Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase
- CDK
- Ciclo celular/Parada
- Chk
- c-Myc
- Dinamina
- DYRK
- Ferroptose
- HSP
- Integrinas
- Cinesina
- KSP
- LIM Quinase
- Microtúbulo associado
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Produtos da "Ciclo celular/Ponto de verificação"
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2'-O-(2-Azidoethyl)adenosine
CAS:2'-O-(2-azidoethyl)adenosine is a purine nucleoside analog with potential antitumor activity.Fórmula:C12H16N8O4Pureza:95%Cor e Forma:SolidPeso molecular:336.31N-desmethyl Netupitant
CAS:N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.Fórmula:C29H30F6N4OPureza:98%Cor e Forma:SolidPeso molecular:564.57PKMYT1-IN-4
PKMYT1-IN-4 (compound 27) functions as a PKMYT1 inhibitor with an IC50 value under 50 nM.Fórmula:C19H15F3N4O2Cor e Forma:SolidPeso molecular:388.34NSC23005
CAS:NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).Fórmula:C13H17NO4SPureza:99.71%Cor e Forma:SolidPeso molecular:283.34WEE1-IN-3
CAS:WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.Fórmula:C28H31N7O2Pureza:98.33%Cor e Forma:SolidPeso molecular:497.59Ref: TM-T8916
1mg70,00€5mg156,00€10mg239,00€25mg419,00€50mg562,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)170,00€A-286982
CAS:A 286982 blocks the LFA-1 and ICAM-1 integrin-ligand interaction.Fórmula:C24H27N3O4SPureza:97.81%Cor e Forma:SolidPeso molecular:453.55Ref: TM-T21781
1mg35,00€2mg50,00€5mg74,00€10mg107,00€25mg210,00€50mg350,00€100mg522,00€1mL*10mM (DMSO)81,00€CDK2-IN-19
CDK2-IN-19 (Compound 32) is a selective, orally active inhibitor of CDK2 (K i: 0.18 nM) that exhibits anticancer activity in mice with OVCAR3 tumors [1].Fórmula:C20H21FN6O4SPureza:98%Cor e Forma:SolidPeso molecular:460.48CC-671
CAS:CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.Fórmula:C28H28N6O4Pureza:98.35% - 98.65%Cor e Forma:SolidPeso molecular:512.56Ref: TM-T4482
1mg52,00€5mg111,00€10mg180,00€25mg359,00€50mg540,00€100mg775,00€500mg1.596,00€1mL*10mM (DMSO)127,00€Rhosin
CAS:Rhosin is a specific inhibitor of RhoA GTPases (Kd: ~0.4 uM), blocking RhoA-GEF interaction, not affecting Cdc42/Rac1/LARG, and induces apoptosis.Fórmula:C20H18N6OPureza:98%Cor e Forma:SolidPeso molecular:358.43MB-PP1
CAS:3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.Fórmula:C17H21N5Pureza:99.97%Cor e Forma:White SolidPeso molecular:295.38Ref: TM-T21678
5mg52,00€10mg96,00€25mg170,00€50mg269,00€100mg394,00€500mgA consultar1mL*10mM (DMSO)58,00€2-Chloropyrazine
CAS:2-Chloropyrazine is used in chemical industry.Fórmula:C4H3ClN2Pureza:98.98% - 99.81%Cor e Forma:Clear Colorless To Yellowish LiquidPeso molecular:114.53Trilaciclib
CAS:Trilaciclib is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6, respectively).Fórmula:C24H30N8OPureza:98%Cor e Forma:SolidPeso molecular:446.55NG 52
CAS:NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.Fórmula:C16H19ClN6OPureza:98% - 99.36%Cor e Forma:SolidPeso molecular:346.81Ref: TM-T2028
1mg74,00€2mg97,00€5mg158,00€10mg269,00€25mg515,00€50mg743,00€100mg1.035,00€500mg2.080,00€1mL*10mM (DMSO)158,00€5-Bromouridine
CAS:5-Bromouridine is a antitumor uracil derivative that induces apoptosis in cancer cells by inhibiting DNA synthesis and is also a marker for DNA and RNA.Fórmula:C9H11BrN2O6Pureza:99.89%Cor e Forma:White PowderPeso molecular:323.1CDK9-IN-15
CAS:CDK9-IN-15: potent CDK9 inhibitor, blocks P-TEFb phosphorylation, inhibits transcription, reduces mRNA, induces tumor cell apoptosis.Fórmula:C16H11N3OSPureza:97.24%Cor e Forma:SolidPeso molecular:293.34Ref: TM-T60619
