STAT
As proteínas STAT são componentes críticos da via de sinalização JAK/STAT, que transmite sinais extracelulares de citocinas e fatores de crescimento para o núcleo da célula, influenciando a expressão gênica. As proteínas STAT estão envolvidas na regulação de respostas imunológicas, crescimento celular, diferenciação e sobrevivência. A desregulação da sinalização STAT está implicada em várias doenças, incluindo câncer, distúrbios autoimunes e inflamação crônica. Na CymitQuimica, oferecemos uma ampla gama de moduladores da via STAT para apoiar sua pesquisa em transdução de sinal, imunologia e desenvolvimento terapêutico.
Produtos da "STAT"
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Stafib-2
CAS:Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,Fórmula:C28H26N2O12P2Pureza:98.97%Cor e Forma:SolidPeso molecular:644.46Ref: TM-T9646
1mg208,00€5mg518,00€10mg740,00€25mg1.093,00€50mg1.473,00€100mg2.015,00€1mL*10mM (DMSO)737,00€AS2863619
CAS:AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Fórmula:C16H14Cl2N8OPureza:100%Cor e Forma:SolidPeso molecular:405.24Ref: TM-T8378
1mg131,00€2mg180,00€5mg274,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€1mL*10mM (DMSO)303,00€RO8191
CAS:RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Fórmula:C14H5F6N5OPureza:98.85% - ≥98%Cor e Forma:SolidPeso molecular:373.21Atractylenolide I
CAS:Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Fórmula:C15H18O2Pureza:97.55% - 99.83%Cor e Forma:SolidPeso molecular:230.3KT-333
CAS:KT-333 is a potent, highly selective, heterobifunctional degrader of STAT3 for the treatment of a variety of STAT3-dependent pathologies, antitumor.Fórmula:C60H74ClN10O14PSPureza:98.12%Cor e Forma:SolidPeso molecular:1257.78Tetramethylcurcumin
CAS:Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it alsoFórmula:C25H28O6Pureza:99.94% - ≥98%Cor e Forma:SolidPeso molecular:424.49PMMB-187
CAS:PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 μM in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.Fórmula:C27H23BrN2O6S2Cor e Forma:SolidPeso molecular:615.52Stafia-1
CAS:Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.Fórmula:C24H27O10PPureza:98.08%Cor e Forma:SolidPeso molecular:506.44Ref: TM-T9339
1mg86,00€5mg187,00€10mg309,00€25mg525,00€50mg757,00€100mg1.035,00€500mg2.110,00€1mL*10mM (DMSO)217,00€Protosappanin A
CAS:Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.Fórmula:C15H12O5Pureza:100% - 99.42%Cor e Forma:SolidPeso molecular:272.25Ref: TM-TJS1779
1mg87,00€5mg216,00€10mg354,00€25mg582,00€50mg825,00€100mg1.111,00€1mL*10mM (DMSO)197,00€UC-514321
CAS:UC-514321 directly targets STAT3/5 and represses TET1 expression.Fórmula:C26H35NO5Pureza:97%Cor e Forma:SolidPeso molecular:441.56Ref: TM-T13950
1mg78,00€5mg169,00€10mg264,00€25mg528,00€50mg810,00€100mg1.169,00€200mg1.568,00€1mL*10mM (DMSO)178,00€Morusin
CAS:Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.Fórmula:C25H24O6Pureza:98.68% - 99.8%Cor e Forma:SolidPeso molecular:420.45Antitumor agent-73
CAS:Antitumor Agent-73, derived from Diosgenin, blocks STAT3 and activates Pdia3, showing strong cancer cell line efficacy.Fórmula:C50H82BrO4PPureza:98%Cor e Forma:SolidPeso molecular:858.06Picroside I
CAS:Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B.Fórmula:C24H28O11Pureza:99.70%Cor e Forma:SolidPeso molecular:492.47SC-43
CAS:SC-43 is a potent and orally active agonist of SHP-1 (PTPN6).Fórmula:C21H13ClF3N3O2Pureza:98.44%Cor e Forma:SolidPeso molecular:431.8S3I-201
CAS:S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.Fórmula:C16H15NO7SPureza:97.83%Cor e Forma:SolidPeso molecular:365.36BD750
CAS:BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM inFórmula:C14H13N3OSPureza:99.02%Cor e Forma:SolidPeso molecular:271.34Stattic
CAS:Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation.Fórmula:C8H5NO4SPureza:98.54% - 99.76%Cor e Forma:SolidPeso molecular:211.19Ref: TM-T6308
5mg35,00€10mg51,00€25mg85,00€50mg124,00€100mg187,00€200mg279,00€500mg465,00€1mL*10mM (DMSO)55,00€WP1066
CAS:WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.Fórmula:C17H14BrN3OPureza:98.92% - 99.73%Cor e Forma:SolidPeso molecular:356.22SC99
CAS:SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Fórmula:C15H8Cl2FN3OPureza:99.56%Cor e Forma:SolidPeso molecular:336.15Ref: TM-T8719
1mg46,00€5mg93,00€10mg140,00€25mg240,00€50mg363,00€100mg452,00€200mg630,00€1mL*10mM (DMSO)99,00€AS1517499
CAS:AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nMFórmula:C20H20ClN5O2Pureza:98.27% - 98.7%Cor e Forma:SolidPeso molecular:397.86Ref: TM-T4476
1mg40,00€2mg52,00€5mg88,00€10mg119,00€25mg235,00€50mg376,00€100mg469,00€500mg1.064,00€1mL*10mM (DMSO)87,00€
