Canal TRP/TRPV
Os canais TRP (Potencial do Receptor Transitório), incluindo a subfamília TRPV, são um grupo de canais iônicos envolvidos em vários processos sensoriais, como sensação de temperatura, percepção da dor e osmorregulação. Os canais TRP são amplamente expressos em diferentes tecidos e desempenham um papel nas respostas fisiológicas aos estímulos ambientais. Os canais TRPV, em particular, estão envolvidos na detecção de mudanças de temperatura e estão implicados em condições como dor crônica, inflamação e câncer. Na CymitQuimica, oferecemos uma gama abrangente de moduladores de canais TRP/TRPV para apoiar sua pesquisa em biologia sensorial, manejo da dor e transdução de sinais.
Produtos da "Canal TRP/TRPV"
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MK-2295
CAS:MK-2295 is a potent TRPV1 antagonist. MK-2295 can be used in studies about the treatment of chronic pain.Fórmula:C27H31FN6O2Pureza:98.1% - 98.83%Cor e Forma:SolidPeso molecular:490.57SET 2
CAS:SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.Fórmula:C17H21F3N4O2SPureza:98.43%Cor e Forma:SolidPeso molecular:402.43Ref: TM-T37097
5mg58,00€10mg96,00€25mg177,00€50mg300,00€100mg437,00€500mgA consultar1mL*10mM (DMSO)71,00€SB 452533
CAS:SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).Fórmula:C18H22BrN3OPureza:98.52%Cor e Forma:SolidPeso molecular:376.29Ref: TM-T23322
2mg42,00€5mg64,00€10mg97,00€25mg183,00€50mg284,00€100mg411,00€200mg585,00€1mL*10mM (DMSO)85,00€Pyr6
CAS:Pyr6 (N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide) is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influxFórmula:C17H9F7N4OPureza:98.89%Cor e Forma:SolidPeso molecular:418.27ICILIN
CAS:ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.Fórmula:C16H13N3O4Pureza:97.61% - ≥95%Cor e Forma:Light Yellow SolidPeso molecular:311.29ML-SI3
CAS:CCG-143140 is a GLP-1 receptor inverse agonists.Fórmula:C23H31N3O3SPureza:99.75%Cor e Forma:SolidPeso molecular:429.58Fingolimod hydrochloride
CAS:Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).Fórmula:C19H34ClNO2Pureza:99.26% - 99.83%Cor e Forma:White SolidPeso molecular:343.93CBP-1008
CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) with MMAE, targeting folate receptor (FRα) and TRPV6. It exhibits high binding affinity to FRα and low affinity to TRPV6. CBP-1008 shows antitumor activity and can be utilized for research in advanced solid tumors such as colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma, and follicular dendritic cell sarcoma.Cor e Forma:Odour SolidEvifacotrep
CAS:Evifacotrep: TRPC5 antagonist for neurological disease research (WO2020061162, compound 100).Fórmula:C18H12ClF4N5O2Pureza:98.6%Cor e Forma:SolidPeso molecular:441.77Ref: TM-T40042
1mg96,00€5mg188,00€10mg303,00€25mg465,00€50mg692,00€100mg1.026,00€200mg1.549,00€1mL*10mM (DMSO)160,00€AM-0902
CAS:AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).Fórmula:C17H15ClN6O2Pureza:100%Cor e Forma:SolidPeso molecular:370.79SN 2
CAS:SN 2 is a novel and potent TRPML3 ion channel activator(EC50 = 1.13 μM). SN 2 also shares a similar antiviral effect against DENV2 and ZIKV.Fórmula:C17H21NOPureza:99.20%Cor e Forma:SolidPeso molecular:255.35Ref: TM-T12941
5mg52,00€10mg75,00€25mg149,00€50mg283,00€100mg415,00€200mg582,00€1mL*10mM (DMSO)52,00€Olvanil
CAS:Olvanil (N-Vannilyloleoylamide) is a vanilloid receptor agonist with EC50 of 0.7nM.Fórmula:C26H43NO3Pureza:95.06%Cor e Forma:SolidPeso molecular:417.62GSK1702934A
CAS:GSK1702934A is a TRPC3 agonist with pro-arrhythmic and positive inotropic effects and is used in the study of diabetes mellitus.Fórmula:C22H25N3O2SPureza:98.15%Cor e Forma:SolidPeso molecular:395.529-Phenanthrol
CAS:9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.Fórmula:C14H10OPureza:98.72%Cor e Forma:SolidPeso molecular:194.23Chembridge-5861528
CAS:Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM.Fórmula:C19H23N5O3Pureza:99.97%Cor e Forma:SolidPeso molecular:369.42TRPV4 agonist-1
