Receptor do Factor de Crescimento Fibroblasto (FGFR)
Os inibidores de FGFR (receptores do fator de crescimento de fibroblastos) são terapias direcionadas que bloqueiam a atividade dos FGFRs, que estão envolvidos na proliferação celular, diferenciação e angiogênese. A sinalização de FGFR contribui para a formação de novos vasos sanguíneos em tumores, promovendo seu crescimento e sobrevivência. Inibir FGFR pode, portanto, reduzir a angiogênese e a progressão tumoral. Na CymitQuimica, oferecemos uma gama de inibidores de FGFR de alta qualidade para apoiar sua pesquisa em câncer, biologia do desenvolvimento e angiogênese.
Produtos da "Receptor do Factor de Crescimento Fibroblasto (FGFR)"
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FGFR3-IN-7
CAS:FGFR3-IN-7 is a potent, selective inhibitor of FGFR 3, demonstrating an IC50 value of less than 350 nM , and is utilized in cancer research [1].Fórmula:C25H24FN9OPureza:98%Cor e Forma:SolidPeso molecular:485.52SU 5402
CAS:SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.Fórmula:C17H16N2O3Pureza:98.91% - 99.64%Cor e Forma:Yellow-Green SolidPeso molecular:296.32Fazpilodemab
CAS:Fazpilodemab (BFKB8488A) is a humanized agonistic bispecific antibody that targets fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ.Pureza:98%Cor e Forma:LiquidAZD4547
CAS:AZD4547 is an FGFR family inhibitor, and is able to act on FGFR1, FGFR2, FGFR3 and FGFR4. IC50:165 nM).Cost-effective and quality-assured.Fórmula:C26H33N5O3Pureza:99.37% - 99.88%Cor e Forma:SolidPeso molecular:463.57Ref: TM-T1948
2mg39,00€5mg49,00€10mg63,00€25mg88,00€50mg113,00€100mg156,00€200mg219,00€500mg366,00€1mL*10mM (DMSO)55,00€PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Fórmula:C22H25N7O2Pureza:98.34% - 99.62%Cor e Forma:SolidPeso molecular:419.48FGFR1 inhibitor-9
FGFR1 inhibitor-9 (Compound 7) is an FGFR1 inhibitor with potent binding affinity, exhibiting an IC50 of 0.85 nM.Fórmula:C27H20ClNO5Pureza:98%Cor e Forma:SolidPeso molecular:473.9Infigratinib
CAS:Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 andFórmula:C26H31Cl2N7O3Pureza:98% - 98.97%Cor e Forma:SolidPeso molecular:560.48FGFR-IN-15
FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.Fórmula:C22H23N5O5SCor e Forma:SolidPeso molecular:469.51Heparan Sulfate
CAS:Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG). Cost effective and quality assured.Fórmula:C12H19NO20S3(monomer)Pureza:98%Cor e Forma:SolidPeso molecular:593.47(monomer)SU4984
CAS:SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).Fórmula:C20H19N3O2Pureza:100%Cor e Forma:SolidPeso molecular:333.38FGFR1 inhibitor-10
CAS:FGFR1 inhibitor-10 (Compound 4i), with an IC50 of 28 nM, effectively inhibits FGFR1 phosphorylation.Fórmula:C26H30F3N7O2SPureza:98%Cor e Forma:SolidPeso molecular:561.62PD168393
CAS:PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Fórmula:C17H13BrN4OPureza:99.13% - 99.7%Cor e Forma:SolidPeso molecular:369.22Ref: TM-T6932
1mg39,00€2mg49,00€5mg66,00€10mg89,00€25mg155,00€50mg222,00€100mg310,00€1mL*10mM (DMSO)56,00€PP58
CAS:PP58 is an inhibitor of PDGFR, FGFR and Src family.Fórmula:C22H19Cl2N5O2Pureza:99.21%Cor e Forma:SolidPeso molecular:456.32FGFR1 inhibitor 7
FGFR1 Inhibitor 7 (compound 5), a potent FGFR1 tyrosine kinase inhibitor, exhibits an IC50 of 0.33 nM against its target and demonstrates broad-spectrumFórmula:C25H16ClNO4Pureza:98%Cor e Forma:SolidPeso molecular:429.85PD-161570
CAS:Fórmula:C26H35Cl2N7OPureza:>98.0%(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:532.51FGFR3-IN-6
CAS:FGFR3-IN-6 is a potent, selective inhibitor of FGFR 3, exhibiting an IC50 value of less than 350 nM , and is utilized in cancer research [1].Fórmula:C25H23FN8O2Pureza:98%Cor e Forma:SolidPeso molecular:486.5FGFR1 inhibitor-16
CAS:FGFR1inhibitor-16 (Compound 89) functions as an FGFR1 inhibitor, demonstrating an inhibition rate of 53.00% at a concentration of 50 μM and 24.95% at 10 μM. It is utilized in tumor research.Fórmula:C16H9N5O3SCor e Forma:SolidPeso molecular:351.339Dovitinib lactate hydrate
CAS:Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).Fórmula:C24H27FN6O4Pureza:99.82%Cor e Forma:SolidPeso molecular:482.51Roblitinib
CAS:Roblitinib (FGF-401), an FGFR4 inhibitor, potentially blocks tumor growth by halting cell proliferation and survival.Fórmula:C25H30N8O4Pureza:97.27% - 99%Cor e Forma:SolidPeso molecular:506.56Ref: TM-T4235
1mg58,00€2mg84,00€5mg103,00€10mg169,00€25mg306,00€50mg535,00€100mg752,00€500mg1.586,00€Nintedanib
CAS:Fórmula:C31H33N5O4Pureza:>95.0%(T)(HPLC)Cor e Forma:White to Yellow to Yellow green powder to crystalPeso molecular:539.64
