Receptor do Factor de Crescimento Fibroblasto (FGFR)
Os inibidores de FGFR (receptores do fator de crescimento de fibroblastos) são terapias direcionadas que bloqueiam a atividade dos FGFRs, que estão envolvidos na proliferação celular, diferenciação e angiogênese. A sinalização de FGFR contribui para a formação de novos vasos sanguíneos em tumores, promovendo seu crescimento e sobrevivência. Inibir FGFR pode, portanto, reduzir a angiogênese e a progressão tumoral. Na CymitQuimica, oferecemos uma gama de inibidores de FGFR de alta qualidade para apoiar sua pesquisa em câncer, biologia do desenvolvimento e angiogênese.
Produtos da "Receptor do Factor de Crescimento Fibroblasto (FGFR)"
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FIIN-3
CAS:FIIN-3 is an irreversible inhibitor of FGFR.Fórmula:C34H36Cl2N8O4Pureza:97.63% - 98.92%Cor e Forma:SolidPeso molecular:691.61IMC-D11
IMC-D11 (LY-3076226 antibody) is an IgG1 monoclonal antibody targeting FGFR3. It serves as the antibody component of LY3076226. For its isotype control, refer to Human IgG1 kappa, Isotype Control.Cor e Forma:Odour LiquidAprutumab ixadotin
CAS:Aprutumab ixadotin (BAY 1187982) is the first antibody-drug conjugate (ADC) targeting FGFR2, and is also the inaugural ADC to employ an auristatin-based active payload.Cor e Forma:LiquidGandotinib
CAS:LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).Fórmula:C23H25ClFN7OPureza:99.33% - 99.86%Cor e Forma:SolidPeso molecular:469.94Ref: TM-T2638
5mg51,00€10mg88,00€25mg160,00€50mg296,00€100mg469,00€500mg1.035,00€1mL*10mM (DMSO)57,00€FGFR2-IN-1
CAS:FGFR2-IN-1 is an FGFR inhibitor that inhibits FGFR1, FGFR2, and FGFR3, and can be used to study FGFR2-associated cancers.Fórmula:C22H19N3O2Pureza:98.71%Cor e Forma:SolidPeso molecular:357.41Erdafitinib
CAS:Erdafitinib (JNJ-42756493) is a quinoxaline derivative compound, acts on FGFR1/2/3/4.Fórmula:C25H30N6O2Pureza:97% - 99.07%Cor e Forma:SolidPeso molecular:446.54Zoligratinib
CAS:Zoligratinib (CH5183284) is a selective and orally available FGFR inhibitor, which is for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.Fórmula:C20H16N6OPureza:95.28% - 99.51%Cor e Forma:SolidPeso molecular:356.38FGFR4-IN-8
CAS:FGFR4-IN-8 is a selective, ATP-competitive FGFR4 inhibitor with IC50s as low as 0.25 nM, halting growth of Hep3B cells at 29 nM and showing in vivo efficacy.Fórmula:C32H34Cl2FN7O3Pureza:98%Cor e Forma:SolidPeso molecular:654.562,5-Dihydroxybenzoic acid
CAS:2,5-Dihydroxybenzoic acid (Gentisic acid) is an active metabolite of salicylic acid degradation with a broad spectrum of biological activity.Fórmula:C7H6O4Pureza:99.63%Cor e Forma:SolidPeso molecular:154.12Lenvatinib mesylate
CAS:Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.Fórmula:C22H23ClN4O7SPureza:99.03% - 99.79%Cor e Forma:SolidPeso molecular:522.96FGFR1 inhibitor-15
CAS:FGFR1inhibitor-15 (Compound 23) is an FGFR1 inhibitor with an IC50 value of 27 μM, useful for tumor research.Fórmula:C17H13FN4OCor e Forma:SolidPeso molecular:308.31Ferulic Acid
CAS:Ferulic Acid (Coniferic acid) is a highly abundant phenolic phytochemical and a organic compound found in the Ferula assafoetida L. or Ligusticum chuanxiong.Fórmula:C10H10O4Pureza:99.72%Cor e Forma:SolidPeso molecular:194.18Futibatinib
CAS:Futibatinib (TAS-120) is an orally active, potent,and irreversible FGFR inhibitor of FGFR1, FGFR2, FGFR3, and FGFR4.Cost-effective and quality-assured.Fórmula:C22H22N6O3Pureza:97.66% - 99.14%Cor e Forma:SolidPeso molecular:418.45Ref: TM-T5044
1mg52,00€5mg120,00€10mg170,00€25mg329,00€50mg512,00€100mg662,00€200mg939,00€1mL*10mM (DMSO)134,00€Fazpilodemab
CAS:Fazpilodemab (BFKB8488A) is a humanized bispecific antibody that targets and activates the Klotho β and fibroblast growth factor receptor 1c receptor complex.Cor e Forma:LiquidSulfatinib
CAS:Sulfatinib (KDR-IN-1) (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC 50 s ranging from 1 toFórmula:C24H28N6O3SPureza:100% - 99.21%Cor e Forma:SolidPeso molecular:480.58S6K2-IN-1
S6K2-IN-1 (Compound 2) is an inhibitor of S6K2 with an IC50 of 22 nM and also exhibits inhibitory activity against FGFR4 with an IC50 of 216 nM.Fórmula:C24H23ClF3N9O2Pureza:98%Cor e Forma:SolidPeso molecular:561.95FIIN-2
CAS:FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.Fórmula:C35H38N8O4Pureza:97.82% - 99.65%Cor e Forma:Crystalline SolidPeso molecular:634.73PD-166866
CAS:PD-166866 is a selective FGFR tyrosine kinase inhibitor.Fórmula:C20H24N6O3Pureza:98.29%Cor e Forma:SolidPeso molecular:396.44Vofatamab
CAS:Vofatamab (B-701) is a fully human monoclonal antibody targeting FGFR3, often used in combination with other compounds to treat cancer.Pureza:> 95% - > 95%Cor e Forma:LiquidPeso molecular:150 kDaJK-P3
CAS:JK-P3: a pyrazole inhibitor of VEGFR-2 (IC50: 7.8 μM), stalls FGFR 1/3 in vitro, halts HUVEC wound healing/tube formation, not cell growth.Fórmula:C18H17N3O3Pureza:99.57%Cor e Forma:SolidPeso molecular:323.35