2mg42,00€5mg64,00€10mg97,00€25mg183,00€50mg273,00€100mg393,00€200mg550,00€1mL*10mM (DMSO)62,00€Fosifloxuridine nafalbenamide
CAS:Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.Fórmula:C29H29FN3O9PPureza:95.87%Cor e Forma:SolidPeso molecular:613.53Ref: TM-T33762
1mg88,00€5mg160,00€10mg216,00€25mg393,00€50mg550,00€100mg753,00€500mg1.549,00€1mL*10mM (DMSO)210,00€Retifanlimab
CAS:Retifanlimab (MGA-012) is a monoclonal antibody targeting programmed cell death protein 1 (PD-1). Retifanlimab is used in studies of Merkel cell carcinoma.Pureza:95% - 95%Cor e Forma:Liquid2'-O-Methyl-2-thiouridine
CAS:2'-O-Methyl-2-thiouridine, a purine nucleoside analog present in synthetic thermophilic bacterial tRNAs, is more selective for A than unmodified U.Fórmula:C10H14N2O5SPureza:99.89%Cor e Forma:SolidPeso molecular:274.292'-O-Methylinosine
CAS:2'-O-Methylinosine (2'-(o-Methyl)-inosine) is an orally bioavailable purine nucleoside analog with antihypertensive activity.Fórmula:C11H14N4O5Pureza:99.88%Cor e Forma:SolidPeso molecular:282.25B I09
CAS:B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells.Fórmula:C16H17NO5Pureza:99.23%Cor e Forma:SolidPeso molecular:303.31Activated Protein C (390-404), human acetate
Activated Protein C (390-404), human acetate (Activated Protein C ) inhibits APC anticoagulant activity.Fórmula:C93H134N22O25Pureza:99.92%Cor e Forma:SolidPeso molecular:1960.19ML-60218
CAS:ML-60218 inhibits RNA pol III in yeast/humans with IC50s of 32/27 μM; disrupts and prevents viroplasms.Fórmula:C19H15Cl2N3O2S2Pureza:98.1%Cor e Forma:SolidPeso molecular:452.38Ref: TM-T40661
1mg56,00€5mg119,00€10mg187,00€25mg411,00€50mg638,00€100mg908,00€200mg1.225,00€1mL*10mM (DMSO)131,00€Filanesib
CAS:Filanesib (ARRY 520) is a selective inhibitor of kinesin spindle protein (KSP, IC50 = 6 nM) with potent anti-proliferative activity.Fórmula:C20H22F2N4O2SPureza:98.06%Cor e Forma:SolidPeso molecular:420.48Rabusertib
CAS:Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.Fórmula:C18H22BrN5O3Pureza:98.86% - 99.63%Cor e Forma:SolidPeso molecular:436.3BMS-1166
CAS:BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor.Fórmula:C36H33ClN2O7Pureza:99.22%Cor e Forma:SolidPeso molecular:641.11Ref: TM-T5697
1mg74,00€5mg155,00€10mg225,00€25mg429,00€50mg635,00€100mg944,00€200mg1.264,00€1mL*10mM (DMSO)208,00€6-AZATHYMINE
CAS:6-azathymine inhibits D-3-aminoisobutyrate-pyruvate aminotransferase; 6-azauracil competes with beta-alanine, uncompetitive with pyruvic acid, Ki ~8.9 mM.Fórmula:C4H5N3O2Pureza:99.47%Cor e Forma:SolidPeso molecular:127.1CHK1-IN-3
CAS:CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).Fórmula:C20H23N9OPureza:98.78%Cor e Forma:SolidPeso molecular:405.46Ref: TM-T10791
1mg185,00€2mg279,00€5mg424,00€10mg627,00€25mg938,00€50mg1.311,00€100mg1.795,00€1mL*10mM (DMSO)470,00€Y16 acetate(429653-73-6 free base)
Y16 acetate(429653-73-6 free base) is a G-protein-coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoAFórmula:C51H74N14O13Pureza:98%Cor e Forma:SolidPeso molecular:1091.24Sangivamycin
CAS:Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.Fórmula:C12H15N5O5Pureza:98.11%Cor e Forma:SolidPeso molecular:309.28Ref: TM-T9605
1mg126,00€5mg274,00€10mg416,00€25mg677,00€50mg944,00€100mg1.264,00€1mL*10mM (DMSO)360,00€Thiarabine
CAS:Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.Fórmula:C9H13N3O4SPureza:98%Cor e Forma:SolidPeso molecular:259.28CP-07