CAS:TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).Fórmula:C25H23ClF2N4O2Pureza:98%Cor e Forma:SolidPeso molecular:484.93TRPV3 antagonist 74a
CAS:TRPV3 antagonist 74a (TRPV3 74a) is a specific TRPV3 antagonist for the study of neurological disorders.Fórmula:C17H17F3N2O2Pureza:≥98.0%Cor e Forma:SolidPeso molecular:338.32JC-229
CAS:JC-229 is a potent and selective TbRPA1 inhibitor that can inhibit RPA1 in Trypanosoma brucei. JC-229 can be used to study human African Trypanosomiasis (HAT).Fórmula:C20H14Cl4N2O3SPureza:97.14%Cor e Forma:SolidPeso molecular:504.21AMG2850
CAS:AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).Fórmula:C19H17F6N3OPureza:99.05%Cor e Forma:SolidPeso molecular:417.35Ref: TM-T10300
1mg74,00€5mg170,00€10mg248,00€25mg445,00€50mg662,00€100mg848,00€1mL*10mM (DMSO)182,00€TC-I2000
CAS:TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.Fórmula:C23H18F4N2OPureza:98.87%Cor e Forma:SolidPeso molecular:414.4ML204
CAS:ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.Fórmula:C15H18N2Pureza:98.1% - 99.72%Cor e Forma:SolidPeso molecular:226.32Ref: TM-T2298
2mg35,00€5mg50,00€10mg74,00€25mg111,00€50mg145,00€100mg220,00€200mg284,00€500mg467,00€1mL*10mM (DMSO)52,00€ASP7663
CAS:ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.Fórmula:C14H14FNO3Pureza:98.61%Cor e Forma:SolidPeso molecular:263.26GSK3395879
CAS:GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).Fórmula:C20H15F4N3O5SPureza:98%Cor e Forma:SolidPeso molecular:485.41Mesendogen
CAS:Mesendogen is an inhibitor of transient receptor potential cation channel, subfamily M, member 6 (TRPM6) and 7 (TRPM7) and acts by inhibiting TRPM6/TRPM7Fórmula:C18H16ClF3N2OSPureza:98.90%Cor e Forma:SolidPeso molecular:400.85Apcin A HCL
CAS:Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to synthesize the PROTAC CP5V [1].Fórmula:C10H15Cl4N5O2Pureza:99.30%Cor e Forma:SolidPeso molecular:379.07Ref: TM-T001
1mgA consultar2mg63,00€5mgA consultar10mgA consultar25mgA consultar50mgA consultar100mgA consultar200mgA consultar500mg2.792,00€Vanilloid receptor antagonist 1
CAS:Vanilloid receptor antagonist 1 (4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile) is a potent vanilloid receptor TRPV1 antagonist.Fórmula:C18H15N3O2Pureza:98.14%Cor e Forma:SolidPeso molecular:305.33Ref: TM-T9247
1mg99,00€5mg235,00€10mg354,00€25mg602,00€50mg847,00€100mg1.206,00€1mL*10mM (DMSO)47,00€TRPA1-IN-2
CAS:TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.Fórmula:C24H25F3N4OPureza:98.05%Cor e Forma:SoildPeso molecular:442.48Ref: TM-T77511
1mg85,00€5mg187,00€10mg284,00€25mg482,00€50mg672,00€100mg905,00€200mg1.216,00€1mL*10mM (DMSO)207,00€FEMA-4809
CAS:FEMA-4809 activates TRPM8, the ion channel for cold sensation, and is used as a cooling agent.Fórmula:C17H17N3O2SPureza:99.19%Cor e Forma:SolidPeso molecular:327.4Ref: TM-T27308
1mg35,00€5mg78,00€10mg116,00€25mg190,00€50mg269,00€100mg383,00€200mg525,00€1mL*10mM (DMSO)88,00€TC-I 2014
CAS:TC-I 2014 shows antiallodynic properties in pain models.Fórmula:C23H19F6N3OPureza:98.75%Cor e Forma:SolidPeso molecular:467.41Ref: TM-T17006
1mg60,00€5mg127,00€10mg202,00€25mg406,00€50mg655,00€100mg1.074,00€200mg1.454,00€1mL*10mM (DMSO)133,00€AMG9810
CAS:AMG 9810 blocks capsaicin's action on TRPV1; human IC50=24.5 nM, rat IC50=85.6 nM.Fórmula:C21H23NO3Pureza:99.79% - 99.83%Cor e Forma:SolidPeso molecular:337.41JYL 1421
CAS:JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).Fórmula:C20H26FN3O2S2Pureza:98.83%Cor e Forma:SolidPeso molecular:423.57Ref: TM-T15634
1mg70,00€5mg187,00€10mg305,00€25mg612,00€50mg938,00€100mg1.491,00€200mg1.985,00€1mL*10mM (DMSO)173,00€RN-1747
CAS:RN-1747: TRPV4 agonist (EC50: human 0.77 μM, mouse 4.0 μM, rat 4.1 μM), TRPM8 antagonist (IC50: 4 μM).Fórmula:C17H18ClN3O4SPureza:99.29%Cor e Forma:SolidPeso molecular:395.86Ref: TM-T16763
