GluR
Inibidores do Receptor de Glutamato são compostos que bloqueiam a atividade dos receptores de glutamato, os principais receptores de neurotransmissores excitatórios no cérebro. Esses receptores desempenham um papel crucial na transmissão sináptica, plasticidade, aprendizado e memória. A desregulação da sinalização do glutamato está associada a vários distúrbios neurológicos, como epilepsia, AVC e doenças neurodegenerativas. Os inibidores dos receptores de glutamato são essenciais para investigar os mecanismos de excitotoxicidade e desenvolver estratégias neuroprotetoras. Na CymitQuimica, oferecemos uma gama de inibidores de receptores de glutamato para apoiar sua pesquisa em função sináptica, neuroproteção e distúrbios cognitivos.
Produtos da "GluR"
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3-MATIDA
CAS:3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a).Fórmula:C8H9NO4SPureza:98.41% - 99.05%Cor e Forma:SolidPeso molecular:215.23KRP-199 sodium
KRP-199 sodium sodium is highly potent and selective for AMPA-R in vitro and exhibits good neuroprotection in vivo.Fórmula:C22H12F3N5Na2O7Pureza:96.85%Cor e Forma:SoildPeso molecular:561.33Ref: TM-T27748L
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€500mg3.734,00€LY3020371 hydrochloride
CAS:LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.Fórmula:C15H16ClF2NO5SCor e Forma:SolidPeso molecular:395.81JNJ-46778212
CAS:JNJ-46778212 (VU 0409551) is a selective and potent mGlu5 allosteric modulator (EC50: 260 nM) for the study of neurodissection.Fórmula:C20H17FN2O3Pureza:99.24%Cor e Forma:SolidPeso molecular:352.36A-794282
CAS:A-794282 is a selective antagonist of mGluR1.Fórmula:C19H18N4OSPureza:≥98%Cor e Forma:SolidPeso molecular:350.44GET73
CAS:GET73 (Gamma hydroxybutyric acid analogue) is an negative allosteric modulator of mGluR5.Fórmula:C13H16F3NO2Pureza:99.54%Cor e Forma:SolidPeso molecular:275.27Ref: TM-T11393
1mg65,00€5mg131,00€10mg202,00€25mg340,00€50mg452,00€100mg638,00€200mg842,00€1mL*10mM (DMSO)177,00€γ-DGG
CAS:gamma-DGG is a competitive blocker of AMPA receptor.Fórmula:C7H12N2O5Pureza:98%Cor e Forma:SolidPeso molecular:204.18VU0483605
CAS:VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.Fórmula:C20H10Cl3N3O3Pureza:97.03%Cor e Forma:SolidPeso molecular:446.67Ref: TM-T21747
2mg42,00€5mg64,00€10mg97,00€25mg183,00€50mg284,00€100mg425,00€200mg562,00€1mL*10mM (DMSO)78,00€E4CPG
CAS:E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.Fórmula:C11H13NO4Pureza:99.96%Cor e Forma:SolidPeso molecular:223.23L-AP4
CAS:L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).Fórmula:C4H10NO5PPureza:98%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:183.1LY-2300559
CAS:LY-2300559 is an agonist of metabotropic glutamate receptor 2 (mGluR2) and can be used in studies about the treatment of migraine.Fórmula:C26H26O6Pureza:100%Cor e Forma:SolidPeso molecular:434.48Ref: TM-T27932
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€(S)-MCPG
CAS:(S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.Fórmula:C10H11NO4Pureza:98.72%Cor e Forma:SolidPeso molecular:209.20VU 0357121
CAS:VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.Fórmula:C17H17F2NO2Pureza:99% - 99.99%Cor e Forma:SolidPeso molecular:305.32Fenobam
CAS:Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM).Fórmula:C11H11ClN4O2Pureza:99.93%Cor e Forma:SolidPeso molecular:266.68Ref: TM-T15275
1mg35,00€5mg64,00€10mg101,00€25mg170,00€50mg248,00€100mg359,00€200mg497,00€1mL*10mM (DMSO)96,00€DNQX
CAS:DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)Fórmula:C8H4N4O6Pureza:97.15% - 99.10%Cor e Forma:Off-White Powder With A Yellow TingePeso molecular:252.14JNJ-40411813
CAS:JNJ-40411813 (ADX-71149) (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).Fórmula:C20H25ClN2OPureza:99.74%Cor e Forma:SolidPeso molecular:344.88Ref: TM-TQ0094
1mg55,00€5mg117,00€10mg183,00€25mg306,00€50mg437,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)131,00€S 18986
CAS:S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties inFórmula:C10H12N2O2SPureza:99.25%Cor e Forma:SolidPeso molecular:224.281H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-
CAS:1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)- is a low activity isomer of S 18986.Fórmula:C10H12N2O2SPureza:99.69%Cor e Forma:SoildPeso molecular:224.28VU0155041
CAS:VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).Fórmula:C14H15Cl2NO3Pureza:99.52% - 99.56%Cor e Forma:SolidPeso molecular:316.18Ref: TM-T3565
2mg40,00€5mg58,00€10mg85,00€25mg145,00€50mg188,00€100mg301,00€200mg435,00€1mL*10mM (DMSO)64,00€(S)-ATPO
CAS:(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.Fórmula:C11H19N2O7PPureza:98.37% - 99.41%Cor e Forma:SolidPeso molecular:322.25
![1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT60224.webp&w=3840&q=75)
