Receptor Sigma
Os receptores sigma são sítios de ligação únicos que, ao contrário dos GPCRs tradicionais, não se enquadram nas categorias clássicas de proteínas receptoras. Eles estão envolvidos na modulação dos sistemas de neurotransmissores e têm sido implicados em vários distúrbios neurológicos e psiquiátricos. Os receptores sigma também estão associados à sobrevivência celular, e seus ligantes estão sendo explorados para aplicações terapêuticas em neuroproteção, câncer e manejo da dor. Na CymitQuimica, oferecemos uma seleção de moduladores de receptores sigma de alta qualidade para apoiar sua pesquisa em neurociência, oncologia e biologia de receptores.
Produtos da "Receptor Sigma"
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4-IBP
CAS:4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .Fórmula:C19H21IN2OPureza:98.99%Cor e Forma:SolidPeso molecular:420.29AD353
AD353 is a selective sigma-1 receptor ligand. It demonstrates high efficacy in models of capsaicin-induced allodynia and PGE2-induced mechanical hyperalgesia. Additionally, AD353 exhibits favorable pharmacokinetic properties.Fórmula:C23H30N2O2Cor e Forma:SolidPeso molecular:366.5Blonanserin
CAS:Blonanserin (AD-5423), approved in Japan (2008), is an atypical antipsychotic with fewer side effects like EPS, sedation, or hypotension.Fórmula:C23H30FN3Pureza:99.85%Cor e Forma:SolidPeso molecular:367.5BD 1008 dihydrobromide
CAS:BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.Fórmula:C15H24Br2Cl2N2Pureza:97.81%Cor e Forma:SolidPeso molecular:463.08Ref: TM-T21788
1mg65,00€5mg133,00€10mg202,00€25mg341,00€50mg507,00€100mg722,00€1mL*10mM (DMSO)157,00€BD-1047 dihydrobromide
CAS:BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacyFórmula:C13H22Br2Cl2N2Pureza:98.13% - 99.39%Cor e Forma:SolidPeso molecular:437.04Ref: TM-T1740
1mg37,00€2mg48,00€5mg73,00€10mg95,00€25mg168,00€50mg290,00€100mg490,00€1mL*10mM (DMSO)74,00€UMB24
CAS:UMB24 is an effective antagonist of the σ2 receptor, exhibiting dissociation constants (Ki values) of 170 nM for the σ2 receptor and 322 nM for the σ1 receptor. This compound mitigates cocaine-induced convulsions and hyperactivity without causing mortality.Fórmula:C17H21N3Cor e Forma:SolidPeso molecular:267.37EST64454 hydrochloride
CAS:EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.Fórmula:C18H23ClF2N4O2Pureza:99.15%Cor e Forma:SolidPeso molecular:400.85Ref: TM-T8834
2mg44,00€5mg65,00€10mg97,00€25mg197,00€50mg320,00€100mg509,00€200mg698,00€1mL*10mM (DMSO)81,00€S1R agonist 2
CAS:S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.Fórmula:C21H27NOPureza:99.04%Cor e Forma:SolidPeso molecular:309.45PRE-084 hydrochloride
CAS:PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).Fórmula:C19H28ClNO3Pureza:99.54%Cor e Forma:SolidPeso molecular:353.88Ref: TM-T3198L
5mg44,00€10mg65,00€25mg120,00€50mg207,00€100mg369,00€200mg565,00€1mL*10mM (DMSO)72,00€WLB-89462
CAS:WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-Fórmula:C21H29N5O3Pureza:98%Cor e Forma:SolidPeso molecular:399.49AB21 HCl
AB21 HCl: σ1 receptor antagonist, Ki 13 nM; less potent at σ2 (102 nM). Reduces mechanical hypersensitivity.Fórmula:C23H29ClN2OPureza:99.89%Cor e Forma:SolidPeso molecular:384.2Dimemorfan phosphate
CAS:Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.Fórmula:C18H25N·H3O4PPureza:99.65%Cor e Forma:SolidPeso molecular:353.4Sigma-2 Radioligand 2
CAS:Sigma-2 Radioligand 2 (compound 4) exhibits low nanomolar affinity for the σ2 receptor (Ki=2.30 nM) and high subtype selectivity (Ki(σ1)/Ki(σ2) > 1500).Fórmula:C23H28FN3O3Cor e Forma:SolidPeso molecular:413.49