5mg44,00€10mg74,00€25mg126,00€50mg188,00€100mg316,00€200mg452,00€1mL*10mM (DMSO)47,00€HC067047 Hydrochloride(883031-03-6 free base)
CAS:HC-067047 hydrochloride, a TRPV4 antagonist, selectively inhibits human, rat, and mouse currents with IC50s: 486 nM, 133 nM, and 17 nM.Fórmula:C26H29ClF3N3O2Pureza:99.95%Cor e Forma:SolidPeso molecular:507.98Ref: TM-T4680L
1mg88,00€5mg172,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)217,00€RN9893
CAS:RN9893 is a selective and potent TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for TRPV4 receptors in mouse, human and rat, respectively.Fórmula:C21H23F3N4O5SPureza:99.89%Cor e Forma:SolidPeso molecular:500.49D-3263 hydrochloride
CAS:D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.Fórmula:C21H32ClN3O3Pureza:99.85%Cor e Forma:SolidPeso molecular:409.95PF-4840154
CAS:PF-4840154: potent TrpA1 agonist; EC50 of 97 nM (rat) & 23 nM (human); triggers nociception in mice.Fórmula:C26H38N6O2Pureza:98.48%Cor e Forma:SolidPeso molecular:466.62A 425619
CAS:A 425619 (1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA) is a potent TRPV1 antagonistFórmula:C18H14F3N3OPureza:99.35%Cor e Forma:SolidPeso molecular:345.32Ref: TM-T8562
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)177,00€HC-070
CAS:HC-070 is a TRPC5 and TRPC4 antagonist (IC50 = 9.3 nM and 46 nM).Fórmula:C22H20Cl2N4O4Pureza:97.06%Cor e Forma:SolidPeso molecular:475.32Ref: TM-T15465
1mg88,00€5mg170,00€10mg259,00€25mg429,00€50mg605,00€100mg815,00€200mg1.093,00€1mL*10mM (DMSO)168,00€A-967079
CAS:A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectivelyFórmula:C12H14FNOPureza:98.34% - 99.75%Cor e Forma:SolidPeso molecular:207.24Ononetin
CAS:Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).Fórmula:C15H14O4Pureza:98.15%Cor e Forma:SolidPeso molecular:258.27GSK2193874
CAS:GSK2193874 was identified as a selective, orally active TRPV4 blocker.Fórmula:C37H38BrF3N4OPureza:98.79% - ≥95%Cor e Forma:SolidPeso molecular:691.62Ref: TM-T5640
1mg43,00€2mg57,00€5mg81,00€10mg127,00€25mg246,00€50mg404,00€100mg602,00€1mL*10mM (DMSO)111,00€AMTB hydrochloride
CAS:AMTB HCl: Novel TRPM8 blocker, relieves pain, treats urinary issues, moderates bladder reflexes in rats.Fórmula:C23H27ClN2O2SPureza:99.08%Cor e Forma:SolidPeso molecular:430.99Ref: TM-T19723
1mg37,00€5mg79,00€10mg126,00€25mg264,00€50mg449,00€100mg662,00€200mg939,00€1mL*10mM (DMSO)92,00€Pico145
CAS:Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels.Fórmula:C23H20ClF3N4O5Pureza:99.06%Cor e Forma:SolidPeso molecular:524.88Ref: TM-T16532
1mg77,00€5mg165,00€10mg240,00€25mg408,00€50mg562,00€100mg800,00€200mg1.074,00€1mL*10mM (DMSO)187,00€AMG 333
CAS:AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.Fórmula:C20H12F5N3O4Pureza:99.95%Cor e Forma:SolidPeso molecular:453.32SB-705498
CAS:SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.Fórmula:C17H16BrF3N4OPureza:99.16% - ≥95%Cor e Forma:SolidPeso molecular:429.23EIPA hydrochloride
CAS:EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.Fórmula:C11H19Cl2N7OPureza:98%Cor e Forma:SolidPeso molecular:336.22GFB-8438
CAS:GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).Fórmula:C16H14ClF3N4O2Pureza:99.58%Cor e Forma:SolidPeso molecular:386.76Ref: TM-T11394
2mg35,00€5mg52,00€10mg81,00€25mg117,00€50mg170,00€100mg250,00€200mg369,00€1mL*10mM (DMSO)58,00€AMG-0347
CAS:AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.Fórmula:C24H26F3N3O2Pureza:99.7%Cor e Forma:SolidPeso molecular:445.48Ref: TM-T29968
1mg226,00€5mg552,00€10mg735,00€25mg1.111,00€50mg1.491,00€100mg2.005,00€200mg2.707,00€1mL*10mM (DMSO)567,00€ML-SA1
CAS:ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity.Fórmula:C22H22N2O3Pureza:99.71%Cor e Forma:SolidPeso molecular:362.42Ref: TM-T23004
2mg37,00€5mg51,00€10mg81,00€25mg150,00€50mg244,00€100mg364,00€200mg550,00€1mL*10mM (DMSO)58,00€JT010
CAS:JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).Fórmula:C16H19ClN2O3SPureza:98.5%Cor e Forma:SolidPeso molecular:354.85