CP-07 is a selective and effective PROTAC CDK9 degrader (DC50: 43 nM), demonstrating inhibition of 22RV1 cell proliferation (IC50: 62 nM) and colony formationFórmula:C45H48N6O8Pureza:98%Cor e Forma:SolidPeso molecular:800.95,6-Dihydro-5-methyluracil
CAS:5,6-Dihydro-5-methyluracil (Dihydrothymine) is an intermediate breakdown product of thymine.Fórmula:C5H8N2O2Pureza:98.53%Cor e Forma:SolidPeso molecular:128.13Dostarlimab
CAS:Dostarlimab (TSR-042) is an immune checkpoint inhibitor targeting PD-1, blocking its interaction with its ligands PD-L1 and PD-L2.Pureza:>95%Cor e Forma:LiquidGW406108X(Z/E)
CAS:GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .Fórmula:C20H11Cl2NO4Pureza:98.23%Cor e Forma:SolidPeso molecular:400.21Ref: TM-T9207L
1mg131,00€5mg286,00€10mg430,00€25mg647,00€50mg969,00€100mg1.301,00€1mL*10mM (DMSO)283,00€MBQ-167
CAS:MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Fórmula:C22H18N4Pureza:98.07% - 98.74%Cor e Forma:SolidPeso molecular:338.41Ref: TM-T16021
1mg37,00€2mg52,00€5mg79,00€10mg111,00€25mg208,00€50mg376,00€100mg567,00€1mL*10mM (DMSO)87,00€RP-6685
CAS:RP-6685 is a potent, selective DNA Polθ inhibitor with strong oral efficacy, an IC50 of 5.8 nM, and marked antitumor effects in mice.Fórmula:C22H14F7N5OPureza:98.34%Cor e Forma:SoildPeso molecular:497.37Ref: TM-T60187
1mg88,00€5mg160,00€10mg230,00€25mg378,00€50mg538,00€100mg755,00€1mL*10mM (DMSO)170,00€dAURK-4 hydrochloride
dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Fórmula:C52H53Cl2FN8O12Pureza:99.44%Cor e Forma:SolidPeso molecular:1071.93CDK9-IN-35
CDK9-IN-35 (compound 10j) acts as an inhibitor of CDK9/CyclinT1, exhibiting an IC50 of 10.2 nM. It also shows an IC50 of 20 nM against the HCT-116 cell line.Fórmula:C26H24ClFN4O4SCor e Forma:SolidPeso molecular:543.01Anticancer agent 73
CAS:Anticancer agent 73 inhibits TRBP, disrupting TRBP-Dicer, and hinders HCC growth and spread by altering HCC miRNA and protein expression.Fórmula:C14H15NO4Pureza:99.19%Cor e Forma:SolidPeso molecular:261.27Rifaximin
CAS:Rifaximin: an oral semi-synthetic antibiotic from rifamycin SV; targets bacterial RNA polymerase to halt growth.Fórmula:C43H51N3O11Pureza:98.05% - 99.40%Cor e Forma:Red-Orange Crystalline PowderPeso molecular:785.88Men 10376
CAS:Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.Fórmula:C57H68N12O10Pureza:98%Cor e Forma:SolidPeso molecular:1081.22Nivolumab
CAS:Nivolumab is a monoclonal antibody, a humanized IgG4 antibody to PD-1. Nivolumab has antitumor activity. Cost-effective and quality-assured.Pureza:98% - 98%Cor e Forma:LiquidPeso molecular:146 kDa2',3'-Bis-(O-t-butyldimethylsilyl)uridine
CAS:2',3'-Bis-(O-t-butyldimethylsilyl)uridine is a nucleoside derivative protect the NH2/OH groups of nucleosides.inhibitory on viral replication,AIDS and herpes.Fórmula:C21H40N2O6Si2Pureza:99.88%Cor e Forma:SolidPeso molecular:472.72Ref: TM-TNU1182
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€Vitamin D2
CAS:Ergocaliferol (Vitamin D2), derived from ergosterol by UV, inhibits bladder tumor promotion and leukemia, and blocks DNA Polymerase.Fórmula:C28H44OPureza:98.73% - ≥98%Cor e Forma:Prisms From Acetone 1998)Peso molecular:396.65Aurora Kinases-IN-4
CAS:Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.Fórmula:C26H28N8OPureza:98%Cor e Forma:SolidPeso molecular:468.55P8RI acetate
P8RI acetate mimics CD31, activates CDP8RI, and suppresses the immune response by restoring CD31 pathway.Fórmula:C53H81N13O11Pureza:99.61%Cor e Forma:SolidPeso molecular:1076.29Beaucage reagent
