Receptor Sigma
Os receptores sigma são sítios de ligação únicos que, ao contrário dos GPCRs tradicionais, não se enquadram nas categorias clássicas de proteínas receptoras. Eles estão envolvidos na modulação dos sistemas de neurotransmissores e têm sido implicados em vários distúrbios neurológicos e psiquiátricos. Os receptores sigma também estão associados à sobrevivência celular, e seus ligantes estão sendo explorados para aplicações terapêuticas em neuroproteção, câncer e manejo da dor. Na CymitQuimica, oferecemos uma seleção de moduladores de receptores sigma de alta qualidade para apoiar sua pesquisa em neurociência, oncologia e biologia de receptores.
Produtos da "Receptor Sigma"
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Glycerol phenylbutyrate
CAS:Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).Fórmula:C33H38O6Pureza:99.00% - 99.74%Cor e Forma:SolidPeso molecular:530.65AF-710B
CAS:AF710B is an enantiomer of AF710. AF-710B is also a sigma and M1 muscarinic receptors agonist.Fórmula:C20H27N3OSPureza:98.62% - 99.89%Cor e Forma:SolidPeso molecular:357.51KSK67
CAS:KSK67 is a selective dual antagonist of sigma-2 and histamine H3 receptors with inhibitory effects on H3 receptors, sigma-1, and sigma-2 receptors, with KiFórmula:C22H27N3O2Pureza:99.11%Cor e Forma:SoildPeso molecular:365.47PD 144418 oxalate
CAS:PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; potential antipsychotic.Fórmula:C20H24N2O5Pureza:99.08%Cor e Forma:SolidPeso molecular:372.42Siramesine
CAS:Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potentFórmula:C30H31FN2OPureza:98%Cor e Forma:SolidPeso molecular:454.58σ1 Receptor ligand 1
σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value of 3.9 nM. It demonstrates a high plasma protein binding rate (89%) and exhibits good metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 is applicable in neuroscience and cancer research.Fórmula:C22H28N2O2Cor e Forma:SolidPeso molecular:352.47S1R agonist 1 hydrochloride
CAS:S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstratedFórmula:C20H26ClNOPureza:98%Cor e Forma:SolidPeso molecular:331.88S1R agonist 2 hydrochloride
Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R.Fórmula:C21H28ClNOPureza:98%Cor e Forma:SolidPeso molecular:345.91BMY-14802
CAS:BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.Fórmula:C18H22F2N4OPureza:98.93%Cor e Forma:SoildPeso molecular:348.39Ref: TM-T67739
1mg40,00€5mg88,00€10mg137,00€25mg264,00€50mg432,00€100mg638,00€500mg1.359,00€1mL*10mM (DMSO)87,00€Sigma-1 receptor antagonist 6
CAS:Sigma-1 receptor antagonist 6 (Compound 12), a σ1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (σ1R). This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel.Fórmula:C32H34N6Cor e Forma:SolidPeso molecular:502.65Sigma-1 receptor antagonist 5
Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic action on sigma receptorsFórmula:C26H27N3OPureza:98%Cor e Forma:SolidPeso molecular:397.51Cutamesine dihydrochloride
CAS:Cutamesine dihydrochloride is a σ1 receptor agonist, selective over σ2, combating cardiomyocyte hypertrophy and improving stroke recovery.Fórmula:C23H32N2O2·2HClPureza:98.83% - 99%Cor e Forma:SolidPeso molecular:441.43Ref: TM-T3597
2mg38,00€5mg55,00€10mg96,00€25mg178,00€50mg281,00€100mg445,00€200mg640,00€1mL*10mM (DMSO)60,00€σ1 Receptor antagonist-1
CAS:σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.Fórmula:C21H23NOSPureza:99.80%Cor e Forma:SolidPeso molecular:337.48Ref: TM-T9244
2mg38,00€5mg55,00€10mg88,00€25mg170,00€50mg269,00€100mg391,00€200mg562,00€1mL*10mM (DMSO)59,00€OPC-14523 hydrochloride
CAS:OPC-14523 hydrochloride, an oral sigma/5-HT1A agonist, shows potent antidepressant activity with strong receptor affinity.Fórmula:C23H29Cl2N3O2Pureza:99.70%Cor e Forma:SolidPeso molecular:450.4AD186
AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R.Fórmula:C22H28N2Pureza:98%Cor e Forma:SolidPeso molecular:320.47Siramesine hydrochloride
CAS:Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibitFórmula:C30H32ClFN2OPureza:100% - 99.75%Cor e Forma:SolidPeso molecular:491.04Ref: TM-T1885
1mg60,00€2mg88,00€5mg111,00€10mg173,00€25mg354,00€50mg528,00€100mg743,00€1mL*10mM (DMSO)120,00€Roluperidone
CAS:Roluperidone (CYR-101) is a novel cyclic amide derivative.Fórmula:C22H23FN2O2Pureza:96.46% - 97.77%Cor e Forma:SolidPeso molecular:366.43NE-100 hydrochloride
CAS:NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity.Fórmula:C23H34ClNO2Pureza:98.85%Cor e Forma:SolidPeso molecular:391.98Ref: TM-T20797
1mg46,00€2mg57,00€5mg92,00€10mg137,00€25mg221,00€50mg329,00€100mg490,00€200mg700,00€500mg1.035,00€4-PPBP maleate
CAS:4-PPBP maleate: potent σ1 agonist, selective NR1a/2B NMDA antagonist, neuroprotective.Fórmula:C25H31NO4Pureza:99.54%Cor e Forma:SolidPeso molecular:409.52Ref: TM-T22513
5mg48,00€10mg74,00€25mg135,00€50mg210,00€100mg313,00€200mg442,00€1mL*10mM (DMSO)56,00€Blarcamesine hydrochloride
CAS:Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).Fórmula:C19H24ClNOPureza:98.62% - 99.57%Cor e Forma:SolidPeso molecular:317.85Ref: TM-T4111
1mg46,00€2mg59,00€5mg93,00€10mg139,00€25mg255,00€50mg457,00€100mg655,00€500mg1.406,00€1mL*10mM (DMSO)97,00€
