyrrole-2-carboxylate

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Applications Diethyl 1-Methylbutylmalonate is used in the in vitro reaction of barbiturates with formaldehyde to evaluate forensic toxicology on the cause of death. References Gannet, P.M., et al.: J. Anal. Toxicol., 25, 443 (2001)

Versatile small molecule scaffold

4-Chloro-o-xylene is a xylene that is used as a solvent and in the production of other chemicals. It has an evaporation rate of 2.3 times that of pentane, making it useful for drying purposes. 4-Chloro-o-xylene also reacts with thianthrene to form chlorinated xylenes, which are used in the production of plastics and synthetic rubber. It can react with chloride to form chlorinated hydrocarbons such as dichloromethane and chloroform, or with chlorine to produce polychlorinated biphenyls (PCBs). The reaction of 4-chloro-o-xylene and ammonium nitrate will produce nitrobenzene, which is used in the production of TNT explosives. Finally, 4-chloro-2,5-dimethoxyaniline can be synthesised from this chemical by reacting it with magnesium metal and nitrobenzene

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Amino-3-[1-(tert-butoxycarbonyl)piperidin-4-yl]propanoic acid hydrochloride

Versatile small molecule scaffold

Versatile small molecule scaffold

Ethyl 1-(3-formylpyridin-2-yl)piperidine-4-carboxylate

Versatile small molecule scaffold

Versatile small molecule scaffold

(R)-tert-Butyl 3-(oxetan-3-ylamino)piperidine-1-carboxylate

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4,5-Dichloro-2,6-dimethylpyrimidine

Versatile small molecule scaffold

Versatile small molecule scaffold

4-chlorobenzaldehyde diethyl acetal is a benzene derivative that is selectively converted to 4-chlorobenzaldehyde diethyl acetal in the presence of catalysts. This compound reacts with diethyl acetal and undergoes hydrolysis with acid or base to produce an ester. The reaction order for this process is 1, meaning that the rate at which this reaction occurs is dependent on the concentration of the reactants.

Versatile small molecule scaffold

3-tert-Butyl-3,4-dihydro-2H-1,4-benzoxazine

2-Phenylpropylene Oxide is a chemical compound that belongs to the epoxide group. It is an activated monomer, which means it has a hydroxyl group. 2-Phenylpropylene Oxide is used in cationic polymerization reactions as well as alpha-methyl styrene, which produces polymers with high molecular weights and excellent mechanical properties. The reaction mechanism of 2-phenylpropylene oxide is oxidation of the phenyl ring to produce free radicals that react with the double bond of the epoxide ring to form an epoxy group. This process results in a mixture of products that depend on the rate and extent of the reaction. Health effects have not been fully evaluated.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

(S)-3-Methoxypyrrolidine hydrochloride

Versatile small molecule scaffold

1-Methyl-1,2,3,6-tetrahydropyridine hydrochloride

Versatile small molecule scaffold

Versatile small molecule scaffold

Tetrahydropyran-2-carboxylic acid

6-Bromo-1-cyclopropyl-1,3-dihydro-2H-benzimidazol-2-one

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

N1-[(Diphenylphosphoryl)(thien-2-yl)methyl]-3-(trifluoromethyl)aniline

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4,6-Dichloro-7-fluoroquinazoline

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4,7-Dimethyl-1H-indole

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-(Formylamino)benzoic acid is a metabolite of the amino acid phenylalanine. It reduces the production of cholesterol and has been shown to have a possible therapeutic effect on autoimmune diseases. 2-(Formylamino)benzoic acid has been shown to inhibit copper-catalyzed oxidation of low-density lipoprotein-cholesterol (LDL-C). The enzyme that catalyzes this reaction is 3-hydroxyanthranilic acid oxidoreductase, which converts anthranilic acid into 3-hydroxyanthranilic acid. 2-(Formylamino)benzoic acid inhibits the activity of this enzyme by binding to it, thereby preventing oxidation of LDL-C. This results in a decrease in LDL levels and an increase in high density lipoprotein (HDL) levels, leading to reduced risk for atherosclerosis and other cardiovascular diseases.

2-(Aminomethyl)-2-(hydroxymethyl)propane-1,3-diol (DMAPP) is a plant amino acid that is an intermediate in the synthesis of aminobutyric acid. It is also involved in the synthesis of ethylene, which is important for fruit ripening. DMAPP has been shown to be a precursor for the α-subunit of carbonic anhydrase and it has been detected in urine samples and assays. The uptake of DMAPP from water by plants has been studied using gas chromatography and ultracentrifugation. DMAPP has also been used as a biochemical marker for plant physiology studies.

Versatile small molecule scaffold

Versatile small molecule scaffold

[2-(1H-1,2,4-Triazol-1-yl)phenyl]methanol

Versatile small molecule scaffold

(1H-Benzoimidazol-2-ylmethyl)-methyl-amine

Versatile small molecule scaffold

Versatile small molecule scaffold

Pteridine is a model system for the study of leishmania and the enzyme activities that are involved in this organism's life cycle. Pteridines are found in plants and fungi and have been shown to inhibit the activity of hl-60 cells. Pteridine has also been shown to affect mitochondrial membrane potential, which can lead to bowel disease. Inhibitors of pteridine, dinucleotide phosphate, or receptor activity have been shown to be effective against infectious diseases. Pteridine has also been shown to influence matrix effect and biochemical properties.

2-(N-Morpholino)ethanesulfonic acid monohydrate is a buffering agent that belongs to the group of acidic compounds. It is used as an analytical reagent in microbiology and biochemistry. 2-(N-Morpholino)ethanesulfonic acid monohydrate can be used to measure the toll-like receptor (TLR) response of cells, which has been shown to be involved in cancer cell viability, infectious diseases, and plant metabolism. This compound also has been shown to inhibit bacterial growth by binding to the bacterial ribosome. 2-(N-Morpholino)ethanesulfonic acid monohydrate binds with malonic acid for fluorescence probe analysis and can be used as a model system for plant metabolism and redox potential.

Versatile small molecule scaffold

4-(1H-1,2,3-Triazol-1-yl)phenol is a small molecule that has been shown to enhance the efficiency of diagnosing certain conditions. It can be used in microwells as a sensor for measuring the concentration of analytes such as antibodies, enzymes, proteins, and other compounds. This compound is immobilized on a solid surface and reacts with light to produce chemiluminescence. 4-(1H-1,2,3-Triazol-1-yl)phenol can be used as an immobilization agent for magnetic beads and also has fluorescent properties. It has been shown to inhibit hepatitis B virus replication by binding to the viral antigen. 4-(1H-1,2,3-Triazol-1-yl)phenol is also able to detect peroxide in biological fluids or luminol in animal tissue.

9-Isopropyl-9H-carbazole