CAS:Beaucage reagent, which is found to be effective in causing DNA cleavage.Fórmula:C7H4O3S2Pureza:95.19%Cor e Forma:White To Off-White PowderPeso molecular:200.23Abemaciclib metabolite M20
CAS:Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂,可用于癌症治疗的相关研究。Fórmula:C27H32F2N8OPureza:98.32% - 99.29%Cor e Forma:SolidPeso molecular:522.59CDK2/Bcl2-IN-1
CDK2/Bcl2-IN-1 (compound 1) is a saponin-based inhibitor of CDK-2 (IC50=117.6 nM) that exhibits potent cytotoxic effects on cancer cells.Fórmula:C35H56O10SPureza:98%Cor e Forma:SolidPeso molecular:668.88RAD51-IN-1
CAS:Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.Fórmula:C22H16ClN3OPureza:99.95%Cor e Forma:SolidPeso molecular:373.833-Deazauridine
CAS:3-Deazauridine (NSC-126849), a uridine analog, blocks CTP synthesis by competing with CTP synthetase.Fórmula:C10H13NO6Pureza:98.55%Cor e Forma:SolidPeso molecular:243.21Mevociclib
CAS:Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.Fórmula:C31H35ClN8O2Pureza:98.02% - 98.02%Cor e Forma:SolidPeso molecular:587.112-Methylbutyrylcarnitine chloride
2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.Fórmula:C12H24ClNO4Cor e Forma:SolidPeso molecular:281.78GS-443902
CAS:Remdesivir triphosphate (GS-443902) inhibits RSV/HCV RdRp with IC50s: 1.1/5 µM.Fórmula:C12H16N5O13P3Pureza:98%Cor e Forma:SolidPeso molecular:531.2MU1409
CAS:MU1409 is an MRE11 nuclease inhibitor with an IC50 of 12.1 μM. It also inhibits FEN1 and EXO1, with IC50 values of 24.2 μM and 176.4 μM, respectively. MU1409 impacts cellular DNA repair and prevents the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for studying BRCA2 mutation-induced cancers.Fórmula:C20H14BrN3O3SCor e Forma:SolidPeso molecular:456.312Senexin A
CAS:Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.Fórmula:C17H14N4Pureza:99.74%Cor e Forma:SolidPeso molecular:274.32Ref: TM-T5673
1mg37,00€5mg77,00€10mg99,00€25mg187,00€50mg340,00€100mg485,00€200mg657,00€1mL*10mM (DMSO)74,00€Centrinone-B
CAS:Centrinone-B (LCR-323) is a Plk4 inhibitor with potential anticancer activity for the study of triple-negative breast cancer.Fórmula:C27H27F2N7O5S2Pureza:98.71%Cor e Forma:SolidPeso molecular:631.67PD-1/PD-L1-IN-9
CAS:PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction.Fórmula:C22H24N2O2Pureza:99.37%Cor e Forma:SolidPeso molecular:348.44Ref: TM-T9651
1mg60,00€2mg89,00€5mg134,00€10mg188,00€25mg314,00€50mg429,00€100mg565,00€500mg1.121,00€1mL*10mM (DMSO)148,00€T7 RNA polymerase
CAS:T7 RNA polymerase, expressed by Escherichia coli from the T7 bacteriophage RNA polymerase gene, is a highly specific enzyme utilized for in vitro transcriptionPureza:98%Cor e Forma:SolidPD-L1-IN-7
CAS:PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.Fórmula:C46H50N6O7Cor e Forma:SolidPeso molecular:798.93BET/Aurora kinase-IN-1
CAS:BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.Fórmula:C25H30FN7OCor e Forma:SolidPeso molecular:463.555-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS:5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.Fórmula:C8H13N3SPureza:99.03%Cor e Forma:SolidPeso molecular:183.27PD-1/PD-L1 inhibitory peptide C8
PD-1/PD-L1 inhibitory peptide C8 disrupts the PD-1/PD-L1 interaction, leading to the activation of CD8+ and CD4+ T cells and an increase in IFN-γ secretion. In mouse models, PD-1/PD-L1 inhibitory peptide C8 has demonstrated antitumor activity.Fórmula:C51H72N14O14S2Cor e Forma:SolidPeso molecular:1169.33MRK-952
MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.Fórmula:C20H20ClF3N6Cor e Forma:SolidPeso molecular:436.861CKK-E12
CAS:CKK-E12 is an ionizable lipid for RNA delivery via lipid nanoparticles, with high liver cell selectivity in vivo.Fórmula:C60H120N4O6Pureza:98.328%Cor e Forma:SolidPeso molecular:993.62AZA197
CAS:AZA197 (AZA-197) is a selective Cdc42 inhibitor.Fórmula:C24H36N6Pureza:100%Cor e Forma:SolidPeso molecular:408.58Lobucavir
CAS:Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).Fórmula:C11H15N5O3Cor e Forma:SolidPeso molecular:265.27CCG-257081
CAS:CCG-257081 blocks Rho/MRTF/SRF pathway; prevents fibrosis in mice; useful in cancer and fibrosis research.Fórmula:C24H19ClF3N3O2Pureza:98% - 99.92%Cor e Forma:SolidPeso molecular:473.87TCS7010
CAS:TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay.Fórmula:C31H31ClFN7O2Pureza:98.49% - 99.62%Cor e Forma:SolidPeso molecular:588.07Risdiplam
CAS:Risdiplam (RG7916) is a centrally and peripherally distributed and orally administrable small molecule SMN2 pre-mRNA splicing modifier.Cost-effective and quality-assured.Fórmula:C22H23N7OPureza:98.68% - 99.43%Cor e Forma:SolidPeso molecular:401.46GSK3335103
CAS:GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.Fórmula:C27H36FN3O4Cor e Forma:SolidPeso molecular:485.59(S)-DI-87
CAS:(S)-DI-87 is an isomer of DI-87, a oral dCK inhibitor,reduce dNTP production and cell cycle arrest. significantly inhibits tumor growth with thymidine.Fórmula:C23H30N6O3S2Pureza:99.42%Cor e Forma:SoildPeso molecular:502.65Ref: TM-T39550L
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€KWR095
CAS:KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.Fórmula:C33H31ClF3N9O4Cor e Forma:SolidPeso molecular:710.105Thymectacin
CAS:Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.Fórmula:C21H25BrN3O9PPureza:98.41% - 99.82%Cor e Forma:SolidPeso molecular:574.32Voruciclib
CAS:Voruciclib: oral, selective CDK inhibitor (Ki: 0.626-9.1 nM), reduces MCL-1, targets CDK9 in diffuse large B-cell lymphoma.Fórmula:C22H19ClF3NO5Pureza:99.89%Cor e Forma:SolidPeso molecular:469.84CDK4/6-IN-6
CAS:CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.Fórmula:C22H27ClFN5O3Pureza:95.63%Cor e Forma:SolidPeso molecular:463.93DNA polymerase-IN-3
CAS:DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications inFórmula:C13H12O4Pureza:98%Cor e Forma:SolidPeso molecular:232.23ARB-272572 hydrochloride
CAS:ARB-272572 hydrochloride is a PD-L1 inhibitor that inhibits PD-1/PD-L1 cell signaling by inducing PD-L1 protein homology interactions.Fórmula:C32H36N6O4·xClHPureza:99%Cor e Forma:SoildPeso molecular:568.68(Free base）5-OHdU
CAS:5-OHdU (5-OHdU) is a major oxidation product of 2'-Deoxycytidine and can be incorporated into DNA in vitro.Fórmula:C9H12N2O6Pureza:98.32%Cor e Forma:SolidPeso molecular:244.2Ref: TM-T19152
1mg47,00€2mg60,00€5mg89,00€10mg131,00€25mg212,00€50mg316,00€100mg474,00€1mL*10mM (DMSO)90,00€Palbociclib
CAS:Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.Fórmula:C24H29N7O2Pureza:98% - 99.9%Cor e Forma:SolidPeso molecular:447.53Clofarabine-5'-diphosphate trisodium
Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Fórmula:C10H10ClFN5Na3O9P2Cor e Forma:SolidPeso molecular:529.58BRD9876
CAS:BRD9876 is a selective inhibitor of MM1S growth.Fórmula:C16H14N2Pureza:97.81%Cor e Forma:SolidPeso molecular:234.3Bractoppin
