Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase
- CDK
- Ciclo celular/Parada
- Chk
- c-Myc
- Dinamina
- DYRK
- Ferroptose
- HSP
- Integrinas
- Cinesina
- KSP
- LIM Quinase
- Microtúbulo associado
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Produtos da "Ciclo celular/Ponto de verificação"
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Carmofur
CAS:Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.Fórmula:C11H16FN3O3Pureza:98.59% - 99.48%Cor e Forma:SolidPeso molecular:257.265-Ethynyluridine
CAS:5-Ethynyluridine marks new RNA for RICK, capturing proteins on various RNAs, even nonpolyadenylated types.Fórmula:C11H12N2O6Pureza:100%Cor e Forma:SolidPeso molecular:268.22Ref: TM-T36971
5mg51,00€10mg88,00€25mg145,00€50mg250,00€100mg363,00€200mg545,00€1mL*10mM (DMSO)57,00€CDK2/4-IN-2
CAS:CDK2/4-IN-2 (compound 56) serves as a dual inhibitor for CDK2 and CDK4, exhibiting an IC50 of less than 100 nM. It is applicable in cancer research.Fórmula:C18H20F3N7O3S2Cor e Forma:SolidPeso molecular:503.52Abemaciclib
CAS:Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.Fórmula:C27H32F2N8Pureza:99.39% - 99.87%Cor e Forma:SolidPeso molecular:506.595-(Methoxycarbonyl)methyluridine
CAS:5-(Methoxycarbonyl)methyluridine is an important modifying nucleotide in tRNAs, and the lack of the mcm5U modification leads to increased protein aggregation.Fórmula:C12H16N2O8Pureza:99.71%Cor e Forma:SolidPeso molecular:316.26GSK-1520489A
CAS:GSK-1520489A is an active PKMYT1 inhibitor.Fórmula:C21H23N5O3SPureza:97.25%Cor e Forma:SolidPeso molecular:425.5D5B
D5B is an effective and selective PD-L1 inhibitor that has been modified with DBCO. It degrades PD-L1 in 4T1 and B16-F10 tumor cells with EC50 values of 5.4 μM and 6.2 μM, respectively. D5B can block the PD-L1/PD-1 interaction and exhibits antitumor activity.Fórmula:C58H66N2O12Cor e Forma:SolidPeso molecular:983.15TH287 hydrochloride
CAS:TH287 inhibits MTH1 (IC50: 0.8 nM), causing DNA damage in cancer cells through oxidized dNTP incorporation, leading to cytotoxicity in mouse xenografts.Fórmula:C11H11Cl3N4Pureza:99.5%Cor e Forma:SolidPeso molecular:305.59ANI-7
CAS:ANI-7, an AhR pathway activator, selectively impedes MCF-7 breast cancer cell growth (GI50: 0.56 μM).Fórmula:C13H8Cl2N2Pureza:99.21%Cor e Forma:SolidPeso molecular:263.12CDK4/6-IN-3
CAS:CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.Fórmula:C25H31FN8Pureza:98%Cor e Forma:SolidPeso molecular:462.57Danusertib
CAS:Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.Fórmula:C26H30N6O3Pureza:97.88% - 98.44%Cor e Forma:White PowderPeso molecular:474.55Ref: TM-T2094
1mg59,00€2mg85,00€5mg116,00€10mg188,00€25mg365,00€50mg555,00€100mg795,00€500mg1.605,00€1mL*10mM (DMSO)120,00€DNA polymerase-IN-2
DNA polymerase-IN-2 (Compd 3c), a coumarin derivative, demonstrates inhibitory activity towards Taq DNA polymerase, with an IC50 value of 48.25 μM, and holdsFórmula:C14H12O5SPureza:98%Cor e Forma:SolidPeso molecular:292.31TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Fórmula:C23H22Cl2FN5O3Pureza:98.69%Cor e Forma:SolidPeso molecular:506.36Ref: TM-T34787
1mg97,00€5mg235,00€10mg378,00€25mg748,00€50mg1.169,00€100mg1.644,00€1mL*10mM (DMSO)261,00€ENMD-2076
CAS:ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Fórmula:C21H25N7Pureza:97.63% - ≥95%Cor e Forma:SolidPeso molecular:375.47Ref: TM-T2358
1mg51,00€2mg72,00€5mg105,00€10mg159,00€25mg279,00€50mg462,00€100mg648,00€1mL*10mM (DMSO)116,00€Mefenidil
CAS:Mefenidil (McN-2378), a selective cerebral vasodilator, was shown to increase CBF in healthy brains without stimulating O2 uptake in a dog anesthesia model.Fórmula:C12H11N3Pureza:98.17%Cor e Forma:SolidPeso molecular:197.24Volociximab
CAS:Volociximab (M200) is an IgG4 monoclonal antibody targeting the α5β1 integrin , with antiangiogenic, antitumor and anticancer activity, inhibits the growth of rabbit VX2 tumors and is used to study solid tumors.Pureza:95%Cor e Forma:LiquidPKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.Fórmula:C24H26FN5O2Cor e Forma:SolidPeso molecular:435.49MKC3946
CAS:MKC3946 is an effective and soluble IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines.Fórmula:C21H20N2O3SPureza:99.65%Cor e Forma:SolidPeso molecular:380.46Ref: TM-TQ0101
1mg66,00€5mg170,00€10mg265,00€25mg444,00€50mg653,00€100mg929,00€1mL*10mM (DMSO)157,00€ML216
CAS:ML216 (CID-49852229) inhibits BLM helicase (IC50: 1.8 μM), 28-fold selective over RECQ1, RECQ5, and UvrD (IC50s > 50 μM).Fórmula:C15H9F4N5OSPureza:98.12%Cor e Forma:SolidPeso molecular:383.323'-Deoxy-3'-fluoroguanosine
CAS:3'-Deoxy-3'-fluoroguanosine is a nucleoside phosphorylase inhibitor that inhibits RNA replication by binding replons.Fórmula:C10H12FN5O4Pureza:99.33%Cor e Forma:SolidPeso molecular:285.23
