Ras
As proteínas Ras são pequenas GTPases que atuam como interruptores moleculares na via de sinalização MAPK, controlando o crescimento, a diferenciação e a sobrevivência celular. Ras ativado inicia uma cascata de sinalização que inclui Raf, MEK e ERK, levando a várias respostas celulares. As mutações nos genes Ras são comuns em cânceres, tornando Ras um foco importante da pesquisa sobre o câncer. Na CymitQuimica, oferecemos uma variedade de moduladores de Ras para apoiar sua pesquisa em biologia do câncer, transdução de sinais e desenvolvimento terapêutico.
Produtos da "Ras"
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KRAS G12C inhibitor 32
CAS:KRAS G12C Inhibitor 32, an eight-membered heterocyclic compound with nitrogen, acts as a potent inhibitor of KRAS G12C [1].Fórmula:C29H30Cl3FN6O3Pureza:98%Cor e Forma:SolidPeso molecular:635.94Pan-RAS-IN-1
CAS:Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.Fórmula:C36H41Cl2F3N6O2Pureza:98.57%Cor e Forma:SolidPeso molecular:717.65Ref: TM-T16432
1mg80,00€2mg97,00€5mg144,00€10mg216,00€25mg439,00€50mg660,00€100mg938,00€500mg1.882,00€1mL*10mM (DMSO)221,00€SOS1-IN-16
CAS:SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 ofFórmula:C30H31F3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:552.59KRAS inhibitor-8
CAS:KRAS inhibitor-8 is a potent KRAS G12C inhibitor.Fórmula:C26H24ClF4N5O3Pureza:98%Cor e Forma:SolidPeso molecular:565.95KRAS G12C inhibitor 5
CAS:KRAS G12C inhibitor 5 is a KRas G12C inhibitor.Fórmula:C32H37N7O2Pureza:98%Cor e Forma:SolidPeso molecular:551.68KB-5246
CAS:KB-5246, displays antibacterial activities.is a tetracyclic quinolone.Fórmula:C18H17ClFN3O4SPureza:98%Cor e Forma:SolidPeso molecular:425.86ERK-IN-3
CAS:ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.Fórmula:C22H25ClFN7O2Pureza:99.55% - 99.76%Cor e Forma:SolidPeso molecular:473.93KRAS inhibitor-37
CAS:KRAS inhibitor-37 (compound 2) is a potent inhibitor of KRAS, exhibiting low dissociation constants (KD) with various KRAS mutations: wild type (0.004 nM), G12D (0.041 nM), G12C (0.019 nM), and G12V (0.144 nM). This compound effectively inhibits cell proliferation, demonstrating half-maximal inhibitory concentrations (IC50) ranging from <2 nM to 14 nM in H358, SW620, and PANC08.13 cell lines. KRAS inhibitor-37 holds potential for cancer research applications.Fórmula:C32H33ClFN7O3Cor e Forma:SolidPeso molecular:618.10ZT-12-037-01
CAS:Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).Fórmula:C21H31N5O2Pureza:99.56%Cor e Forma:SolidPeso molecular:385.5PROTAC K-Ras Degrader-3
CAS:PROTAC K-Ras Degrader-3 is a PROTAC degrader targeting K-Ras, exhibiting a DC50 value of ≤ 1 nM against SW620 KRAS G12D and a GI50 value of ≤ 10 nM in inhibiting the growth of SW620 3D cells. It is used in cancer research.Fórmula:C57H67F2N9O6Cor e Forma:SolidPeso molecular:1012.20RGT-018
CAS:RGT-018 is a potent oral SOS1 inhibitor with antitumor properties. It exerts its anticancer activity by inhibiting KRAS activation, thereby hindering cancer cell proliferation.Fórmula:C27H24F3N7O2Cor e Forma:SolidPeso molecular:535.52J-104871
CAS:J-104871 (UNII-6137X5QNJF) is an FTase inhibitor that inhibits tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.Fórmula:C38H32N2O12Pureza:98%Cor e Forma:SolidPeso molecular:708.67KRAS inhibitor-7
CAS:KRAS inhibitor-7 is a potent KRAS G12C inhibitor.Fórmula:C26H27ClF2N6O2Pureza:98%Cor e Forma:SolidPeso molecular:528.98ML-098
CAS:ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).Fórmula:C19H19NO3Pureza:99.06% - 99.52%Cor e Forma:SolidPeso molecular:309.36Ref: TM-T4619
1mg39,00€2mg49,00€5mg70,00€10mg99,00€25mg200,00€50mg283,00€100mg394,00€500mg934,00€1mL*10mM (DMSO)88,00€Glecirasib
CAS:Glecirasib (JAB-21822,KRAS G12C inhibitor 36) is an orally active KRAS G12C inhibitor that selectively binds to and inhibits KRAS G12C-dependent signalingFórmula:C31H26ClF4N7O2Pureza:100% - 100%Cor e Forma:SolidPeso molecular:640.03pan-KRAS-IN-17
CAS:pan-KRAS-IN-17 (Example 34) is an inhibitor that targets multiple forms of the KRAS protein.Fórmula:C34H33F3N5O8PCor e Forma:SolidPeso molecular:727.623MRTF-A-IN-1
MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.Fórmula:C22H21N3Cor e Forma:SolidPeso molecular:327.42XRP44X
CAS:XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.Fórmula:C21H21ClN4OPureza:97.51%Cor e Forma:SolidPeso molecular:380.87SOS1-IN-11
CAS:SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).Fórmula:C22H24F3N5OPureza:98.79%Cor e Forma:SolidPeso molecular:431.45Ref: TM-T60029
1mg75,00€5mg169,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€1mL*10mM (DMSO)180,00€BI-2852
CAS:BI-2852: nanomolar affinity KRAS switch I/II pocket inhibitor; blocks signaling, halts KRAS mutant cell growth.Fórmula:C31H28N6O2Pureza:98.98%Cor e Forma:SolidPeso molecular:516.59Ref: TM-T10533
1mg116,00€5mg276,00€10mg410,00€25mg680,00€50mg938,00€100mg1.293,00€1mL*10mM (DMSO)314,00€