CAS:Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibitsFórmula:C25H23FN4OPureza:98.38%Cor e Forma:SolidPeso molecular:414.47Ref: TM-T8873
1mg49,00€5mg104,00€10mg166,00€25mg325,00€50mg490,00€100mg737,00€500mg1.483,00€1mL*10mM (DMSO)115,00€Werner syndrome RecQ helicase-IN-4
CAS:Werner syndrome RecQ helicase-IN-4 is a WRN inhibitor with anticancer and anti-proliferative activity, used in colorectal and gastric cancer research.Fórmula:C32H33F3N8O5Pureza:98.27%Cor e Forma:SolidPeso molecular:666.65YKL-5-124
CAS:YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displaysFórmula:C28H33N7O3Pureza:99.5%Cor e Forma:SolidPeso molecular:515.61Ref: TM-T22461
1mg96,00€2mg135,00€5mg188,00€10mg341,00€25mg548,00€50mg782,00€100mg1.035,00€1mL*10mM (DMSO)225,00€SNX7
CAS:SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.Fórmula:C15H14N2OPureza:99.05%Cor e Forma:SolidPeso molecular:238.28MIRA-1
CAS:MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activityFórmula:C8H9NO4Pureza:99.38%Cor e Forma:SolidPeso molecular:183.16CDK4/6/1 Inhibitor
CAS:CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).Fórmula:C28H30F2N6Pureza:97.99% - 99.26%Cor e Forma:SolidPeso molecular:488.57TAK-632
CAS:TAK-632 is a potent pan-Raf inhibitor.Fórmula:C27H18F4N4O3SPureza:98% - 98.92%Cor e Forma:SolidPeso molecular:554.52bio-THZ1
CAS:bio-THZ1 is a biotinylated version of THZ1. THZ1 is a selective and irreversibly covalent CDK7 inhibitor (IC50: 3.2 nM).Fórmula:C52H65ClN12O8SPureza:98%Cor e Forma:SolidPeso molecular:1053.67Roxifiban acetate
CAS:Roxifiban acetate(DMP 754 acetate) is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used inFórmula:C23H33N5O8Pureza:99.33% - 99.56%Cor e Forma:SolidPeso molecular:507.54CDK2-IN-31
CAS:CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.Fórmula:C37H52N6O5Cor e Forma:SolidPeso molecular:660.85Levomefolate calcium
CAS:Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.Fórmula:C20H23CaN7O6Pureza:97.35% - 98%Cor e Forma:Off-White To Pale Yellow SolidPeso molecular:497.52Deoxycytidine triphosphate trisodium salt
CAS:Deoxycytidine triphosphate trisodium salt (2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI) contributes to antibiotic lethality in stationary-phase mycobacteria.Fórmula:C9H13N3Na3O13P3Pureza:99.80%Cor e Forma:SolidPeso molecular:533.1ZYN57939
CAS:ZYN57939 (MTR-106), an RNA polymerase I inhibitor, treats related diseases with a 0.855 μM IC50 against HT-29 cells.Fórmula:C28H27N7O2SPureza:99.68%Cor e Forma:SolidPeso molecular:525.62Trifluridine/tipiracil hydrochloride mixture
CAS:Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in aFórmula:C29H34Cl2F6N8O12Pureza:99.37% - ≥98%Cor e Forma:SolidPeso molecular:871.53Ref: TM-T3658
2mg39,00€5mg57,00€10mg87,00€25mg157,00€50mg250,00€100mg378,00€200mg568,00€500mg889,00€1mL*10mM (DMSO)78,00€PD173952
CAS:PD173952 is a Src kinase and Myt1 inhibitor with antitumor activity, inhibits Lyn, Abl and Csk, and induces Bcr-Abl-dependent hematopoietic cell apoptosis.Fórmula:C24H21Cl2N5O2Pureza:99.5%Cor e Forma:SolidPeso molecular:482.36BMS-3
CAS:BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.Fórmula:C17H12Cl2F2N4OSPureza:99.19% - 99.31%Cor e Forma:SolidPeso molecular:429.27Avotaciclib
CAS:Avotaciclib (BEY1107) is a potent and orally active cyclin dependent kinase 1 (CDK1) inhibitor.Avotaciclib can be used to study locally advanced or metastaticFórmula:C13H11N7OPureza:97.98%Cor e Forma:SolidPeso molecular:281.27
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