Anidrase carbónica
A anidrase carbônica é uma enzima que catalisa a conversão reversível de dióxido de carbono e água em bicarbonato e prótons. Esta enzima desempenha um papel crucial na manutenção do equilíbrio ácido-base, respiração e transporte de dióxido de carbono no sangue. Inibidores da anidrase carbônica são usados no tratamento de glaucoma, epilepsia e mal da altitude, bem como em pesquisas sobre homeostase ácido-base e troca gasosa. Na CymitQuimica, oferecemos uma gama de inibidores e reagentes de anidrase carbônica de alta qualidade para apoiar sua pesquisa em enzimologia, fisiologia respiratória e desenvolvimento terapêutico.
Produtos da "Anidrase carbónica"
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Carbonic anhydrase inhibitor 15
Carbonic Anhydrase Inhibitor 15 (Compound 8), with an inhibitory constant (K_i) of 8.5 nM for hCA II, exhibits analgesic effects [1].Fórmula:C27H33N5O2S2Pureza:98%Cor e Forma:SolidPeso molecular:523.71SH7s
SH7s is an effective carbonic anhydrase inhibitor, exhibiting Ki values of 15.9 nM for hCA IX and 55.2 nM for hCA XII. Additionally, SH7s acts as a hypoxia-mediated chemosensitizer in colorectal cancer cells.Fórmula:C24H19ClF3N5O4SCor e Forma:SolidPeso molecular:565.95Polmacoxib
CAS:Polmacoxib, a first-class NSAID, dual inhibitor of CA and COX-2, may hinder colorectal cancer growth in mice.Fórmula:C18H16FNO4SPureza:97.88%Cor e Forma:SolidPeso molecular:361.39Ref: TM-T21294
2mg47,00€5mg70,00€10mg107,00€25mg173,00€50mg259,00€100mg378,00€200mg563,00€1mL*10mM (DMSO)77,00€ALP/Carbonic anhydrase-IN-1
CAS:Compound 1e, also known as ALP/Carbonic anhydrase-IN-1, is a dual inhibitor targeting both carbonic anhydrase (CA) isozymes II, IX, and XII, as well as alkalineFórmula:C15H16N2Pureza:98%Cor e Forma:SolidPeso molecular:224.3CAIX/CAXII-IN-4
CAIX/CAXII-IN-4 (Compound 7h) is an inhibitor of carbonic anhydrase (CA) that binds to CAIX, CA XII, and CAII with Ki values of 1.324 μM, 0.435 μM, and 3.035 μM, respectively. This compound exhibits broad-spectrum anti-tumor activity and inhibits the proliferation of central nervous system tumor cells U251, with a GI50 of 0.361 μM.Fórmula:C23H21N5O3SCor e Forma:SolidPeso molecular:447.51CAIX/CAXII-IN-3
CAIX/CAXII-IN-3 (compound 11) serves as an inhibitor for CAIX/CAXII, exhibiting an IC50 value of less than 65 nM. Additionally, this compound effectively inhibits the proliferation of human melanoma cells.Cor e Forma:Odour SolidWES-1
CAS:WES-1 (Compound 8g), a carbonic anhydrase IX inhibitor (Ki: 55.9 μM), exhibits broad-spectrum antiproliferative activity against various cancer cell lines,Fórmula:C20H20N4O3SPureza:98%Cor e Forma:SolidPeso molecular:396.46Zonisamide
CAS:Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures.Fórmula:C8H8N2O3SPureza:99.05% - 99.9%Cor e Forma:Off-White PowderPeso molecular:212.23hCAII/XII-IN-1
hCAII/XII-IN-1 (compound 4l) is a potent inhibitor of hCAXII and hCAII, with Ki values of 8.4 nM and 9.4 nM, respectively. It plays a significant role in cancer research.Fórmula:C22H20N4O6S2Peso molecular:500.547Chlorothiazide
CAS:Chlorothiazide (Diuril) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.Fórmula:C7H6ClN3O4S2Pureza:95.42%Cor e Forma:Crystals Physical Description Crystals; White Powder (Ntp 1992)Peso molecular:295.72hCAII-IN-9
CAS:hCAII-IN-9 inhibits hCA II/IX/XII with IC50s of 1.18, 0.17, 2.99 μM; not BBB permeable.Fórmula:C15H16ClN3O5S2Pureza:98.63%Cor e Forma:SolidPeso molecular:417.89Carbonic anhydrase inhibitor 12
CAS:CA Inhibitor 12 strongly blocks CA II (K_i 1.72 nM), also inhibits CA I (271 nM), shows anticancer effects.Fórmula:C27H22BrN5O5S2Pureza:98%Cor e Forma:SolidPeso molecular:640.53CA Ⅱ-IN-1
CAⅡ-IN-1 (compound 2i) is an inhibitor of the CA Ⅱ isozyme, exhibiting an IC50 of 0.44 µM. This compound is utilized in metabolic research.Fórmula:C18H19NO6SCor e Forma:SolidPeso molecular:377.41U-104
CAS:U-104 (NSC-213841) is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM).Fórmula:C13H12FN3O3SPureza:100% - 99.6%Cor e Forma:SolidPeso molecular:309.32Ref: TM-T2017
5mg35,00€10mg52,00€25mg87,00€50mg142,00€100mg250,00€200mg399,00€500mg652,00€1mL*10mM (DMSO)58,00€Dichlorphenamide
CAS:Dichlorphenamide (Diclofenamide) is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma.Fórmula:C6H6Cl2N2O4S2Pureza:96.87% - 98.51%Cor e Forma:Needles From Dimethylsulfoxide + Water SolidPeso molecular:305.16Ref: TM-T6469
5mg50,00€10mg65,00€25mg87,00€50mg96,00€100mg140,00€200mg202,00€500mg340,00€1mL*10mM (DMSO)59,00€CAIX Inhibitor S4
CAS:CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively.Fórmula:C15H17N3O4SPureza:98.35%Cor e Forma:SolidPeso molecular:335.38Ref: TM-T36758
2mg40,00€5mg60,00€10mg96,00€25mg188,00€50mg354,00€100mg528,00€500mg1.159,00€1mL*10mM (DMSO)66,00€EMAC10101d
CAS:compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with anFórmula:C17H15Cl2N3O2S2Pureza:99.96%Cor e Forma:SolidPeso molecular:428.36hCAI/II/IV-IN-28
CAS:hCAI/II/IV-IN-28(WAY-638358) is a potent carbonic anhydrase inhibitor with potential anticonvulsant activity.Fórmula:C14H15N3O3SPureza:96.48%Cor e Forma:SolidPeso molecular:305.35Carbonic anhydrase inhibitor 26
Compound 6T, designated as Carbonic anhydrase inhibitor26, acts as an inhibitor of Carbonic Anhydrase II (Carbonic AnhydraseII), exhibiting an IC50 value of 9.10 ± 0.26 μM.Fórmula:C17H14N6O4Cor e Forma:SolidPeso molecular:366.33Perfluorohexane sulfonamide
CAS:Perfluorohexane sulfonamide (FHxSA) serves as an inhibitor of carbonic anhydrase (CA), effectively inhibiting bovine CA and human CAII with IC50 values of 0.122 and 1.38 μM, respectively. Additionally, it acts as a delayed-action insecticide for controlling red imported fire ants (Solenopsis invicta). Furthermore, Perfluorohexane sulfonamide is considered a potential environmental pollutant.Fórmula:C6H2F13NO2SCor e Forma:SolidPeso molecular:399.13
