Ras
As proteínas Ras são pequenas GTPases que atuam como interruptores moleculares na via de sinalização MAPK, controlando o crescimento, a diferenciação e a sobrevivência celular. Ras ativado inicia uma cascata de sinalização que inclui Raf, MEK e ERK, levando a várias respostas celulares. As mutações nos genes Ras são comuns em cânceres, tornando Ras um foco importante da pesquisa sobre o câncer. Na CymitQuimica, oferecemos uma variedade de moduladores de Ras para apoiar sua pesquisa em biologia do câncer, transdução de sinais e desenvolvimento terapêutico.
Produtos da "Ras"
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Antifungal agent 46
CAS:Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].Fórmula:C26H28BrF3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:565.43Phellodendrine chloride
CAS:Phellodendrine chloride combats kidney inflammation by blocking macrophage and T cell activity in glomeruli.Fórmula:C20H24ClNO4Pureza:98.85% - 99.05%Cor e Forma:SolidPeso molecular:377.86AMG410
CAS:AMG410 is a non-covalent, bimodal GDP (OFF) and GTP (ON)-binding pan-KRAS inhibitor , binds on the variegated pocket, in KRAS G12D, G12V, G12C, G13D.Fórmula:C31H32ClF2N7O5Cor e Forma:SoildPeso molecular:656.08AM-001
CAS:AM-001 is a non-competitive inhibitor of Epac1, preventing the activation of its downstream effector Rap1 in cultured cells. This compound is utilized in research related to cardiac diseases.Fórmula:C24H16FN3OS2Cor e Forma:SolidPeso molecular:445.53KRAS G12D inhibitor 25
CAS:KRAS G12D inhibitor 25 (Compound 148) acts as an inhibitor for KRAS G12C and HSP90α, displaying IC50 values of <0.1 μM and 0.1-1 μM respectively. Additionally, it suppresses the proliferation of MIA PaCa-2 and NCI-H358 cell lines, with EC50 values of <0.1 μM and 0.1-1 μM correspondingly. This compound also promotes the degradation of ERBB2, exhibiting a DC50 of 0.1-1 μM.Fórmula:C56H62ClN11O6Cor e Forma:SolidPeso molecular:1020.62ZCL278
CAS:ZCL278 is a selective Cdc42 GTPase inhibitor.Fórmula:C21H19BrClN5O4S2Pureza:96.29% - 99.72%Cor e Forma:SolidPeso molecular:584.89Ref: TM-T1855
5mg50,00€10mg79,00€25mg136,00€50mg221,00€100mg310,00€200mg497,00€500mg805,00€1mL*10mM (DMSO)79,00€KRAS inhibitor-34
CAS:KRAS inhibitor-34 (compound 27) is a KRAS inhibitor with an IC50 of 6.4 nM and is utilized in oncological research.Fórmula:C43H41F3N6O3Cor e Forma:SolidPeso molecular:746.82ARS-1620
CAS:ARS-1620 is a covalent inhibitor of K-RASG12C.Fórmula:C21H17ClF2N4O2Pureza:98.86%Cor e Forma:SolidPeso molecular:430.84Ref: TM-T7609
1mg92,00€2mg117,00€5mg188,00€10mg274,00€25mg543,00€50mg780,00€100mg938,00€1mL*10mM (DMSO)212,00€K-Ras(G12C) inhibitor 12
CAS:K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).Fórmula:C15H17ClIN3O3Pureza:97.16%Cor e Forma:SolidPeso molecular:449.67MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Fórmula:C33H39N7O2Pureza:96.59% - 99.07%Cor e Forma:SolidPeso molecular:565.71Ref: TM-T16143
1mg64,00€2mg89,00€5mg131,00€10mg220,00€25mg371,00€50mg557,00€100mg797,00€1mL*10mM (DMSO)170,00€Kobe0065
CAS:Kobe0065: novel small-molecule, inhibits Ras-Raf, Ki=46±13 μM, blocks H-Ras·GTP/c-Raf-1 RBD binding.Fórmula:C15H11ClF3N5O4SPureza:100% - 99.58%Cor e Forma:SolidPeso molecular:449.79BAY-293
CAS:BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Fórmula:C25H28N4O2SPureza:96.8%Cor e Forma:SolidPeso molecular:448.586H05 (TFA)
CAS:6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.Fórmula:C22H31ClF3N3O4S3Pureza:≥95%Cor e Forma:SolidPeso molecular:590.14Ref: TM-T7326
1mg69,00€2mg95,00€5mg134,00€10mg230,00€25mg378,00€50mg568,00€100mg807,00€1mL*10mM (DMSO)170,00€TH-Z835
CAS:TH-Z835 is a selective inhibitor for the KRAS (G12D) mutation, demonstrating an inhibitory concentration (IC50) of 1.6 μM.Fórmula:C30H38N6OPureza:98%Cor e Forma:SolidPeso molecular:498.66RMC-6236
CAS:RMC-6236 is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.Fórmula:C44H58N8O5SPureza:98.24% - 99.92%Cor e Forma:SolidPeso molecular:811.05K-Ras(G12C) Inhibitor 6
CAS:Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.Fórmula:C17H22Cl2N2O3SPureza:89.07% - 97.09%Cor e Forma:SolidPeso molecular:405.33Ref: TM-T3725
1mg63,00€2mg88,00€5mg133,00€10mg230,00€25mg477,00€50mg667,00€100mg932,00€1mL*10mM (DMSO)133,00€BI1701963
BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.Fórmula:C47H62N8O4SCor e Forma:SolidPeso molecular:835.11MLS000532223
CAS:MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).Fórmula:C15H9NO3Pureza:98.60%Cor e Forma:SolidPeso molecular:251.24Ref: TM-T8473
1mg130,00€2mg183,00€5mg306,00€10mg462,00€25mg755,00€50mg1.035,00€100mg1.415,00€1mL*10mM (DMSO)319,00€1A-116
CAS:1A-116 is a specific Rac1 inhibitor.Fórmula:C16H16F3N3Pureza:98.43%Cor e Forma:SolidPeso molecular:307.31Ref: TM-T14004
1mg50,00€5mg111,00€10mg166,00€25mg283,00€50mg444,00€100mg655,00€200mg924,00€1mL*10mM (DMSO)123,00€(S)-AMG-510
CAS:(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.Fórmula:C30H30F2N6O3Pureza:98.01% - 99.76%Cor e Forma:SolidPeso molecular:560.59Ref: TM-T22258
2mg37,00€5mg52,00€10mg85,00€25mg156,00€50mg274,00€100mg426,00€500mg938,00€1mL*10mM (DMSO)77,00€
