Mdm2
Os inibidores de Mdm2 têm como alvo a proteína Mdm2, uma ligase de ubiquitina E3 que regula negativamente o supressor tumoral p53. A Mdm2 promove a degradação de p53, impedindo assim a apoptose em células que deveriam passar por morte celular. Inibir a Mdm2 estabiliza p53, aumentando sua atividade supressora de tumores e promovendo a apoptose em células cancerígenas. Os inibidores de Mdm2 são cruciais na pesquisa e terapia do câncer, especialmente para cânceres com vias de p53 intactas. Na CymitQuimica, oferecemos inibidores de Mdm2 de alta qualidade para apoiar sua pesquisa em biologia do câncer, apoptose e desenvolvimento terapêutico.
Produtos da "Mdm2"
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SAR405838
CAS:MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.Fórmula:C29H34Cl2FN3O3Pureza:98.04%Cor e Forma:SolidPeso molecular:562.5Ref: TM-T6585
1mg49,00€2mg90,00€5mg133,00€10mg213,00€25mg419,00€50mg617,00€100mg879,00€500mg1.776,00€p53-MDM2-IN-1
CAS:p53-MDM2-IN-1 (Example 30), an inhibitor targeting the p53-MDM2/X protein interaction, exhibits a K i value of 23.35 µM.Fórmula:C23H20ClN3O3Pureza:98.3%Cor e Forma:SoildPeso molecular:421.88SJ-172550
CAS:SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).Fórmula:C22H21ClN2O5Pureza:99.87%Cor e Forma:SolidPeso molecular:428.87Ref: TM-T16888
2mg44,00€5mg65,00€10mg96,00€25mg185,00€50mg354,00€100mg607,00€500mg1.264,00€1mL*10mM (DMSO)72,00€SP-141
CAS:SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.Fórmula:C22H16N2OPureza:98.01%Cor e Forma:SolidPeso molecular:324.38MG-277
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.Fórmula:C41H42Cl2FN5O5Pureza:98%Cor e Forma:SolidPeso molecular:774.71PK11007
CAS:PK11007 is an anti-p53 drug.Fórmula:C15H11ClFN5O3S2Pureza:≥98%Cor e Forma:SolidPeso molecular:427.86p53-Mdm2 inhibitor 4
CAS:p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.Fórmula:C23H20FN3O3Pureza:99.63%Cor e Forma:SoildPeso molecular:405.42RO8994
CAS:RO8994: potent MDM2 spiroindolinone inhibitor, IC50: 20 nM (proliferation), 5 nM (binding).Fórmula:C31H31Cl2FN4O4Pureza:99.31% - 99.44%Cor e Forma:SolidPeso molecular:613.51Ref: TM-T3517
1mg40,00€2mg52,00€5mg87,00€10mg127,00€25mg230,00€50mg364,00€100mg540,00€1mL*10mM (DMSO)105,00€Milademetan
CAS:Milademetan (DS-3032), an MDM2 inhibitor, exhibits antitumor activity, induces G1 cell cycle arrest and apoptosis, and can be used to study solid tumors.Fórmula:C30H34Cl2FN5O4Pureza:100%Cor e Forma:SolidPeso molecular:618.53Ref: TM-T12040
1mg170,00€5mg518,00€10mg753,00€25mg1.035,00€50mg1.454,00€100mg1.882,00€1mL*10mM (DMSO)35,00€MX69
CAS:MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.Fórmula:C27H26N2O4SPureza:97.27% - 99.57%Cor e Forma:SolidPeso molecular:474.57Ref: TM-T3653
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg227,00€50mg368,00€100mg547,00€500mg1.198,00€1mL*10mM (DMSO)82,00€XI-006
CAS:NSC-207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and regulates MDM2, an E3 ligase.Fórmula:C11H13N5O4Pureza:99.12%Cor e Forma:SolidPeso molecular:279.25Ref: TM-T6610
1mg56,00€2mg81,00€5mg119,00€10mg187,00€25mg432,00€50mg638,00€100mg908,00€500mg1.825,00€1mL*10mM (DMSO)114,00€MD-224
CAS:MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.Fórmula:C48H43Cl2FN6O6Pureza:100% - 99.07%Cor e Forma:SolidPeso molecular:889.8Ref: TM-T11980
1mg70,00€5mg153,00€10mg274,00€25mg467,00€50mg655,00€100mg932,00€200mg1.283,00€1mL*10mM (DMSO)166,00€Brigimadlin
CAS:Brigimadlin (BI 907828) is an orally active and highly potent antagonist of the E3 ubiquitin-protein ligase MDM2-p53 with antitumor activity.Fórmula:C31H25Cl2FN4O3Pureza:98.17%Cor e Forma:SolidPeso molecular:591.46CP-31398 dihydrochloride
CAS:CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines.Fórmula:C22H28Cl2N4OPureza:98.23%Cor e Forma:SolidPeso molecular:435.4Ref: TM-T21648
5mg49,00€10mg74,00€25mg134,00€50mg207,00€100mg339,00€200mg470,00€1mL*10mM (DMSO)58,00€
