Building Blocks

4-(4-Bromo-2-fluorobenzyl)morpholine

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Hydrazino-6-nitro-1,3-benzothiazole

Versatile small molecule scaffold

2-Bromocyclooctan-1-one is a chiral, fluorinated ketone that has been used as a reagent in conformational studies. It is also the precursor to other compounds of interest. 2-Bromocyclooctan-1-one reacts with thioacetamide to form an intermediate that can be hydrolyzed by water or acid to produce 2,4,6-trichlorobenzene sulphonyl chloride. In acetonitrile, it displays repulsion between the two bromine atoms. The conformation of this compound is dependent on solvent and conformational studies have been done using solvents such as acetonitrile and chloroform.

1-Phenylpyrrolidine-2-carboxylic acid is a neutral compound that is soluble in water. It has been shown to inhibit the growth of bacteria by binding to the DNA, RNA, and proteins. 1-Phenylpyrrolidine-2-carboxylic acid has also been shown to be effective in inhibiting bacterial infections caused by methicillin resistant Staphylococcus aureus (MRSA), which are resistant to many other antibiotics. The drug has shown clinical development potential as an antibiotic and may have therapeutic benefits for diseases such as tuberculosis or malaria.

6-Bromo-3,4-dihydroisoquinolin-1(2H)-one

4-Amino-5-(difluoromethyl)-4H-1,2,4-triazole-3-thiol

6-Bromochroman

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 2-cyclobutylacetate is an amide that is used as a pharmaceutical intermediate. It can be synthesized by reacting ethyl formate, pyridylamine, and pyridine in the presence of lithium diisopropylamide. The cyclopropane ring is then formed by the reaction with chloroacetic acid. The yield of this compound is about 60%. Methyl 2-cyclobutylacetate can also be synthesized by reacting methyl cyclobutylcarbinol, thiourea, and ethyl formate in the presence of lithium diisopropylamide. This yields methyl 2-cyclobutylacetate with a yield of about 50%.

Versatile small molecule scaffold

Versatile small molecule scaffold

Methyl 3-hydroxyisonicotinate

2-Amino-6-chloro-1,3-benzothiazole

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Ethyl 2-amino-4-(difluoromethyl)-1,3-thiazole-5-carboxylate

JMS-17-2 is a small molecule that was shown to have a potent and selective inhibitory effect on the production of chemokines in cancer cells. It blocks the interaction between CXCL12 and its receptor, CXCR4. This interaction is important for normal bone tissue development and function, as well as for chemotaxis and metastasis of cancer cells. JMS-17-2 has been shown to prevent tumor growth in animal models by inhibiting angiogenesis, or the formation of new blood vessels to supply nutrients to tumors. The drug also inhibits tumor growth by decreasing the number of primary tumors, reducing bone lesions, and inhibiting the progression of pancreatic cancer. Clinical trials are currently being conducted to assess the efficacy of JMS-17-2 in humans with advanced solid tumors.

4-Chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine

Versatile small molecule scaffold

2,6-Dichloro-4-methoxyaniline is a chemical that belongs to the group of methyl derivatives. It is used as an industrial chemical and as a precursor to other chemicals in the production of pesticides, herbicides, and other products. 2,6-Dichloro-4-methoxyaniline can be found in brominated flame retardants and phenolic resins. It is also present in pentachlorophenol (PCP) and hydroxylated congeners. 2,6-Dichloro-4-methoxyaniline has been detected in humans at levels ranging from 10 to 100 parts per billion. The chemical structure of 2,6-dichloro-4-methoxyaniline is similar to that of triclosan, which has been shown to have antimicrobial activity against bacteria such as Staphylococcus aureus and Escherich

5-Methoxy-1-methyl-1H-indole

Versatile small molecule scaffold

N-tert-Butylmethacrylamide is a reactive monomer that can be used to create polymers with a wide range of properties. It undergoes electrophilic substitution reactions and forms strong hydrogen bonds with other molecules. N-tert-Butylmethacrylamide has been shown to be reactive towards S. aureus, which can lead to the formation of chlorinated derivatives. These derivatives are more stable and less toxic than the parent molecule and may be used as antibacterial agents in devices such as catheters or other medical equipment. N-tert-Butylmethacrylamide also has the ability to form amide groups that are resistant to peroxide degradation, which may make it useful for applications such as coatings for plastic pipes, food packaging, and medical devices.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold