STAT
As proteínas STAT são componentes críticos da via de sinalização JAK/STAT, que transmite sinais extracelulares de citocinas e fatores de crescimento para o núcleo da célula, influenciando a expressão gênica. As proteínas STAT estão envolvidas na regulação de respostas imunológicas, crescimento celular, diferenciação e sobrevivência. A desregulação da sinalização STAT está implicada em várias doenças, incluindo câncer, distúrbios autoimunes e inflamação crônica. Na CymitQuimica, oferecemos uma ampla gama de moduladores da via STAT para apoiar sua pesquisa em transdução de sinal, imunologia e desenvolvimento terapêutico.
Produtos da "STAT"
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STAT5-IN-1
CAS:STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.Fórmula:C16H11N3O3Pureza:99.44% - ≥95%Cor e Forma:SolidPeso molecular:293.28Antitumor agent-195
Antitumor agent-195 (compound 16c) is a dual-targeting agent that simultaneously targets STAT3 and NQO1. At a concentration of 1 μM, it significantly inhibits the phosphorylation of STAT3 at the Tyr705 site and effectively induces apoptosis in MDA-MB-231 and MDA-MB-468 breast cancer cells. As a substrate of NQO1, Antitumor agent-195 markedly increases ROS production, causing severe DNA damage in a dose-dependent manner. It also demonstrates strong antitumor properties in MDA-MB-231 xenograft models.Fórmula:C22H22N2O4Cor e Forma:SolidPeso molecular:378.42Anticancer agent 259
Anticanceragent 259 (Compound 3g) is a telmisartan-based cell death regulator that disrupts the STAT5 signaling pathway, thereby increasing the sensitivity of resistant cells to imatinib, with an SC50 of 1.5 μM.Fórmula:C30H26N2O2Cor e Forma:SolidPeso molecular:446.54Mogrol
CAS:Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.Fórmula:C30H52O4Pureza:98.21% - 99.85%Cor e Forma:SolidPeso molecular:476.73Ref: TM-TN2346
1mg37,00€5mg74,00€10mg111,00€25mg180,00€50mg269,00€100mg399,00€500mg905,00€1mL*10mM (DMSO)79,00€SH-4-54
CAS:SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.Fórmula:C29H27F5N2O5SPureza:98% - 99.12%Cor e Forma:SolidPeso molecular:610.59Ref: TM-T6669
1mg50,00€2mg66,00€5mg96,00€10mg160,00€25mg311,00€50mg502,00€100mg730,00€1mL*10mM (DMSO)135,00€Compound SC-1
CAS:SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib.Fórmula:C21H13ClF3N3O2Pureza:99.41%Cor e Forma:SolidPeso molecular:431.8Ref: TM-T22424
1mg90,00€5mg160,00€10mg245,00€25mg444,00€50mg638,00€100mg848,00€200mg1.121,00€1mL*10mM (DMSO)178,00€Stafib-1
CAS:Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.Fórmula:C26H24N2O11P2Pureza:97.18%Cor e Forma:SolidPeso molecular:602.42Napabucasin
CAS:Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.Fórmula:C14H8O4Pureza:98.43% - 99.61%Cor e Forma:SolidPeso molecular:240.21Angoline
CAS:Angoline hydrochloride: IL6/STAT3 inhibitor, IC50: 11.56 μM, blocks STAT3 phosphorylation and cancer cell growth.Fórmula:C22H21NO5Pureza:99.43% - 99.96%Cor e Forma:SolidPeso molecular:379.41Ref: TM-TN6739
1mg66,00€5mg144,00€10mg207,00€25mg344,00€50mg512,00€100mg740,00€1mL*10mM (DMSO)158,00€AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Fórmula:C17H14N2O3Pureza:98.6% - 99.39%Cor e Forma:Yellow SolidPeso molecular:294.3HODHBt
CAS:HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.Fórmula:C7H5N3O2Pureza:99.45% - 99.95%Cor e Forma:Off-White To Yellow SolidPeso molecular:163.13Ascochlorin
CAS:Ascochlorin, an isoprenoid antibiotic, inhibits STAT3 to combat tumors, induces apoptosis, and reduces inflammation.Fórmula:C23H29ClO4Pureza:98%Cor e Forma:SolidPeso molecular:404.93Diosgenin
CAS:Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants.Fórmula:C27H42O3Pureza:98.87% - 99.87%Cor e Forma:Flaky Or Needle CrystalPeso molecular:414.62ML115
CAS:ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.Fórmula:C15H15ClN2O4Pureza:99.35%Cor e Forma:SolidPeso molecular:322.74Ref: TM-T35544
1mg95,00€5mg227,00€10mg359,00€25mg630,00€50mg882,00€100mg1.188,00€200mg1.596,00€500mg2.357,00€1mL*10mM (DMSO)251,00€STX-0119
CAS:STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.Fórmula:C22H14N4O3Pureza:99.42%Cor e Forma:SolidPeso molecular:382.37Ref: TM-T60160
5mg64,00€10mg92,00€25mg177,00€50mg283,00€100mg425,00€500mgA consultar1mL*10mM (DMSO)64,00€HJC0152 hydrochloride
CAS:HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.Fórmula:C15H14Cl3N3O4Pureza:98.33% - 98.62%Cor e Forma:SolidPeso molecular:406.64STAT3-IN-35
CAS:STAT3-IN-35 is a STAT3 inhibitor that binds to the SH2 domain. This compound inhibits the phosphorylation of STAT3 and exhibits antiproliferative activity in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 has demonstrated toxicity and potent antitumor activity in TNBC xenograft models.Fórmula:C21H23NO4Cor e Forma:SolidPeso molecular:353.41Artesunate
CAS:Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.Fórmula:C19H28O8Pureza:99.53% - 99.91%Cor e Forma:White Crystalline PowderPeso molecular:384.42TPCA-1
CAS:TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinasesFórmula:C12H10FN3O2SPureza:95.03% - 97.86%Cor e Forma:SolidPeso molecular:279.29
